Article
Infectious Diseases
Yogesh Dutt, Ramendra Pati Pandey, Mamta Dutt, Archana Gupta, Arpana Vibhuti, V. Samuel Raj, Chung-Ming Chang, Anjali Priyadarshini
Summary: Silver nanoparticles (AgNPs) have opened up new possibilities in nanobiotechnology due to their large surface area-to-volume ratios and small size. The phytofabrication of AgNPs using plant extracts is a cost-effective and environmentally friendly method with various catalytic activities. The medicinal plant Azadirachta indica possesses phytochemicals that contribute to the pharmaceutical and biological activities of AgNPs. AgNPs have potential applications in drug delivery, bioimaging, cancer treatment, and cell biology.
Article
Microbiology
Gandhimathi Chinnasamy, Smitha Chandrasekharan, Tong Wey Koh, Somika Bhatnagar
Summary: The study presented a green synthesis route to produce AI-AgNPs with enhanced antibacterial and free-radical scavenging efficacy. The biocompatibility and antibacterial properties of AI-AgNPs were confirmed through various experiments, highlighting their potential use in wound healing applications.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Amina M. Haroun, Wael M. El-Sayed, Rasha E. Hassan
Summary: This study investigated the detrimental effects of CuO NPs on hepatic and serum biochemical parameters in mice, as well as the potential ameliorative effects of quercetin and l-arginine. The results demonstrated that CuO NPs induced liver injury through copper accumulation, oxidative stress, inflammation, and apoptosis. However, treatment with quercetin and l-arginine mitigated these effects by acting as antioxidants, anti-inflammatory agents, and metal chelators.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Plant Sciences
Cinthia I. Landa-Moreno, Cristian M. Trejo-Hurtado, Jenaro Lemus-de la Cruz, Donovan J. Pena-Montes, Marina Murillo-Villicana, Maribel Huerta-Cervantes, Rocio Montoya-Perez, Rafael Salgado-Garciglia, Salvador Manzo-Avalos, Christian Cortes-Rojo, Juan Luis Monribot-Villanueva, Jose Antonio Guerrero-Analco, Alfredo Saavedra-Molina
Summary: The ethyl acetate extract of Potentilla indica has antioxidant effects and can improve kidney function in streptozotocin-induced diabetic male rats.
Review
Pharmacology & Pharmacy
Shashank M. Patil, Prithvi S. Shirahatti, Ramith Ramu
Summary: The research provides a critical review on the pharmacological activities and phytochemistry of Azadirachta indica related to diabetes management, showing its potential as an antidiabetic herbal medicine. However, gaps in research indicate a need for further systematic evaluation.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Plant Sciences
Mohammad Hamidian, Mohsen Movahhedi Dehnavi, Ghazaleh Mirzaei, Fatemeh Aghaei
Summary: Jasmonates play a crucial role in improving plant growth and physiology under stress conditions. The application of methyl jasmonate (MeJ) under drought stress, along with the presence of mycorrhizal symbiosis, can enhance plant growth and fortify antioxidant defense. However, caution should be exercised as MeJ may cause damage to chlorophyll under non-stress conditions. The combination of MeJ and mycorrhizal symbiosis shows potential in reducing MeJ-induced damage and promoting plant growth under both stress and non-stress conditions.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Review
Pharmacology & Pharmacy
Marina R. Wylie, D. Scott Merrell
Summary: Azadirachta indica, or neem tree, has been traditionally used to treat human ailments and is recognized for its broad-spectrum antimicrobial activities. Recent studies suggest that neem may serve as an untapped source of novel therapeutics, particularly in addressing drug-resistant pathogens and biofilm-forming organisms. Further research is needed to explore the specific mechanisms of action, clinical efficacy, and safety of neem as a potential treatment for human pathogens.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jayantee Kalita, Ruchi Shukla, Prakash C. Pandey, Usha K. Misra
Summary: This study indicates that there is an up-regulation of death signals and suppression of survival signals in patients with tuberculous meningitis.
