Article
Neurosciences
Mariajose Metcalfe, Brian T. David, Brett C. Langley, Caitlin E. Hill
Summary: Spinal cord injury leads to tissue damage and functional deficits. Administering NR can increase NAD+ levels in the injured spinal cord, protect tissue, and improve motor function.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Borut Poljsak, Vito Kovac, Irina Milisav
Summary: The use of NAD+ boosters as dietary supplements has gained popularity due to increasing interest in anti-ageing strategies and health-promoting lifestyles. However, there are uncertainties regarding dosage, timing, safety, and side effects. More clinical trials and research are needed to determine proper dosages, treatment durations, and long-term consequences of increased NAD+ levels.
Article
Nutrition & Dietetics
Nengzhi Pang, Qianrong Hu, Yujia Zhou, Ying Xiao, Wenli Li, Yijie Ding, Yunan Chen, Mingtong Ye, Lei Pei, Qiuyan Li, Yingying Gu, Yan Sun, Evandro Fei Fang, Mianrong Chen, Zhenfeng Zhang, Lili Yang
Summary: The study aimed to explore the health benefits of boosting NAD levels with NR on HCC. The results showed that NR supplementation alleviated HCC-induced weight loss and metastasis to the lung, and decreased HCC progression and metastasis in both in vivo and in vitro experiments. Therefore, supplementing NR may serve as an effective treatment for the suppression of HCC progression.
Article
Biochemistry & Molecular Biology
Cuiting Liao, Li Zhang, Rong Jiang, Juanjuan Xu, Jiarui Tang, Kai Hu, Shifang Jiang, Longhui Li, Yongqiang Yang, Jiayi Huang, Li Tang, Longjiang Li
Summary: The expression of NADK is positively correlated with APAP-induced acute liver injury, and inhibition of NADK can alleviate liver injury by increasing hepatic NAD(+) level and improving antioxidant capacity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Yongxian Zhuang, Allison B. B. Haugrud, Meg A. A. Schaefer, Shanta M. M. Messerli, W. Keith Miskimins
Summary: Depletion of cellular NAD+ is a critical factor in the sensitivity of cancer cells to the cytotoxic effects of metformin. NAMPT plays a key role in maintaining sufficient levels of NAD+, and cancer cells that express elevated levels of NAMPT are resistant to metformin's killing effect.
FRONTIERS IN ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Fan Yang, Xuan Deng, Ye Yu, Lei Luo, Xianda Chen, Jinping Zheng, Yugang Qiu, Feng Xiao, Xiaomei Xie, Yuzheng Zhao, Jun Guo, Feifei Hu, Xuguang Zhang, Zhenyu Ju, Yong Zhou
Summary: The association between whole blood NAD(+) contents and aging differed significantly between males and females, with a loss of blood NAD(+) observed only in males, especially in the male middle-aged population. Considering gender differences is crucial in future studies related to NAD(+).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Claudia Christiano Silva Chini, Heidi Soares Cordeiro, Ngan Le Kim Tran, Eduardo Nunes Chini
Summary: The geroscience hypothesis suggests that addressing the biology of aging can prevent or mitigate chronic diseases. The relationship between NAD metabolism and cellular senescence is complex, but understanding it is necessary for exploring NAD replacement therapies.
Article
Biochemistry & Molecular Biology
Chengting Luo, Changmei Yang, Xueying Wang, Yuling Chen, Xiaohui Liu, Haiteng Deng
Summary: Research showed that nicotinamide supplementation can reduce fat mass in obese mice, improve glucose tolerance, and enhance mitochondrial function in adipose tissue. Nicotinamide activates NAMPT and increases cellular NAD(+) levels to reprogram cellular metabolism for better adipose tissue function.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Neurosciences
Chen Shen, Cong Chen, Tong Wang, Tong-Yao Gao, Min Zeng, Yun-Bi Lu, Wei-Ping Zhang
Summary: Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme in the salvaging synthesis pathway of nicotinamide adenine dinucleotide (NAD). Depletion of NAMPT can lead to cognitive deficiency in hippocampus neurons and increase the risk of neurodegeneration due to mitochondrial dysfunction.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Cell Biology
Lola E. Navas, Amancio Carnero
Summary: NAD+ plays a crucial role in cell homeostasis, participating in both redox and nonredox reactions. Tumor cells need to maintain high levels of NAD+ through the salvage pathway to meet their demands. NAMPT, the rate-limiting enzyme in this pathway, has been identified as a potential target for cancer therapy.
Review
Physiology
Julianna D. Zeidler, Sonu Kashyap, Kelly A. Hogan, Eduardo Nunes Chini
Summary: During the COVID-19 pandemic, it has been observed that the elderly and individuals with age-related syndromes are more susceptible to severe immune responses. CD38 has been implicated in the altered immunometabolism resulting from COVID-19 infection, suggesting it as a potential therapeutic target.
PHYSIOLOGICAL REVIEWS
(2022)
Review
Plant Sciences
Chen Guo, Qingxia Huang, Yisa Wang, Yao Yao, Jing Li, Jinjin Chen, Mingxia Wu, Zepeng Zhang, E. Mingyao, Hongyu Qi, Peng Ji, Qing Liu, Daqing Zhao, Hang Su, Wenxiu Qi, Xiangyan Li
Summary: This research provides a summary of the latest findings on the prevention and treatment of various diseases through the regulation of NAD(+) metabolism by natural products. The natural products mainly include phenols, flavonoids, glycosides, quinones, terpenoids, pyrazines, alkaloids, and phenylpropanoids, which have antioxidant, energy-producing, anti-inflammatory, anti-apoptotic, and anti-aging effects.
