期刊
NEUROIMAGE
卷 59, 期 3, 页码 1979-1987出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2011.09.057
关键词
Phase contrast; MRI; Myelin quantification; Phase imaging; Dysmyelination; Shiverer
资金
- Swiss National Fund [33CM30-124101, 132821]
- CIBM of the UNIL
- UNIGE
- HUG
- CHUV
- EPFL
- Boninchi
- De Reuter
- Leenaards and Jeantet Foundations
- Swiss National Science Foundation (SNF) [33CM30-124101] Funding Source: Swiss National Science Foundation (SNF)
The present study evaluated the potential of using the phase of T-2* weighted MR images to characterize myelination during brain development and pathology in rodents at 9.4 T. Phase contrast correlated with myelin content assessed by histology and suggests that most contrast between white and cortical gray matter is modulated by myelin. Ex vivo experiments showed that gray-white matter phase contrast remains unchanged after iron extraction. In dysmyelinated shiverer mice, phase imaging correlated strongly with myelin staining, showing reduced contrast between white and gray matter when compared to healthy controls. We conclude that high-resolution phase images, acquired at high field, allow assessment of myelination and dysmyelination. (C) 2011 Elsevier Inc. All rights reserved.
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