Review
Biochemistry & Molecular Biology
Petra Hnilicova, Ema Kantorova, Stanislav Sutovsky, Milan Grofik, Kamil Zelenak, Egon Kurca, Norbert Zilka, Petra Parvanovova, Martin Kolisek
Summary: Alzheimer's disease (AD) is an incurable neurodegenerative disease characterized by perturbed cerebral perfusion and metabolism, induced proinflammatory processes, and the aggregation of amyloid beta and hyperphosphorylated Tau proteins. Various imaging methods can detect subclinical AD changes, and new insights suggest a link between brain insulin resistance and AD pathogenesis. This article discusses the use of non-neuronal imaging modalities to assess AD-related structural changes in the liver and pancreas, which may be clinically important during the prodromal phase of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Sule Tinaz
Summary: Accurate and timely diagnosis of atypical parkinsonian syndromes (APS) remains a challenge. However, recent advances in MRI technology have introduced promising imaging modalities to aid in the diagnosis of APS.
FRONTIERS IN NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tsung-Tai Lin, Cheng-Chuan Hu, Yi-Chih Hsu, Chih-Chien Wang, Shih-Wei Chiang, Chao-Ying Wang, Wei-Chou Chang, Guo-Shu Huang
Summary: Using MRS technology, we found that divers with hip pain had increased water content, increased unsaturation index of lipids, and decreased total lipid fraction in the femoral heads. These findings suggest that dysbaric changes in the femoral heads can be detected using MRS.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Oncology
Noriaki Minami, Donghyun Hong, Nicholas Stevers, Carter J. Barger, Marina Radoul, Chibo Hong, Lee Chen, Yaewon Kim, Georgios Batsios, Anne Marie Gillespie, Russel O. Pieper, Joseph F. Costello, Pavithra Viswanath, Sabrina M. Ronen
Summary: This study indicates that MRS-detectable GSH, lactate, and lactate production could serve as metabolic biomarkers of response to emerging TERT-targeted therapies for GBM, ultimately improving patient management.
Article
Radiology, Nuclear Medicine & Medical Imaging
Haiying Zhou, Jianguang Zhang, Xiao Ming Zhang, Tianwu Chen, Jiani Hu, Zonglin Jing, Shunhai Jian
Summary: The study found that renal diffusion kurtosis imaging is valuable for the diagnosis of early diabetic nephropathy, with mean kurtosis values serving as a more sensitive biomarker than mean diffusivity values. The MR DKI technique may be noninvasive and effective in detecting early DN.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yiqi Hu, Qilan Hu, Chenao Zhan, Ting Yin, Tao Ai
Summary: This study investigated the intraobserver and interobserver reproducibility of diffusion-weighted imaging (DWI) measurements, diffusion-kurtosis imaging (DKI) parameters, and image quality evaluation in breast lesions between single-shot echo-planar imaging (ss-EPI) and readout-segmented echo-planar imaging (rs-EPI). The results showed that compared to ss-EPI, rs-EPI had higher intraobserver and interobserver reproducibility for quantitative diffusion-related parameters and image quality assessments.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Konrad A. Kruk, Tobias J. Dietrich, Simon Wildermuth, Sebastian Leschka, Andreas Toepfer, Stephan Waelti, Chan-Hi Olaf Kim, Sabine Guesewell, Tim Fischer
Summary: This study evaluated the feasibility of diffusion-weighted imaging (DWI) in diagnosing osteomyelitis and bone marrow edema in the forefoot. The measurement of apparent diffusion coefficient (ADC) values allowed for differentiation between healthy and abnormal bone and provided specific cutoff values for the confirmation or exclusion of osteomyelitis.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Engineering, Biomedical
Mehdi Sadighi, Mert Sisman, Berk C. Acikgoz, Hasan H. Eroglu, B. Murat Eyuboglu
Summary: DT-MREIT is an imaging modality based on diffusion tensor imaging and MREIT techniques, allowing for the reconstruction of low-frequency anisotropic conductivity distribution. A novel reconstruction algorithm is proposed in this study to reconstruct conductivity tensor images using a single current injection, increasing clinical applicability. The method is evaluated using simulated measurements and physical experiments, demonstrating successful reconstruction of anisotropic conductivity distribution.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Salva R. Yurista, Robert A. Eder, Deborah H. Kwon, Christian T. Farrar, Yi Fen Yen, W. H. Wilson Tang, Christopher T. Nguyen
Summary: As one of the highest energy consuming organs in the body, the heart relies on various fuel sources to generate ATP for its continuous work. Magnetic resonance imaging (MRI) plays a crucial role in understanding the metabolic changes in the failing heart, and noninvasive quantification of metabolic changes has potential clinical applications. Novel MRI techniques, such as magnetic resonance spectroscopy (MRS), hyperpolarized MRS, and chemical exchange saturation transfer, provide detailed investigation of cardiac metabolism in heart failure.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefania Montemezzi, Giuseppe Cardano, Silvia Storer, Nicolo Cardobi, Carlo Cavedon, Lucia Camera
Summary: This study demonstrates the feasibility and efficacy of using DWI in MRI-guided breast biopsies for accurate lesion targeting and device positioning. DWI can effectively detect both mass and non-mass lesions with a minimum size of 5 mm.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huan Yang, Peng Lv, Ranying Zhang, Caixia Fu, Jiang Lin
Summary: The study found that low b-value DWI has significant advantages in detecting inflamed vessels in active Takayasu arteritis, with higher image quality and blood suppression compared to T2-weighted imaging. Additionally, the signal-to-noise ratio and contrast-to-noise ratio of the diseased vessel walls were significantly higher on DWI compared to T2WI.
