Article
Clinical Neurology
Sepide Kashefiolasl, Matthias S. Leisegang, Valeska Helfinger, Christoph Schuermann, Beatrice Pflueger-Mueller, Voahanginirina Randriamboavonjy, Andrea E. Vasconez, Geert Carmeliet, Klaus Badenhoop, Gudrun Hintereder, Volker Seifert, Katrin Schroeder, Juergen Konczalla, Ralf P. Brandes
Summary: The study found that 1,25-VitD3 attenuates CVS after SAH by inducing SDF1 alpha. Plasma levels of vitamin D3 were inversely correlated with the severity of CVS.
Article
Medicine, General & Internal
Helena Merkel, Dirk Lindner, Khaled Gaber, Svitlana Ziganshyna, Jennifer Jentzsch, Simone Mucha, Thilo Gerhards, Sabine Sari, Annika Stock, Felicitas Vothel, Lea Falter, Ulf Quaeschling, Karl-Titus Hoffmann, Juergen Meixensberger, Dirk Halama, Cindy Richter
Summary: This study proposes a visual classification scheme for cerebral vasospasm that is suitable for endovascular treatment. The results show good agreement between mathematical clustering and physician scoring. Additionally, the study finds that a threshold-based criterion does not provide additional advantages, and automated vessel analysis is superior in research settings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Matthias Simon, Alexander Grote
Summary: IL-6 is a proinflammatory cytokine that may serve as a potential biomarker in SAH patients, although discrepancies in research findings and lack of defined clinical endpoints hinder its routine clinical use. Further research is needed to better understand the role of IL-6 and neuroinflammation in the pathophysiology of SAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Xiaopeng Li, Lang Zeng, Xuanzhen Lu, Kun Chen, Maling Yu, Baofeng Wang, Min Zhao
Summary: Early brain injury (EBI) following subarachnoid hemorrhage (SAH) is strongly associated with delayed cerebral ischemia and poor prognosis. Various pathological processes, such as microvascular alterations, ionic imbalances, blood-brain barrier disruption, immune-inflammatory responses, oxidative stress, and cell death activation, contribute to neurovascular dysfunction after SAH. Promising therapeutic approaches for preserving neurological function after SAH include calcium channel antagonists, endothelin-1 receptor blockers, antiplatelet agents, anti-inflammatory agents, and anti-oxidative stress agents. Mitigating EBI through neuroprotective measures is critical, and understanding the molecular pathways involved in brain injury, including brain ischemia-hypoxic injury, neuroimmune inflammation activation, and cell-signaling pathway activation, is essential for better treatment outcomes.
Article
Clinical Neurology
E. Francois Aldrich, Randall Higashida, Abdel Hmissi, Elizabeth J. Le, R. Loch Macdonald, Angelina Marr, Stephan A. Mayer, Sebastien Roux, Nicolas Bruder
Summary: Aneurysmal subarachnoid hemorrhage (aSAH) is associated with significant morbidity and mortality. The presence of thick, diffuse subarachnoid blood may indicate a worse clinical course and outcome, independently of other known prognostic factors. Patients with thick and diffuse SAH have higher rates of mortality, vasospasm-related morbidity, and poor clinical outcomes compared to those without thick and diffuse SAH.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Dorothee Mielke, Katja Doering, Daniel Behme, Marios Nikos Psychogios, Veit Rohde, Vesna Malinova
Summary: The study aimed to assess the impact of endovascular rescue therapies on the long-term functional outcome of patients with refractory cerebral vasospasm following aneurysmal subarachnoid hemorrhage.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Sisi Liu, Ning Gan, Jing Xie, Yu Zhang, Fei Su, Tongle Jia
Summary: A retrospective study found that the combination of alprostadil and nimodipine has significant clinical efficacy in treating cerebral vasospasm after subarachnoid hemorrhage. This combination therapy can effectively reduce inflammatory factor levels and improve hemorheological indexes, promoting the repair of neurological function.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Critical Care Medicine
Clement Isola, Jean-Noel Evain, Gilles Francony, Caroline Baud, Anne Millet, Amelie Desrumaux, Isabelle Wroblewski, Jean-Francois Payen, Guillaume Mortamet
Summary: This study investigates the occurrence of cerebral vasospasm in pediatric patients, especially following nontraumatic SAH. The use of TCD and milrinone may be beneficial in the diagnosis and treatment of cerebral vasospasm.
