Article
Clinical Neurology
Grace A. Bailey, Anna Rawlings, Fatemeh Torabi, William Owen Pickrell, Kathryn J. Peall
Summary: This study reveals a higher rate of psychiatric diagnoses and prescriptions in individuals diagnosed with idiopathic dystonia compared to controls. There may be a bidirectional relationship between idiopathic dystonia and psychiatric disorders, particularly mood disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Li-Shu Wang, Teng-Fei Yu, Bin Chai, Wen He
Summary: This study evaluated the application of transcranial sonography (TCS) for the differential diagnosis of Parkinson disease (PD) and other movement disorders in Chinese individuals. The results showed that SN positivity effectively differentiated PD from ET, PSP, and MSA, while the incidence of lenticular hyperechoic area also played a role in distinguishing between these diseases.
CHINESE MEDICAL JOURNAL
(2021)
Article
Psychology, Clinical
Tina Meller, Simon Schmitt, Ulrich Ettinger, Phillip Grant, Frederike Stein, Katharina Brosch, Dominik Grotegerd, Katharina Dohm, Susanne Meinert, Katharina Foerster, Tim Hahn, Andreas Jansen, Udo Dannlowski, Axel Krug, Tilo Kircher, Igor Nenadic
Summary: This study found the association between subclinical psychotic-like experiences and brain structural changes, supporting a dimensional model of the neural correlates of symptoms of the psychotic spectrum.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Clinical Neurology
Vanessa Carvalho, Joaquim J. Ferreira, Leonor Correia Guedes
Summary: The landscape of genetic forms of Parkinson's diseases has been expanding rapidly in recent years. A review found that aneuploidies of sex chromosomes were the most common chromosomal abnormalities associated with parkinsonism and tremor syndromes, while structural chromosomal disorders were often linked to Parkinson's disease and 22q11.2 deletion syndrome, with additional case reports of deletion and duplication syndromes also identified.
MOVEMENT DISORDERS
(2021)
Article
Chemistry, Analytical
Julius Welzel, David Wendtland, Elke Warmerdam, Robbin Romijnders, Morad Elshehabi, Johanna Geritz, Daniela Berg, Clint Hansen, Walter Maetzler
Summary: Current research on Parkinson's disease is focusing on identifying objective markers for assessing therapy effects and disease progression. This study found that step length has a significant impact on PD progression, while step time shows minimal change, emphasizing the importance of evaluating quantitative gait parameters for making assumptions about disease progression in chronic progressive diseases like PD.
Article
Multidisciplinary Sciences
Lewis A. Ingram, Vincent K. Carroll, Annie A. Butler, Matthew A. Brodie, Simon C. Gandevia, Stephen R. Lord
Summary: The study evaluated the validity of the upper limb Physiological Profile Assessment (PPA) in people with Parkinson's disease (PD) and found that the PPA can effectively differentiate PD patients from healthy controls and detect differences in upper limb test domains between different medication states. Six key tests, including handgrip strength, finger-press reaction time, 9-hole peg test, bimanual pole test, arm stability, and shirt buttoning, were identified for assessing upper limb function in PD patients. These findings suggest that clinical assessments in PD patients should prioritize tests of muscle strength, unilateral movement and dexterity, bimanual coordination, arm stability and functional tasks.
Article
Psychology, Clinical
Mu Wang, Yanyan Chen, Huazhi Li, Xiaoyu Zhang, Yubing Xu, Zeng-Hui Ding, Zuchang Ma, Yining Sun
Summary: There is an association between drug use and psychological disorders. During non-acute withdrawal, drug craving is positively correlated with psychiatric symptoms in women. As the abstinent time increases, this correlation weakens and the severity of some psychiatric symptoms may ameliorate. Women with drug use disorders can benefit from psychiatric treatment to reduce drug craving and subsequently decrease relapse rate.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2023)
Article
Medicine, General & Internal
Camilla Elefante, Giulio Emilio Brancati, Silvia Bacciardi, Sonia Mazzucchi, Eleonora Del Prete, Giovanni Palermo, Daniela Frosini, Ubaldo Bonuccelli, Roberto Ceravolo, Lorenzo Lattanzi, Icro Maremmani, Giulio Perugi
Summary: Mood and anxiety disorders are common neuropsychiatric syndromes associated with Parkinson's disease. Patients with anxiety disorders in PD tend to have a history of psychiatric symptoms, lifetime major depression, and higher anxiety scores. Current anxiety disorders in PD are linked to more severe psychopathology, depressive symptoms, and avoidant behavior.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Orthopedics
Mark M. Manago, Laura A. Swink, Emily R. Hager, Robyn Gisbert, Gammon M. Earhart, Cory L. Christiansen, Margaret Schenkman
Summary: The study found that during the COVID-19 pandemic, there was a decrease in in-person exercise class participation for people with PD and an increase in virtual classes. However, virtual classes may not fully meet the needs of patients, with primary barriers being technology issues and lack of social interaction.