EUROPEAN RADIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Maja Bruvo, Faisal Mahmood
Summary: There is discrepancy in reported ADC values of the parotid gland, with factors such as gustatory stimulation, diffusion weighting factors, and timing of follow-up after radiotherapy influencing the measurements. Interestingly, the choice of regions of interest may not affect the ADC measurements.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander Rau, Pia M. Jungmann, Thierno D. Diallo, Marco Reisert, Elias Kellner, Michel Eisenblaetter, Fabian Bamberg, Matthias Jung
Summary: Quantitative MRI techniques, such as diffusion microstructure imaging (DMI), can provide additional information about muscular function and microstructure, potentially serving as a potential biomarker for young athletes.
EUROPEAN RADIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pietro Valerio Foti, Mario Travali, Renato Farina, Stefano Palmucci, Corrado Spatola, Luigi Raffaele, Vincenzo Salamone, Rosario Caltabiano, Giuseppe Broggi, Lidia Puzzo, Andrea Russo, Michele Reibaldi, Antonio Longo, Paolo Vigneri, Teresio Avitabile, Giovani Carlo Ettorre, Antonio Basile
Summary: Uveal melanoma is a malignant tumor originating from pigmented melanocytes, with prognosis related to histopathologic and genetic features, tumor size and location. MRI plays a key role in diagnosis and treatment planning, mainly depending on melanin content for tumor visualization. Radiologists and MRI are significant in the clinical management of uveal melanoma.
INSIGHTS INTO IMAGING
(2021)
Article
Mathematics, Applied
Shuhong Wang, Yingjie Liang, Richard L. Magin
Summary: This article discusses the application of diffusion-weighted magnetic resonance imaging in describing the structure of biological tissues, as well as the analysis and fitting of experimental data using the VDC model. The experimental results show that the VDC model can effectively capture the characteristics of signal attenuation, and the ultraslow diffusion model provides the best fit for diffusion in the optic nerve.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2021)
Article
Clinical Neurology
Philipp Ellmerer, Beatrice Heim, Ambra Stefani, Marina Peball, Mario Werkmann, Evi Holzknecht, Melanie Bergmann, Elisabeth Brandauer, Martin Sojer, Laura Zamarian, Margarete Delazer, Klaus Seppi, Birgit Hoegl, Werner Poewe, Atbin Djamshidian
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2020)
Article
Clinical Neurology
Florian Krismer, Vincent Beliveau, Klaus Seppi, Christoph Mueller, Georg Goebel, Elke R. Gizewski, Gregor K. Wenning, Werner Poewe, Christoph Scherfler
Summary: Observer-independent analysis of microstructural integrity in distinguishing MSA and PD patients has high diagnostic accuracy, with better consistency compared to manual analysis. Classification using the C5.0 hierachical decision tree algorithm identified mean diffusivity of the middle cerebellar peduncle and putamen as the most predictive parameters.