NEUROCRITICAL CARE
(2022)
Article
Biology
Jong Kook Rhim, Dong Hyuk Youn, Bong Jun Kim, Youngmi Kim, Sungeun Kim, Heung Cheol Kim, Jin Pyeong Jeon
Summary: Continuous monitoring of plasma copeptin levels facilitates the screening of DCI in poor-grade SAH patients, while the relationship between CRP levels and DCI is not significant. Additionally, predicting DCI by combining TCD with copeptin changes has a better outcome than using TCD alone.
Article
Medicine, General & Internal
Ali Khanafer, Pervinder Bhogal, Victoria Hellstern, Christoph Harmening, Hansjoerg Baezner, Oliver Ganslandt, Hans Henkes
Summary: This study analyzed the diagnosis and management of patients with aneurysmal subarachnoid hemorrhage who died from ischemic brain damage caused by vasospasm. It was found that early recognition of severe vasospasm is crucial for treatment, but aggressive treatment may not prevent death.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ramon Torne, Jhon Hoyos, Laura Llull, Ana Rodriguez-Hernandez, Guido Munoz, Ricard Mellado-Artigas, Daniel Santana, Leire Pedrosa, Alberto Di Somma, Luis San Roman, Sergio Amaro, Joaquim Ensenat
Summary: The study found that improvements in cerebral edema and consciousness level were not associated with the occurrence of CI in severe aSAH patients. Therefore, intensive monitoring should not be reduced even if these indicators show improvement during the first week after bleeding.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
H-K Vo, V-T Le, V-L Nguyen, X-C Dao, D-H Duong, T-L Trinh, V-T Nguyen, H-L Vo, C-H Nguyen, V-L Tran, A-T Nguyen, V-T Hoang, T-A Truong, T-B Nguyen, B-C Chu, T-M Le, T-T-H Dao, T-H Duong, H-Q Ha, T-P-L Trinh, T-T Truong, V-D Phan, T-N-L Pham, T-H Phuong, Q-C Le
Summary: The objective of this study was to evaluate the value of transcranial Doppler (TCD) ultrasonography in diagnosing cerebral vasospasm in SAH patients in Vietnam. The results showed that TCD had a high accuracy in diagnosing vasospasm, with a high predictive diagnostic value. Hemiplegia was the clinical symptom with the highest diagnostic value.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Ling Chen, Yang Jin, Ling Wang, Kai Wei, Xin Li, Tao Jiang, Xiangyang Cao, Liujun Xue, Qiantao Cheng
Summary: This study investigated the impact of human serum albumin (HSA) levels on symptomatic cerebral vasospasm (SCVS) in patients with aneurysmal subarachnoid hemorrhage (aSAH). The results showed that HSA levels lower than the average and lowest levels were associated with the occurrence of SCVS, and the lowest HSA level was a better predictor for SCVS.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Kota Kurisu, Masaaki Hokari, Kazuki Uchida, Katsuyuki Asaoka, Minoru Ajiki, Tatsuro Takada, Koji Itamoto, Miki Fujimura
Summary: This study retrospectively analyzed the clinical experience of treating aneurysmal subarachnoid hemorrhage (aSAH) in the subacute phase. The results showed that treatment in the subacute phase can also lead to favorable clinical outcomes, similar to treatment in the hyperacute phase. However, further research is needed to establish the optimal treatment strategies for these patients.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Clinical Neurology
Tamara M. Mueller, Stephanie Gollwitzer, Ruediger Hopfengartner, Stephan Rampp, Johannes D. Lang, Jenny Stritzelberger, Dominik Madzar, Caroline Reindl, Maximilian Spruegel, Muejgan Dogan Onugoren, Iris Muehlen, Joji B. Kuramatsu, Stefan Schwab, Hagen B. Huttner, Hajo M. Hamer
Summary: The study compared the ability of qEEG and TCD/TCCS to early identify patients who will develop later manifest cerebral infarction, finding that qEEG could differentiate between patients with and without cerebral infarction while TCD/TCCS did not show significant differences.
CLINICAL NEUROPHYSIOLOGY
(2021)