Article
Biochemistry & Molecular Biology
Jingqian Su, Siyuan Chen, Jianbin Xiao, Zhihua Feng, Shan Hu, Qiaofen Su, Qi Chen, Duo Chen
Summary: This study explores the therapeutic potential of aloe-emodin (AE) in the treatment of CLP-induced sepsis, demonstrating its ability to mitigate systemic inflammation and regulate the gut microbiota. The study provides novel insights into the molecular mechanisms underlying the anti-inflammatory effects of AE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Bin Zhang, Feng Zheng, Anpeng Liu, Zhen Li, Fei Zheng, Qiangsheng Liu, Liu Yang, Kai Chen, Yanlin Wang, Zongze Zhang, Qianwen He, Jia Zhan
Summary: Activation of CB2 receptors plays a protective role in sepsis by inhibiting pyroptosis and reducing the release of inflammatory mediators. The protective effect depends on the presence of endogenous CB2 receptors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Josep Bringue, Raquel Guillamat-Prats, Maria Luisa Martinez, Eva Torrents, Marta Camprubi-Rimblas, Lluis Blanch, Antonio Artigas
Summary: The study showed that a single, low dose of MTX can protect against sepsis-induced lung damage by reducing pro-inflammatory cytokines, decreasing infiltration of inflammatory cells in the lung, and regulating adenosine receptor A2aR and metalloproteinases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dayane Aparecida Gomes, Raphaelle Lima de Almeida Beltrao, Flavio Monteiro de Oliveira Junior, Jose Carlos da Silva Junior, Eduarda Patricia Carneiro de Arruda, Eduardo Carvalho Lira, Maria Jose Alves da Rocha
Summary: This article examines the changes in AVP and copeptin blood concentrations in sepsis. Studies suggest that AVP and copeptin behave similarly in the early stages of sepsis. However, during septic shock, there is a disproportionate decrease in copeptin concentrations compared to AVP, with higher levels of copeptin found in nonsurvivors.
Article
Medicine, Research & Experimental
Raquel Pires Nakama, Aparecida Donizette Malvezi, Maria Isabel Lovo-Martins, Lucas Felipe dos Santos, Ana Paula Canizares Cardoso, Gustavo Scacco, Andressa Mendes Dionisio de Freitas, Marli Cardoso Martins-Pinge, Phileno Pinge-Filho
Summary: The study found that metabolic syndrome can improve survival rates in septic mice, prevent damage to hematological and cardiovascular functions, and reduce the typical feature of increased nitric oxide in sepsis.
Article
Biochemistry & Molecular Biology
Pratsanee Hiengrach, Peerapat Visitchanakun, Pakteema Tongchairawewat, Ponphisudti Tangsirisatian, Thitiphat Jungteerapanich, Patcharee Ritprajak, Dhammika Leshan Wannigama, Pattarin Tangtanatakul, Asada Leelahavanichkul
Summary: BAM15 shows potential as an adjuvant therapy against sepsis hyperinflammation by attenuating multiple aspects of septic conditions, such as survival, organ damage, apoptosis, and brain injury, as well as regulating mitochondrial functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Cheng-Long Ge, Wei Chen, Li-Na Zhang, Yu-Hang Ai, Yu Zou, Qian-Yi Peng
Summary: Our study reveals the important role of the HPC-PFC pathway in improving cognitive dysfunction in a mouse model of CLP sepsis and provides a novel pathogenetic mechanism for SAE.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Immunology
Shireen Mohammad, Caroline E. O'Riordan, Chiara Verra, Eleonora Aimaretti, Gustavo Ferreira Alves, Klaus Dreisch, Johan Evenas, Patrizia Gena, Angela Tesse, Michael Rutzler, Massimo Collino, Giuseppe Calamita, Christoph Thiemermann