Article
Environmental Sciences
Ion Papava, Liana Dehelean, Radu Stefan Romosan, Mariana Bondrescu, Cristian Zoltan Dimeny, Eugenia Maria Domuta, Felix Bratosin, Iulia Bogdan, Mirela Loredana Grigoras, Codruta Victoria Tigmeanu, Angelica Gherman, Iosif Marincu
Summary: The severity of the COVID-19 infection can lead to significant inflammatory responses and subsequent mental illnesses. This study aims to investigate if the psychological profiles of COVID-19 patients change according to the severity of illness and if certain inflammatory markers are associated with specific mental symptoms. Through a cross-sectional study on 90 hospitalized patients, it was found that severe COVID-19 patients were more likely to use disengagement coping methods and that negative coping mechanisms and emotion-focused strategies were independent risk factors for psychoticism symptoms.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychiatry
S. Cuoco, V Nistico, A. Cappiello, S. Scannapieco, O. Gambini, P. Barone, R. Erro, B. Demartini
Summary: The study found that patients with FND had differences in depression and avoidant attachment style compared to those with neurological disorders, indicating that the avoidant attachment style may be an important psychological factor influencing mood disorders and alexithymia.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Psychiatry
Mohammad Reza Shegarf Nakhaei, Ahmad Ali Noorbala, Atieh Sadeghniiat Haghighi, Mohammad Arbabi
Summary: The present study investigated the rate of psychiatric consultation requests among Covid-19 patients in a general hospital. The study found a high prevalence of psychiatric disorders, such as insomnia, delirium, and anxiety, among these patients. However, the requests for psychiatric consultations and consideration of psychiatric disorders were remarkably low.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Luigi Battista, Antonietta Romaniello
Summary: The study aimed to investigate the relationship between UPRDS scores and the information provided by a continuous monitoring tool. Results showed that the concise indexes from the tool correlated well with certain items in UPDRS Part III, providing a more direct and immediate meaning to the values detected by the tool for assessing motor symptoms and movement disorders.
NEUROLOGICAL SCIENCES
(2021)
Review
Cell Biology
Xiali Xue, Xinwei Yang, Zhongyi Deng
Summary: This study aimed to summarize previous clinical studies comparing the effectiveness of robot-assisted gait training (RAGT) and conventional training for lower extremity dyskinesia in Parkinson's disease (PD) patients. The results showed that RAGT significantly improved motor function evaluation-related indicators and balance function in PD patients. In conclusion, robot-assisted gait training can significantly improve motor and balance function in PD patients.
AGEING RESEARCH REVIEWS
(2023)
Article
Psychiatry
Rosa De Stefano, Clemente Cedro, Fiammetta Iannuzzo, Carmenrita Infortuna, Clara Lombardo, Gianluca Pandolfo, Maria Rosaria Anna Muscatello, Antonio Bruno
Summary: This study investigated the presence of subthreshold psychopathological symptoms and internet addiction in Italian adults from the general population, and found significant positive correlations between the two.
PSYCHIATRY RESEARCH
(2022)
Article
Critical Care Medicine
Chiara Robba, Francesca Graziano, Angelo Guglielmi, Paola Rebora, Stefania Galimberti, Fabio Taccone, Giuseppe Citerio, SYNAPSE-ICU Investigators
Summary: This study aims to describe the therapeutical approaches used in managing intracranial hypertension in acute brain injured patients and their association with six months mortality and neurological outcome. The results showed that therapies to control high ICP were frequently used during the first week of ICU admission, especially mild-moderate treatments. In some selected patients, the use of aggressive strategies may be beneficial for the six months mortality but not for neurological outcome.
