Article
Cell Biology
Nan Wang, Yingying Yang, Baoshan Qiu, Ying Gao, Anxin Wang, Qin Xu, Xia Meng, Yuming Xu, Bo Song, Yongjun Wang, Yilong Wang
Summary: This study investigated the relationship between the systemic immune-inflammation index (SII) and stroke prognosis. The results showed that higher SII values were associated with a higher risk of poor functional outcomes, all-cause death, and recurrent stroke in patients with acute ischemic stroke.
Article
Medicine, General & Internal
Yu-Xuan Li, Juan Hou, Wen-Ya Liu
Summary: This study aimed to explore the relationship between sarcopenia defined by temporal muscle thickness and physical function and prognosis of patients with acute ischemic stroke (AIS). The results showed that sarcopenia was associated with stroke risk, stroke severity, functional ability, swallow ability, venous thromboembolism risk, activities of daily living, and survival outcome.
Article
Cardiac & Cardiovascular Systems
Huihui Liu, Sifan Qian, Chongke Zhong, Aili Wang, Yanbo Peng, Hao Peng, Tan Xu, Xiaoqing Bu, Tian Xu, Deqin Geng, Yonghong Zhang
Summary: This study found that in ischemic stroke patients with high hsCRP concentrations, higher CysC concentrations were associated with an increased risk of stroke recurrence and vascular events. The predictive value of CysC on stroke recurrence may depend on the inflammation status of patients.
CIRCULATION JOURNAL
(2021)
Article
Medicine, General & Internal
Jooyoung Cho, Seri Jeong, Jong-Han Lee
Summary: This study found a positive association between the procalcitonin to C-reactive protein ratio and 90-day mortality in ischemic stroke patients. This suggests that the PC ratio may be a useful marker for predicting mortality after stroke.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Marcin Wnuk, Justyna Derbisz, Leszek Drabik, Agnieszka Slowik
Summary: A study on 352 AIS patients treated with IVT found that CRP levels were associated with patient outcomes and mortality, with higher CRP levels being an independent risk factor for poor prognosis. In addition, lower WBC levels were associated with 90-day mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Nan Wang, Yingying Yang, Baoshan Qiu, Ying Gao, Anxin Wang, Qin Xu, Xia Meng, Yuming Xu, Bo Song, Yongjun Wang, Yilong Wang
Summary: This study examines the relationship between the systemic immune-inflammation index (SII) and stroke prognosis. The results show that SII is closely related to the short- and long-term prognosis of patients with acute ischemic stroke, with higher SII values indicating a higher risk for poor outcomes.
Article
Neurosciences
Yerim Kim, Sang-Hwa Lee, Min Kyoung Kang, Tae Jung Kim, Han-Yeong Jeong, Eung-Joon Lee, Jeonghoon Bae, Kipyoung Jeon, Ki-Woong Nam, Byung-Woo Yoon
Summary: This study found that higher levels of glycated albumin (GA) were associated with unfavorable short-term functional outcomes in patients with acute ischemic stroke, while glycated hemoglobin (HbA1c) levels were not significantly correlated with outcomes. This association was particularly strong in patients without diabetes, suggesting that GA may be a more reliable prognostic biomarker compared to HbA1c for short-term stroke outcomes.
Article
Cardiac & Cardiovascular Systems
Lihua Zhang, Guangda He, Xiqian Huo, Aoxi Tian, Runqing Ji, Boxuan Pu, Yue Peng
Summary: Long-term cumulative hsCRP levels are associated with worse outcomes in patients hospitalized for acute heart failure, and repeated hsCRP measurements can help identify patients at high risk of death.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Nutrition & Dietetics
Min-Su Kim, Jin San Lee, Sung Joon Chung, Yunsoo Soh
Summary: This study investigated the association between serum vitamin D levels and short-term functional outcomes in patients with acute ischemic stroke. The results showed that vitamin D deficiency may be associated with severe initial stroke and poor short-term post-stroke functional outcomes.
