Article
Radiology, Nuclear Medicine & Medical Imaging
Xunrong Luo, Qingfa Ren, Mingfang Luo, Tianping Li, Yijie Lv, Yan Liu, Kang Rong, Wei Zhang, Xianglin Li
Summary: This study investigated changes in GluCEST value in the hippocampus of rats exposed to chronic unpredictable mild stress, and explored the impact of these changes on the activity of hippocampal glutamatergic neurons. The study found significant correlations between GluCEST values and ALFF as well as ReHo values. The GluCEST technique has the potential to map glutamate changes in rat depression and glutamate neurotransmitters are crucial in affecting abnormal neural activity.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Liang, Ling-Ling Wang, Xiao-Dong Jiang, Dong-Jian Chen, Tian-An Huang, Wen-Bin Ding
Summary: This study investigated changes in hippocampal structure and resting-state functional connectivity (FC) in patients with depression in Parkinson disease (DPD). The results showed that the volume of bilateral hippocampi in patients with DPD was significantly decreased and negatively correlated with the severity of depressive disorder. The weakened FC of the right hippocampus to the right occipital lobe and the left precuneus may play an important role in the neurological basis of DPD.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Psychiatry
Krzysztof Gbyl, Mette Marie Stottrup, Jayachandra Mitta Raghava, Song Xue Jie, Poul Videbech
Summary: Temporary increases in hippocampal subregions volume induced by ECT within patients are associated with memory impairment. Hippocampal alterations following ECT should be a focus in investigating the causes of cognitive side effects.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Article
Neurosciences
Ranchao Wang, Yu Shen, Guohai Li, Rui Du, Aiqin Peng
Summary: This study established a predictive model for treatment response in depression based on short-term changes in hippocampal metabolites and validated its accuracy using a separate dataset.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Soichiro Tatsuo, Keita Watanabe, Satoru Ide, Fumiyasu Tsushima, Sayuri Tatsuo, Masashi Matsuzaka, Hiroshi Murakami, Mizuri Ishida, Takuro Iwane, Makoto Daimon, Hiraku Yodono, Shigeyuki Nakaji, Shingo Kakeda
Summary: Using MRI, this study found that individuals with prediabetes have lower gray matter volume compared to those with normal glucose metabolism. This suggests that abnormal blood sugar levels may have detrimental effects on brain health.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Hossein Sanjari Moghaddam, Mohammad Hadi Aarabi, Jafar Mehvari-Habibabadi, Roya Sharifpour, Bahram Mohajer, Neda Mohammadi-Mobarakeh, Seyed Sohrab Hashemi-Fesharaki, Kost Elisevich, Mohammad-Reza Nazem-Zadeh
Summary: The study demonstrates distinct patterns of hippocampal subfield atrophy in patients with left and right mesial temporal lobe epilepsy (mTLE), suggesting that the pathophysiology of epileptogenesis in left and right mTLE may be different.
NEUROLOGICAL SCIENCES
(2021)
Article
Psychiatry
Jiye Lee, Nambeom Kim, Hyunwoo Jeong, Jin Yong Jun, So Young Yoo, So Hee Lee, Jooyoung Lee, Yu Jin Lee, Seog Ju Kim
Summary: This study investigated differences in thalamic nuclei gray matter volume between North Korean refugees and South Korean residents, as well as the association with psychological symptoms. The results showed that the refugees had larger gray matter volumes in specific thalamic nuclei, which were correlated with fewer depressive symptoms.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Margarita Bronshteyn, Fan Nils Yang, Kyle F. Shattuck, Matthew Dawson, Princy Kumar, David J. Moore, Ronald J. Ellis, Xiong Jiang
Summary: Depressive symptoms are associated with smaller hippocampal volume in PWH, while low CD4 nadir predicts additional hippocampal volume reduction. Antidepressants do not appear to have a detectable effect on hippocampal volume in this population.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Sneha Chenji, Emily Cox, Natalia Jaworska, Rose M. Swansburg, Frank P. MacMaster
Summary: The study explored the relationship between body mass index (BMI) and hippocampal volume in youth with major depressive disorder (MDD). Results showed a reduction in right hippocampal volume in MDD youth with normal BMI, and a negative association between left hippocampal volume and BMI in MDD youth with high BMI. The findings suggest that BMI may play a role in the variability of hippocampal volume in MDD, highlighting the importance of considering BMI effects in future analyses.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Maho Ishikawa, Reika Sawaya, Miki Hirayama, Junpei Ueda, Shigeyoshi Saito
Summary: Pelizaeus-Merzbacher disease (PMD) is an X-linked recessive disorder of the central nervous system. Using magnetic resonance imaging and proton magnetic resonance spectroscopy, abnormalities in the brain white matter structure and metabolism were observed in Tama rats, a rodent PMD model, which are similar to findings in PMD patients and other animal models.