Article
Biochemistry & Molecular Biology
Vlad Dionisie, Adela Magdalena Ciobanu, Vlad Alexandru Toma, Mihnea Costin Manea, Ioana Baldea, Diana Olteanu, Alexandra Sevastre-Berghian, Simona Clichici, Mirela Manea, Sorin Riga, Gabriela Adriana Filip
Summary: The study showed that escitalopram improves sucrose preference, locomotion, and anxiety in depressed rats induced by chronic unpredictable mild stress. It also reduces oxidative damage, improves antioxidant defense, and modulates BDNF, MeCP2, and oligodendrocytes in the brain, suggesting intricate mechanisms of its antidepressant effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wagner Antonio Tamagno, Carla Alves, Diego Tessaro, Nathalia Tafarel Sutorillo, Wallace Santin, Leonardo Jose Gil Barcellos
Summary: This study evaluated the antioxidant potential of micro-encapsulated extract of I. paraguariensis (MEIP) supplemented with Deferoxamine (Dfx) on zebrafish behavior and biochemical biomarkers. The results showed that MEIP exhibited anxiolytic-like behavior, while Dfx alone showed an anxiogenic-like pattern. When MEIP and Dfx were applied together, the antioxidant enzyme function was close to the control group, and the cholinergic system was activated, while the formation of heme radical group was unaffected by Dfx.
Article
Multidisciplinary Sciences
Nabil Mohamed Selim, Mina Michael Melk, Farouk Rasmy Melek, Dalia Osama Saleh, Mansour Sobeh, Seham S. El-Hawary
Summary: This study investigated the chemical composition and hepatoprotective activities of Plumbago indica and P. auriculata. Results showed that both extracts had significant hepatoprotective effects in rats, reducing liver damage and fibrosis. The extract of P. indica exhibited better hepatoprotective activity. However, further research is needed to isolate the compounds, assess toxicity, and explore the mechanism of action.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Esmaeel Kaboosi, Akbar Rahimi, Mohammad Abdoli, Mehdi Ghabooli
Summary: The present study compared the effects of S. indica and effective microorganisms (EM) on maize plants under drought stress. The results showed that drought stress decreased biomass, photosynthetic pigments, nutrient concentration, and yield, while increasing antioxidant activities, malondialdehyde, carbohydrates, and proline content. Plants treated with S. indica and EM showed enhanced biomass and yield, as well as increased photosynthetic pigments, carbohydrates, protein, proline, potassium, phosphorous, and antioxidant enzymes. Encapsulated spores had similar positive effects as mycelium and EM. Overall, these findings suggest that the application of S. indica inoculums, including encapsulated spores, can help alleviate the adverse effects of drought stress.
JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Raghul Murugan, Ravi Rajesh, Ajay Guru, B. Haridevamuthu, Bader O. Almutairi, Mikhlid H. Almutairi, Annie Juliet, S. Renganayagi, Pushparathinam Gopinath, Jesu Arockiaraj
Summary: NF2, a semi-natural compound, has a protective effect in zebrafish larvae by reducing ROS production and inflammatory response.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Sineenart Sanpinit, Palika Wetchakul, Piriya Chonsut, Nuntika Prommee, Chuchard Punsawad, Jaehong Han, Soiphet Net-anong
Summary: This study evaluated the antioxidant activities, cytotoxicity, and chemical constituents of Tri-Yannarose and its plant ingredients. The LC-QTOF-MS analysis revealed trigonelline, succinic acid, citric acid, and other chemical constituents. The extracts showed significant scavenging effects against ABTS and DPPH radicals with low toxicity according to the MTT assay. The SAR analysis indicated prenyl arabinosyl-(1-6)-glucoside and quinic acid as the primary antioxidant compounds in the extract.
Article
Chemistry, Inorganic & Nuclear
V. Gopalakrishnan, R. Singaravelan
Summary: This study describes the biosynthesis of gold nanoparticles using neem blossom extract, resulting in enhanced in vitro anti-diabetic and antioxidant properties. The formation and characteristics of the nanoparticles were confirmed using various methods, such as surface plasmon resonance and Fourier-transform infrared spectroscopy. The particles showed crystalline nature and demonstrated high antioxidant efficiency and enzyme inhibition in assays. The nanoparticles also exhibited exceptional microbicidal efficacy against both gram-positive and gram-negative bacteria, suggesting their potential for biomedical applications.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Oncology
Muneeb U. Rehman, Andleeb Khan, Zuha Imtiyaz, Shafat Ali, Hafiz Antar Makeen, Summya Rashid, Azher Arafah
Summary: Cancer is a major cause of death worldwide, and nanomedicine has the potential to revolutionize cancer treatment. Nanotechnology allows for the development of specific drugs that target cancer cells and increase drug bioavailability. This review article discusses the advances in nanomedicine and the current clinical status of various nanomedicines, as well as their mechanisms of action.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aashiq Hussain Bhat, Khalid Bashir Dar, Andleeb Khan, Saeed Alshahrani, Sultan M. Alshehri, Mohammed M. Ghoneim, Prawez Alam, Faiyaz Shakeel
Summary: D609 is a compound known for its diverse pharmacological properties, including antioxidant, antiapoptotic, anti-inflammatory, and anti-tumor activities. Its mechanism of action involves the inhibition of PCPLC and SMS enzymes, leading to the regulation of cell cycle and proliferation, as well as reduction of inflammation and toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sidharth Mehan, Navneet Arora, Sonalika Bhalla, Andleeb Khan, Muneeb U. Rehman, Badrah S. Alghamdi, Torki Al Zughaibi, Ghulam Md Ashraf
Summary: Brain tumours pose challenges in terms of prognosis and survival rate. Investigating the efficacy of phytochemicals and utilizing nanotechnology may offer potential solutions for the treatment of brain tumours.
