Review
Biochemistry & Molecular Biology
Patricia G. G. Valles, Andrea Fernanda Gil Lorenzo, Rodrigo D. D. Garcia, Valeria Cacciamani, Maria Eugenia Benardon, Valeria Victoria Costantino
Summary: Acute kidney injury (AKI) is a common and devastating condition with no effective pharmacological treatment. Toll-like receptor 4 (TLR4) and its ligands play a crucial role in the pathogenesis of AKI by mediating inflammatory responses. Excessive activation of TLR4 can lead to chronic inflammation. This review discusses the role of TLR4 in ischemic/reperfusion-induced AKI and sepsis-associated AKI, as well as its potential signaling patterns in kidney injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Antonio Hernandez, Naeem K. Patil, Maya Brewer, Rachel Delgado, Lauren Himmel, Lauren N. Lopez, Julia K. Bohannon, Allison M. Owen, Edward R. Sherwood, Mark P. de Caestecker
Summary: This study aimed to investigate whether a novel Toll-like receptor 4 agonist could attenuate acute kidney injury induced by ischemia-reperfusion injury. The results showed that pretreatment with the agonist improved kidney function, reduced renal tissue injury and apoptosis. The findings suggest that the agonist can provide protection against ischemia-reperfusion injury-induced acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Microbiology
Jingjuan Hu, Fan Deng, Bingcheng Zhao, Zebin Lin, Qishun Sun, Xiao Yang, Mei Wu, Shida Qiu, Yu Chen, Zhengzheng Yan, Sidan Luo, Jin Zhao, Weifeng Liu, Cai Li, Ke Xuan Liu
Summary: This study investigated the relationship between the gut microbiome and intestinal ischemia/reperfusion (I/R) injury. It found that Lactobacillus murinus can alleviate intestinal I/R injury in mice through macrophages, and this effect may be achieved by promoting the release of IL-10 from macrophages through TLR2. This study revealed a novel mechanism of intestinal I/R injury and provided a new therapeutic strategy for clinical practice.
Article
Biochemistry & Molecular Biology
Su Woong Jung, Jung-Woo Seo, Seon Hwa Park, Yang Gyun Kim, Ju-Young Moon, Sangdun Choi, Sang-Ho Lee
Summary: TIP1 demonstrated significant protective effects in a mouse model of renal IRI, reducing plasma creatinine levels, alleviating tubular injury, inhibiting inflammatory cytokine expression, decreasing apoptosis and oxidative stress levels, and reducing cell infiltration, suggesting potential benefits in attenuating kidney damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Michal Korostynski, Dzesika Hoinkis, Marcin Piechota, Slawomir Golda, Joanna Pera, Agnieszka Slowik, Tomasz Dziedzic
Summary: TLR4-dependent cytokine synthesis was not associated with greater post-stroke depressive symptoms in this study. However, circulating IL-6 might be associated with depressive symptoms occurring at 3 months after stroke.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Immunology
Niloofar Deravi, Mohadeseh Poudineh, Marzieh Pirzadeh, Hanie Yavarpour-Bali, Hoda Mehrabi, Gisou Erabi, Amene Saghazadeh, Nima Rezaei
Summary: Endothelial cells play a critical role in innate immune and inflammatory responses, and Toll-like receptors (TLRs) are key in activating innate mechanisms in ECs. Endothelial dysfunction may lead to tissue damage in various diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Neurosciences
Abdelrahman Y. Fouda, Wael Eldahshan, Zhimin Xu, Tahira Lemtalsi, Esraa Shosha, Syed A. H. Zaidi, Ammar A. Abdelrahman, Paul Ning-Man Cheng, S. Priya Narayanan, R. William Caldwell, Ruth B. Caldwell
Summary: The study demonstrates that systemic administration of PEG-A1 provides neuroprotection and offers an excellent route to deliver the drug to the retina and brain after acute injury.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chin-Feng Tsai, Hui-Wen Lin, Jiuan-Miaw Liao, Ke-Min Chen, Jen-Wei Tsai, Chia-Sung Chang, Chia-Yu Chou, Hsing-Hui Su, Pei-Hsun Liu, Ya-Chun Chu, Yi-Hsin Wang, Meilin Wang, Shiang-Suo Huang
Summary: This study found that D. salina extract can alleviate myocardial ischemia/reperfusion (I/R) injury and exert anti-inflammatory and anti-apoptotic effects through inhibiting TLR4-mediated signaling pathway, while reducing autophagy activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Yanyun Wang, Yi Wang, Shuyu Li, Yuliang Cui, Xiping Liang, Juanjuan Shan, Wei Gu, Juhui Qiu, Yiliang Li, Guixue Wang