Article
Cardiac & Cardiovascular Systems
Fanghua Liu, Pinni Yang, Yinan Wang, Mengyao Shi, Ruirui Wang, Qingyun Xu, Yanbo Peng, Jing Chen, Jintao Zhang, Aili Wang, Tan Xu, Yonghong Zhang, Jiang He
Summary: This study investigated the relationship between baseline platelet count and HS-CRP on clinical outcomes in patients with ischemic stroke. The results showed an interaction effect between platelet count and HS-CRP on adverse clinical outcomes. Elevated platelet count was significantly associated with adverse clinical outcomes in patients with high HS-CRP levels. Strategies for anti-inflammatory and antiplatelet therapy should be developed based on platelet and HS-CRP testing results.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Yu Wang, Jiejie Li, Yuesong Pan, Mengxing Wang, Xia Meng, Yongjun Wang
Summary: This study investigates the association between hsCRP levels within 24 hours to 8 days after stroke onset and prognosis. The results show that elevated hsCRP levels measured within the first 72 hours after stroke are associated with an increased risk of stroke recurrence within 1 year.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Xueqian Xu, Yuenan Xiao, Jia Li, Liuzhu Chen, Gangqiang Lin, Ledan Dong, Yisi Lin, Luqian Zhan, Jincai He, Xiaoqian Luan
Summary: During the COVID-19 pandemic, there was a decrease in admissions for IVT treatment, an increase in door to needle time, and a significant increase in poor short-term functional prognosis for IVT patients during the pandemic.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Aoming Jin, Shukun Wang, Jiejie Li, Mengxing Wang, Jinxi Lin, Hao Li, Xia Meng, Yongjun Wang, Yuesong Pan
Summary: This study aimed to investigate whether the association between insulin resistance and the prognosis of nondiabetic patients with ischemic stroke was mediated by systemic inflammation. The study found that insulin resistance was associated with poor clinical outcomes in nondiabetic patients with ischemic stroke, which was partially mediated by hs-CRP.
Article
Health Care Sciences & Services
Lidia M. V. R. Moura, Zhiyu Yan, Maria A. Donahue, Louisa H. Smith, Lee H. Schwamm, John Hsu, Joseph P. Newhouse, Sebastien Haneuse, Deborah Blacker, Sonia Hernandez-Diaz
Summary: This study examines the association between benzodiazepine use and poststroke mortality in older adults after acute ischemic stroke. The use of benzodiazepines within 7 days after stroke is associated with an increased risk of mortality within 30 days, but this association is likely biased.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Peixin Liu, Tongyu Zhang, Chao Li, Yiwen Zhang, Zheng Zhou, Zhenhao Zhao, Qinjun Chen, Tao Sun, Chen Jiang
Summary: Metabolic microenvironment dysfunction is a common feature of acute ischemic stroke (AIS) throughout the ischemia, reperfusion, and recovery stages. A polymer-based nanoerythrocyte inspired by the oxygen-carrying mechanism of hemoglobin is designed to remodel the metabolic microenvironment in AIS. In vivo results demonstrate that this nanoerythrocyte restores cellular metabolic homeostasis and responsiveness and has positive effects on long-term prognosis.
Article
Pediatrics
Yakun Liu, Chunhui Peng, Kai Wang, Dongyang Wu, Jun Yan, Wenjun Tu, Yajun Chen
Summary: Liver stiffness measurement by SWE and serum GGT level showed the best discriminative utility in differentiating BA from non-BA patients within 45 days. The change in serum direct bilirubin (DB) level was associated with the need for liver transplantation in later life.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Clinical Neurology
Wen-Jun Tu, Feng Yan, Bao-Hua Chao, Lin Ma, Xun-Ming Ji, Long-De Wang
Summary: The study found that there was no significant difference in 1-year mortality and disability rates between patients with longer DNT times compared to those treated within 45 minutes.