Article
Clinical Neurology
Samantha Hubachek, Morgan Botdorf, Tracy Riggins, Hoi-Chung Leong, Daniel N. Klein, Lea R. Dougherty
Summary: The study found associations between maternal depression and changes in hippocampal volumes in preadolescent offspring, including reduced bilateral head volumes and increased left body volume. Increased depressive symptoms in offspring were associated with reduced bilateral head volumes. The results suggest reductions in hippocampal head volume play an important role in intergenerational risk transmission.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Hongqi Xiao, Minlan Yuan, Hailong Li, Shiyi Li, Yang Du, Mei Wang, Hongru Zhu, Wei Zhang, Changjian Qiu, Xiaoqi Huang
Summary: The study demonstrates that the functional connectivity of the left hippocampus can predict early efficacy of antidepressants. The ROC curve analysis shows that the FC measures between the left hippocampus and the left inferior frontal gyrus and precuneus are crucial for differentiating early improved and non-improved depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Neurosciences
Tom Willems, Katharina Henke
Summary: Research on the physical traces of memories (engrams) has advanced significantly in the past decade, especially in rodents with the use of optogenetics and fluorescent cell tagging. Human engram research lags behind rodent research, but advances in multivariate analysis techniques and machine learning algorithms are allowing for the identification of engram patterns in humans. MRI scanners with an ultrahigh field strength of 7 Tesla are becoming more common worldwide, pushing the field of human engram research.
Review
Neurosciences
Antonio Del Casale, Stefano Ferracuti, Andrea Steven Barbetti, Paride Bargagna, Paolo Zega, Alessia Iannuccelli, Federico Caggese, Teodolinda Zoppi, Gabriele Pasquale De Luca, Giovanna Parmigiani, Isabella Berardelli, Maurizio Pompili
Summary: In this meta-analysis, researchers investigated the grey matter changes in patients with posttraumatic stress disorder (PTSD) compared to trauma-exposed individuals without clinical PTSD. The results showed a significant reduction in grey matter volume in a large left-sided cluster extending from the parahippocampal gyrus to the uncus, including the amygdala, in PTSD patients. These findings suggest that these volumetric reductions may be a major structural correlate of PTSD and contribute to symptom expression.
NEUROPSYCHOBIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander J. Ryu, Vinayak Kumar, Barry A. Borlaug, Armando Manduca, Chaitanya K. Rao, Raymond J. Gibbons, Samuel J. Asirvatham, Bernard J. Gersh, Krishnaswamy Chandrasekaran, Philip A. Araoz, Jae K. Oh, Alexander C. Egbe, Atta Behfar, Nandan S. Anavekar
Summary: The study investigated the ratio of myocardial volume in systole to myocardial volume in diastole (MVs/MVd) to differentiate between normal hearts and various cardiomyopathies with normal ejection fractions.
Results showed significant differences in MVs/MVd ratio between pathological subgroups and normal subjects, suggesting its potential as a novel and easily-captured metric for assessing ventricular function.