Summary: The developed monocyte membranes-coated rapamycin nanoparticles (McM/RNPs) have shown promise in alleviating ischemia/reperfusion injury by reducing inflammation and inhibiting cell proliferation. These nanoparticles demonstrated improved targeting and therapeutic effects in animal models, with good safety profiles observed in vivo studies.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shiyi Li, Ru Zhang, Anni Wang, Yang Li, Miaomiao Zhang, Jisu Kim, Ying Zhu, Qizheng Wang, Yue Zhang, Ying Wei, Jianxin Wang
Summary: Panax notoginseng derived exosome-like nanoparticles (PDN) are nanoparticles extracted from Panax notoginseng that can promote the repair and treatment of neurological damage. PDNs can enter the brain, reduce cerebral infarction, improve behavioral outcomes, and maintain the integrity of the blood-brain barrier. The study also found that PDNs attenuate inflammation by altering microglia phenotype, thereby alleviating cerebral ischemia/reperfusion injury.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Neurosciences
Liang Liu, Tian-Ce Xu, Zi-Ai Zhao, Nan-Nan Zhang, Jing Li, Hui-Sheng Chen
Summary: TLR4 signaling in neurons plays a crucial role in neuronal death and neuroinflammatory responses following brain ischemia. Deletion of TLR4 reduces neuronal death and intracellular Ca2+ influx induced by oxygen and glucose deprivation or lipopolysaccharide treatment. TLR4 interacts with NMDAR2B and affects the interaction between nNOS and PSD-95, contributing to ischemic injury.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Liang Wang, Xuebai Lv, Jue Tian, Xiaoliang Wang, Ye Wu, Hui Rong Liu
Summary: The study found that Nec-1 may reduce myocardial cell death and maintain myocardial architectural integrity, thus inhibiting the reactive fibrosis process in rats during myocardial ischemia/late reperfusion. Administration of Nec-1 at the onset of reperfusion significantly reduced the release of creatine kinase and downregulated autophagy within 24 hours after reperfusion, with a significantly positive correlation between them.
CARDIOVASCULAR THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Wen Luo, Junqing Yang
Summary: ULK4 protects against CIRI by activating the PI3K pathway and inhibiting apoptosis.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Immunology
Cheng Xiong, Zhendong Du, Youwei Zhu, Meilin Xue, Yongsheng Jiang, Yiming Zhong, Lingxi Jiang, Hao Chen, Minmin Shi
Summary: Mycophenolate mofetil (MMF) treatment significantly alleviates hepatic ischemia/reperfusion (I/R) injury by reducing serum biomarker levels and tissue necrosis. The protective effects of MMF are achieved through inhibiting TLR4 activation and NF-kappa B pathway, decreasing inflammatory cytokine expression, inhibiting hepatocyte apoptosis, and inducing autophagy.
TRANSPLANT IMMUNOLOGY
(2021)
Review
Clinical Neurology
Yanling Wang, Yazeed Haddad, Radhika Patel, Xiaokun Geng, Huishan Du, Yuchuan Ding
Summary: The onset of cardiogenic cerebral embolism is sudden and dangerous, with factors such as severity of neurological impairment, types and severity of combined heart diseases, establishment of cerebral collateral circulation, treatments, components of emboli causing cardiogenic cerebral embolism, existence and control of other system complications, distribution and expression of inflammatory immune cells and molecules, and epigenetic changes related to disease prognosis all influencing patient outcomes. Emphasis should be placed on clinical settings, emboli pathological profile, and epigenetic changes in the prevention and treatment of cardiogenic cerebral embolism to improve outcomes and reduce recurrence.
NEUROLOGICAL RESEARCH
(2022)
Article
Clinical Neurology
Haiyue Zhang, Jingwei Guan, Hangil Lee, Chuanjie Wu, Kai Dong, Zongjian Liu, Lili Cui, Haiqing Song, Yuchuan Ding, Ran Meng
Summary: This study investigated the changes in immune cell composition in the peripheral blood of patients with acute ischemic stroke (AIS) based on their age groups. The results showed that the proportions of certain immune cells differed among the age groups, with a decrease in certain cells as age increased. These differences may have implications for clinical outcomes and suggest the need for customized treatment for AIS in different age groups.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hao Sun, Jonathan Warren, James Yip, Yu Ji, Shaolong Hao, Wei Han, Yuchuan Ding
Summary: Gallstone disease is a common digestive system pathology with a 10-20% incidence rate among adults. Cholecystectomy is the main treatment, but it can cause physical pain and greatly impact a patient's quality of life. Clinical research suggests that cholelithiasis is closely related to age, gender, body mass index, and other physical characteristics, as well as obesity, diabetes, non-alcoholic fatty liver, and other diseases.
