Review
Pharmacology & Pharmacy
Purumea Jun, HuiYan Zhao, In Chul Jung, Ojin Kwon, Chang-Hyun Han, Jiyoon Won, Jung-Hee Jang
Summary: This study aimed to evaluate the efficacy of herbal medicine prescribed according to the syndrome differentiation (SD) approach in Parkinson's disease (PD) treatment. The findings suggest that combined treatment of herbal medicine and western medicine significantly improves the overall assessment of PD symptoms and is more beneficial for non-motor symptoms. However, the methodological quality of the included studies needs improvement.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yi Zhang, Xiaoman Xu
Summary: Depression is a common non-motor symptom in patients with Parkinson's disease, which affects their disability rate and quality of life. Traditional anti-PD drug therapy is not ideal for treating depression in PD, but Chinese Herbal Medicine prescriptions may have multi-target effects and improve depressive symptoms through multiple mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Giuseppe Chiarioni, Stefan Lucian Popa, Abdulrahman Ismaiel, Cristina Pop, Dinu Iuliu Dumitrascu, Vlad Dumitru Brata, Traian Adrian Duse, Victor Incze, Teodora Surdea-Blaga, Jose Antonio Uranga
Summary: This systematic review evaluates the efficacy and safety of herbal remedies in the management of IBS-C. The included studies demonstrate some evidence of the beneficial effects of herbal remedies on IBS-C symptoms. However, the heterogeneity of the interventions and outcome measures limits the ability to perform a meta-analysis.
Article
Pharmacology & Pharmacy
Chien-Hung Lin, Hsienhsueh Elley Chiu, Szu-Ying Wu, Shih-Ting Tseng, Tzu-Chan Wu, Yu-Chiang Hung, Chung Y. Hsu, Hsuan-Ju Chen, Sheng-Feng Hsu, Chun-En Kuo, Wen-Long Hu
Summary: The study focused on the use of Chinese herbal products (CHPs) for Parkinson's disease (PD) in Taiwan, with Chaihu-Jia-Longgu-Muli-Tang and Uncaria tomentosa (Willd. ex Schult.) DC. being the most commonly used CHPs. These herbs have shown neuroprotective effects and are often used to manage non-motor symptoms of PD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Yuqing Hu, Sichun Gu, Xiaolei Yuan, Hui Li, Canxing Yuan, Qing Ye
Summary: This study aims to evaluate the therapeutic effect of treating Parkinson's disease at different stages using traditional Chinese medicine and to provide evidence for the development of a standardized scheme of diagnosis and treatment.
Review
Medicine, General & Internal
Chul Jin, Bo-Hyoung Jang, Jin Pyeong Jeon, Ye-Seul Lee, Seung-Bo Yang, Seungwon Kwon
Summary: This study aims to evaluate the efficacy and safety of traditional East Asian herbal medicines for post-stroke constipation, providing high-quality evidence for better treatment options for patients.
Article
Integrative & Complementary Medicine
Sam Chun Sum Yuen, Ka Kit Chua, Linda L. D. Zhong, Kam Wa Chan, Conrad Kwan Ho Chan, Kam Leung Chan, Zhixiu Lin, Vincent Mok, Alexander Y. Lau, Min Li
Summary: This trial aims to assess the effect of Chinese herbal medicine (CHM) on Parkinson's disease (PD) symptoms and patients' quality of life, and evaluate the feasibility of the trial design. The trial will last for 32 weeks and use a pragmatic design with subgroup differentiation. The expected outcomes include preliminary data on the effect of CHM and optimization of future large-scale clinical studies.
Review
Medicine, General & Internal
Casper Skjaerbaek, Karoline Knudsen, Jacob Horsager, Per Borghammer
Summary: Parkinson's disease is the second most common neurodegenerative disease characterized by pathological alpha-synuclein deposits in both the brain and the entire digestive tract. Gastrointestinal symptoms such as dysphagia, bloating, and constipation are common in PD patients. The accumulation of gastrointestinal pathology may begin years before a clinical diagnosis of PD, with constipation shown to increase the risk of PD and truncal vagotomy potentially decreasing the risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Neurosciences
Sang-Min Park, Seung Hyun Lee, HuiYan Zhao, Jeongtae Kim, Jae Young Jang, Yujin Choi, Soyeon Jeong, Soyeong Son, Kyungsook Jung, Jung-Hee Jang
Summary: Alzheimer's disease is a neurodegenerative disease characterized by the deposition of amyloid-beta peptide and neurofibrillary tangles in the brain. The current drugs for Alzheimer's disease have limitations, and the development of drugs targeting amyloid-beta clearance has been unsuccessful. Therefore, a multi-target strategy that considers the modulation of the peripheral system is needed for the diagnosis and treatment of Alzheimer's disease. Traditional herbal medicine based on syndrome differentiation may be beneficial for Alzheimer's disease. This literature review investigates the effectiveness of herbal medicine therapy based on syndrome differentiation and explores interdisciplinary biomarkers and the mechanism of action of herbal medicine in Alzheimer's disease.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Xiao-yi Kuai, Xiao-han Yao, Li-juan Xu, Yu-qing Zhou, Li-ping Zhang, Yi Liu, Shao-fang Pei, Chun-li Zhou
Summary: The study showed that fecal microbiota transplantation (FMT) is effective in improving gastrointestinal dysfunction in Parkinson's disease patients, significantly reducing both motor and non-motor symptoms, regulating the gut microbiota structure, restoring intestinal bacterial overgrowth, and improving constipation symptoms.
