Article
Multidisciplinary Sciences
William L. Schuerman, Kirill Nourski, Ariane E. Rhone, Matthew A. Howard, Edward F. Chang, Matthew K. Leonard
Summary: Vagus nerve stimulation is increasingly used to treat various diseases and disorders, but the acute effects on human cortical neurophysiology are not fully understood. Research shows that VNS causes subtle changes in neural activity across broad cortical networks, which can vary significantly depending on stimulation parameters and modalities among individuals.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Lu Zhang, Lorenzo Pini, DoHyun Kim, Gordon L. Shulman, Maurizio Corbetta
Summary: Recent evidence suggests that spontaneous brain activity patterns and connectivity in the visual and motor cortex code for natural stimuli and actions, respectively. This study examines whether replay patterns occur in resting-state activity in high-order cognitive networks not directly processing sensory inputs or motor outputs. The results show that spontaneous activity patterns in human attention networks code for hand movements.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Jaime Caballero-Insaurriaga, Jose A. Pineda-Pardo, Ignacio Obeso, Antonio Oliviero, Guglielmo Foffani
Summary: This study combined transcranial static magnetic field stimulation (tSMS) with resting-state functional MRI (fMRI) to investigate corticostriatal activity and found that tSMS can noninvasively modulate corticostriatal activity in humans. The results showed that the supplementary motor area (SMA) is the main region with functional connectivity to the striatum, and tSMS can modulate local activity in the SMA, adjacent sensorimotor cortex, and motor striatum. The findings also indicated that the tSMS-induced modulation of striatal activity can be primarily explained by a change in the shared activity between the modulated motor cortical areas and the motor striatum. These results suggest that corticostriatal activity can be targeted, monitored, and modulated noninvasively in humans.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Matteo Guidetti, Alessandro Bertini, Francesco Pirone, Gessica Sala, Paola Signorelli, Carlo Ferrarese, Alberto Priori, Tommaso Bocci
Summary: Non-invasive brain stimulation techniques have shown potential in improving symptoms of neurodegenerative diseases, particularly cognitive and motor impairments in Alzheimer's Disease and Parkinson's Disease. However, their effect on disease progression is still unclear, although recent evidence suggests a possible neuroprotective role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
G. Darmani, T. O. Bergmann, K. Butts Pauly, C. F. Caskey, L. de Lecea, A. Fomenko, E. Fouragnan, W. Legon, K. R. Murphy, T. Nandi, M. A. Phipps, G. Pinton, H. Ramezanpour, J. Sallet, S. N. Yaakub, S. S. Yoo, R. Chen
Summary: Transcranial ultrasound stimulation (TUS) has the potential to alter neural circuits non-invasively in both animals and humans. Unlike other non-invasive brain stimulation methods, TUS can focus on both cortical and deep brain targets with unprecedented spatial resolution. The neuromodulatory effects of TUS are derived from the interaction of ultrasound waves with neuronal membranes, resulting in changes in excitability and firing rate. After years of research, TUS is now being applied in human studies and can be assessed using non-invasive brain mapping techniques. This review provides a comprehensive overview of the principles, mechanisms, effects, and potential applications of TUS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Editorial Material
Biology
Anusha Mishra, Catherine N. Hall, Clare Howarth, Ralph D. Freeman
Summary: Functional neuroimaging using MRI relies on measuring blood oxygen level-dependent (BOLD) signals to infer underlying neuronal activity, but accurate interpretation depends on a full understanding of neurovascular coupling and other mechanisms.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Neurosciences
Behzad Iravani, Artin Arshamian, Peter Fransson, Neda Kaboodvand
Summary: Recent advances in non-linear computational and dynamical modeling have made it possible to parameterize dynamic neural mechanisms driving complex behaviors. By applying a newly developed adaptive frequency-based model to whole-brain oscillations from fMRI data, researchers were able to distinguish differences in neural dynamics between healthy controls and ADHD subjects, and identify distinct behavioral phenotypes within the ADHD cohort. This study demonstrates the potential of the new modeling framework in revealing hidden neurophysiological profiles and establishing tailored clinical interventions.
