Article
Neurosciences
Tao Yin, Zhaoxuan He, Peihong Ma, Ruirui Sun, Kunnan Xie, Tianyu Liu, Li Chen, Jingwen Chen, Likai Hou, Yuke Teng, Yuyi Guo, Zilei Tian, Jing Xiong, Fumin Wang, Shenghong Li, Sha Yang, Fang Zeng
Summary: This study identified abnormal brain dynamics in functional constipation patients, which were correlated with symptom severity. Graph-theoretic analysis showed higher sample entropy at nodal efficiency in the anterior insula of FCon patients.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
James P. Trujillo, Asli Ozyurek, Cornelis C. Kan, Irina Sheftel-Simanova, Harold Bekkering
Summary: Persons with autism and neurotypical individuals process sensory information differently, which directly affects social functioning and communication abilities. This study used functional magnetic resonance imaging to investigate the organization of the action observation network in autistic and neurotypical individuals during a silent gesture recognition task. The results revealed that autistic individuals have a more clustered and locally-oriented network configuration, while neurotypicals exhibit a more integrated network organization. These findings shed light on the complex interplay between social and sensory processing in autism.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2022)
Article
Physiology
Yingjie Song, Kejie Wang, Yu Wei, Yongpeng Zhu, Jinfeng Wen, Yuxi Luo
Summary: Depressed patients exhibit differences in sleep-state functional network topology, including increased global efficiency and node strength, as well as right-lateralization in the delta band. The connectivity patterns between depressed patients and healthy controls are distinct, with depressed patients showing inter-hemispheric connections while healthy controls showing only intra-hemispheric connections. These findings provide insights into the pathology of depression and suggest that functional network topology could be a potential tool for diagnosing depression.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Anatomy & Morphology
W. Tyler Ketchabaw, Andrew T. DeMarco, Sachi Paul, Elizabeth Dvorak, Candace van der Stelt, Peter E. Turkeltaub
Summary: Localization of language function in the brain has shifted towards a distributed network, and the semantic system plays a crucial role in integrating information from multiple cortical regions.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Clinical Neurology
Sheraz Khan, Javeria Ali Hashmi, Fahimeh Mamashli, Matti S. Hamalainen, Tal Kenet
Summary: This study investigated the maturation trajectories of resting-state networks (RSNs) and their hubs from ages 7 to 29 using magnetoencephalography (MEG). The results showed that RSNs mediated by the beta band became more locally efficient with maturation, while RSNs mediated by the gamma band became more globally efficient. Different sets of hubs were associated with each network. Further analysis revealed that maturing hubs in gamma band RSNs were more likely to be associated with bottom-up processes, while maturing hubs in beta band RSNs were more likely to be associated with top-down functions.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychiatry
Chuan Fan, Rujing Zha, Yan Liu, Zhengde Wei, Ying Wang, Hongwen Song, Wanwan Lv, Jiecheng Ren, Wei Hong, Huixing Gou, Pengyu Zhang, Yucan Chen, Yi Zhou, Yu Pan, Xiaochu Zhang
Summary: Nicotine addiction is a neuropsychiatric disorder that affects the function of brain cortices and white matter. This study used the small-world model to compare white matter functional connectivity between nicotine addiction participants and healthy controls. The results showed that the nicotine addiction group had decreased small-worldness index and normalized clustering coefficient compared to controls. These findings suggest that WM functional changes and small-world properties could be potential biomarkers in nicotine addiction.
PSYCHIATRY RESEARCH
(2023)
Article
Neurosciences
Antonia Kaiser, Caroline Broeder, Jessica Cohen, Linda Douw, Liesbeth Reneman, Anouk Schrantee
Summary: This study investigated the effects of methylphenidate on brain network connectivity in children and adults with ADHD and found that the effects were age-dependent. Methylphenidate decreased connectivity and centrality in subcortical regions in children, but increased these measures in adults. Interestingly, no major effects were observed in frontal regions. These findings suggest that the effects of methylphenidate treatment should be studied from a developmental perspective.
