Article
Clinical Neurology
Andreas-Antonios Roussakis, Zhou Zeng, Nicholas P. Lao-Kaim, Antonio Martin-Bastida, Paola Piccini
Summary: The study found that in moderate-stage Parkinson's disease, asymmetry in striatal dopaminergic degeneration becomes less prominent over time, while the asymmetry of motor symptoms remains consistent between the clinically most and least affected body sides.
JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas E. H. Justesen, Per Borghammer, Joel Aanerud, Peter Hovind, Lisbeth Marner
Summary: The commonly used antidepressant sertraline has been found to interfere with the results of [F-18]FE-PE2I PET, leading to reduced binding in the caudate nucleus. It is recommended to take sertraline treatment into account when performing [F-18]FE-PE2I PET, especially in patients with apparent globally reduced PE2I binding. Consideration should be given to pausing sertraline treatment, particularly for doses above 50 mg/day.
Article
Neuroimaging
V. S. Kerstens, P. Fazio, M. Sundgren, J. Brumberg, C. Halldin, P. Svenningsson, A. Varrone
Summary: This study validates the efficacy of [18F]FE-PE2I PET as a measurement tool for longitudinal DAT changes in patients with Parkinson's disease. The results show a significant decline in DAT availability measured by [18F]FE-PE2I PET in early-stage Parkinson's disease patients, with larger effect sizes compared to previous SPECT and PET studies. This suggests that [18F]FE-PE2I can be used as a progression marker in clinical trials.
NEUROIMAGE-CLINICAL
(2023)
Article
Endocrinology & Metabolism
Joachim Brumberg, Vera Kerstens, Zsolt Cselenyi, Per Svenningsson, Mathias Sundgren, Patrik Fazio, Andrea Varrone
Summary: Quantification of dopamine transporter availability using [F-18]FE-PE2I PET can be a potential marker for Parkinson's disease progression. Early peak equilibrium acquisition provides better effectiveness and reliability in distinguishing PD patients from controls.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
My Jonasson, Andreas Frick, Patrik Fazio, Olof Hjorth, Torsten Danfors, Jan Axelsson, Lieuwe Appel, Tomas Furmark, Andrea Varrone, Mark Lubberink
Summary: The aim of this retrospective study was to investigate the relationships between relative cerebral blood flow and striatal dopamine transporter and dopamine D2/3 availability in healthy subjects. The data included dynamic PET scans with two dopamine transporter tracers [C-11]PE2I and [F-18]FE-PE2I, and the D2/3 tracer [C-11]raclopride. The results suggest that there is an association between resting-state striatal dopamine function and relative blood flow in healthy subjects.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Psychiatry
Tsuyoshi Nogami, Ryosuke Arakawa, Takeshi Sakayori, Yumiko Ikeda, Yoshiro Okubo, Amane Tateno
Summary: This study evaluated the dopamine transporter (DAT) occupancy of dl-methylephedrine and its stimulatory effect on the central nervous system. The results showed that the urinary concentration of dl-methylephedrine exceeded the prohibited reference value, but there was no significant difference in DAT occupancy between dl-methylephedrine and placebo.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Raphael Sura Daveau, Ian Law, Otto Molby Henriksen, Steen Gregers Hasselbalch, Ulrik Bjorn Andersen, Lasse Anderberg, Liselotte Hojgaard, Flemming Littrup Andersen, Claes Nohr Ladefoged
Summary: The study demonstrates that using activity reduction and AI-assisted denoising in PET scans can successfully reduce image noise, improve visual quality, and maintain stability of clinical metrics.
Article
Neurosciences
Eve Privman Champaloux, Nathan Donelson, Poojan Pyakurel, Danielle Wolin, Leah Ostendorf, Madelaine Denno, Ryan Borman, Chris Burke, Jonah C. Short-Miller, Maria R. Yoder, Jeffrey M. Copeland, Subhabrata Sanyal, B. Jill Venton
Summary: Recent research shows that RNF11 plays a critical role in dopamine neurotransmission, with RNF11 knockdown significantly increasing dopamine release and overexpression having no effect on dopamine levels. This study demonstrates for the first time that RNF11 affects both dopamine release and uptake.
