Review
Cardiac & Cardiovascular Systems
Xiaoxian Gong, Luowei Chen, Bo Song, Xiang Han, Weihai Xu, Bo Wu, Feng Sheng, Min Lou
Summary: The study found that an increase in total cholesterol and triglycerides is associated with an increased risk of ischemic stroke and a reduced risk of hemorrhagic stroke, while an increase in high-density lipoprotein cholesterol is associated with a reduced risk of ischemic stroke. It is recommended to control total cholesterol and low-density lipoprotein cholesterol levels within certain ranges.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yun-Ya Xie, Shi-Meng Liu, Qian Zhang, Yu Jia, Jian-Ping Ding
Summary: The study found that lower LDL-C levels were associated with severe neurological deficits in haemorrhagic stroke and may increase the risks of unfavourable outcomes at discharge. Patients with higher LDL-C levels had a lower likelihood of severe neurological deficits and unfavourable outcomes.
JOURNAL OF GERIATRIC CARDIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Sang-Wook Yi, Sang Joon An, Hyung Bok Park, Jee-Jeon Yi, Heechoul Ohrr
Summary: In this study, a U-shaped association between low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD) mortality was observed. The optimal range varied across different CVD subtypes. Women and older adults showed weaker positive associations. Adults aged 75-84 years had stronger associations with ischaemic heart disease and ischaemic stroke.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Hongwei Liu, Jianxin Li, Fangchao Liu, Keyong Huang, Jie Cao, Shufeng Chen, Hongfan Li, Chong Shen, Dongsheng Hu, Jianfeng Huang, Xiangfeng Lu, Dongfeng Gu
Summary: In this study, the Mendelian randomization method was used to investigate the causal relationships between LDL-C and efficacy and safety outcomes. Linear rather than non-linear association between genetically proxied LDL cholesterol and coronary artery disease was observed. Potential safety concerns were identified for individuals with low LDL-C levels, including haemorrhagic stroke and dementia.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rui Gao, Kaixin Du, Jinhua Liang, Yi Xia, Jiazhu Wu, Yue Li, Bihui Pan, Li Wang, Jianyong Li, Wei Xu
Summary: This study aims to evaluate the prognostic value of cholesterol levels in CLL and develop a prognostic nomogram that incorporates lipid metabolism. The results showed that lower cholesterol levels at diagnosis were associated with worse prognosis, and post-therapeutic elevation of cholesterol levels correlated with better survival. Therefore, cholesterol profiles can be used as a cheap and readily accessible tool for predicting prognosis in CLL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Pierre C. Amarenco, Philippa S. Lavallee, Jong Kim, Julien Labreuche, Hugo Charles, Maurice Giroud, Byung-Chul Lee, Marie-Helene Mahagne, Elena Meseguer, Norbert Nighoghossian, Philippe Gabriel Steg, Eric Vicaut, Eric Bruckert, Treat Stroke Target Invest
Summary: This study investigated the effects of two different strategies for reducing low-density lipoprotein (LDL) cholesterol on reducing cardiovascular risk. The results showed that among patients with a target LDL cholesterol level of <70 mg/dL, a reduction in LDL cholesterol of >50% from baseline significantly reduced the risk of the primary outcome.