HUMAN BRAIN MAPPING
(2022)
Article
Mathematical & Computational Biology
Xiang Li, Jinyu Cong, Kunmeng Liu, Pingping Wang, Min Sun, Benzheng Wei
Summary: This study explores the aberrant intrinsic functional topology in methamphetamine-dependent individuals after six months of abstinence. The findings indicate decreased shortest path length and increased global and local efficiency at the global level. Significant group differences were also found in nodal degree and nodal efficiency at the regional level. Aberrations in edge-based functional connectivity were observed as well. These results suggest that certain functions may not fully recover after six months of withdrawal.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Clinical Neurology
Matteo Conti, Roberta Bovenzi, Elena Garasto, Tommaso Schirinzi, Fabio Placidi, Nicola B. Mercuri, Rocco Cerroni, Mariangela Pierantozzi, Alessandro Stefani
Summary: In early stages of Parkinson's disease, alterations in EEG functional connectivity were observed, characterized by reduced connectivity in α-β frequency bands, increased connectivity in the γ band, and differences in assortativity coefficient. Network measures analysis helps to understand the complexity of Parkinson's disease physiopathology.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Sandra Martin, Kathleen A. Williams, Dorothee Saur, Gesa Hartwigsen
Summary: This neuroimaging study reveals widespread neural reorganization processes in the aging brain and investigates the behavioral impact of this reorganization. The findings show that older adults experience large-scale network reorganization even when their word retrieval abilities are intact.
Article
Computer Science, Artificial Intelligence
Hongtao Wang, Xucheng Liu, Junhua Li, Tao Xu, Anastasios Bezerianos, Yu Sun, Feng Wan
Summary: This study investigated the discriminative power of functional connectivity for driving fatigue detection and found that the brain network architecture reorganizes towards less efficient structure in fatigue state across all frequency bands. The discriminative connections were mainly connected to frontal areas, showing increased connections from frontal pole to parietal or occipital regions. Additionally, satisfactory classification accuracy (96.76%) was achieved using discriminative connection features in beta band.
IEEE TRANSACTIONS ON COGNITIVE AND DEVELOPMENTAL SYSTEMS
(2021)
Article
Psychiatry
Bin Qin, Longlun Wang, Jinhua Cai, Tingyu Li, Yun Zhang
Summary: This study investigates the functional brain network characteristics of preschool children with autism spectrum disorder (ASD) using resting-state functional MRI (rs-fMRI) and graph theory analysis. The findings show significant changes in subnetwork connectivity in the ASD group compared to the healthy control group. The study also demonstrates alterations in network properties, with increased clustering coefficient and local efficiency in the functional network of the ASD group.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Armita Faghani Jadidi, Winnie Jensen, Ali Asghar Zarei, Eugen Romulus Lontis, S. Farokh Atashzar
Summary: By recording cortical activity using EEG from 12 healthy subjects, this study investigated the effects of PWM TENS on cortical network connectivity. The results showed that PWM TENS had better pain-alleviating effects compared to conventional TENS, supporting its potential as a therapeutic intervention in clinical research.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Wenjing Luo, Abigail S. Greene, R. Todd Constable
Summary: Studies on the organization of the brain using graph theory methods have shown that functional nodes in the brain reconfigure with different brain states. The influence of voxel-level changes leading to node reconfigurations should be considered when investigating connectivity contrasts between brain states and/or groups.
Article
Clinical Neurology
Iole Indovina, Alberto Cacciola, Sergio Delle Monache, Demetrio Milardi, Francesco Lacquaniti, Nicola Toschi, Jerome Cochereau, Gianfranco Bosco
Summary: This study investigated the neural correlates of agoraphobia by comparing the pre- and post-surgery connectivities in the vestibular network of a patient who developed agoraphobia after surgical removal of a glioma. The results showed overall disconnection in the vestibular network after surgery, but functional connectivity analysis revealed a reorganization of the network, indicating altered processing of visuo-vestibular-spatial information that leads to agoraphobia symptoms.
FRONTIERS IN NEUROLOGY
(2023)
Article
Oncology
Florien W. Boele, Patricia W. M. den Otter, Jaap C. Reijneveld, Philip C. de Witt Hamer, Hinke F. van Thuijl, Linda M. C. Lorenz, Pieter Wesseling, Frank J. Lagerwaard, Martin J. B. Taphoorn, Mathilde C. M. Kouwenhoven, Tom J. Snijders, Linda Douw, Martin Klein
Summary: HRQOL and NCF do not appear greatly impacted during long-term survivorship in LGG, but depressive symptoms and fatigue are persistent.
Article
Multidisciplinary Sciences
Jantine G. Rottgering, Vera Belgers, Mathilde C. M. Kouwenhoven, Maaike Schuur, Tjeerd J. Postma, Claudia M. Nijboer, Myra E. van Linde, Philip C. de Witt Hamer, Linda Douw, Martin Klein
Summary: This study evaluated the frequency and burden of symptoms in glioma patients with stable disease and assessed their willingness to consider treatment. Fatigue, memory problems, reduced physical fitness, concentration problems, and drowsiness were the most common and burdensome symptoms. However, patients had a relatively low inclination for symptom management interventions.
