Article
Immunology
Courtney Mowat, Shayla R. Mosley, Afshin Namdar, Daniel Schiller, Kristi Baker
Summary: The recruitment and activation of CD8(+) T cells in dMMR CRCs depend on the overexpression of CCL5 and CXCL10, which is essential for successful anti-tumor immunity. This strategy represents a potential therapeutic approach to enhance TIL recruitment and local priming in CRCs.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Oncology
Emilio Esteban, Francisco Exposito, Guillermo Crespo, Julio Lambea, Alvaro Pinto, Javier Puente, Jose A. Arranz, Miriam Redrado, Cristina Rodriguez-Antona, Carlos de Andrea, Marta Lopez-Brea, Esther Redin, Angel Rodriguez, Diego Serrano, Jorge Garcia, Enrique Grande, Daniel Castellano, Alfonso Calvo
Summary: High levels of CXCL10, CXCL11, HGF, and IL-6 before treatment were found to be associated with poor prognosis in metastatic renal cell carcinoma patients treated with sunitinib or pazopanib. These factors may constitute a secretory cluster that acts coordinately to promote tumor growth and resistance to antiangiogenic therapy. A prognostic index incorporating these biomarkers can predict higher risk of relapse in mRCC patients.
Article
Clinical Neurology
Antonio Oliviero, Fernando de Castro, Francesca Coperchini, Luca Chiovato, Mario Rotondi
Summary: COVID-19, caused by SARS-CoV-2, is a viral pandemic that originated in East Asia and resulted in significant clinical consequences such as acute respiratory distress syndrome. Reports have indicated peculiar neurological symptoms in patients infected by SARS-CoV-2, including hyposmia/anosmia and dysgeusia. The pro-inflammatory chemokine CXCL10 plays a role in the cytokine storm and ARDS in COVID-19, potentially linking pulmonary and olfactory dysfunctions.
Article
Immunology
Steffen Pfeuffer, Leoni Rolfes, Timo Wirth, Falk Steffen, Marc Pawlitzki, Andreas Schulte-Mecklenbeck, Catharina C. Gross, Marcus Brand, Stefan Bittner, Tobias Ruck, Luisa Klotz, Heinz Wiendl, Sven G. Meuth
Summary: Immunoadsorption demonstrated better outcomes compared to double-dose methylprednisolone for treating steroid-refractory acute multiple sclerosis relapses, and modulation of B cell function may be a potential mechanism of action for immunoadsorption.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Peripheral Vascular Disease
Beatriz Moreno, Luisa Hueso, Rebeca Ortega, Esther Benito, Sergio Martinez-Hervas, Marta Peiro, Miguel Civera, Maria-Jesus Sanz, Laura Piqueras, Jose T. Real
Summary: The study analyzed the role of CXCR3 ligands on insulin resistance and endothelial dysfunction in obese patients. It found that CXCL10 and CXCL11 are associated with insulin resistance and enhance leukocyte endothelial arrest in obese subjects, suggesting that targeting CXCR3 signaling could be a new therapeutic approach for preventing obesity-associated cardiovascular co-morbidities.
MICROVASCULAR RESEARCH
(2022)
Article
Chemistry, Analytical
Sara Guerrero, Esther Sanchez-Tirado, Lourdes Agui, Araceli Gonzalez-Cortes, Paloma Yanez-Sedeno, Jose M. Pingarron
Summary: This paper reports an electrochemical immunoplatform for rapid detection of CCL5 chemokine in multiple sclerosis patients, showing excellent analytical performance and low detection limit.
Article
Microbiology
Farzaneh Hassanshahi, Mojgan Noroozi Karimabad, Elahe Miranzadeh, Gholamhossein Hassanshahi, Seyedeh Atekeh Torabizadeh, Ali Jebali
Summary: The study investigated the association between Brucella infection and the chemokines CXCL9, 10, and 11. The results showed that the serum levels of these chemokines were significantly increased in patients with acute brucellosis, suggesting their potential as markers for the disease.
