Article
Pharmacology & Pharmacy
Yanli Wang, Qiaohuan Deng, Zhenyue Gao, Guangwen Liu, Zhengjie Su, Yicheng Zhao, Lixiu Zhang, Haimiao Yang
Summary: This study investigated the pharmacokinetics, bioequivalence, and safety of generic sunitinib and its original product Sutent (R) in healthy Chinese subjects through a phase-I clinical trial. The results demonstrated that the two drugs had comparable pharmacokinetics and were bioequivalent. Both drugs also exhibited good safety profiles.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Selvaraj Vimalraj
Summary: Angiogenesis is the formation of new blood vessels from existing ones. Abnormal angiogenesis, seen in tumor microenvironments, is characterized by distorted and leaky blood vessels with various shapes and high perfusion efficiency. Tumor angiogenesis plays a crucial role in cancer growth, invasion, and metastasis, and is tightly regulated by signaling networks. Targeting multiple signaling pathways involved in angiogenesis is important for effective antiangiogenic therapy. New therapeutic approaches, such as blocking specific proteins or genes, are being explored to dissect alternative angiogenesis mechanisms in tumor microenvironments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Oncology
Jessica W. Lee, John P. Kirkpatrick, Frances McSherry, James E. Herndon, Eric S. Lipp, Annick Desjardins, Dina M. Randazzo, Henry S. Friedman, David M. Ashley, Katherine B. Peters, Margaret O. Johnson
Summary: In this study of older patients with GBM, age and KPS were associated with the choice between short-course and standard RT. Both regimens showed similar overall survival, but some patients experienced worsening symptoms and discontinued treatment during RT. Further research into predictors of RT completion and survival could help improve adjuvant therapy and supportive care for older patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Brianna N. Kerr, Daniel Duffy, Caitriona E. McInerney, Ashton Hutchinson, Inaya Dabaja, Rana Bazzi, Stephane Roux, Kevin M. Prise, Karl T. Butterworth
Summary: This study aimed to evaluate the radiosensitizing and immunomodulatory properties of differentially PEGylated GNPs in GBM cells. The results showed that PEGylation improved the radiobiological efficacy, with double-strand break induction being identified as a mechanism. PEGylated GNPs also enhanced the immunogenicity of radiotherapy, correlating with upregulation of inflammatory cytokines. These findings suggest that ID11 and ID12 could be potential candidates for RT-drug combination in future GBM preclinical investigations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Khushbu Rauniyar, Honey Bokharaie, Michael Jeltsch
Summary: This study comprehensively analyzed the evolutionary relationships of PDGF/VEGF growth factors and proposed a phylogenetic tree. Whole-genome duplications in vertebrates contribute to the diversity of PDGF/VEGF, but limited duplications are necessary to explain the emergence pattern. The oldest phylogenetically PDGF/VEGF-like growth factor likely had a BR3P signature in the C-terminus, similar to modern lymphangiogenic growth factors. Some younger VEGF genes are absent in specific vertebrate clades, while PDGF/VEGF gene duplications frequently occur in fish on top of fish-specific whole-genome duplications.
Review
Oncology
Xanthene Miles, Charlot Vandevoorde, Alistair Hunter, Julie Bolcaen
Summary: Inhibition of the MDM2/X-p53 interaction as a potential anti-cancer strategy, especially in treating GB, by reactivating p53 plays a central role in cell survival and cancer therapy effectiveness. Suppression of MDM2 presents an opportunity for new therapeutic interventions for GB, with combination with radiation showing promise as a valuable treatment approach.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hong Shik Yun, Jennifer Lee, Whoon Jong Kil, Tamalee R. Kramp, Philip J. Tofilon, Kevin Camphausen
Summary: AZD0530, a potent small-molecule inhibitor of the Src kinase family, enhances the radiosensitivity of glioblastoma cells and glioblastoma stem-like cells, showing potential as a clinical radiosensitizer for the treatment of glioblastoma.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Vinochani Pillay, Lipi Shukla, Prad Herle, Simon Maciburko, Nadeeka Bandara, Isabella Reid, Steven Morgan, Yinan Yuan, Jennii Luu, Karla J. Cowley, Susanne Ramm, Kaylene J. Simpson, Marc G. Achen, Steven A. Stacker, Ramin Shayan, Tara Karnezis
