Article
Neurosciences
Qiuting Wen, Shannon L. Risacher, Linhui Xie, Junjie Li, Jaroslaw Harezlak, Martin R. Farlow, Frederick W. Unverzagt, Sujuan Gao, Liana G. Apostolova, Andrew J. Saykin, Yu-Chien Wu
Summary: The study explored the spatial pattern of tau-white matter (WM) associations across the whole brain and found a distinct spatial pattern resembling the typical propagation of tau pathology in Alzheimer's disease (AD). The association between tau and WM degeneration highlights the important role of WM alterations in the AD pathological cascade.
Article
Neurosciences
Alison R. Weiss, Zheng Liu, Xiaojie Wang, William A. Liguore, Christopher D. Kroenke, Jodi L. McBride
Summary: Macaques are widely used in neuroscience research, and a brain atlas was created from 18 adult rhesus macaques to better define brain regions across multiple imaging modalities. The atlas includes templates for macroscopic brain structure and diffusion imaging, allowing consistent identification of regions in different imaging modalities.
Article
Immunology
Chase E. Hawes, Sonny R. Elizaldi, Danielle Beckman, Giovanne B. Diniz, Yashavanth Shaan Lakshmanappa, Sean Ott, Blythe P. Durbin-Johnson, Ashok R. Dinasarapu, Andrea Gompers, John H. Morrison, Smita S. Iyer
Summary: Research highlights the immune surveillance of the rhesus CNS by innate and adaptive immune cells during homeostasis. Following SHIV infection, vulnerabilities of key cognitive and motor function brain regions to HIV-1 during the acute phase were demonstrated by viral entry and integration within multiple brain regions.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Maya Yablonski, Benjamin Menashe, Michal Ben-Shachar
Summary: The study demonstrates significant correlations between the bilateral ventral tracts and morphological processing, extending beyond reading to oral production. Additionally, significant correlations were found in the dorsal tract associated with oral fluency and speech production.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hediye Pinar Gunbey, Arzu Ceylan Has, Kerim Aslan, Dilek Saglam, Ugur Avci, Asli Tanrivermis Sayit, Lutfi Incesu
Summary: This study investigated the effects of hypothyroidism on white matter integrity using TBSS, finding significant reductions in FA and AD, and an increase in RD in several WM tracts. The results suggest a demyelination process underlying the clinical aspects of hypothyroidism.
Article
Neurosciences
Aleksi J. Sihvonen, Paula Virtala, Anja Thiede, Marja Laasonen, Teija Kujala
Summary: This study utilized a hodological approach to investigate the relationships between structural white matter connectivity and reading skills and phonological processing. The findings revealed specific brain regions associated with reading skills and phonological processing, as well as structural connectivity anomalies in dyslexics.
Article
Computer Science, Artificial Intelligence
Simon Oxenford, Ana Sofia Rios, Barbara Hollunder, Clemens Neudorfer, Alexandre Boutet, Gavin J. B. Elias, Jurgen Germann, Aaron Loh, Wissam Deeb, Bryan Salvato, Leonardo Almeida, Kelly D. Foote, Robert Amaral, Paul B. Rosenberg, David F. Tang-Wai, David A. Wolk, Anna D. Burke, Marwan N. Sabbagh, Stephen Salloway, M. Mallar Chakravarty, Gwenn S. Smith, Constantine G. Lyketsos, Michael S. Okun, William S., Zoltan Mari, Francisco A. Ponce, Andres Lozano, Wolf-Julian Neumann, Bassam Al-Fatly, Andreas Horn
Summary: Spatial normalization is a method to map subject brain images to an average template brain, allowing comparison of brain imaging results. We introduce a novel tool called WarpDrive, which enables manual refinements of image alignment after automated registration. The tool improves accuracy of data representation and aids in understanding patient outcomes.