Article
Clinical Neurology
Lucy Pointon, Robin Grant, Sharon Peoples, Sara Erridge, Paula Sherwood, Martin Klein, Florien Boele
Summary: This study aimed to identify and characterize caregivers' unmet needs, determine associations between unmet needs and wish for support, and evaluate the acceptability and feasibility of the Caregiver Needs Screen (CNS) in clinical practice. The study found that family caregivers have many unmet needs, but this is not directly related to their wish for support.
NEURO-ONCOLOGY PRACTICE
(2023)
Letter
Oncology
Jantine Geertruida Rottgering, Martin Klein, Linda Douw
Review
Oncology
Laurien De Roeck, Celine R. Gillebert, Robbie C. M. van Aert, Amber Vanmeenen, Martin Klein, Martin J. B. Taphoorn, Karin Gehring, Maarten Lambrecht, Charlotte Sleurs
Summary: In this meta-analysis, the researchers aimed to investigate the longer-term test-specific cognitive outcomes in adult glioma patients. The results showed that semantic fluency was the most sensitive test to detect cognitive decline over time. Glioma patients performed worse than controls on various cognitive tests, indicating significant cognitive impairment after treatment.
Article
Sport Sciences
Franziska Katharina Haase, Annika Prien, Linda Douw, Nina Feddermann-Demont, Astrid Junge, Claus Reinsberger
Summary: This study compared the brain cortical thickness and neurocognitive performance of retired female soccer players and non-contact sport athletes. The results showed similar cortical thickness and neurocognitive performance between the two groups, except for verbal memory and psychomotor speed. However, frequent headers had increased cortical thickness in the right inferior parietal region. Caution is needed in interpreting these results due to small sample sizes, subjective header assessment, and the case-control study design.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Letter
Psychiatry
Ilona van de Meent, Arija Maat, Mikel Boute, Edwin van Dellen, Wiepke Cahn
SCHIZOPHRENIA RESEARCH
(2023)
Article
Oncology
J. G. Rottgering, T. M. C. K. Varkevisser, M. Gorter, V. Belgers, P. C. De Witt Hamer, J. C. Reijneveld, M. Klein, T. F. Blanken, L. Douw
Summary: In this study, we used symptom network analysis to explore the relationship between symptoms and health-related quality of life in glioma patients. We found that fatigue, depression, and social functioning were highly correlated with other symptoms. Interestingly, the network connectivity was stronger in fatigued patients compared to non-fatigued patients.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Review
Medicine, General & Internal
Tessa N. A. Slagboom, Dirk Jan Stenvers, Elsmarieke van de Giessen, Stefan D. D. Roosendaal, Maartje M. L. de Win, Joseph C. J. Bot, Eleonora Aronica, Rene Post, Jantien Hoogmoed, Madeleine L. L. Drent, Alberto M. M. Pereira
Summary: The study provides a structured analysis of the diagnostic accuracy and clinical use of molecular imaging in patients with ACTH-dependent Cushing's syndrome, as well as the role of multidisciplinary counseling in decision making. It proposes a complementary diagnostic algorithm for both de novo and recurrent or persistent Cushing's disease. The use of molecular imaging modalities is of added and complementary value in the detection of pituitary microadenoma in ACTH-dependent Cushing's syndrome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Valentina La Cognata, Agata Grazia D'Amico, Grazia Maugeri, Giovanna Morello, Maria Guarnaccia, Benedetta Magri, Eleonora Aronica, Velia D'Agata, Sebastiano Cavallaro
Summary: Amyotrophic lateral sclerosis (ALS) is characterized by motor neuron (MN) depletion. CXCR2 has been implicated in ALS pathology and its expression is increased in cortical neurons of sporadic ALS patients. Inhibition of CXCR2 prevents MN degeneration in vitro and improves neuromuscular function in SOD1-G93A mice.
Article
Pharmacology & Pharmacy
Vera Belgers, Jantine G. Rottgering, Linda Douw, Martin Klein, Johannes C. F. Ket, Peter M. van de Ven, Thomas Wurdinger, Myra E. van Linde, Johanna M. Niers, Markus Weber, Marcel G. Olde Rikkert, Jose Lopez-Sendon, Oscar Arrieta, Kristina B. Svendsen, Marcos H. N. Chagas, Carlos M. O. de Almeida, Mathilde C. M. Kouwenhoven, Philip C. de Witt Hamer
Summary: This meta-analysis suggests that cannabinoids do not have a significant effect on HRQoL and mental well-being in patients with cancer or CNS disease.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.