Summary: This study described the characteristics and effects of a novel small molecule AQP9 inhibitor, RG100204, in a polymicrobial infection model. The results showed that RG100204 could attenuate the cardiac and renal dysfunction caused by sepsis, indicating that AQP9 may be a potential drug target for polymicrobial sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Duo Li, Yibing Weng, Guan Wang, Genshen Zhen
Summary: 7-OBA treatment significantly increased survival rate and normalized temperature of sepsis mice, reduced levels of pro-inflammatory cytokines, increased anti-inflammatory cytokines, and reversed CLP-induced abnormalities in kidney, liver, and heart function. The anti-sepsis effect of 7-OBA may be associated with the regulation of NF-κB and JAK2-STAT3 signaling pathways.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Medicine, General & Internal
Aliaa Anter, Al-Shaimaa F. Ahmed, Asmaa S. A. Hammad, Waleed Hassan Almalki, Sara Mohamed Naguib Abdel Hafez, AlShaimaa W. Kasem, Mohamed A. El-Moselhy, Mohammad W. Alrabia, Ahmed R. N. Ibrahim, Mahmoud El-Daly
Summary: The study aimed to evaluate the effect of menthol against sepsis-induced mortality, acute lung injury (ALI), and acute kidney injury (AKI). Menthol improved survival after sepsis and alleviated the development of ALI and AKI. Additionally, menthol also suppressed inflammation and apoptosis markers, showing its protective role in experimental sepsis.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Warerat Kaewduangduen, Peerapat Visitchanakun, Wilasinee Saisorn, Ariya Phawadee, Charintorn Manonitnantawat, Chirapas Chutimaskul, Paweena Susantitaphong, Patcharee Ritprajak, Naraporn Somboonna, Thanya Cheibchalard, Dhammika Leshan Wannigama, Patipark Kueanjinda, Asada Leelahavanichkul
Summary: Bacteria-free DNA in sepsis mice is partly derived from gut translocation, influencing systemic inflammation and exacerbating sepsis severity. Inhibition of TLR-9 can attenuate the effects of bacterial DNA in macrophages, potentially improving sepsis hyper-inflammation in some cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Donghwan Park, MyungJa Ro, A-Jin Lee, Dong-Wook Kwak, Yunro Chung, Jae-Hong Kim
Summary: The study found that BLT2, a receptor for leukotriene B-4 with low affinity, plays a role in sepsis, a systemic inflammatory response syndrome caused by infection. Levels of BLT2 ligands and synthesizing enzymes for LTB4 and 12(S)-HETE were significantly increased in lung and liver tissues in a septic mouse model. Blocking BLT2 suppressed the production of sepsis-associated cytokines and alleviated lung inflammation in the sepsis group, suggesting that BLT2 may be a potential therapeutic target for sepsis patients.
MOLECULES AND CELLS
(2021)
Article
Physiology
Jose Maria Moreno-Navarrete, Ferran Comas, Vincent de Jager, Jose Manuel Fernandez-Real, Hjalmar R. Bouma
Summary: The study found that sepsis reduces the expression of adipogenesis-related genes in white adipose tissue while promoting inflammation in adipose tissue. In contrast, sepsis increases inflammation in brown adipose tissue without affecting the expression of thermogenic genes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Samar Imbaby, Yuichi Hattori
Summary: This study investigates the cardioprotective effects of Stattic, a STAT3 inhibitor, on cardiac inflammation and dysfunction in a mouse model of sepsis. The results show that Stattic reverses the cardiac abnormalities induced by sepsis and restores cardiac function, possibly through its anti-inflammatory activities.