CURRENT MICROBIOLOGY
(2023)
Article
Health Care Sciences & Services
Cristina Ramo-Tello, Yolanda Blanco, Luis Brieva, Bonaventura Casanova, Eva Martinez-Caceres, Daniel Ontaneda, Lluis Ramio-Torrenta, Alex Rovira
Summary: Minimizing the risk of relapse is crucial in the treatment of multiple sclerosis (MS). This article aims to improve the quality of care for this neurological process by addressing key concepts, clinical examination recommendations, classification criteria, imaging techniques, biomarkers, and specific therapeutic advice for special populations. An algorithm for treating MS relapses is also provided.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Microbiology
Xin Yu, Ying Chen, Lele Cui, Kaming Yang, Xumeng Wang, Linyuan Lei, Yanping Zhang, Xinyi Kong, Wanwen Lao, Zhenlin Li, Yang Liu, Yuetong Li, Changlong Bi, Chao Wu, Aixia Zhai
Summary: This study found that CXCL8, CXCL9, CXCL10, and CXCL11 can be used as serum biomarkers to forecast liver injury caused by HBV infection, using a combination of bioinformatics, cell experiments, and clinical correlation analysis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Developmental Biology
Yue Zhang, YingJiao Chen, Linyu Zhang, YiLun Wu, Ying Feng, Fang Ma
Summary: Trophoblast cells are crucial for embryo recognition, localization, and placental development during embryo implantation. High-throughput sequencing identified 438 differentially expressed mRNAs and 41 lncRNAs associated with embryo cessation. CLRN1-AS1 was found to significantly affect the adhesion function of trophoblast cells. It modulates the adhesion ability of trophoblast cells to the extracellular matrix by influencing the chemokines CXCL10/CXCL11.
Article
Allergy
Johanna Huoman, Sadia Haider, Angela Simpson, Clare S. Murray, Adnan Custovic, Maria C. Jenmalm
Summary: Studies found that in children with asthma and/or allergic sensitization, elevated CCL18 levels at ages 1 and/or 8 were associated with a higher risk of developing asthma from early school age to adolescence. Similarly, chemokines CXCL10 and CXCL11 were also linked to the development of both allergic sensitization and asthma, with differential temporal effects present.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Oncology
Yue Han, Zhewei Guo, Lijuan Jiang, Xinyue Li, Jiahui Chen, Ling Ouyang, Yan Li, Xiaoying Wang
Summary: This study aimed to identify biomarkers of ovarian cancer, focusing on tumors with homologous recombination deficiency (HRD), to optimize immunotherapy. Using transcriptome data from the TCGA database, differentially expressed genes coding for CXCL10 and CCL5 were screened, and the results were validated using tissue sections. Single-cell sequencing data from the GEO database and TMB and SNP data from the TCGA database were used to determine the cellular origin of CXCL10 and CCL5. The expression levels of CXCL10 and CCL5 were correlated with HRD score, suggesting their potential as novel biomarkers for guiding immunotherapy in ovarian cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Stephanie N. Blandford, Neva J. Fudge, Craig S. Moore
Summary: In this study, elevated levels of CXCL10 were detected in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) cases, and these levels were associated with increased T cell numbers but not with peripheral CXCR3 expression. These findings support the importance of CXCL10 in MS and suggest the presence of alternative mechanisms of CXCL10 beyond solely influencing immune cell trafficking.
Article
Biochemistry & Molecular Biology
Alessandro Leuti, Emanuela Talamonti, Antonietta Gentile, Marta Tiberi, Alessandro Matteocci, Diego Fresegna, Diego Centonze, Valerio Chiurchiu
Summary: This study demonstrated a shift in the balance of M1/M2 macrophages during MS, with M1 macrophages showing a more proinflammatory profile in EAE compared to control mice, while M2 macrophages lost their M2-like phenotype. Immunization with MOG35-55 led to hyperactivation of M1 macrophages and a shift from anti-inflammatory M2 to pro-inflammatory M1. These findings suggest a potential role for developing new macrophage-centered therapeutic strategies in MS.
