Review
Cell Biology
Xiaohua Liu, Yuxiang Du, Zhonghan Zhao, Jun Zou, Xiaojing Zhang, Lingli Zhang
Summary: White adipose tissue (WAT) functions as both an energy storage reservoir and a metabolically active endocrine organ. It can secrete various adipocytokines and synthesize and secrete exosomes, which play important roles in intercellular communication and physiological processes. The skeleton, on the other hand, acts as a protective organ, gives the body its shape, and is regulated by cytokines secreted by WAT. The link between WAT and bone lipid regulation has been identified, suggesting potential targets for treating skeletal diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Katy Diallo, Numa Simons, Souraya Sayegh, Michel Baron, Yannick Degboe, Jean-Frederic Boyer, Andrey Kruglov, Sergei Nedospasov, Julien Novarino, Meryem Aloulou, Nicolas Fazilleau, Arnaud Constantin, Alain Cantagrel, Jean-Luc Davignon, Benjamin Rauwel
Summary: The study shows that the binding of anti-TNF biologics to tmTNF can reduce the severity of arthritis by increasing the expression of anti-inflammatory markers and decreasing inflammation. This suggests a complementary explanation for the effects of anti-TNF biologics in treating inflammatory diseases and opens the door to studies on new arginase-1-dependent therapeutic targets.
Article
Pharmacology & Pharmacy
Uzma Saleem, Sundas Hira, Fareeha Anwar, Muhammad Ajmal Shah, Samia Bashir, Roua S. Baty, Reem H. Badr, Renald Blundell, Gaber El-Saber Batiha, Bashir Ahmad
Summary: The study found that the methanolic extract of Viola odorata exhibited memory-enhancing activity in LPS-treated mice, showing potential therapeutic effects on Alzheimer's disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Diana Szucs, Vanda Miklos, Tamas Monostori, Melinda Guba, Aniko Kun-Varga, Szilard Poliska, Erika Kis, Balazs Bende, Lajos Kemeny, Zoltan Vereb
Summary: Adipose-derived mesenchymal stem cells are used in regenerative medicine for burns and ulcers treatment. Inflammatory microenvironment can induce different biological pathways in these cells as shown by gene expression analysis. The secretion of cytokines and wound healing assay further support the accelerated wound healing potential of these cells under inflammation conditions.
Review
Biochemistry & Molecular Biology
Andy Ruiz, Yadira Palacios, Irene Garcia, Leslie Chavez-Galan
Summary: Tumor necrosis factor (TNF) is a key cytokine regulating inflammatory responses and plays a crucial role in granuloma formation during mycobacterial infections. The interactions between soluble and transmembrane TNF with their receptors influence effector mechanisms, providing insights into potential therapeutic strategies against mycobacterial infections. Understanding the structural and activation pathways of TNF and its receptors can offer valuable knowledge for developing more efficient therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Maha Sellami, Nicola Luigi Bragazzi, Baha Aboghaba, Mohamed A. Elrayess
Summary: This review summarizes the effects of acute and chronic exercise on immunoglobulins and cytokines in the elderly. Acute endurance exercise increases salivary SIgA, while acute muscle strengthening exercise raises levels of IL-6, IL-8, and TNF-alpha. Chronic exercise, both short-term and long-term, leads to improvements in immune function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Holger Loerchner, Laia Canes Esteve, Maria Elisa Goes, Roxanne Harzenetter, Nathalie Brachmann, Praveen Gajawada, Stefan Guenther, Nicolas Doll, Jochen Poeling, Thomas Braun
Summary: This study reveals that TNF alpha recruits VEGFA-expressing neutrophils for muscle tissue revascularization through the CCL20-CCR6 axis. This finding provides a promising approach for revascularization, especially in diabetic conditions.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Elzbieta Lazar-Poloczek, Ewa Romuk, Wojciech Jachec, Wiktoria Stanek, Bartosz Stanek, Monika Szoltysik, Tomasz Techmanski, Maja Hasterok, Celina Wojciechowska
Summary: This study aimed to compare the levels of adipokines, TNF-alpha, and soluble receptors in heart failure patients with different BMI. The study found that obese patients had the lowest NT-proBNP concentrations and higher leptin levels. TNF-alpha concentrations were positively correlated with sTNFr1 in all groups. Higher levels of sTNFr1 were associated with higher sTNFr2 and CRP levels. Obese patients may respond better to anti-TNF therapy.
Review
Oncology
Wei-Cheng Tseng, Hou-Chuan Lai, Yi-Hsuan Huang, Shun-Ming Chan, Zhi-Fu Wu
Summary: Cancer is a leading cause of death worldwide, and surgical resection is the main treatment for solid tumors. However, surgery-induced stress responses can lead to immunosuppression and cancer regrowth and spread. The tumor microenvironment, particularly the presence of tumor necrosis factor alpha (TNF-alpha), plays a crucial role in cancer progression and immune surveillance. Anesthetic agents and perioperative management have varying effects on inflammation, immune responses, and cancer-promoting signaling pathways, which may affect long-term cancer outcomes.
Review
Medicine, Research & Experimental
Farid Ghorbaninezhad, Patrizia Leone, Hajar Alemohammad, Basira Najafzadeh, Niloufar Nourbakhsh, Marcella Prete, Eleonora Malerba, Hossein Saeedi, Neda Tabrizi, Vito Racanelli, Behzad Baradaran
Summary: This study reviews the dual role of tumor necrosis factor-alpha (TNF-alpha) in systemic lupus erythematosus (SLE), as well as the efficacy and safety of anti-TNF-alpha therapies in SLE.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yi-Wen Duan, Shao-Xia Chen, Qiao-Yun Li, Ying Zang
Summary: This review focuses on the neuroimmune mechanism of neuropathic pain. TNF-alpha plays a crucial role in inducing and modulating neuropathic pain by facilitating peripheral and central sensitization. It controls cell survival and death through an inflammatory response and programmed cell death mechanisms. Overproduction of TNF-alpha in certain brain structures has an important role in pain-associated emotional disorders and memory deficits. The review also highlights the research prospects of the TNF-alpha-necroptosis pathway in pain modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Tiantian Chu, Shuhong Hu, Jiaqian Qi, Xueqian Li, Xiang Zhang, Yaqiong Tang, Meng Yang, Yang Xu, Chang-Geng Ruan, Yue Han, De-Pei Wu
Summary: This study investigated the effects of TNF alpha on megakaryocyte and platelet generation and found that TNF alpha had differential effects on their production at different concentrations.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Chemistry, Multidisciplinary
Sarah Belperain, Zi Yae Kang, Andrew Dunphy, Brandon Priebe, Norman H. L. Chiu, Zhenquan Jia
Summary: CNDs, as a novel form of nanoparticles, have shown potential anti-inflammatory properties in reducing TNF-alpha induced endothelial cell inflammation. This finding may open up a new direction for the treatment of cardiovascular diseases.
Editorial Material
Hematology
Federico Simonetta
Summary: The study demonstrates that dual blockade of TNF-α and IL-6R provides a significant advantage over single-cytokine blockade in protecting mice from lethal graft-versus-host disease.
Article
Education, Scientific Disciplines
Takashi Ishijima, Kazuyuki Nakajima
Summary: Through utilizing an animal model with LPS-induced rat brain, the study revealed that microglia induce different inflammatory cytokines through specific combinations of MAPKs and by the presence or absence of nitric oxide.