期刊
NEUROLOGIST
卷 16, 期 6, 页码 375-378出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/NRL.0b013e3181b126e3
关键词
autologous peripheral hematopoietic stem cell transplantation; neuromyelitis optics; therapy
资金
- Sun Yat-Sen University [2007027]
- Science and technology Project of Guangzhou [2060402]
- Science and technology Project of Guangdong Province [2006B36004003]
Autologous peripheral hematopoietic stem cell transplantation (APHSCT) was performed to treat a patient with neuromyelitis optica. We observed that the patient achieved clinical remission after APHSCT during 12 months of follow-up. The patient improved on the expanded disability status scale neurologic assessment and the Scripps neurologic rating scale worksheet scores on follow-up examination compared with baseline. The MRI abnormalities on T1WI and T2WI improved. The postpartum maternal blood helper T (CD3(+)CD4(+) T cell) and the CD4(+)/CD8(+) ratio were decreased, and the cytotoxic T (CD3(+)CD8(+) T) cell increased. This shows that APHSCT in this patient with neuromyelitis optica appears to reduce the frequency of attacks with improvement in disability. However, a larger study with more patients and a longer follow-up would be required to assess the encouraging preliminary results.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据