Review
Virology
Noha Mousaad Elemam, Iman Mamdouh Talaat, Azzam A. Maghazachi
Summary: Chemokines play a crucial role in regulating leukocyte migration and activation, particularly in managing viral infections where their expression profile shapes the immune response and regulates viral clearance. The CXCL10/CXCR3 axis is important in host defense against RNA and DNA viral infections.
Review
Clinical Neurology
Piotr Iwanowski, Jacek Losy
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2015)
Article
Medicine, General & Internal
Mine Hayriye Sorgun, Zerin Aksun, Yahya Burak Atalay, Canan Yucesan
TURKISH JOURNAL OF MEDICAL SCIENCES
(2015)
Article
Medicine, Research & Experimental
Adam Maciejewski, Marlena Wojcicka, Magdalena Roszak, Jacek Losy, Katarzyna Lacka
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2015)
Article
Immunology
Alicja Kalinowska-Lyszczarz, Slawomir Michalak, Mikolaj A. Pawlak, Jacek Losy, Wojciech Kozubski
JOURNAL OF NEUROIMMUNOLOGY
(2016)
Article
Immunology
Adam Niezgoda, Slawomir Michalak, Jacek Losy, Alicja Kalinowska-Lyszczarz, Wojciech Kozubski
IMMUNOLOGY LETTERS
(2017)
Article
Biochemistry & Molecular Biology
Slawomir Michalak, Alicja Kalinowska-Lyszczarz, Danuta Wegrzyn, Adam Niezgoda, Jacek Losy, Krystyna Osztynowicz, Wojciech Kozubski
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Clinical Neurology
Piotr Iwanowski, Jacek Losy, Lucyna Kramer, Marlena Wojcicka, Elzbieta Kaufman
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2017)
Article
Neurosciences
Tomasz Grzegorski, Jacek Losy
REVIEWS IN THE NEUROSCIENCES
(2017)
Article
Neurosciences
Ewa Ferensztajn-Rochowiak, Mariusz Kaczmarek, Marlena Wojcicka, Elzbieta Kaufman-Szukalska, Sebastian Dziuda, Agnieszka Remlinger-Molenda, Agnieszka Szeliga-Neymann, Jacek Losy, Janusz K. Rybakowski
NEUROPSYCHOBIOLOGY
(2018)
Article
Neurosciences
Tomasz Grzegorski, Jacek Losy
REVIEWS IN THE NEUROSCIENCES
(2019)
Article
Dentistry, Oral Surgery & Medicine
Tomasz Grzegorski, Jacek Losy, Agata Zarembska, Marek Stajgis, Wojciech Kozubski
JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE
(2018)
Editorial Material
Clinical Neurology
Piotr Iwanowski, Marta Kowalska, Michal Prendecki, Jolanta Dorszewska, Wojciech Kozubski, Malgorzata Rydzanicz, Rafal Ploski, Jacek Losy
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2019)
Article
Neurosciences
Tomasz Grzegorski, Jacek Losy
REVIEWS IN THE NEUROSCIENCES
(2020)
Review
Clinical Neurology
Jacek Losy
Summary: This paper presents the neurological aspects of COVID-19, emphasizing the importance of understanding the virus's impact on the nervous system for physicians in diagnosis and prevention. COVID-19 infection may lead to symptoms of both the central nervous system and the peripheral nervous system, requiring prompt diagnosis and treatment.
NEUROLOGY AND THERAPY
(2021)
Article
Clinical Neurology
Tomasz Grzegorski, Jacek Losy
AKTUALNOSCI NEUROLOGICZNE
(2016)