Article
Medicine, General & Internal
Wenjing Dong, Xiaoyan Zhong, Ke Yuan, Mengyuan Miao, Yujia Zhai, Bizhong Che, Tan Xu, Xiang Xu, Chongke Zhong
Summary: Elevated plasma Lp(a) levels were associated with an increased risk of major disability and death at 6 months in patients with acute ischemic stroke. Especially, discordantly high Lp(a)/low LDL-C levels were linked to an unfavorable functional outcome, highlighting the predictive potential of plasma Lp(a) after ischemic stroke, particularly when discordant with LDL-C.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
C. J. MacDonald, A. L. Madika, G. Severi, A. Fournier, M. C. Boutron-Ruault
Summary: The study found that non-O blood groups, particularly the A group, are associated with an increased risk of dyslipidaemia. Current smokers have a 30% higher risk of dyslipidaemia compared to never-smokers. These results could be useful for personalized approaches to preventing cardiovascular risk factors.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Hao Zhao, Wei Gui, Xin Tan, Ying Chen, Yao Ning, Xin Wang
Summary: This study investigated the relationship between neonicotinoid insecticides (NNIs) and their metabolites in urine with serum lipid profiles in adults. The results showed a significant positive correlation between N-desmethyl-acetamiprid and total cholesterol (TC) levels, especially in participants aged over 46 years. Body mass index (BMI) also modified the association between N-desmethyl-acetamiprid and LDL-C and Apo-B levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Medicine, General & Internal
Istvan Reiber, Laszlo Mark, Gyorgy Paragh, Peter Toth
Summary: This study compares direct and calculated LDL-C levels, and evaluates the variation in remnant lipoprotein cholesterol. The results indicate that in some cases, the use of a new calculation method yields a more accurate LDL-C value.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Obstetrics & Gynecology
Qingqing Lin, Wenchao Liu, Song Xu, Liping Sun
Summary: Preoperative high LDL-C level is significantly associated with worse overall survival, while high HDL-C level is significantly associated with better progression-free survival in patients with epithelial ovarian cancer. Patients with low LDL-C levels have longer overall survival, and patients with high HDL-C levels have better progression-free survival.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Han Na Jung, Min-Ju Kim, Hwi Seung Kim, Woo Je Lee, Se Hee Min, Ye-Jee Kim, Chang Hee Jung
Summary: This study investigated the age-related association between low-density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (ASCVD). The results showed a positive association between LDL-C and ASCVD risk across all age groups, and individuals aged 75 and above with higher LDL-C levels still had an increased risk of ASCVD. Therefore, managing LDL-C is crucial for the prevention of primary ASCVD in the elderly population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Chua Ming, Emma M. S. Toh, Qai Ven Yap, Leonard L. L. Yeo, Ching-Hui Sia, Andrew F. W. Ho, Yiong Huak Chan, Fathima Ashna Nastar, Amanda Y. L. Lim, Benjamin Y. Q. Tan
Summary: This study investigated the relationship between lipid levels and outcomes in patients with acute ischemic stroke who received intravenous tissue plasminogen activator (tPA). The results showed that low-density lipoprotein cholesterol (LDL-C) was associated with increased mortality, while high-density lipoprotein cholesterol (HDL-C) may be protective against poor functional outcome.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Naoki Nanashima, Kayo Horie, Maiko Kitajima, Shizuka Takamagi, Kasumi Mikami, Naoya In, Toshiko Tomisawa
Summary: The daily intake of blackcurrant extract for 29 days can lower total cholesterol levels in healthy women, particularly affecting total very-low-density lipoprotein (VLDL) cholesterol, small VLDL cholesterol, and large low-density lipoprotein cholesterol, showing efficacy in preventing arteriosclerosis.
Article
Gastroenterology & Hepatology
Siew C. Ng, Zhilu Xu, Joyce Wing Yan Mak, Keli Yang, Qin Liu, Tao Zuo, Whitney Tang, Louis Lau, Rashid N. Lui, Sunny H. Wong, Yee Kit Tse, Amy Y. L. Li, Kitty Cheung, Jessica Y. L. Ching, Vincent W. S. Wong, Alice P. S. Kong, Ronald C. W. Ma, Elaine Y. K. Chow, Simon K. H. Wong, Ivan Chak Hang Ho, Paul K. S. Chan, Francis K. L. Chan
Summary: Repeated FMTs enhance microbiota engraftment in obese patients with T2DM, leading to more favorable changes in recipients' microbiota and improvement in lipid profile and liver stiffness when combined with lifestyle intervention.