Article
Neurosciences
Yasuharu Yamamoto, Keisuke Takahata, Manabu Kubota, Harumasa Takano, Hiroyoshi Takeuchi, Yasuyuki Kimura, Yasunori Sano, Shin Kurose, Hiroshi Ito, Masaru Mimura, Makoto Higuchi
Summary: The study revealed a significant positive correlation between DA synthesis capacity and DA transporter availability in the putamen, but no significant correlation between DA synthesis capacity and D2 receptor availability in the striatum, indicating a relationship between DA synthesis capacity and reuptake, while the total abundance of D2 receptors may not directly participate in the regulatory mechanism.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ganglin Liang, Jinpeng Zhou, Zixiang Chen, Liwen Wan, Xieraili Wumener, Yarong Zhang, Dong Liang, Ying Liang, Zhanli Hu
Summary: This study proposes a new method to improve the signal-to-noise ratio of dynamic PET images using deep learning, resulting in significantly improved structural similarity and peak SNR of the Ki parameter maps generated from 30 minutes scans, with a decrease in error compared to traditional 1-hour scans. Further clinical validation is necessary before implementing this approach in routine clinical applications.
Article
Endocrinology & Metabolism
Jessie Fanglu Fu, Cristina Lois, Justin Sanchez, J. Alex Becker, Zoe B. Rubinstein, Emma Thibault, Andrew N. Salvatore, Hasan Sari, Michelle E. Farrell, Nicolas J. Guehl, Marc D. Normandin, Georges El Fakhri, Keith A. Johnson, Julie C. Price
Summary: This study investigated the kinetics and longitudinal changes of [F-18]MK-6240 PET in cognitively-normal and cognitively-impaired subjects. The results suggest that eroded cerebral white matter or pons may be preferred for longitudinal studies, while eroded cerebellar gray matter showed larger cross-sectional effect sizes for group differentiation. The study also found high variability in extracerebral signal, which exhibited irreversible kinetics and nonsignificant longitudinal changes with high individual variability.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anthony J. Young, Austin R. Pantel, Varsha Viswanath, Tiffany L. Dominguez, Mehran Makvandi, Hsiaoju Lee, Shihong Li, Erin K. Schubert, Daniel A. Pryma, Michael D. Farwell, Robert H. Mach, Fiona Simpkins, Lilie L. Lin, David A. Mankoff, Robert K. Doot
Summary: The PARP family of proteins is involved in various functions, including the DNA damage response. PARP inhibitors have shown therapeutic efficacy in cancer treatment, and F-18-fluorthanatrace uptake can serve as a biomarker for response to PARP inhibitor therapy. SUVmax and SUVpeak are robust measures of PARP-1 binding.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Yuan, Guojin Zhang, Taotao Sun, Jingyun Ren, Qing Zhang, Zeyin Xiang, Entao Liu, Lei Jiang
Summary: The kinetic features of F-18-PSMA-11 were visualized in healthy subjects and patients with prostate cancer using total-body dynamic PET scans. F-18-PSMA-11 showed rapid accumulation in prostate cancer tissue as early as 45 seconds after injection. It was quickly cleared from blood circulation and mainly excreted through the urinary system. High and rapid radiotracer accumulation was observed in the liver, spleen, lacrimal glands, and salivary glands, whereas gradual accumulation was observed in the skeleton. Prostate cancer tissue is visible in parametric images, with the best visualization in DV and Patlak Ki images. Patlak Ki showed a good correlation with 2TC K-i values and less noise. A scanning time point of 30-35 minutes post injection is suggested for a better tumor to background ratio.