Article
Immunology
Claudia V. de Araujo, Frederik Denorme, W. Zac Stephens, Qing Li, Mark J. Cody, Jacob L. Crandell, Aaron C. Petrey, Kimberly A. Queisser, John L. Rustad, Judah L. Evangelista, Michael S. Kay, Joshua D. Schiffman, Robert A. Campbell, Christian C. Yost
Summary: Neutrophil extracellular traps (NETs) can contribute to host inflammatory tissue damage during sepsis. This study investigated a novel therapeutic agent, neonatal NET-Inhibitory Factor (nNIF), and found that nNIF inhibited NET formation and improved survival in a mouse model of sepsis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Anderson de Oliveira Souza, Carlos Antonio Couto-Lima, Carlos Henrique Rocha Catalao, Nilton Nascimento Santos-Junior, Julia Fernanda dos Santos, Maria Jose Alves da Rocha, Luciane Carla Alberici
Article
Physiology
Bruna M. Santos, Glance C. Nascimento, Camila P. Capel, Gabriela S. Borges, Thales Rosolen, Joao P. J. Sabino, Christie R. A. Leite-Panissi, Luiz G. S. Branco
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Article
Physiology
Joao Paulo J. Sabino, Renato N. Soriano, Bruna M. Santos, Alberto F. Donatti, Rodrigo R. Fernandez, Glauber S. F. da Silva, Luiz G. S. Branco
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2019)
Article
Immunology
Mateus R. Amorim, Junia L. de Deus, Rafael A. Cazuza, Clarissa M. D. Mota, Luiz E. V. da Silva, Gabriela S. Borges, Marcelo E. Batalhao, Evelin C. Carnio, Luiz G. S. Branco
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Physiology
Bruna M. Santos, Heloisa D. C. Francescato, Flavia C. Turcato, Jose Antunes-Rodrigues, Terezila M. Coimbra, Luiz G. S. Branco
Review
Biochemistry & Molecular Biology
Anderson Vulczak, Carlos Henrique Rocha Catalao, Luiz Alexandre Pedro de Freitas, Maria Jose Alves Rocha
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Nutrition & Dietetics
Yandara A. Martins, Camila A. E. F. Cardinali, Maria Ida Ravanelli, Kellen Brunaldi
Article
Physiology
Clarissa M. D. Mota, Luiz G. S. Branco, Shaun F. Morrison, Christopher J. Madden
Article
Biology
Jonatas E. Nogueira, Brenda K. L. Agostinho, Clarissa M. D. Mota, Luiz G. S. Branco
JOURNAL OF THERMAL BIOLOGY
(2019)
Article
Plant Sciences
Clarissa M. D. Mota, Caroline Rodrigues-Santos, Ruither O. G. Carolino, Janete A. Anselmo-Franci, Luiz G. S. Branco
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Neurosciences
Jonatas E. Nogueira, Junia L. de Deus, Mateus R. Amorim, Marcelo E. Batalhao, Ricardo M. Leao, Evelin C. Carnio, Luiz G. S. Branco
NEUROSCIENCE LETTERS
(2020)
Article
Biochemistry & Molecular Biology
Emanuela G. Garattini, Bruna M. Santos, Daniele P. Ferrari, Camila P. Capel, Heloisa D. C. Francescato, Terezila M. Coimbra, Christie R. A. Leite-Panissi, Luiz G. S. Branco, Glauce C. Nascimento
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2019)
Article
Neurosciences
Carlos Henrique Rocha Catalao, Nilton Nascimento Santos-Junior, Luis Henrique Angenendt da Costa, Anderson Oliveira Souza, Evelin Capellari Carnio, Adriano Sebollela, Luciane Carla Alberici, Maria Jose Alves Rocha
NEUROTOXICITY RESEARCH
(2020)
Article
Neurosciences
Luis Henrique Angenendt da Costa, Nilton Nascimento Santos-Junior, Carlos Henrique Rocha Catalao, Maria Jose Alves Rocha
Summary: The study findings demonstrate that microglial activation modulates the secretion of several hormones to varying degrees during sepsis, and this process is associated with inflammatory mediators produced both centrally and peripherally.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Endocrinology & Metabolism
Nilton Nascimento dos Santos-Junior, Luis Henrique Angenendt da Costa, Carlos Henrique Rocha Catalao, Maria Jose Alves Rocha
Summary: This study investigates the dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis in sepsis survivors. The results indicate that the HPA axis recovers soon after sepsis induction, with normal secretion of adrenocorticotropic hormone (ACTH) and corticosterone (CORT) observed in both naive and sepsis survivor animals. The study also suggests that inflammatory mediators may play a role in the physiological response to sepsis.
NEUROIMMUNOMODULATION
(2022)