Article
Pharmacology & Pharmacy
Chih-Kuang Liang, Ming-Yueh Chou, Ying-Hsin Hsu, Yu-Chun Wang, Mei-Chen Liao, Miao-Ting Chen, Pei-Yu Hsiao, Liang-Kung Chen, Yu-Te Lin
Summary: This study analyzed data from older patients aged >= 65 years to examine the correlations between drug-use indicators and postdischarge healthcare services use. The study found that potentially inappropriate medications, polypharmacy, and anticholinergic burden were associated with future healthcare service utilization. These associations were particularly significant among patients without dementia, aged >80 years, and with frailty.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Neuroimaging
Yajuan Zhang, Qiong Xiang, Chu-Chung Huang, Jiajia Zhao, Yuchen Liu, Ching-Po Lin, Dengtang Liu, Chun-Yi Zac Lo
Summary: The effect of antipsychotic medications on the brain functions of patients with first-episode psychosis (FEP) remains unclear. This study used resting-state functional magnetic resonance images to examine the changes in brain function after antipsychotic treatment. The results showed that drug-naive FEP patients had different patterns of functional connectivity compared to healthy volunteers, especially involving the right thalamus. After two months of treatment, patients showed reductions in ReHo and nodal clustering in visual networks, indicating improvements in psychotic symptoms. However, the functional alterations at baseline were not fully modulated by antipsychotic medications, suggesting limited effects in regions involved in disease pathophysiology.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Neurosciences
Jie Zhang, Ye Yao, Jin-song Wu, Edmund T. Rolls, Ce-chen Sun, Ling-hao Bu, Jun-feng Lu, Ching-po Lin, Jian-feng Feng, Ying Mao, Liang-fu Zhou
Summary: This study used multi-modal neuroimaging analyses to localize the cortical regions and white matter tracts responsible for auditory language comprehension. The results showed that cortical areas in the posterior temporal lobe are crucial for language comprehension. The fiber integrity of the arcuate fasciculus and the inferior longitudinal fasciculus was strongly correlated with auditory comprehension and the grey matter volume of the inferior temporal and middle temporal gyri.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Xiaoyi Sun, Jinrong Sun, Xiaowen Lu, Qiangli Dong, Liang Zhang, Wenxu Wang, Jin Liu, Qing Ma, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Chu-Chung Huang, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Ching-Po Lin, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Yong He, Mingrui Xia
Summary: Major depressive disorder is a highly heterogeneous disorder with two reproducible neurophysiological subtypes identified in the study, showing severe and moderate deviation patterns in functional connectivity. These subtypes have predictive value for antidepressant treatment outcomes.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Chih-Chin Heather Hsu, Shin Tai Chong, Yi-Chia Kung, Kuan-Tsen Kuo, Chu-Chung Huang, Ching-Po Lin
Summary: This article presents a semi-automated pipeline tool called iDIO for preprocessing and analysis of diffusion magnetic resonance imaging (dMRI) data. The tool integrates features from various advanced dMRI software tools and provides a set of suggested processing steps based on the image header of the input data. Additionally, the pipeline offers post-processing options such as estimation of diffusion tensor metrics and whole-brain tractography-based connectomes reconstruction. iDIO also generates an easy-to-interpret quality control report for data assessment.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Lei Wang, Qing Ma, Xiaoyi Sun, Zhilei Xu, Jiaying Zhang, Xuhong Liao, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Chu-Chung Huang, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tianmei Si, Shijun Qiu, Ching-Po Lin, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Yong He, Mingrui Xia, Yihe Zhang
Summary: This study conducted frequency-resolved connectome analysis on a large sample of MDD patients and healthy controls, revealing significant frequency-dependent connectome alterations in MDD. These alterations mainly occur in the left parietal, temporal, precentral, and fusiform cortices, as well as bilateral precuneus. Additionally, the connectome alteration in the high frequency band (0.16-0.24 Hz) is significantly associated with illness duration.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu-Hsiu Juan, Chia-Hung Wu, Te-Ming Lin, Ching-Po Lin, Feng-Chi Chang