Review
Behavioral Sciences
Elisa Tatti, Angela L. Phillips, Rachel Paciorek, Sara M. Romanella, Davide Dettore, Giorgio Di Lorenzo, Giulio Ruffini, Simone Rossi, Emiliano Santarnecchi
Summary: Mental health disorders and substance use disorders pose significant challenges to public health systems. Evidence-based psychotherapy is commonly used to address mental health issues, but treatment adherence, relapses, and practical barriers hinder psychological change. Non-invasive brain stimulation techniques have emerged as promising tools to directly target dysfunctional neural circuitry and promote lasting plastic changes. Combining psychotherapy with brain stimulation may personalize treatment and provide more direct control of neuronal changes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Psychiatry
Cletus Cheyuo, Jurgen Germann, Kazuaki Yamamoto, Artur Vetkas, Aaron Loh, Can Sarica, Vanessa Milano, Ajmal Zemmar, Oliver Flouty, Irene E. Harmsen, Mojgan Hodaie, Suneil K. Kalia, David Tang-Wai, Andres M. Lozano
Summary: Deep brain stimulation (DBS) and non-invasive neuromodulation are being investigated for treating Alzheimer's Disease (AD). This study provides evidence that DBS may improve cognitive outcomes in older AD patients, while non-invasive neuromodulation may have a favorable effect in younger patients. Brain stimulation in AD may modulate specific brain networks, such as the default mode network, salience network, central executive network, and the Papez circuit.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Chemistry, Multidisciplinary
Y. Hong, J. Wang, J. Li, Z. Xu, X. Yang, M. Bai, P. Gong, Y. Xie, X. Zhang, P. Xu, X. Chen, R. Li, X. Liu, G. Ruan, G. Xu
Summary: This study explores an alternative strategy of non-invasive brain delivery of nanoparticles and finds that this method can enhance the neural stimulation effects of transcranial magnetic stimulation (TMS). The use of Tat-SPIONs in combination with TMS shows significant improvement in stroke recovery in rats. Mechanistic studies suggest that the neural stimulation enhancement is mediated by neuroplasticity and magnetoelectric effect, primarily through the binding of Tat-SPIONs to neurons' plasma membranes. This research provides a technological platform for the medical applications of nanoparticles in remote brain stimulation for stroke and other neurological disorders.
MATERIALS TODAY CHEMISTRY
(2022)
Review
Cell Biology
Alberto Benussi, Giorgi Batsikadze, Carina Franca, Rubens G. Cury, Roderick P. P. W. M. Maas
Summary: This paper comprehensively reviews the clinical and neurophysiological effects of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and dentate nucleus deep brain stimulation (DBS) in patients with hereditary ataxias, as well as the underlying mechanisms at the cellular and network level and future research perspectives.
Article
Clinical Neurology
Lubos Brabenec, Patricia Klobusiakova, Patrik Simko, Milena Kostalova, Jiri Mekyska, Irena Rektorova
Summary: This study evaluated the long-term effects of repetitive transcranial magnetic stimulation on hypokinetic dysarthria in Parkinson's disease, showing that real stimulation led to improvements in speech articulation compared to sham stimulation. The neural mechanisms of these improvements involve activation increases in specific brain regions and enhanced intrinsic connectivity.
Review
Neurosciences
Wanting Guo, Yuchen He, Wenquan Zhang, Yiwei Sun, Junling Wang, Shuang Liu, Dong Ming
Summary: Neuromodulation technology has great potential in treating neuropsychiatric disorders, but challenges like invasiveness, energy consumption, and public acceptance need to be addressed. Temporally interfering electrical stimulation, using low-frequency envelope waveform, shows promise in targeting specific brain areas without invasive procedures. Recent studies have focused on investigating the stimulation qualities and application of this technique, aiming to provide reference for future research.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Meytal Wilf, Celine Dupuis, Davide Nardo, Diana Huber, Sibilla Sander, Joud Al-Kaar, Meriem Haroud, Henri Perrin, Eleonora Fornari, Sonia Crottaz-Herbette, Andrea Serino
Summary: This study investigates the plasticity of the brain and associated neural modulation during naturalistic sensorimotor experiences using virtual reality (VR) training and functional neuroimaging. The findings demonstrate that short-term VR training can alter large-scale cortical connectivity and bias visual responses to naturalistic sensory inputs.