Article
Computer Science, Artificial Intelligence
Yanna Cruz Cavalcanti, Thomas Oberlin, Vinicius Ferraris, Nicolas Dobigeon, Maria Ribeiro, Clovis Tauber
Summary: When arterial input function is not available, a reference time-activity curve (TAC) needs to be extracted for quantification of dynamic PET images. This paper introduces a novel nonlinear factor analysis approach that utilizes a compartment model to compute the kinetic parameters of specific binding tissues jointly. It integrates data-driven parametric imaging methods to establish a physical description of the PET data, thereby relating specific binding with non-specific binding kinetics in the tissues of interest. The performance of the method is evaluated using synthetic and real data, demonstrating its potential significance.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Computer Science, Interdisciplinary Applications
Kuang Gong, Ciprian Catana, Jinyi Qi, Quanzheng Li
Summary: This study proposes an unsupervised deep learning framework for direct parametric reconstruction from dynamic PET, which combines the PET statistical model, the patient's anatomical prior image, and the embedded linear kinetic model to achieve better reconstruction results.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Clinical Neurology
Johan Virhammar, Harald Blohme, Dag Nyholm, Charalampos Georgiopoulos, David Fallmar
Summary: The study found that measuring sagittal midbrain area is more accurate and reliable than visual assessment in distinguishing between PSP patients, iNPH patients, and healthy controls. However, the presence of the hummingbird sign alone cannot fully differentiate between these two diseases, and other symptoms need to be considered in combination.
JOURNAL OF NEUROIMAGING
(2022)
Review
Psychiatry
Lisa Klevebrant, Andreas Frick
Summary: The results of the study indicate that caffeine has anxiogenic and panicogenic effects on patients with panic disorder, with patients being more vulnerable to panic attacks and subjective anxiety following caffeine compared to healthy controls. However, limitations in the study range and dose range restricted further analysis of dose-response relationships between caffeine-induced anxiety and panic attacks.
GENERAL HOSPITAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Andreas Frick, Johannes Bjorkstrand, Mark Lubberink, Allison Eriksson, Mats Fredrikson, Fredrik Ahs
Summary: Research has shown that humans release dopamine in the amygdala and striatum during fear learning, and the amount of dopamine release is linked to strength of conditioned fear responses and linearly coupled to learning-induced activity in the amygdala. This suggests an evolutionary conserved neurochemical mechanism for aversive memory formation in humans.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Helena Gauffin, Anne-Marie Landtblom, Patrick Vigren, Andreas Frick, Maria Engstroem, Anita McAllister, Thomas Karlsson
Summary: This study compared cognitive function and quality of life in young adults with focal or generalized epilepsy. The results showed similar impairments in cognitive function between the two types of epilepsy. Participants with focal epilepsy reported lower quality of life and both epilepsy groups had lower self-esteem values.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Johannes Bjorkstrand, Daniel S. Pine, Andreas Frick
Summary: This study used an internet-delivered version of the Screaming Lady paradigm to evaluate the effects on negative affective ratings and response time to an auditory probe, and observed fear acquisition and extinction. The findings suggest the feasibility and importance of employing remotely delivered fear conditioning paradigms.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Mona Guath, Johan Lundin Kleberg, Jan Weis, Ebba Widegren, Matilda Frick, Stefan Moller, Lisa Klevebrant, Barry Karlsson, David Fallmar, Johanna Martensson, Daniel S. Pine, Karin Brocki, Malin Gingnell, Andreas Frick
Summary: Depressive symptoms are associated with altered pupillary responses during learning and reward prediction as well as with changes in neurometabolite levels. The present pilot study found that pupil dilation during learning was related to depressive symptoms and choline concentrations in the dorsal anterior cingulate cortex (dACC). However, glutamate and GABA were not related to depressive symptoms or pupillary responses.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Psychiatry
Simon Cervenka, Andreas Frick, Robert Boden, Mark Lubberink
Summary: Mental disorders are a growing source of disability and high costs worldwide. Molecular imaging techniques like PET have the potential to advance knowledge and treatment approaches for these disorders. However, PET research in psychiatric disorders has largely focused on monoaminergic neurotransmission, leading to limited progress. This article outlines methodological developments in new radioligands, PET data quantification, PET systems, multimodal imaging, and study protocols to overcome these obstacles.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Olof Hjorth, Andreas Frick, Malin Gingnell, Jonas Engman, Johannes Bjorkstrand, Vanda Faria, Iman Alaie, Per Carlbring, Gerhard Andersson, My Jonasson, Mark Lubberink, Gunnar Antoni, Margareta Reis, Kurt Wahlstedt, Mats Fredrikson, Tomas Furmark