INTENSIVE CARE MEDICINE
(2023)
Article
Neurosciences
Margherita Tecilla, Michael Grossbach, Giovanni Gentile, Peter Holland, Sebastian Sporn, Angelo Antonini, Maria Herrojo Ruiz
Summary: This study examines the impact of dynamically inferring action-reward contingencies on motor performance. The results show that stronger predictions about the tendency of the action-reward contingency lead to faster movement tempo, but have little effect on reaction time. Additionally, we found no significant differences in this effect between age and Parkinson's disease.
JOURNAL OF NEUROSCIENCE
(2023)
Letter
Clinical Neurology
Guenther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Stefanie Jost, Marie-Ann Kaldenbach, Angelo Antonini, Pablo Martinez-Martin, Lars Timmermann, Per Odin, Regina Katzenschlager, Rupam Borgohain, Alfonso Fasano, Fabrizio Stocchi, Nobutaka Hattori, Prashanth Lingappa Kukkle, Mayela Rodriguez-Violante, Cristian Falup-Pecurariu, Sebastian Schade, Jan Niklas Petry-Schmelzer, Vinod Metta, Daniel Weintraub, Guenther J. Deuschl, Alberto J. Espay, Eng-King Tan, Roongroj Bhidayasiri, Victor S. C. Fung, Francisco Cardoso, Claudia Trenkwalder, Peter Jenner, K. S. Ray Chaudhuri, Haidar Dafsari
Summary: This study reviewed the investigations on drug therapy for Parkinson's disease since 2010 and proposed a new drug conversion formula. These conversion formulas can help us compare drug regimens across different clinical trials. The results are important for studying the pharmacological efficacy of Parkinson's disease treatments as well as other non-pharmacological interventions.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Aron Emmi, Michele Sandre, Francesco Paolo Russo, Giulia Tombesi, Federica Garri, Marta Campagnolo, Miryam Carecchio, Roberta Biundo, Gaya Spolverato, Veronica Macchi, Edoardo Savarino, Fabio Farinati, Piero Parchi, Andrea Porzionato, Luigi Bubacco, Raffaele De Caro, Gabor G. Kovacs, Angelo Antonini
Summary: This study revealed the presence of neuronal dysfunction and reactive gliosis in the duodenum of patients with Parkinson's disease, suggesting that the enteric nervous system is involved in the pathophysiology of the disease.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Vanessa Porrini, Andrea Pilotto, Marika Vezzoli, Annamaria Lanzillotta, Michele M. Gennari, Sonia Bonacina, Antonella Alberici, Rosanna Turrone, Arianna Bellucci, Angelo Antonini, Alessandro Padovani, Marina Pizzi
Summary: Although the key neuropathological hallmarks of Parkinson's disease (PD) are known, the underlying pathogenic mechanisms of the disease still need to be elucidated. This study focused on evaluating the levels and activity of c-Rel protein, which may be involved in PD pathophysiology. The findings suggest that PD is characterized by the loss of NF-κB/c-Rel activity, and the reduction of c-Rel DNA-binding could potentially serve as a novel biomarker for PD.