MICROBIAL CELL FACTORIES
(2021)
Review
Nutrition & Dietetics
Ji Hee Jun, Tae Young Choi, Hye Won Lee, Lin Ang, Myeong Soo Lee
Summary: RCT studies on herbal medicine decoctions for treating Behcet's disease showed significant effects on the total response rate and erythrocyte sedimentation rate, but not on C-reactive protein level. Herbal medicine also significantly decreased the recurrence rate after three months of follow-up.
Review
Plant Sciences
Mingxiao Yang, Ye Feng, Yi Lily Zhang, Colleen M. Smith, Yen-Nien Hou, Hui Wang, Gary Deng, Jun J. Mao
Summary: This study evaluated the efficacy of herbal formula MaZiRenWan (Hemp Seed Pill, HSP) in Asian patients with functional constipation, showing significant improvements in complete response rate and complete spontaneous bowel movements without increasing adverse events.
Review
Pharmacology & Pharmacy
Hyejin Jun, Seok-Jae Ko, Keumji Kim, Jinsung Kim, Jae-Woo Park
Summary: This study assessed the methodology and quality of evidence of systematic reviews (SRs) on the use of herbal medicines (HMs) for irritable bowel syndrome (IBS). The findings suggest that HM can be considered as an effective and safe treatment for IBS. However, the methodological quality of the included SRs and the quality of evidence were generally low. Well-designed randomized controlled trials are needed to better evaluate the safety and efficacy of HM in IBS treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Psychiatry
Wen-Wang Rao, Juan-Juan Yang, Han Qi, Sha Sha, Wei Zheng, Ling Zhang, Gabor S. Ungvari, Chee H. Ng, Yu-Tao Xiang
Summary: The study concluded that traditional Chinese herbal medicine (TCM) was more effective in treating antipsychotic-related constipation compared to Western medicine (WM) with fewer side effects, such as rash.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
Qing Li, Changying Xing, Yanggang Yuan
Summary: Chronic kidney disease is a global public health issue, and patients often seek traditional Chinese medicine as an alternative treatment option. Mitochondrial dysfunction plays a crucial role in CKD, and herbal medicine can alleviate renal injury by restoring mitochondrial function.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Urology & Nephrology
Ryuji Sakakibara
INTERNATIONAL JOURNAL OF UROLOGY
(2021)
Review
Clinical Neurology
Ryuji Sakakibara
Summary: This article provides an overview of gastrointestinal tract dysfunction in patients with Parkinson's disease and other movement disorders, including clinical presentation, investigations, and treatment options. Bowel dysfunction is common in these patients and may present as constipation, fecal incontinence, and GI emergencies such as intestinal pseudo-obstruction and volvulus. Management options include bulking agents, softening agents, probiotics, and specialized procedures like botulinum toxin injections.
NEUROLOGICAL SCIENCES
(2021)
Article
Urology & Nephrology
Yuuka Sugizaki, Ryuji Sakakibara, Fuyuki Tateno, Tsuyoshi Ogata, Yosuke Aiba, Hiroyoshi Suzuki, Masashi Yano
Summary: This study analyzed 141 cases of older adults with LUTS, finding that both urologic and neurologic etiologies were common, as well as a combination of both; triple-disease etiology was most common in octogenarians and increased with age, though the differences were not significant.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Clinical Neurology
Fuyuki Tateno, Ryuji Sakakibara, Yosuke Aiba, Koichi Nakagawa, Yoshiya Sugiura, Nobuyuki Hiruta
Summary: An older woman developed severe neuropathy and mild encephalopathy after experiencing long-lasting systemic inflammation in a non-ICU hospital ward. Electrophysiology and autopsy findings confirmed the diagnosis of critical illness polyneuropathy, with presumed Wallerian degeneration in the spinal dorsal column.
NEUROLOGY AND CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Ryuji Sakakibara, Ayako Iimura, Tsuyoshi Ogata, Keiichiro Terayama, Shuichi Katsuragawa, Takaaki Nagao, Keiko Suzuki, Kaori Izawa, Kiwa Nakajima, Shinichi Haruki, Nobuyuki Okada, Setsu Sawai, Fuyuki Tateno, Yosuke Aiba, Masaaki Nemoto
Summary: The study analyzed cases of patients with aspiration pneumonia (AP), finding that they were generally older in age, predominantly male, and exhibited age-related brain diseases with gait and attention/cognitive issues. The ratio of neural disorders to organic disorders was approximately 1:30.
