Article
Radiology, Nuclear Medicine & Medical Imaging
Isabelle Riederer, Mark Muehlau, Claus Zimmer, Magaly Gutbrod-Fernandez, Nico Sollmann, Jan S. Kirschke
Summary: The study found that pre-contrast T1-w imaging does not significantly increase diagnostic confidence or detection rate of contrast-enhancing lesions in spinal cord MRI follow-up exams for patients with multiple sclerosis (MS).
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Britta Matusche, Ludmila Litvin, Ruth Schneider, Barbara Bellenberg, Mark Muehlau, Viola Pongratz, Achim Berthele, Sergiu Groppa, Muthuraman Muthuraman, Frauke Zipp, Friedemann Paul, Heinz Wiendl, Sven G. Meuth, Philipp Saemann, Frank Weber, Ralf A. Linker, Tania Kuempfel, Ralf Gold, Carsten Lukas
Summary: The aim of this study was to analyze the extent of pseudoatrophy in the upper spinal cord during the first 2 years after therapy initiation and compare this to the brain. The results suggest that pseudoatrophy occurs not only in the brain, but also in the spinal cord during the first year of interferon-beta treatment.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Claudia E. Weber, Julia Kramer, Matthias Wittayer, Johannes Gregori, Sigurd Randoll, Florian Weiler, Stefan Heldmann, Christina Rossmanith, Michael Platten, Achim Gass, Philipp Eisele
Summary: In patients with relapsing MS, the presence of IRLs was associated with more aggressive MRI disease characteristics both in terms of cross-sectional and longitudinal analyses. The study found that patients with IRLs had higher EDSS scores, lesion loads, and brain atrophy rates compared to those without IRLs.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Christina Mueller, Jessica F. Baird, Robert W. Motl
Summary: This study found that brain metabolites measured with Magnetic Resonance Spectroscopy (MRS), specifically myo-inositol (MI) and N-acetylaspartate (NAA), are associated with walking performance in older adults with multiple sclerosis (MS). These findings suggest that MI and NAA may be useful imaging end-points for measuring walking ability in this population.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Article
Oncology
Xiaoyun Su, Xiangquan Kong, Xiangchuang Kong, Zuneng Lu, Chuansheng Zheng
Summary: This case report describes a rare case of multiple myeloma with involvement of the spinal cord and peripheral nervous system. The patient presented with elevated levels of serum beta 2-macroglobulin and cerebrospinal fluid protein, and imaging studies revealed diffuse infiltration of MM bone marrow and swelling in the spinal cord and nerve branches. The importance of MRI in detecting extramedullary involvement in multiple myeloma is highlighted.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Takeshi Hirata, Takahide Itokazu, Atsushi Sasaki, Fuminori Sugihara, Toshihide Yamashita
Summary: The lack of established biomarkers for monitoring the therapeutic response and identifying key biological processes in multiple sclerosis (MS) hinders drug development. In this study, high-field MR imaging was used to evaluate the effects of a potential MS drug, anti-repulsive guidance molecule-a (RGMa) antibody, in EAE mice. The results showed that anti-RGMa antibody treatment improved blood-spinal cord barrier (BSCB) disruption and functional recovery. MRI assessment of BSCB disruption could predict demyelination, but this predictive ability was compromised by the antibody treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
BingYang Bian, BoXu Zhou, ZhiQing Shao, XiaoNa Zhu, YiGe Jie, Dan Li
Summary: This study aimed to use diffusion kurtosis imaging (DKI) to assess gray matter, white matter, lesions, and therapeutic effect in multiple sclerosis (MS). The DKI metrics showed significant differences between MS and healthy individuals, as well as between patients with and without T2 hyperintensity in the cervical spinal cord. The study results indicate that DKI metrics can detect and quantitatively evaluate the changes in micropathological structure of the cervical spinal cord.
Review
Clinical Neurology
Daniel J. Kreiter, Job van den Hurk, Christopher J. Wiggins, Raymond M. M. Hupperts, Oliver H. H. Gerlach
Summary: Magnetic resonance imaging (MRI) is essential for diagnosing and monitoring multiple sclerosis (MS), and the use of ultra-high field (UHF) MRI in spinal cord imaging brings additional challenges. This review discusses the potential benefits of UHF spinal cord MRI in MS research and the technical challenges that need to be addressed.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giuseppe Pontillo, Simone Penna, Sirio Cocozza, Mario Quarantelli, Michela Gravina, Roberta Lanzillo, Stefano Marrone, Teresa Costabile, Matilde Inglese, Vincenzo Brescia Morra, Daniele Riccio, Andrea Elefante, Maria Petracca, Carlo Sansone, Arturo Brunetti
Summary: Using unsupervised machine learning, patients with multiple sclerosis (pwMS) were stratified based on brain MRI-derived volumetric features, providing reliable and predictive stratification of pwMS.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Ziya Eksi, Muhammed Emin Ozcan, Murat cakiroglu, Cemil Oz, Ayse Aralasmak
Summary: This study successfully differentiated multiple sclerosis (MS) and low-grade brain tumors using MRS data and CAD methods, achieving 100% accuracy, sensitivity, and specificity. MR spectroscopy and artificial intelligence methods may serve as complementary imaging techniques to MRI in the differentiation of MS lesions and brain tumors.
NEUROLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Sadayuki Ito, Hiroaki Nakashima, Naoki Segi, Jun Ouchida, Masahiro Oda, Ippei Yamauchi, Ryotaro Oishi, Yuichi Miyairi, Kensaku Mori, Shiro Imagama
Summary: An automated system using deep learning and MRI was developed for the detection and diagnosis of spinal schwannomas and meningiomas. The accuracy of object detection based on T1W, T2W, and T1W + T2W images was 84.8%, 90.3%, and 93.8% respectively. The accuracy of diagnosis based on T1W, T2W, and T1W + T2W images was 76.4%, 83.3%, and 84.1% respectively. The developed method showed potential in supporting radiological diagnosis, reducing the workload of radiologists.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
James G. Harper, Elizabeth N. York, Rozanna Meijboom, Agniete Kampaite, Michael J. Thrippleton, Patrick K. A. Kearns, Maria del C. Valdes Hernandez, Siddharthan Chandran, Adam D. Waldman
Summary: This study aimed to quantify brain microstructural changes in recently diagnosed relapsing-remitting multiple sclerosis (RRMS) patients using T-1 measures, and determine their associations with clinical disability. The results showed that T-1 is sensitive to brain microstructural changes in early RRMS, and prolonged T-1 in lesions and subtle changes in normal-appearing white matter and gray matter structures are associated with disability.
EUROPEAN RADIOLOGY
(2023)
Review
Clinical Neurology
Christopher Hollen, Lee E. Neilson, Ramon F. Barajas, Ian Greenhouse, Rebecca I. Spain
Summary: Conventional MRI is important for evaluating patients with multiple sclerosis, but its role in detecting the underlying pathophysiology of neurodegeneration is limited. Biomarkers that identify processes underlying neurodegeneration before irreversible damage occurs are needed. Oxidative stress is believed to play a major role in the pathogenesis of multiple neurodegenerative diseases, including multiple sclerosis. Non-invasive imaging techniques offer real-time assessment of oxidative stress within the brain, which is an area of unrealized potential.
FRONTIERS IN NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ling Wang, Shengqiang Wang, Weimin Zheng, Beining Yang, Yanhui Yang, Xin Chen, Qian Chen, Xuejing Li, Yongsheng Hu, Jubao Du, Wen Qin, Jie Lu, Nan Chen
Summary: This study reveals the specific functional changes in the brain of children after complete spinal cord injury, providing potential neural mechanisms for the sensory motor and cognitive-emotional deficits they face during rehabilitation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Critical Care Medicine
Tomas Horak, Magda Horakova, Alena Svatkova, Zdenek Kadanka, Petr Kudlicka, Jan Valosek, Tomas Rohan, Milos Kerkovsky, Eva Vlckova, Zdenek Kadanka, Dinesh K. Deelchand, Pierre-Gilles Henry, Josef Bednarik, Petr Bednarik
Summary: This study utilized proton magnetic resonance spectroscopy to reveal progressive neurochemical alterations in non-myelopathic stage (NMDC) and degenerative cervical myelopathy (DCM). The findings showed changes in neurochemical ratios and volumes in DCM patients, suggesting that MRS can detect neurochemical changes before the onset of myelopathy symptoms, while volumetry only reflects clinically manifest myelopathy.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
Christina M. Marra
Summary: Stroke can be a complication of CNS infections, especially caused by VZV and T pallidum. Treatment with adjunctive dexamethasone for acute pneumococcal meningitis is recommended, but it may lead to the emergence of DCV syndrome.
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Selima Siala, Nabil Rahoui, Benjamin Cho, Carlos A. Zamora
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Renato Hoffmann Nunes, Diogo Goulart Correa, Felipe Torres Pacheco, Ana Paula Alves Fonseca, Luiz Celso Hygino da Cruz Jr, Antonio Jose da Rocha
Summary: Vasculopathy is a significant consequence of various infections, and early recognition is essential as many of these diseases have poor outcomes if left untreated. Neuroimaging techniques such as MRI, CTA, and MRA can be used to visualize the complications associated with infectious vasculopathy, while high-resolution intracranial vessel wall imaging can directly assess the presence of vasculitis.
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Sheng-Che Hung, Carolina Guimaraes
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Omar Hamam, Samuel C. Cartmell, Javier M. Romero
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Manish K. Saha
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Alison M. Bays
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Carlos A. Zamora, Mahmud Mossa-Basha, Mauricio Castillo
Summary: Assessment of cerebral vasculopathies can be challenging, but a comprehensive understanding of different imaging methods can facilitate the process. There are various angiographic techniques with unique advantages and disadvantages, such as bolus-based methods that enhance arterial depiction and non-contrast techniques that show high-resolution arteries. MRI can assess vessel wall pathology and aid in diagnosing vasculitis and non-inflammatory vasculopathies.
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Paulo Puac-Polanco, Alex Rovira, Lubdha M. Shah, Richard H. Wiggins, Francisco Rivas Rodriguez, Carlos Torres
Summary: Cocaine-induced CNS vasculitis and midline destructive lesion, as well as reversible vasoconstriction syndrome triggered by substance abuse, are all important conditions that are associated with drugs and their risk factors.
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Aaron Bangad, Mehdi Abbasi, Sam Payabvash, Adam de Havenon
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