MEDICAL IMAGE ANALYSIS
(2024)
Article
Biochemical Research Methods
Xiaofu He, Mihaela Stefan, David Pagliaccio, Lana Khamash, Martine Fontaine, Rachel Marsh
Summary: A semi-automated method was proposed to enhance the detection and recovery of incomplete white matter tracts, with steps outlined to optimize the quality of preprocessed DTI data, leading to improved speed and quality control compared to existing methods. This method allows TRACULA users to automatically assess the quality of reconstructed white matter tracts and semi-automatically recover those that are incomplete.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Neurosciences
Steven L. Meisler, John D. E. Gabrieli
Summary: Reading involves a widely distributed brain network and white matter tracts play an important role in transmitting information between constituent network nodes. A study with a large dataset of 686 children found that while white matter FA increased with age, there were no significant correlations between overall reading abilities and tract FAs. However, higher FA in specific tracts was associated with better nonword reading skills in older children.
Article
Neurosciences
Venla Kumpulainen, Harri Merisaari, Eero Silver, Anni Copeland, Elmo P. Pulli, John D. Lewis, Ekaterina Saukko, Satu J. Shulist, Jani Saunavaara, Riitta Parkkola, Tuire Laehdesmaeki, Linnea Karlsson, Hasse Karlsson, Jetro J. Tuulari
Summary: The rapid early-life white matter maturation is followed by slower and long-lasting development, accompanied by the learning of more complex skills. By the age of 5, differences in behavior and cognition between females and males as well as brain lateralization functions such as language skills start to appear. Diffusion tensor imaging (DTI) can be used to measure the fractional anisotropy (FA) within the white matter, with higher values indicating more advanced brain development. This study examined the normal features of white matter development in early childhood using DTI data from 166 healthy infants (mean age 3.8 weeks) and 144 healthy children (mean age 5.4 years). The results showed sex differences and age-dependent changes in white matter development, as well as the presence of asymmetry in white matter microstructure in infants.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Heather M. Clark, Nirubol Tosakulwong, Stephen D. Weigand, Farwa Ali, Hugo Botha, Nha Trang Thu Pham, Christopher G. Schwarz, Robert Reid, Matthew L. Senjem, Clifford R. Jack, Val J. Lowe, J. Eric Ahlskog, Keith A. Josephs, Jennifer L. Whitwell
Summary: This study found that impairments in swallowing function were associated with specific brain regions' reduced gray matter volumes and abnormal white matter integrity. The impairments in the oral and pharyngeal phases of swallowing corresponded to different regions of neuroanatomical impairment.
MOVEMENT DISORDERS
(2021)
Article
Immunology
Danting Jiang, Ria Goswami, Maria Dennis, Holly Heimsath, Pamela A. Kozlowski, Amir Ardeshir, Koen K. A. Van Rompay, Kristina De Paris, Sallie R. Permar, Neeraj K. Surana
Summary: The composition of early-life gut microbial communities in nursery-reared rhesus macaques is influenced by age, birth year, and vaccination status. The study identified a positive correlation between certain microbial species, such as Sutterella and Rodentibacter, and vaccine-elicited antibody responses. Metagenomic analysis revealed metabolic pathways associated with improved antibody responses following HIV vaccination. The findings suggest a bidirectional relationship between the microbiota and vaccines, highlighting the importance of understanding this interplay in developing more effective vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jingwen Zhu, Anqi Qiu
Summary: This study constructed a multimodal brain atlas for a Chinese aging population, including T1, HARDI, and rs-fMRI atlases. Using spectral clustering, 20 brain functional networks were generated, and joint independent component analysis was used to explore coherent markers for aging and gender.
