期刊
NEUROLOGIC CLINICS
卷 31, 期 3, 页码 799-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2013.03.007
关键词
Parkinson disease; Deep brain stimulation; Patient selection; Beta band oscillations
资金
- NIMH [1K23MH092735]
- CleveMed/Great Lakes Neurotechnologies
- Michael J Fox Foundation
Advances in functional neurosurgery have expanded the treatment of Parkinson disease (PD) to targeted electrical stimulation of specific nodes in the basal ganglia circuitry. Deep brain stimulation (DBS), applied to selected patients and difficult-to-manage motor fluctuations, yields substantial reductions in off time and dyskinesia. Emerging concepts in DBS include examination of new targets, such as the potential efficacy of pedunculopontine nucleus stimulation for treatment of freezing and falls, the use of pathologic oscillations in the beta band to construct an adaptive closed-loop DBS, and new technologies, including segmented electrodes to steer current toward specific neural populations.
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