MOVEMENT DISORDERS
(2021)
Editorial Material
Clinical Neurology
Sofia Reimao, Carla Guerreiro, Klaus Seppi, Joaquim J. Ferreira, Werner Poewe
MOVEMENT DISORDERS
(2020)
Article
Clinical Neurology
Alessandra Fanciulli, Nicole Campese, Georg Goebel, Jean Pierre Ndayisaba, Sabine Eschlboeck, Christine Kaindlstorfer, Cecilia Raccagni, Roberta Granata, Ubaldo Bonuccelli, Roberto Ceravolo, Klaus Seppi, Werner Poewe, Gregor K. Wenning
Article
Clinical Neurology
Victoria Sidoroff, Cecilia Raccagni, Christine Kaindlstorfer, Sabine Eschlboeck, Alessandra Fanciulli, Roberta Granata, Bjorn Eskofier, Klaus Seppi, Werner Poewe, Johann Willeit, Stefan Kiechl, Philipp Mahlknecht, Heike Stockner, Kathrin Marini, Oliver Schorr, Gregorio Rungger, Jochen Klucken, Gregor Wenning, Heiko Gassner
Summary: The study compared gait variability at different walking speeds between patients with Parkinson-variant multiple system atrophy, idiopathic Parkinson's disease, and a control group of older adults. Multiple system atrophy patients displayed higher gait variability in various parameters compared to controls, while Parkinson's patients did not. Variability parameters were significantly correlated with the postural instability/gait difficulty subscore in both disease groups.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Federico Carbone, Philipp Ellmerer, Marcel Ritter, Sabine Spielberger, Philipp Mahlknecht, Eva Hametner, Anna Hussl, Anna Hotter, Roberta Granata, Klaus Seppi, Sylvia Boesch, Werner Poewe, Atbin Djamshidian
Summary: The study found that patients with cervical dystonia exhibit more errors and inhibition failures in eye movement tasks, possibly due to dysfunctional corticostriatal networks. Further research is needed to confirm the effects of available therapies on these abnormalities and whether similar impairments are present in other focal dystonias.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Beatrice Heim, Stephanie Mangesius, Florian Krismer, Gregor K. Wenning, Anna Hussl, Christoph Scherfler, Elke R. Gizewski, Michael Schocke, Regina Esterhammer, Andrea Quattrone, Werner Poewe, Klaus Seppi
Summary: Quantitative MR planimetric measurements derived from the brainstem show high diagnostic accuracy in differentiating PSP from non-PSP parkinsonism in early disease stages, especially when clinical criteria are not fully met. The inclusion of the third ventricle width in P/M2.0 and MRPI2.0 calculations improves accuracy in diagnosing early stage PSP patients compared to P/M and MRPI.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Clinical Neurology
Jules M. Janssen Daalen, Anouk Tosserams, Philipp Mahlknecht, Klaus Seppi, Bastiaan R. Bloem, Sirwan K. L. Darweesh
Summary: Olfactory dysfunction is associated with a significantly increased risk of incident Parkinson's disease, especially in studies with a higher proportion of women, older individuals, or shorter follow-up duration. Subgroup-specific risk estimates are needed to refine prodromal PD criteria.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Clinical Neurology
Jose-Alberto Palma, Patricio Millar Vernetti, Miguel A. Perez, Florian Krismer, Klaus Seppi, Alessandra Fanciulli, Wolfgang Singer, Phillip Low, Italo Biaggioni, Lucy Norcliffe-Kaufmann, Maria Teresa Pellecchia, Maria Jose Marti, Han-Joon Kim, Marcelo Merello, Iva Stankovic, Werner Poewe, Rebecca Betensky, Gregor Wenning, Horacio Kaufmann
Summary: The UMSARS, a clinical rating scale for multiple system atrophy, has limitations in detecting changes and may lead to a ceiling effect. Due to these limitations, there is a need to develop and validate an improved COA for use in future clinical trials.
CLINICAL AUTONOMIC RESEARCH
(2021)
Article
Clinical Neurology
Verena Rass, Ronny Beer, Alois Josef Schiefecker, Mario Kofler, Anna Lindner, Philipp Mahlknecht, Beatrice Heim, Victoria Limmert, Sabina Sahanic, Alex Pizzini, Thomas Sonnweber, Ivan Tancevski, Christoph Scherfler, Laura Zamarian, Rosa Bellmann-Weiler, Guenter Weiss, Atbin Djamshidian, Stefan Kiechl, Klaus Seppi, Judith Loeffler-Ragg, Bettina Pfausler, Raimund Helbok
Summary: Neurological symptoms were prevalent at the 3-month follow-up in COVID-19 patients, with smelling disorders being persistent in a large proportion of patients even after recovery from the acute infection.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Marie-Therese Groetsch, Gesine Respondek, Carlo Colosimo, Yaroslau Compta, Jean Christophe Corvol, Joaquim Ferreira, Meret Koroni Huber, Martin Klietz, Lea F. M. Krey, Johannes Levin, Milica Jecmenica-Lukic, Daniel Macias-Garcia, Wassilios G. Meissner, Pablo Mir, Huw Morris, Christer Nilsson, James B. Rowe, Klaus Seppi, Maria Stamelou, John C. van Swieten, Gregor Wenning, Teodoro Del Ser, Lawrence I. Golbe, Guenter U. Hoglinger
Summary: The study developed a revised rating scale focusing on meaningful disease milestones, retained sensitive items for disease progression, and showed similar power in clinical trials compared to the original scale.