Summary: This study retrospectively analyzed the risk factors for in-stent restenosis (ISR) in patients with post-irradiated carotid stenosis (PIRCS) after receiving percutaneous transluminal angioplasty and stenting (PTAS). The results showed that stenotic lesions located from the internal carotid artery (ICA) to common carotid artery (CCA) and longer stenotic lesion length (SLL) at baseline were associated with the occurrence of ISR after PTAS. Therefore, intensive post-procedural follow-up is recommended for these patients.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Geriatrics & Gerontology
Chen-Yuan Kuo, Pei-Lin Lee, Li-Ning Peng, Pei-Ning Wang, Wei-Ju Lee, Liang-Kung Chen, Kun-Hsien Chou, Chih-Ping Chung, Ching-Po Lin
Summary: The study examined the association between advanced brain biological age and accelerated age-related physical and cognitive functional decline. A brain age prediction model was constructed using gray matter features from the MRI of 1482 healthy individuals. The difference between predicted and chronological age (brain age gap) was analyzed in a community-dwelling population aged 50 years and above. Participants with the physio-cognitive decline syndrome (PCDS) had a significantly higher brain age gap compared to other groups, indicating that advanced brain aging may contribute to physical and cognitive decline in older individuals.
NEUROBIOLOGY OF AGING
(2023)
Article
Geriatrics & Gerontology
Chieh Shen, Yi-Chin Lin, Hung-Yu Lin, Liang-Kung Chen, Fei-Yuan Hsiao
Summary: The study examines the impacts of declines in personal mastery on healthy aging among community-dwelling middle-aged and older adults. The findings suggest that declines in personal mastery are associated with declines in self-perceived mobility, but not with other indicators of healthy aging.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
H. -Y. Lin, Y. -C. Lin, L-K Chen, F-Y Hsiao
Summary: Social isolation is closely associated with anorexia and sarcopenia in older adults, significantly exacerbating the long-term mortality risk. While social isolation alone appears to have some mortality risk, the synergistic effects are more pronounced in this study.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Geriatrics & Gerontology
Yi-Chin Lin, Hung-Yu Lin, Liang-Kung Chen, Fei-Yuan Hsiao
Summary: This study examines the associations between subjective aging and the psychological and behavioral responses of older individuals, specifically focusing on the longitudinal changes in biological age. The results indicate that there are no significant associations between changes in biological age and subjective aging across different chronological age groups.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Rheumatology
H. Y. Liu, P. L. Lee, K. H. Chou, Y. F. Wang, S. P. Chen, K. L. Lai, L. L. Pan, C. P. Lin, S. J. Wang, W. T. Chen
Summary: This study investigated the relationship between fatigue severity and brain morphometry changes in fibromyalgia patients. The results showed that higher fatigue severity was associated with decreased bilateral thalamic volumes and increased right inferior temporal cortex volumes.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Geriatrics & Gerontology
Ying-Hsin Hsu, Ming-Yueh Chou, Wei-Cheng Chang, Miao-Ting Chen, Yu-Chun Wang, Mei-Chen Liao, Chih-Kuang Liang, Liang-Kung Chen, Yu-Te Lin
Summary: This study evaluated the association between the change in the number of potentially inappropriate medications (PIMs) in older adults during hospitalization and adverse outcomes. The results showed that increasing PIM use was strongly associated with higher functional decline, prolonged length of stay, and mortality rate. Older adults with three or more PIMs had the greatest risk for adverse outcomes during hospitalization.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Clinical Neurology
B. -A. Chen, W. -J. Lee, C. -P. Chung, L. -N. Peng, Liang-Kung Chen
Summary: This study found associations between inflammatory biomarkers and cognitive function in healthy middle-aged and older populations. Specifically, higher levels of fibrinogen were negatively associated with cognitive function, particularly in participants aged 65 years or older.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.