Article
Neurosciences
Mengqi Wang, Xiaoqin Wu, Duo Lan, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng
Summary: This study aimed to compare the similarities and differences between acquired stenosis and anatomical slenderness of the internal jugular vein (IJV). Imaging features, along with clinical symptoms, can be used to differentiate between the two conditions.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Endocrinology & Metabolism
Jiali Xu, Gary B. Rajah, Houdi Zhang, Cong Han, Xuxuan Shen, Bin Li, Zhengxing Zou, Wenbo Zhao, Changhong Ren, Guiyou Liu, Yuchuan Ding, Qi Yang, Sijie Li, Xunming Ji
Summary: This study used high-resolution magnetic resonance imaging to investigate the characteristics of patients with moyamoya disease and anterior intracerebral hemorrhage. The results showed that the length of lenticulostriate arteries was shorter and the lumen area of the terminal internal carotid artery was larger in the hemorrhagic group compared to the ischemic group and asymptomatic group. Multivariate analysis revealed that these features were significantly associated with anterior intracerebral hemorrhage. Additionally, the coexistence of reduced lenticulostriate arteries and relatively preserved lumen area of the terminal internal carotid artery may serve as a potential predictor of anterior intracerebral hemorrhage in moyamoya disease patients.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Biochemical Research Methods
Di Wu, Jian Chen, Longfei Wu, Hangil Lee, Jingfei Shi, Mo Zhang, Yanhui Ma, Xiaoduo He, Zixin Zhu, Feng Yan, Chuanjie Wu, Yunxia Duan, Yongjuan Fu, Sijie Li, Xinglong Zhi, Xuxiang Zhang, Shengli Li, Yuchuan Ding, Xunming Ji
Summary: The article describes a protocol for developing a stroke model in rhesus monkeys and highlights the advantages of using this model in simulating patients with ischemic stroke.
Article
Rheumatology
Baozhen Huang, Xinning Wang, Yanlin Niu, Yuchuan Ding, Xiaolei Wang, Qingqing Tan, Yucong Li, Yuan Liu, Ying Chi, Yuan Wang, Zhixuan Zhou, Jianguo Li
Summary: This study evaluated the use of JAKi in treating JDM and found it to be a relatively safe and effective alternative. Cytokine profiles were able to reflect the inflammatory status of JDM patients.
Review
Clinical Neurology
Shuyuan Hu, Hangil Lee, Haiping Zhao, Yuchuan Ding, Jiangang Duan
Summary: Cerebral venous thrombosis is a rare but important type of stroke, where inflammation plays a significant role in its pathophysiology and anti-inflammatory therapy shows promise.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Honglian Duan, Zhe Cheng, Ho Jun Yun, Lipeng Cai, Yanna Tong, Zhenzhen Han, Xiaokun Geng, Yuchuan Ding
Summary: This study investigates the relationship between serum bilirubin, stroke severity, and prognosis in patients with acute ischemic stroke (AIS). The results suggest that serum bilirubin levels are independently associated with stroke severity and prognosis.
NEUROLOGICAL RESEARCH
(2023)
Review
Neurosciences
Shuling Wan, Chaitu Dandu, Guangyu Han, Yibing Guo, Yuchuan Ding, Haiqing Song, Ran Meng
Summary: Cerebral small vessel disease (CSVD) is a group of pathological processes affecting small arteries, arterioles, capillaries, and small veins of the brain. Inflammation plays an important role in the pathophysiology of CSVD. MRI is the main diagnostic method for CSVD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Behavioral Sciences
Fengwu Li, Xiaokun Geng, Roxanne Ilagan, Shangying Bai, Yuhua Chen, Yuchuan Ding
Summary: This study explored the effect of post-stroke exercise conditioning on brain injury and gluconeogenesis regulation. The results showed that exercise reduced brain infarct volumes, cell death, and neurological deficits after stroke. This neuroprotection was associated with the activation of the PI3K/AKT/FoxO1 signaling pathway and inhibition of gluconeogenesis.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Zhongao Wang, Chaitu Dandu, Yibing Guo, Meini Gao, Zixiang Wang, Duo Lan, Liqun Pan, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng
Summary: This study aimed to explore the characteristics of high jugular bulb (JB) in patients with non-thrombotic internal jugular venous stenosis (IJVS) and/or transverse sinus stenosis (TSS) in order to investigate the pathogenesis of high JB formation. The results showed that IJVS and asymmetric transverse sinus were independently and positively associated with high JB, especially dominant-side IJVS with dominant-side high JB.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Neurosciences
Bin Jiang, Xiaojie Wang, Jianping Ma, Aminah Fayyaz, Li Wang, Pei Qin, Yuchuan Ding, Xunming Ji, Sijie Li
Summary: Stroke is a major global health concern, and remote ischemic conditioning (RIC) has emerged as a convenient, simple, non-intrusive, and effective method for treating stroke. RIC improves brain tolerance to ischemia, increases cerebral blood perfusion, and reduces the risk of brain tissue damage.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Shuyu Lv, Xiaokun Geng, Ho Jun Yun, Yuchuan Ding
Summary: The study demonstrates that the combined treatment of phenothiazines can reduce autophagy levels, decrease apoptosis, and increase neuroprotection by inhibiting ER stress-mediated pathways. Phenothiazines exert their beneficial effects through the PERK-eIF2 alpha pathway, potentially paving the way for more targeted and effective treatments for stroke patients.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Clinical Neurology
Hangil Lee, Enoch Kim, Martin Mccandless, Reid Johnson, Rohin Singh, Yuchuan Ding
Summary: The COVID-19 pandemic has had significant consequences for patients with cerebrovascular disorders requiring interventions. The study found an increase in cerebrovascular accidents, a decrease in elective carotid endarterectomies, and an increase in carotid stenting during the pandemic. Patients from ethnic and racial minorities were disproportionately affected, and delayed care and prolonged operative times resulted in worse outcomes.
WORLD NEUROSURGERY
(2023)