Review
Psychiatry
Amanda R. Arulpragasam, Mascha van 't Wout-Frank, Jennifer Barredo, Christiana R. Faucher, Benjamin D. Greenberg, Noah S. Philip
Summary: This article introduces a new emerging non-invasive neuromodulatory technology called low intensity focused ultrasound (LIFU). LIFU has the potential to deliver non-invasive and reversible deep brain neuromodulation at millimeter precision through acoustic sonication. Its spatial precision and non-invasive nature make it different from current technologies. Studies have shown that LIFU can safely modulate human brain activity. The novelty of this technique underscores the need for foundational papers to introduce it to the community.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Harper Lee Kaye, Daniel San-Juan, Ricardo Salvador, Maria Chiara Biagi, Laura Dubreuil-Vall, Ugur Damar, Alvaro Pascual-Leone, Giulio Ruffini, Mouhsin M. Shafi, Alexander Rotenberg
Summary: This study demonstrates the safety and efficacy of multifocal, personalized, multichannel cathodal transcranial direct current stimulation in reducing seizure frequency in patients with drug-resistant focal epilepsy. However, there is a possibility of seizure exacerbation in some patients.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Otorhinolaryngology
Nathan Watson, Frederic L. W. V. J. Schaper, Sandrine Jabbour, Samantha Sadler, Paul A. Bain, Michael D. Fox, James G. Naples
Summary: Objective chronic tinnitus affects a significant portion of the adult population, and repetitive transcranial magnetic stimulation (rTMS) has shown promise as a treatment. This systematic review reveals significant heterogeneity in the literature regarding the optimal rTMS site for treating tinnitus. Preliminary findings suggest that the temporoparietal junction midway between T3 and P3 or T4 and P4 is a promising nonauditory rTMS target for chronic tinnitus.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Geriatrics & Gerontology
Tammy T. Hshieh, Eva M. Schmitt, Tamara G. Fong, Steve Arnold, Michele Cavallari, Bradford C. Dickerson, Simon T. Dillon, Richard N. Jones, Towia A. Libermann, Edward R. Marcantonio, Alvaro Pascual-Leone, Mouhsin M. Shafi, Alexandra Touroutoglou, Thomas G. Travison, Ray Yun Gou, Douglas Tommet, Ayesha Abdeen, Brandon Earp, Lisa Kunze, Jeffrey Lange, Kamen Vlassakov, Sharon K. Inouye
Summary: The SAGES II study aims to enhance our understanding of the correlation between delirium and dementia by examining various biomarkers in older adults undergoing major surgery. The study utilizes a range of assessment methods and techniques, including cognitive testing, neuroimaging, and neurophysiology. This study provides valuable insights into the relationship between delirium and dementia.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Jessica M. Ross, Emiliano Santarnecchi, Shu Jing Lian, Tamara G. Fong, Alexandra Touroutoglou, Michele Cavallari, Thomas G. Travison, Edward R. Marcantonio, Towia A. Libermann, Eva M. Schmitt, Sharon K. Inouye, Mouhsin M. Shafi, Alvaro Pascual-Leone
Summary: Post-surgical delirium is a serious complication that can lead to cognitive decline and loss of function. This study found that neurophysiologic measures, such as resting-state EEG and transcranial magnetic stimulation, could predict the risk of delirium in older patients undergoing surgery.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Chun Liang Hsu, Brad Manor, Thomas Travison, Alvaro Pascual-Leone, Lewis A. Lipsitz
Summary: This study investigated differences in sensorimotor network (SMN) and frontoparietal network (FPN) in older adults with/without decline in gait speed and their association with cognitive function. The results showed that maintainers had lower baseline connectivity in SMN and higher connectivity in FPN compared to decliners. Lower connectivity in primary motor-premotor network was correlated with maintenance of delayed-recall performance on HVLT.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Neurosciences
Ali Jannati, Lindsay M. Oberman, Alexander Rotenberg, Alvaro Pascual-Leone
Summary: Transcranial magnetic stimulation (TMS) is a promising non-invasive technique for the diagnosis and treatment of neurological and psychiatric disorders. This review focuses on repetitive TMS (rTMS) protocols and their metrics of brain plasticity, such as theta-burst stimulation (TBS). It also discusses the use of TMS-EEG technique, neuronavigation, and the effects of age and genetic factors on TBS aftereffects. Furthermore, it summarizes alterations of TMS-TBS measures of plasticity in major neurological and psychiatric disorders.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Alexander L. Cohen, Mallory R. Kroeck, Juliana Wall, Peter McManus, Arina Ovchinnikova, Mustafa Sahin, Darcy A. Krueger, E. Martina Bebin, Hope Northrup, Joyce Y. Wu, Simon K. Warfield, Jurriaan M. Peters, Michael D. Fox, Tuberous Sclerosis Complex Autism Center Of Excellence Network Study Group
Summary: This study found a significant association between tubers involving the right fusiform face area and ASD diagnosis in TSC, with a 3.7-fold increased risk. This highlights a potentially causative mechanism for developing autism in TSC, which may guide research into ASD symptoms more generally.