Article
Geriatrics & Gerontology
Wen-Xin Li, Jing Yuan, Fei Han, Li-Xin Zhou, Jun Ni, Ming Yao, Shu-Yang Zhang, Zheng-Yu Jin, Li-Ying Cui, Fei-Fei Zhai, Yi-Cheng Zhu
Summary: This study aimed to investigate the global and topographic changes of white matter integrity and cortical structure related to cognitive impairments in a community-based population. The results showed that disrupted white matter integrity is associated with visuomotor processing speed, semantic memory, and executive function, while cortical surface area is related to cognitive scores. These findings contribute to a better understanding of the pathological process underlying cognitive impairments.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Bingxin Zhao, Tengfei Li, Yue Yang, Xifeng Wang, Tianyou Luo, Yue Shan, Ziliang Zhu, Di Xiong, Mads E. Hauberg, Jaroslav Bendl, John F. Fullard, Panagiotis Roussos, Yun Li, Jason L. Stein, Hongtu Zhu
Summary: The study identified common genetic variants influencing white matter microstructure and detected multiple associated loci, some of which were related to brain diseases. Additionally, genetic correlations were observed between white matter microstructure and a wide range of complex traits and diseases.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ting Gong, Qiqi Tong, Zhiwei Li, Hongjian He, Hui Zhang, Jianhui Zhong
Summary: A deep learning-based technique was developed to reduce residual motion effects in diffusion MRI data, showing stable performance across different levels of data rejection. This method combines data rejection and deep learning algorithms to overcome limitations of traditional techniques and offers potential benefits for individual scans and population studies.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Editorial Material
Psychiatry
Ned H. Kalin, Elisabeth Binder, Kathleen T. Brady, David A. Lewis, Daniel S. Pine, Carolyn Rodriguez, Madhukar H. Trivedi, Matthew L. Edwards
AMERICAN JOURNAL OF PSYCHIATRY
(2021)
Article
Neurosciences
Ioana Hill, Marco Palombo, Mathieu Santin, Francesca Branzoli, Anne-Charlotte Philippe, Demian Wassermann, Marie-Stephane Aigrot, Bruno Stankoff, Anne Baron-Van Evercooren, Mehdi Felfli, Dominique Langui, Hui Zhang, Stephane Lehericy, Alexandra Petiet, Daniel C. Alexander, Olga Ciccarelli, Ivana Drobnjak
Summary: A computational model was developed using machine learning to estimate axonal permeability parameters. Results showed reliable estimation of microstructure parameters, and agreement with experimental and histology measurements in a mouse model, suggesting the potential of this approach for studying demyelinating pathologies.
Editorial Material
Psychiatry
Ned H. Kalin
AMERICAN JOURNAL OF PSYCHIATRY
(2021)
Review
Neurosciences
Margaux M. Kenwood, Ned H. Kalin, Helen Barbas
Summary: Anxiety is a response to distal or uncertain threats, involving changes in subjective state, autonomic responses, and behavior. Primates can regulate anxiety through the prefrontal cortex, with pathways poised to reduce noise, enhance signals, and regulate anxiety processing and autonomic drive.
NEUROPSYCHOPHARMACOLOGY
(2022)
Editorial Material
Psychiatry
Ned H. Kalin
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Editorial Material
Psychiatry
Ned H. Kalin
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Correction
Neurosciences
Margaux M. Kenwood, Ned H. Kalin, Helen Barbas
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Nakul Aggarwal, Lisa E. Williams, Do P. M. Tromp, Daniel S. Pine, Ned H. Kalin
Summary: This longitudinal study found a dynamic relationship between whole-brain white matter microstructural integrity and anxiety symptoms in girls with pathological anxiety. The findings suggest that targeting white matter development could be a viable approach in the treatment of anxiety-related psychopathology.
TRANSLATIONAL PSYCHIATRY
(2022)
Editorial Material
Psychiatry
Ned H. Kalin
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Editorial Material
Psychiatry
Ned H. Kalin
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Editorial Material
Psychiatry
Ned H. Kalin
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Jason F. Moody, Nakul Aggarwal, Douglas C. Dean, Do P. M. Tromp, Steve R. Kecskemeti, Jonathan A. Oler, Ned H. Kalin, Andrew L. Alexander
Summary: Alterations in white matter development are related to neuropsychiatric disorders. Quantitative relaxometry can be used to evaluate white matter microstructural changes. A study on infant non-human primates found correlations between quantitative relaxometry and diffusion tensor imaging metrics, with gestational age being a stronger predictor for relaxometry metrics. This provides a basis for future studies.
Editorial Material
Psychiatry
Ned H. Kalin
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.