The study concluded that MVs/MVd ratio can effectively distinguish normal ventricular function from different cardiomyopathies, indicating its clinical utility in assessing heart disease.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Neurosciences
Yifeng Luo, Zhihong Cao, Yu Liu, Liwei Wu, Hairong Shan, Yiwen Liu, Tieliang Ma, Xuee Zhu, Dan Zhou, Binghu Jiang, Jichen Wang
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2016)
Article
Clinical Neurology
Yifeng Luo, Hairong Shan, Yu Liu, Liwei Wu, Xiaojie Zhang, Tieliang Ma, Wenjiao Zhu, Yue Yang, Jichen Wang, Zhihong Cao
JOURNAL OF AFFECTIVE DISORDERS
(2016)
Article
Clinical Neurology
Yifeng Luo, Yu Liu, Yaxin Qin, Xiaojie Zhang, Tieliang Ma, Wenbo Wu, Yue Yang, Di Jiang, Hairong Shan, Zhihong Cao
NEUROLOGICAL SCIENCES
(2017)
Article
Clinical Neurology
Yifei Weng, Rongfeng Qi, Li Zhang, Yifeng Luo, Jun Ke, Qiang Xu, Yuan Zhong, Jianjun Li, Feng Chen, Zhihong Cao, Guangming Lu
NEUROLOGICAL SCIENCES
(2019)
Article
Clinical Neurology
Yifeng Luo, Rongfeng Qi, Li Zhang, Zhao Qing, Yifei Weng, Wenyun Wang, Xiaojie Zhang, Hairong Shan, Lingjiang Li, Zhihong Cao, Guangming Lu
JOURNAL OF AFFECTIVE DISORDERS
(2019)
Article
Psychology, Clinical
Rongfeng Qi, Yifeng Luo, Li Zhang, Yifei Weng, Wesley Surento, Qiang Xu, Neda Jahanshad, Lingjiang Li, Zhihong Cao, Guang Ming Lu, Paul M. Thompson
Summary: Adults who have lost their only child may experience disrupted hippocampal network connectivity and NR3C1 gene methylation status, regardless of whether they have developed PTSD.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Rongfeng Qi, Yifeng Luo, Li Zhang, Yifei Weng, Wesley Surento, Lingjiang Li, Zhihong Cao, Guang Ming Lu
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Psychiatry
Rongfeng Qi, Yifeng Luo, Li Zhang, Yifei Weng, Wesley Surento, Neda Jahanshad, Qiang Xu, Yan Yin, Lingjiang Li, Zhihong Cao, Paul M. Thompson, Guang Ming Lu
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Neurosciences
Yifeng Luo, Yu Liu, Zhao Qing, Li Zhang, Yifei Weng, Xiaojie Zhang, Hairong Shan, Lingjiang Li, Rongfeng Qi, Zhihong Cao, Guangming Lu
Summary: This study found that wives without PTSD who lost their only child had worse re-experiencing symptoms compared to their husbands, which was associated with alterations in functional connectivity between the hippocampal subregions and the thalamus. Among sexes, only female subjects showed marked differences in functional connectivity in certain brain regions.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Rongfeng Qi, Zhihong Cao, Wesley Surento, Li Zhang, Lianli Qiu, Zhuoman Xia, Christopher R. K. Ching, Qiang Xu, Yan Yin, Long Jiang Zhang, Lingjiang Li, Yifeng Luo, Guang Ming Lu
Summary: This study found an interaction effect between RORA gene and PTSD symptom severity on the thickness of the transverse temporal gyrus in adults who lost their only child. The T/T genotype was positively associated with bilateral transverse temporal gyrus thickness, while the G/T genotype was negatively associated with left transverse temporal gyrus thickness. No significant effects were found in any subcortical regions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Rongfeng Qi, Yifeng Luo, Li Zhang, Yifei Weng, Wesley Surento, Neda Jahanshad, Qiang Xu, Yan Yin, Lingjiang Li, Zhihong Cao, Paul M. Thompson, Guang Ming Lu
NEUROBIOLOGY OF STRESS
(2020)