NEUROLOGY AND CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Ryuji Sakakibara, Fuyuki Tateno, Yosuke Aiba, Setsu Sawai, Tsuyoshi Ogata, Hitoshi Terada, Tsutomu Inaoka, Tomoya Nakatsuka, Shuichi Katsuragawa
Summary: This study investigated the clinical manifestations of Lewy body diseases (LBDs) and white matter diseases (WMD) through neuroimaging analysis. The results showed that patients with dual diseases exhibited a combination of symptoms from both diseases, while those with LBD had more severe cognitive disorders, and WMD patients mainly showed purely akinetic symptoms. Constipation was common in LBD and dual disease groups.
NEUROLOGY AND CLINICAL NEUROSCIENCE
(2022)
Review
Clinical Neurology
Ryuji Sakakibara, Setsu Sawai, Tsuyoshi Ogata, Ayako Iimura
Summary: This article reviewed the occurrence of autonomic dysfunction in older individuals, finding that in octogenarians, the estimated incidences of white matter disease (WMD), Alzheimer's disease (AD), and dementia with Lewy bodies (DLB) were 80%, 33%, and 7%-8% respectively. The most common combination was AD + WMD. The incidence of diabetes-induced small fiber neuropathy in octogenarians was estimated to be 30%. Orthostatic hypotension, overactive bladder, and bowel motility dysfunction also increased with age. The relationships between these disorders are still unclear, but possible associations have been suggested between orthostatic hypotension with DLB and diabetes, between overactive bladder with WMD and DLB (partly AD), and between bowel motility dysfunction with DLB and diabetes.
NEUROLOGY AND CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Ayako Iimura, Ryuji Sakakibara, Setsu Sawai, Tsuyoshi Ogata, Keiichiro Terayama, Hirohito Mizuno, Shuichi Katsuragawa, Takaaki Nagao, Masaaki Nemoto, Keiko Suzuki, Kaori Izawa, Shin-ichi Haruki, Nobuyuki Okada, Yasushi Ohashi, Keisuke Yamazaki
Summary: This study aimed to investigate the correlation between brain symptoms and brain diseases in patients undergoing hemodialysis (HD). The results showed that age-related brain symptoms increased with age in HD patients, and the most common underlying brain disease seemed to be a combination of white matter disease and Alzheimer's disease.
NEUROLOGY AND CLINICAL NEUROSCIENCE
(2022)
Letter
Clinical Neurology
Osamu Takahashi, Ryuji Sakakibara, Setsu Sawai, Tsuyoshi Ogata
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Clinical Neurology
Ryuji Sakakibara, Ayami Shimizu, Osamu Takahashi, Tsuyoshi Ogata, Setsu Sawai, Tomoyuki Uchiyama, Tatsuya Yamamoto
Summary: This study investigated whether Parkinson's disease (PD) patients have nocturnal polyuria (NP). It found that 56% of PD patients had NP, and it was closely related to detrusor overactivity.
NEUROLOGY AND CLINICAL NEUROSCIENCE
(2023)
Review
Geriatrics & Gerontology
Udit Saraf, Amit Batla, Ryuji Sakakibara, Jalesh N. Panicker
Summary: Lower urinary tract symptoms are common in Parkinson's disease and can significantly affect quality of life. A thorough evaluation is necessary to determine the cause of the symptoms, considering the effects of medications and co-existing medical conditions. Treatment options include behavioral therapy and oral medications, but caution is needed due to potential adverse effects and interactions.
Article
Neurosciences
Tatsuya Yamamoto, Ryuji Sakakibara, Tomoyuki Uchiyama, Satoshi Kuwabara
Summary: STN-DBS modulates the activities of mPFC induced by PAG stimulation, leading to normalization of bladder contraction. This study provides insights into the mechanism of how STN-DBS can affect bladder function in Parkinson's disease.
IBRO NEUROSCIENCE REPORTS
(2023)
Article
Clinical Neurology
Jean Jacques Wyndaele, Michel I. A. J. Wyndaele, Ryuji Sakakibara
Summary: This study found that gently squeezing the testes can provide information about dorsal column pathways from spinal cord level T10-L2 upwards, aiding in precise neurological diagnosis after spinal cord injury. It is recommended to include this simple test in neuro-urologic clinical examinations.
SPINAL CORD SERIES AND CASES
(2021)
Article
Clinical Neurology
Ryuji Sakakibara, Tsuyoshi Ogata, Yosuke Aiba, Fuyuki Tateno, Tomoyuki Uchiyama, Tatsuya Yamamoto
Summary: This study found that Parkinson's disease patients with depression were more likely to experience constipation and sensation of residual urine, suggesting that depression may exacerbate bladder and bowel symptoms in PD patients.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2021)
Article
Clinical Neurology
Hirokazu Doi, Ryuji Sakakibara, Fuyuki Tateno, Yosuke Aiba
Summary: While subjective constipation is rare in PSP patients, prolonged colonic transit time (CTT) is observed. This gastrointestinal feature requires appropriate management and care, potentially reflecting the brainstem/sacral spinal cord pathology in PSP.
NEUROLOGY AND CLINICAL NEUROSCIENCE
(2021)