Review
Biochemistry & Molecular Biology
Andleeb Khan, Sivakumar Sivagurunathan Moni, M. Ali, Syam Mohan, Huma Jan, Saiema Rasool, Mohammad A. Kamal, Saeed Alshahrani, Maryam Halawi, Hassan A. Alhazmi
Summary: Fungal infections are on the rise worldwide, particularly in immunocompromised individuals. Candida spp. is the most common disease-causing fungus, causing various infections. Understanding the morphological and developmental pathways of Candida is crucial for developing new antifungal drugs. Conventional antifungal drugs have developed resistance, necessitating the exploration of new sources such as phytochemicals and their secondary metabolites.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jorge Alberto Aguilar-Pineda, Silvana G. Paco-Coralla, Camilo Febres-Molina, Pamela L. Gamero-Begazo, Pallavi Shrivastava, Karin J. Vera-Lopez, Gonzalo Davila-Del-Carpio, Patricia Lopez-C, Badhin Gomez, Christian L. Lino Cardenas
Summary: This study investigates the molecular properties of the ApoE4-Aβ interactions and the binding affinity of enoxaparin on the ApoE4 binding sites using molecular dynamics simulations, molecular docking, and binding free energy calculations. The results reveal that the closed form of the ApoE4 protein remains stabilized by hydrogen bonds under different pH conditions, allowing the generation of energetically favorable ApoE4-Aβ interaction sites. Enoxaparin shows strong energetic affinity for these sites and can disrupt ApoE4-Aβ complex formation.
Review
Biotechnology & Applied Microbiology
Mashooq Ahmad Dar, Azher Arafah, Kaisar Ahmad Bhat, Andleeb Khan, Mosin Saleem Khan, Aarif Ali, Syed Mudasir Ahmad, Shahzada Mudasir Rashid, Muneeb U. Rehman
Summary: The publication of the full human genome has revolutionized medical research and paved the way for the use of multi-omics technologies in diagnosing, managing, and discovering novel disease biomarkers.
BRIEFINGS IN FUNCTIONAL GENOMICS
(2023)
Review
Biochemistry & Molecular Biology
Liam Goldman, Ehraz Mehmood Siddiqui, Andleeb Khan, Sadaf Jahan, Muneeb U. Rehman, Sidharth Mehan, Rajat Sharma, Stepan Budkin, Shashi Nandar Kumar, Ankita Sahu, Manish Kumar, Kumar Vaibhav
Summary: Acquired Brain Injury (ABI) refers to any type of brain injury that occurs after birth and is not caused by congenital disorders, degenerative diseases, or brain trauma at birth. Despite the protection provided by layers of tissue and bone, the brain remains vulnerable to harm and impairment. ABI can lead to changes in the normal activity and structure of neuronal tissue in one or multiple areas of the brain, thereby affecting normal brain functions. The duration of impairment varies depending on the severity of the injury, and patients may face difficulties reintegrating into the community due to potential psychological and physiological outcomes.