Summary: The combination of internet-based cognitive behavioral therapy (ICBT) and selective serotonin reuptake inhibitors (SSRIs) is an effective treatment for social anxiety disorder (SAD). In this study, the effects of this treatment combination on monoaminergic signaling were investigated using positron emission tomography (PET). The results suggest that the co-expression of serotonin and dopamine transporter proteins influences symptom severity and treatment success in SAD. However, the modulation of monoamine transporters differs when ICBT is combined with either an SSRI medication or a placebo.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Developmental Biology
Livio Tarchi, Stefano Damiani, Paolo La Torraca Vittori, Andreas Frick, Giovanni Castellini, Pierluigi Politi, Paolo Fusar-Poli, Valdo Ricca
Summary: Homotopic connectivity during resting state is considered a risk marker for neurologic and psychiatric conditions. This study examined voxel-mirrored homotopic connectivity (VMHC) in a sample of individuals aged 7-50 years, finding that VMHC decreased with age in minors but not in adults. Four functional networks showed negative correlations between VMHC and age in minors, suggesting that interhemispheric interactions shape late neurodevelopment.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Behavioral Sciences
Magdalena Wlad, Andreas Frick, Jonas Engman, Olof Hjorth, Johanna M. Hoppe, Vanda Faria, Kurt Wahlstedt, Johannes Bjorkstrand, Kristoffer N. T. Mansson, Sara Hultberg, Iman Alaie, Jorgen Rosen, Mats Fredrikson, Tomas Furmark, Malin Gingnell
Summary: Social anxiety disorder (SAD) is not associated with cognitive processing biases during non-emotional challenges like the Multisource Interference Task (MSIT). This study found no differences in task performance or neural reactivity between SAD patients and controls during MSIT. There was a significant negative correlation between dACC activity and depressive symptoms in SAD patients.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Endocrinology & Metabolism
My Jonasson, Andreas Frick, Patrik Fazio, Olof Hjorth, Torsten Danfors, Jan Axelsson, Lieuwe Appel, Tomas Furmark, Andrea Varrone, Mark Lubberink
Summary: The aim of this retrospective study was to investigate the relationships between relative cerebral blood flow and striatal dopamine transporter and dopamine D2/3 availability in healthy subjects. The data included dynamic PET scans with two dopamine transporter tracers [C-11]PE2I and [F-18]FE-PE2I, and the D2/3 tracer [C-11]raclopride. The results suggest that there is an association between resting-state striatal dopamine function and relative blood flow in healthy subjects.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Gustav Cedergren Weber, Jonathan Timpka, Filip Bergquist, David Backstrom, Nil Dizdar, Karin Gunnarsson, Dag Nyholm, Per Svenningsson, Per Odin
Summary: This study explored the impact of COVID-19 on motor, nonmotor, and general health aspects of Parkinson's disease and investigated the perception of symptom changes in PD patients after contracting COVID-19. The results showed that although SARS-CoV-2 infection does not seem to have a major impact on PD symptoms, COVID-19 patients reported slightly improved subjective experiences in pain, quality of life, and general motor function, sleep quality, and mood compared to the control group.
ACTA NEUROLOGICA SCANDINAVICA
(2023)
Article
Health Care Sciences & Services
Liran Karni, Ilir Jusufi, Dag Nyholm, Gunnar Oskar Klein, Mevludin Memedi
Summary: This article introduces a home monitoring system called EMPARK, aimed at improving patient empowerment and clinical care for Parkinson's Disease (PD) patients. Through design science research and user-centered design, patient and clinician interfaces were developed and evaluated. The evaluation results showed high utility and user acceptance for both the patient and clinician interfaces. The EMPARK system has the potential to empower PD patients and be used in daily care and research.
JMIR FORMATIVE RESEARCH
(2022)
Meeting Abstract
Clinical Neurology
T. Birnberg, L. Adar, W. Poewe, D. Nyholm, M. Bjornsson, M. Karlsson
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Dag Nyholm, Wolfgang H. Jost
Summary: As Parkinson's disease progresses, treatment needs to be adjusted to maintain symptom control. Device-aided therapy, such as levodopa-entacapone-carbidopa intestinal gel (LECIG) infusion, can provide continuous dopaminergic stimulation for patients with advanced PD. LECIG infusion has been shown to be clinically effective, with similar motor function improvement as standard levodopa-carbidopa intestinal gel (LCIG) infusion, but at lower overall levodopa doses. Real-world data will continue to be collected to establish the long-term efficacy and safety of LECIG infusion.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.