NEUROLOGICAL SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Yakun Liu, Ruone Xu, Dongyang Wu, Kai Wang, Wenjun Tu, Chunhui Peng, Yajun Chen
Summary: In this study, a useful diagnostic nomogram and simplified scoring system were developed for diagnosing biliary atresia. The nomogram showed good discrimination and calibration abilities, and the simplified scoring system demonstrated significant clinical utility.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Clinical Neurology
Xiaowen Song, Hancheng Qiu, Wenjun Tu, Shuo Wang, Yong Cao, Chen Li, Shuo Yang, Jizong Zhao
Summary: This study introduces a new shaping method using 3D printed vessel models for optimal microcatheter shaping during endovascular coiling procedures. The results show that the new shaping method can reduce procedure time and the number of coils deployed, with no significant difference in occlusion rates and complication rates between the two groups.
NEUROSURGICAL REVIEW
(2022)
Article
Nutrition & Dietetics
Yakun Liu, Cailin Ding, Ruone Xu, Kai Wang, Dan Zhang, Wenbo Pang, Wenjun Tu, Yajun Chen
Summary: Vitamin D supplementation during pregnancy is associated with improved offspring vitamin D sufficiency status, improved fetal linear growth, and reduced fetal or neonatal mortality. However, no significant effects were found on birth weight, risk of low birth weight, and risk of preterm birth.
CLINICAL NUTRITION
(2022)
Review
Biotechnology & Applied Microbiology
Yimeng Xue, Xianwei Zeng, Wen-Jun Tu, Jizong Zhao
Summary: Currently, there are no clear markers that can meet the needs of clinical prediction and treatment for stroke. The inflammatory cascade, in which inflammatory factors like TNF play a critical role, worsens stroke outcomes and increases mortality. Recent research suggests that TNF-α could be a potential marker for stroke due to its essential role in the disease process.
Article
Immunology
Hetao Bian, Feng Yan, Weili Li, Wenjun Tu, Xunming Ji
Summary: This study demonstrated that TBHQ could effectively improve inflammation-related depression-like behavior induced by LPS through modulating neuroinflammation and microglia activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Letter
Medicine, General & Internal
Wen-Jun Tu, Yimeng Xue, Ding Nie
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Letter
Pediatrics
Yakun Liu, Wenjun Tu, Yajun Chen
Letter
Medicine, General & Internal
Yakun Liu, Wenjun Tu, Yajun Chen
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Letter
Clinical Neurology
Wen-Jun Tu, Feng Yan, Bao-Hua Chao, Lei Cao, Longde Wang
Article
Clinical Neurology
Tao Wang, Yicheng Xu, Deying Li, Wenjun Tu, Yanan Li, Shuai Miao, Jilai Li, Peifu Wang, Fei Zhao, Lingzhong Fan, Shengyuan Yu
Summary: Structural abnormalities in the hippocampus are consistently reported in TGA cases, but lesions in other brain locations can also cause TGA. The default mode network may play a role in the pathophysiology of TGA.
NEUROLOGICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Wen-Jun Tu, Yicheng Xu, Hengwen Chen, Jilai Li, Jichen Du
Summary: During the COVID-19 pandemic lockdown, hospitalized stroke patients decreased by 12.6%, with substantial increases in out-of-pocket rates (9.3%) and in-hospital case fatality rates (18.0%).
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Letter
Hematology
Wen-Jun Tu, Yicheng Xu
THROMBOSIS RESEARCH
(2023)
Article
Mathematical & Computational Biology
Wenlu Zhang, Ziyue Ma, Hong Wang, Juan Deng, Pengfei Li, Yu Jia, Yabin Dong, Hong Sha, Feng Yan, Wenjun Tu
Summary: In this study, a system for determining the puncture point and path planning in lumbar puncture surgery was proposed based on robotic-assisted ultrasound scanning. The system controls a robotic arm to clamp down onto an ultrasonic probe for automatic scanning and image acquisition. A three-dimensional reconstruction program was used to reconstruct the lumbar spine model. Although the reconstructed structure had defects, the location of the spinous process gap was determined using sagittal and coronal images.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)