Review
Physiology
David Walzik, Wiebke Jonas, Niklas Joisten, Sergen Belen, Rob C. I. Wuest, Gilles Guillemin, Philipp Zimmer
Summary: Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme with various cell functions and has been found to be associated with diseases and aging. Exercise is suggested to restore NAD(+) homeostasis through metabolic adaption. This review discusses the impact of acute exercise and exercise training on NAD(+) metabolism and highlights their potential value as NAD(+)-boosting strategies.
Article
Chemistry, Analytical
Jie Zhang, Zengchen Liu, Fengshou Tian, Yahong Chen
Summary: A fluorescent compound derived from coumarin and hemicyanine was synthesized and characterized in this paper, showing higher ratiometric fluorescence response activity toward NAD(P)H compared to other commonly coexisting compounds in the cell microenvironment. The fluorescence identification mechanism was deduced to be a redox reaction between the sensor and NAD(P)H. This ratiometric fluorescent probe provides a theoretical basis for sensing NAD(P)H in vitro and in vivo, and was used to build a sensitive detection platform of NAD(P)H-dependent enzyme activity based on the fluorescence method.
ANALYTICAL METHODS
(2021)
Article
Biochemistry & Molecular Biology
Ning Xia, Gisela Reifenberg, Christian Schirra, Huige Li
Summary: The dysfunction of perivascular adipose tissue (PVAT) in obese mice is found to be associated with reduced SIRT1 activity, likely due to a deficiency in NAD(+). Restoring NAD(+) levels in PVAT leads to a normalization of vascular function.
Article
Neurosciences
Mingzi Ran, Zhaoju Li, Lujia Yang, Li Tong, Lina Zhang, Hailong Dong
Article
Anesthesiology
Y. Chen, H. Nie, L. Tian, L. Tong, J. Deng, Y. Zhang, H. Dong, L. Xiong
BRITISH JOURNAL OF ANAESTHESIA
(2015)
Article
Biochemistry & Molecular Biology
Yu Chen, Min Cai, Jiao Deng, Li Tian, Shiquan Wang, Li Tong, Hailong Dong, Lize Xiong
NEUROCHEMICAL RESEARCH
(2016)
Article
Endocrinology & Metabolism
Li-Na Zhang, Cen Yang, Peng-Rong Ouyang, Zhi-Chao Zhang, Ming-Zi Ran, Li Tong, Hai-Long Dong, Yong Liu
Article
Physiology
Zhijuan Cao, Adithya Balasubramanian, Sean P. Marrelli
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2014)
Article
Anesthesiology
Zhi-Hua Wang, Xin-Li Ni, Jian-Nan Li, Zhao-Yang Xiao, Chen Wang, Li-Na Zhang, Li Tong, Hai-Long Dong
ANESTHESIA AND ANALGESIA
(2014)
Article
Anesthesiology
L. Tong, M. Cai, Y. Huang, H. Zhang, B. Su, Z. Li, H. Dong
BRITISH JOURNAL OF ANAESTHESIA
(2014)
Article
Medicine, General & Internal
Marina Dobrivojevic, Ivan Bohacek, Igor Erjavec, Dunja Gorup, Srecko Gajovic
CROATIAN MEDICAL JOURNAL
(2013)
Article
Pharmacology & Pharmacy
Teng Guan, Qian Liu, Yisong Qian, Haopeng Yang, Jiming Kong, Junping Kou, Boyang Yu
EUROPEAN JOURNAL OF PHARMACOLOGY
(2013)
Article
Integrative & Complementary Medicine
Fafeng Cheng, Yi Lu, Xianggen Zhong, Wenting Song, Xueqian Wang, Xiaoguang Sun, Jianguo Qin, Shaoying Guo, Qingguo Wang
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2013)
Article
Neurosciences
Li Tong, Zhixin Wu, Mingzi Ran, Yu Chen, Lujia Yang, Haopeng Zhang, Lina Zhang, Hailong Dong, Lize Xiong
MOLECULAR NEUROBIOLOGY
(2015)
Article
Neurosciences
Yanping Song, Ruitong Chu, Fuyang Cao, Yanfeng Wang, Yanhong Liu, Jiangbei Cao, Yongxin Guo, Weidong Mi, Li Tong
Summary: The study found that the dopaminergic system in the VTA promotes emergence from anesthesia in rats under sevoflurane, and the VTA(DA)-PrL pathway facilitates emergence from sevoflurane anesthesia.
NEUROSCIENCE BULLETIN
(2022)
Article
Oncology
Yanping Song, Jingjing Liu, Mingxing Lei, Yanfeng Wang, Qiang Fu, Bailin Wang, Yongxin Guo, Weidong Mi, Li Tong
Summary: The study developed an algorithm to predict postoperative pneumonia in elderly lung cancer patients undergoing video-assisted thoracoscopic surgery. The algorithm, consisting of seven variables, was internally and externally validated to be effective in predicting the risk of postoperative pneumonia. The algorithm showed a C-index of 0.70 in the training group, 0.67 in the internal validation group, and 0.71 in the external validation dataset.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Analytical
Rujin Zhang, Chaowei Zhuang, Zilin Wang, Guihua Xiao, Kunsha Chen, Hao Li, Li Tong, Weidong Mi, Hao Xie, Jiangbei Cao
Summary: The study combined extended-field-of-view microscopy with a novel prism-based cranial window to achieve simultaneous imaging of deep-brain regions and the superficial cortex in mouse brains, providing promising results for dynamic imaging in both layers.
Article
Anesthesiology
Min Cai, Li Tong, Beibei Dong, Wugang Hou, Likai Shi, Hailong Dong