NEUROBIOLOGY OF DISEASE
(2023)
Correction
Clinical Neurology
Federica Garri, Dario Ciprietti, Lisa Lerjefors, Andrea Landi, Manuela Pilleri, Roberta Biundo, Leonardo Salviati, Miryam Carecchio, Angelo Antonini
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Fabrizio Stocchi, Paolo Barone, Giuseppe Bellelli, Andrea Fagiolini, Luigi Ferini Strambi, Sandro Sorbi, Alessandro Padovani
Summary: The diagnosis of depression in Parkinson's disease is challenging due to overlapping symptoms. A panel of Italian specialists reached a consensus that depression is a risk factor for Parkinson's disease, with neuropathological abnormalities playing a role. Multimodal and SSRI antidepressants are confirmed as effective options for treating depression in Parkinson's disease.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Angelo Antonini, Heinz Reichmann, Giovanni Gentile, Michela Garon, Chiara Tedesco, Anika Frank, Bjoern Falkenburger, Spyridon Konitsiotis, Konstantinos Tsamis, Georgios Rigas, Nicholas Kostikis, Adamantios Ntanis, Constantinos Pattichis
Summary: This article describes the results of two clinical studies validating the performance of a new wearable monitoring device, PDMonitor, in detecting Parkinson's disease-related motor symptoms. The studies demonstrated high accuracy and correlation between the severity of symptoms and expert evaluations, confirming the effectiveness of the system as a continuous telemonitoring solution for facilitating treatment decisions in patients with Parkinson's disease.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Valentina D'Onofrio, Nicoletta Manzo, Andrea Guerra, Andrea Landi, Valentina Baro, Sara Maeaettae, Luca Weis, Camillo Porcaro, Maurizio Corbetta, Angelo Antonini, Florinda Ferreri
Summary: Deep brain stimulation (DBS) is a promising treatment for neurological disorders, but its mechanisms of action are not fully understood. Transcranial magnetic stimulation (TMS) combined with DBS provides a unique approach to investigate the neurophysiology of the brain. Experimental studies have shown that DBS modulates cortical excitability and plasticity, which may contribute to its therapeutic effects. However, safety concerns limit the application of the TMS-DBS approach.
Article
Neurosciences
Aron Emmi, Stefania Rizzo, Luisa Barzon, Michele Sandre, Elisa Carturan, Alessandro Sinigaglia, Silvia Riccetti, Mila Della Barbera, Rafael Boscolo-Berto, Patrizia Cocco, Veronica Macchi, Angelo Antonini, Monica De Gaspari, Cristina Basso, Raffaele De Caro, Andrea Porzionato
Summary: Neurological manifestations are common in COVID-19 patients, and this study found evidence of SARS-CoV-2 infection in the central nervous system. The researchers observed viral RNA and SARS-CoV-2-immunoreactive neurons in specific regions of the brain in COVID-19 patients. In addition, inflammation was observed in affected brainstem regions, indicating a role of brainstem inflammation in COVID-19. Further investigations are needed to understand the potential implications for neurodegenerative diseases like Parkinson's.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Angelo Antonini, Aron Emmi, Marta Campagnolo
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Angelo Antonini, Valentina D'Onofrio, Andrea Guerra
Summary: Advanced Parkinson's disease patients often experience poor mobility and functional decline despite medication adjustments. Drug delivery systems have been developed to bypass issues with oral levodopa absorption and have been proven effective in trials and real-world use. Future efforts should focus on early detection and global availability of these treatments.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Immunology
Lorenzo Lupi, Anna Bordin, Gabriele Sales, Davide Colaianni, Adriana Vitiello, Alberto Biscontin, Alberto Reale, Alfredo Garzino-Demo, Angelo Antonini, Giancarlo Ottaviano, Carla Mucignat, Cristina Parolin, Arianna Calistri, Cristiano De Pitta
Summary: COVID-19 is a respiratory syndrome that can cause various symptoms, including deficits in smell and taste. Transcriptome analysis of olfactory mucosa revealed altered gene expression levels in patients with persistent olfactory deficits, with associations with inflammatory response and zinc homeostasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Jason Aldred, Eric Freire-Alvarez, Alexander V. Amelin, Angelo Antonini, Bruno Bergmans, Filip Bergquist, Manon Bouchard, Kumar Budur, Camille Carroll, K. Ray Chaudhuri, Susan R. Criswell, Erik H. Danielsen, Florin Gandor, Jia Jia, Thomas E. Kimber, Hideki Mochizuki, Weining Z. Robieson, Amy M. Spiegel, David G. Standaert, Saritha Talapala, Maurizio F. Facheris, Victor S. C. Fung
Summary: This article reports the results of a 52-week open-label registrational trial that evaluated the safety, tolerability, and efficacy of 24-hour foslevodopa/foscarbidopa continuous subcutaneous infusion in patients with advanced Parkinson's disease. The findings suggest that this treatment has the potential to improve motor control, sleep quality, and quality of life in patients with Parkinson's disease.
NEUROLOGY AND THERAPY
(2023)