Summary: Surgery and radiotherapy are major cancer treatments that can cause damage to the lymphatic system, leading to lymphoedema. However, the molecular mechanisms underlying this damage to lymphatic vessels and endothelial cells remain poorly understood.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Alessandro Certelli, Paolo Valente, Andrea Uccelli, Andrea Grosso, Nunzia Di Maggio, Rosalinda D'Amico, Priscilla S. Briquez, Jeffrey A. Hubbell, Thomas Wolff, Lorenz Gurke, Edin Mujagic, Roberto Gianni-Barrera, Andrea Banfi
Summary: In diabetic mouse skin, controlled co-delivery of TG-VEGF and TG-PDGF-BB recombinant proteins effectively induces angiogenesis and arteriogenesis, with similar efficacy to normal littermate control mice at therapeutically relevant doses. This approach also prevents abnormal vascular enlargement caused by high TG-VEGF levels and promotes effective arteriogenesis in the dermal layer.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
William Lory, Bridgette Wellslager, Chao Sun, Ozlem Yilmaz, Hong Yu
Summary: S1PR2 antagonist JTE013 enhances expression of VEGFA, PDGFA, and GDF15 genes, activates TGFβ/Smad and Akt signaling, and promotes angiogenesis and alveolar bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ryan Miller, Andrew Song, Ayesha Ali, Muneeb Niazi, Voichita Bar-Ad, Nina Martinez, Jon Glass, Iyad Alnahhas, David Andrews, Kevin Judy, James Evans, Christopher Farrell, Maria Werner-Wasik, Inna Chervoneva, Michele Ly, Joshua Palmer, Haisong Liu, Wenyin Shi
Summary: This study evaluated the safety of concurrent use of TTFields and chemoradiation. The results showed that it is a feasible and well-tolerated treatment option with limited toxicity. Ongoing randomized clinical trials are investigating its clinical benefits.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Amit Ben Antony Bennan, Jan Unkelbach, Niklas Wahl, Patrick Salome, Mark Bangert
Summary: This study demonstrates the optimization of combined photon-carbon ion treatments for infiltrative tumors, aiming for more targeted application of carbon ions while reducing radiation dose in healthy tissues. The joint optimization of IMRT-CIRT treatments leads to a new spectrum of plans that better address physical and radiobiological treatment planning challenges.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Plant Sciences
Jing-Zhou Li, Xiao-Xia Zhou, Wei-Yin Wu, Hai-Feng Qiang, Guo-Sheng Xiao, Yan Wang, Gang Li
Summary: This study investigated the angiogenic role of Con A in endothelial cells and ischaemic hind-limb mice. Con A promoted tube formation and increased the secretion of angiogenic factors. It also enhanced cell viability and regulated cell cycle progression. The effects of Con A were mediated by the activation of the PI3K and MEK pathways. Additionally, Con A exhibited a repair effect in ischaemic hind-limb mice.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Karthikeyan Thirugnanam, Shubhangi Prabhudesai, Emma Van Why, Amy Pan, Ankan Gupta, Koji Foreman, Rahima Zennadi, Kevin R. Rarick, Surya M. Nauli, Sean P. Palecek, Ramani Ramchandran
Summary: In the developing vasculature, the formation of cilia in endothelial cells greatly influences the stability of blood vessels. However, the underlying mechanisms of ciliogenesis are not fully understood. This study used zebrafish models and cell culture systems to investigate the critical role of ciliogenesis in brain vascular stability. The researchers discovered that the protein ADP Ribosylation Factor Like GTPase 13B (Arl13b) is significantly decreased in a zebrafish mutant with vascular instability, and overexpression of Arl13b can rescue the cilia numbers and prevent cerebral hemorrhage. Further studies in human brain microvascular endothelial cells revealed that ligands platelet-derived growth factor-BB (PDGF-BB) and vascular endothelial growth factor-A (VEGF-A) trigger ciliogenesis through the cell surface VEGFR-2 receptor. These findings provide new insights into the mechanisms of ciliogenesis and its importance in promoting vascular stability.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Rosalinda D'Amico, Camilla Malucelli, Andrea Uccelli, Andrea Grosso, Nunzia Di Maggio, Priscilla S. Briquez, Jeffrey A. Hubbell, Thomas Wolff, Lorenz Gurke, Edin Mujagic, Roberto Gianni-Barrera, Andrea Banfi
Summary: Chronic wounds in type-2 diabetic patients often have severe local skin ischemia despite normal blood flow. By using fibrin hydrogels decorated with engineered growth factors, wound closure and microvascular growth can be promoted.
JOURNAL OF TISSUE ENGINEERING
(2022)