期刊
NEUROIMAGE
卷 62, 期 3, 页码 2007-2020出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2012.05.015
关键词
Aging; Contextual interference; fMRI; Practice condition; TMS
资金
- American Heart Association
- Center of Experimental Neurorehabilitation Training
- National Science Foundation
- Howard Hughes Medical Institutes
- National Science Council [NSC 100-2218-E-010-001-MY2]
- Ministry of Education, Taiwan
- Ministry of Education, Aim for the Top University Plan [100 AC-B12]
- Brain Mapping Medical Research Organization
- Brain Mapping Support Foundation
- Pierson-Lovelace Foundation
- Ahmanson Foundation
- Northern Piedmont Community Foundation
- Tamkin Foundation
- Jennifer Jones-Simon Foundation
- Capital Group Companies Charitable Foundation
- Robson Family and the Northstar Fund
- National Center for Research Resources (NCRR) [RR12169, RR13642, RR00865]
- Division Of Behavioral and Cognitive Sci
- Direct For Social, Behav & Economic Scie [0848246] Funding Source: National Science Foundation
Practice of tasks in an interleaved order generally induces superior retention compared to practicing in a repetitive order. Younger and older adults practiced serial reaction time tasks that were arranged in a repeated or an interleaved order on 2 successive days. Retention was tested on Day 5. For both groups, reaction times in the interleaved condition were slower than the repetitive condition during practice, but the reverse was true during retention on Day 5. After interleaved practice, changes in M1 excitability measured by paired-pulse TMS were greater than after repetitive practice, and this effect was more pronounced in older adults. Moreover, the increased M1 excitability correlated with the benefit of interleaved practice. BOLD signal was also increased for interleaved compared to repetitive practice in both groups. However, the pattern of correlations between increased BOLD during practice and subsequent benefit of the interleaved condition differed by group. In younger adults, dorsolateral-prefrontal activity during practice was related to this benefit, while in older adults, activation in sensorimotor regions and rostral prefrontal cortex during practice correlated with the benefit of interleaving on retention. Older adults may engage compensatory mechanisms during interleaved practice such as increasing sensorimotor recruitment which in turn benefits learning. (C) 2012 Elsevier Inc. All rights reserved.
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