MOVEMENT DISORDERS
(2021)
Letter
Clinical Neurology
Kathrin Marini, Klaus Seppi, Lena Tschiderer, Stefan Kiechl, Heike Stockner, Peter Willeit, Johann Willeit, Atbin Djamshidian, Gregorio Rungger, Werner Poewe, Philipp Mahlknecht
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Vincent Beliveau, Florian Krismer, Elisabeth Skalla, Michael M. Schocke, Elke R. Gizewski, Gregor K. Wenning, Werner Poewe, Klaus Seppi, Christoph Scherfler
Summary: This study utilized DTI and tractography to analyze the microstructural characteristics of MCP and putamen in MSA patients, demonstrating high diagnostic accuracy in distinguishing MSA from PD. Normalized putamen volume measurements further improved the classification accuracy between MSA and PD.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Clinical Neurology
Iva Stankovic, Alessandra Fanciulli, Vladimir S. Kostic, Florian Krismer, Wassilios G. Meissner, Jose Alberto Palma, Jalesh N. Panicker, Klaus Seppi, Gregor K. Wenning
Summary: Additional laboratory work-up beyond imaging and AFT should be considered for patients with possible MSA to optimize clinical diagnostic accuracy.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2021)
Article
Clinical Neurology
Andrea Quattrone, Angelo Antonini, David E. Vaillancourt, Klaus Seppi, Roberto Ceravolo, Antonio P. Strafella, Maurizio Morelli, Salvatore Nigro, Basilio Vescio, Maria G. Bianco, Roberta Vasta, Pier Paolo Arcuri, Luca Weis, Eleonora Fiorenzato, Roberta Biundo, Roxana G. Burciu, Florian Krismer, Nikolaus R. McFarland, Christoph Mueller, Elke R. Gizewski, Mirco Cosottini, Eleonora Del Prete, Sonia Mazzucchi, Aldo Quattrone
Summary: The measurement of third ventricle width can distinguish Parkinson's disease (PD) from progressive supranuclear palsy (PSP).
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Christina M. Marra
Summary: Stroke can be a complication of CNS infections, especially caused by VZV and T pallidum. Treatment with adjunctive dexamethasone for acute pneumococcal meningitis is recommended, but it may lead to the emergence of DCV syndrome.
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Selima Siala, Nabil Rahoui, Benjamin Cho, Carlos A. Zamora
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Renato Hoffmann Nunes, Diogo Goulart Correa, Felipe Torres Pacheco, Ana Paula Alves Fonseca, Luiz Celso Hygino da Cruz Jr, Antonio Jose da Rocha
Summary: Vasculopathy is a significant consequence of various infections, and early recognition is essential as many of these diseases have poor outcomes if left untreated. Neuroimaging techniques such as MRI, CTA, and MRA can be used to visualize the complications associated with infectious vasculopathy, while high-resolution intracranial vessel wall imaging can directly assess the presence of vasculitis.
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Sheng-Che Hung, Carolina Guimaraes
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Omar Hamam, Samuel C. Cartmell, Javier M. Romero
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Manish K. Saha
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Alison M. Bays
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Carlos A. Zamora, Mahmud Mossa-Basha, Mauricio Castillo
Summary: Assessment of cerebral vasculopathies can be challenging, but a comprehensive understanding of different imaging methods can facilitate the process. There are various angiographic techniques with unique advantages and disadvantages, such as bolus-based methods that enhance arterial depiction and non-contrast techniques that show high-resolution arteries. MRI can assess vessel wall pathology and aid in diagnosing vasculitis and non-inflammatory vasculopathies.
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Paulo Puac-Polanco, Alex Rovira, Lubdha M. Shah, Richard H. Wiggins, Francisco Rivas Rodriguez, Carlos Torres
Summary: Cocaine-induced CNS vasculitis and midline destructive lesion, as well as reversible vasoconstriction syndrome triggered by substance abuse, are all important conditions that are associated with drugs and their risk factors.
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)
Article
Neurosciences
Aaron Bangad, Mehdi Abbasi, Sam Payabvash, Adam de Havenon
NEUROIMAGING CLINICS OF NORTH AMERICA
(2024)