Article
Chemistry, Medicinal
Mohd Kamil Hussain, Shaista Ahmed, Andleeb Khan, Arif Jamal Siddiqui, Shahnaaz Khatoon, Sadaf Jahan
Summary: Mucormycosis is a fungal infection that worsens over time if left undiagnosed and untreated. It is specifically associated with the current COVID-19 pandemic. Immuno-compromised patients are particularly vulnerable to both COVID-19 and mucormycosis. Risk factors for this infection include diabetes, corticosteroid medicines, and a weakened immune system. Treatments for mucormycosis are available but less effective, so researchers are focusing on promising agents such as liposomal amphotericin B, manogepix, echino-candins, isavuconazole, and posacanazole.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Pradip K. Kamat, Mohammad Badruzzaman Khan, Cameron Smith, Shahneela Siddiqui, Babak Baban, Krishnan Dhandapani, David C. Hess
Summary: The circadian system, controlled by clock genes, plays an important role in stroke outcomes. The circadian clock is present in the brain's suprachiasmatic nucleus and operates through molecular circadian clocks in neurons and other brain cells. Variations in the circadian cycle and clock genes can affect stroke occurrence and severity, with peak stroke occurring in the morning and worsening outcomes at midnight. Sleep blood pressure, influenced by the circadian rhythm, is a primary determinant of stroke risk.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Clinical Neurology
Andreia Morais, Joseph J. J. Locascio, Lauren H. H. Sansing, Jessica Lamb, Karisma Nagarkatti, Takahiko Imai, Klaus van Leyen, Jaroslaw Aronowski, James I. I. Koenig, Francesca Bosetti, Patrick Lyden, Cenk Ayata, SPAN Investigators
Summary: The Stroke Preclinical Assessment Network (SPAN) is a multicenter preclinical trial platform that uses rodent models of transient focal cerebral ischemia to address translational failure in experimental stroke. In this study, we report the heterogeneity introduced by allowing variations in biological and experimental model variables among the 6 SPAN laboratories and its impact on middle cerebral artery occlusion (MCAo) performance.
Article
Clinical Neurology
Mohammad Badruzzaman Khan, Haroon Alam, Shahneela Siddiqui, Muhammad Fasih Shaikh, Abhinav Sharma, Amna Rehman, Babak Baban, Ali S. Arbab, David C. Hess
Summary: Vascular cognitive impairment and dementia (VCID) is a growing threat to public health with no known treatment. This study examined the effect of physical exercise (EXR) in a mouse model of chronic cerebral hypoperfusion (CCH) induced by bilateral common carotid artery stenosis (BCAS). The results showed that EXR therapy improved cerebral blood flow (CBF), cognitive function, and reduced white matter damage in the BCAS model.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Neurosciences
Meenakshi Ahluwalia, Hannah Mcmichael, Manish Kumar, Mario P. Espinosa, Asamoah Bosomtwi, Yujiao Lu, Hesam Khodadadi, Abbas Jarrahi, Mohammad Badruzzaman Khan, David C. Hess, Scott Y. Rahimi, John R. Vender, Fernando L. Vale, Molly Braun, Babak Baban, Krishnan M. Dhandapani, Kumar Vaibhav
Summary: In this study, the authors found that traumatic brain injury leads to a loss of endocannabinoids, exacerbating neurovascular injury, compromising brain-cerebrospinal fluid barriers, and causing behavioral dysfunction. They also observed increased expression of endocannabinoid-metabolizing enzymes and CB2 receptors, as well as a reduction in cerebral blood flow in post-TBI mice. These findings highlight the importance of endocannabinoids in maintaining brain and brain-cerebrospinal fluid barrier integrity.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Cell Biology
Bharati Mendhe, Mohammad B. Khan, Damon Dunwody, Khairat Bahgat Youssef El Baradie, Kathryn Smith, Wenbo Zhi, Ashok Sharma, Tae Jin Lee, Mark W. Hamrick
Summary: Ischemia-reperfusion (I/R) injury is a common complication affecting multiple organs and tissues. Extracellular vesicles (EVs) derived from adipose stem cells may be a potential therapeutic resource for preventing tissue damage associated with I/R injury. However, while EVs may enhance reperfusion, they can also negatively impact muscle tissue and possibly remote organs. Alternative approaches, such as targeting mitochondrial permeability, may be more effective at mitigating I/R injury.
Review
Clinical Neurology
Sidharth Mehan, Sonalika Bhalla, Ehraz Mehmood Siddiqui, Nidhi Sharma, Ambika Shandilya, Andleeb Khan
Summary: Dementia is a chronic condition characterized by memory loss, cognitive decline, and mental instability. Insulin dysfunction and abnormal protein deposition are closely related to the development of neurological diseases, including dementia. GLP-1 receptor agonists have shown potential as a therapeutic target for dementia, as they reduce oxidative stress, cytokine production, and abnormal protein deposition.
DEGENERATIVE NEUROLOGICAL AND NEUROMUSCULAR DISEASE
(2022)
Article
Toxicology
Rajeshwar Kumar Yadav, Sidharth Mehan, Rakesh Sahu, Sumit Kumar, Andleeb Khan, Hafiz Antar Makeen, Mohammed Al Bratty
Summary: This study demonstrates that APG, as a c-JNK and p38MAPK signaling inhibitor, possesses neuroprotective effects against MeHg-induced neurotoxicity. It improves neurobehavioral parameters and reduces neuroinflammation and oxidative damage.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2022)
