期刊
NEUROLOGICAL SCIENCES
卷 31, 期 5, 页码 531-540出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-010-0245-1
关键词
Parkinson's disease; Antioxidant; Withania somnifera; Neurodegeneration; Canavan disease
Parkinson's disease (PD) is a neurodegenerative disorder, caused by reduced levels of catecholamines and oxidative stress. Symptoms seen in the disease include tremor, rigidity, bradykinesia and postural disability. Oxidative stress plays a key role in neurodegeneration and motor abnormalities seen in PD. Altered levels of the protein caused by these changes lead to defective ubiquitin-proteasonne pathway. Neurodegeneration seen in PD and Canavan disease has a common mechanism. Recent studies suggest that herbal medicines can improve molecular changes and motor functions seen in PD.
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