ANNALS OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Micol Colella, Daniel Z. Press, Rebecca M. Laher, Courtney E. McIlduff, Seward B. Rutkove, Antonino M. Cassara, Francesca Apollonio, Alvaro Pascual-Leone, Micaela Liberti, Giorgio Bonmassar
Summary: Peripheral magnetic stimulation (PMS) is a complementary method to standard electrical stimulation (ES) that can stimulate sensory and motor nerve fibers without discomfort. In this study, a novel PMS coil was developed using flexible technologies and its effectiveness was validated through simulations and experiments.
Article
Neurosciences
Jing Jiang, Michael A. Ferguson, Jordan Grafman, Alexander L. Cohen, Michael D. Fox
Summary: This study found that emotion regulation is associated with a brain network centered on the left ventrolateral prefrontal cortex. Damage to this network is related to difficulties in managing emotions and an increased risk of various neuropsychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Justine Magnuson, Mehmet A. A. Ozdemir, Elon Mathieson, Sofia Kirkman, Brice Passera, Sumientra Rampersad, Alyssa B. B. Dufour, Dana Brooks, Alvaro Pascual-Leone, Peter J. J. Fried, Mouhsin M. M. Shafi, Recep A. A. Ozdemir
Summary: This study comprehensively evaluated the neuromodulatory effects of various rTMS protocols on corticospinal excitability. The results showed that these protocols did not significantly modulate corticospinal excitability and had poor reproducibility. These findings question the effectiveness and reliability of widely used rTMS techniques in modulating corticospinal excitability.
Article
Clinical Neurology
Kilian Abellaneda-Perez, Gabriele Cattaneo, Maria Cabello-Toscano, Javier Solana-Sanchez, Lidia Mulet-Pons, Lidia Vaque-Alcazar, Ruben Perellon-Alfonso, Cristina Sole-Padulles, Nuria Bargallo, Josep M. Tormos, Alvaro Pascual-Leone, David Bartres-Faz
Summary: A higher sense of purpose in life can enhance the brain's resilience against cognitive impairment in middle age and promote better cognitive function. This is achieved through better functional integration of specific brain networks.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Psychiatry
I. Bayes-Marin, M. Cabello-Toscano, G. Cattaneo, J. Solana-Sanchez, D. Fernandez, C. Portellano-Ortiz, J. M. Tormos, A. Pascual-Leone, D. Bartres-Faz
Summary: The study aimed to identify trajectories of mental health during a two-year follow-up of the COVID-19 pandemic and investigate the associations between these trajectories and various factors. They found that most participants belonged to the "resilient" trajectory, while a smaller proportion belonged to the "chronic-worsening" trajectory. Protective factors and risk factors played different roles in different mental health outcomes.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2023)
Correction
Psychology, Clinical
Roger W. Strong, Rachel Grashow, Andrea L. Roberts, Eliza Passell, Luke Scheuer, Douglas P. Terry, Sarah Cohan, Alvaro Pascual-Leone, Marc G. Weisskopf, Ross D. Zafonte, Laura T. Germine
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Article
Psychology, Clinical
Roger W. Strong, Rachel Grashow, Andrea L. Roberts, Eliza Passell, Luke Scheuer, Douglas P. Terry, Sarah Cohan, Alvaro Pascual-Leone, Marc G. Weisskopf, Ross D. Zafonte, Laura T. Germine
Summary: This cross-sectional study examined the association between football exposure and later life cognitive performance in former professional American-style football players. It found that retrospectively reported football concussion symptoms were associated with cognitive performance in later life. However, this association may differ based on pre-concussion cognitive functioning.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Article
Clinical Neurology
Frederic L. W. V. J. Schaper, Janne Nordberg, Alexander L. Cohen, Christopher Lin, Joey Hsu, Andreas Horn, Michael A. Ferguson, Shan H. Siddiqi, William Drew, Louis Soussand, Anderson M. Winkler, Marta Simo, Jordi Bruna, Sylvain Rheims, Marc Guenot, Marco Bucci, Lauri Nummenmaa, Julie Staals, Albert J. Colon, Linda Ackermans, Ellen J. Bubrick, Jurriaan M. Peters, Ona Wu, Natalia S. Rost, Jordan Grafman, Hal Blumenfeld, Yasin Temel, Rob P. W. Rouhl, Juho Joutsa, Michael D. Fox
Summary: It is important to identify the brain regions or networks associated with epilepsy by mapping lesions, which can inform prognosis and guide interventions.
