Article
Medicine, Research & Experimental
Yan Gao, Zhaoyun Yang, Kang He, Zeyu Wang, Tingyu Zhang, Jiang Yi, Lijing Zhao
Summary: This study found that exercise has anti-inflammatory and antioxidant effects on pulmonary fibrosis induced by paraquat, reducing the infiltration of inflammatory cells and fibrotic lesions. Furthermore, exercise also increased the expression of antioxidative distress proteins, improved the degree of epithelial-mesenchymal transition in alveolar epithelial cells, and ultimately alleviated paraquat-induced pulmonary fibrosis.
Article
Anesthesiology
Isabella M. Fuentes, Brittni M. Jones, Aaron D. Brake, Angela N. Pierce, Olivia C. Eller, Rachel M. Supple, Douglas E. Wright, Julie A. Christianson
Summary: Studies suggest that voluntary exercise can alleviate the negative impact of a history of early life stress exposure on patients with chronic pain and mood disorders, with evidence showing that voluntary wheel running may improve outcomes related to urologic chronic pelvic pain syndrome.
Article
Biochemistry & Molecular Biology
Laura Niiranen, Ville Stenback, Mikko Tulppo, Karl-Heinz Herzig, Kari A. Makela
Summary: Exercise has been proven to improve cognitive function, and studies on both humans and animals have shown this. Laboratory mice are often used as a model to study the effects of exercise, and running wheels provide a voluntary and stress-free form of exercise for mice. This study aimed to analyze the relationship between the cognitive state of a mouse and its wheel-running behavior. The results showed that high-runner mice exhibited enhanced learning capabilities and ate more compared to the other groups. Interestingly, individual mice had different reactions when introduced to running wheels, suggesting the importance of considering individual differences in voluntary endurance exercise studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Marie-Luise Ederer, Madlen Guenther, Lena Best, Julia Lindner, Christoph Kaleta, Otto W. Witte, Rowena Simon, Christiane Frahm
Summary: Inflammation is believed to play a role in cognitive decline during aging. This study examines the impact of physical activity and social isolation on cognitive function and inflammation in old mice. The results show that voluntary wheel running improves cognitive function, while social isolation has negative effects. Inflammatory markers increase in both the hippocampus and colon during aging, and voluntary wheel running specifically attenuates intestinal inflammation.
Article
Biotechnology & Applied Microbiology
Phillipe Huber, Brandon J. J. Ausk, K. Lionel Tukei, Steven D. D. Bain, Ted S. S. Gross, Sundar Srinivasan
Summary: The study developed a convolutional neural network model to accurately assess the running frequency of aged mice. The model achieved a 94% accuracy rate. This research method provides a higher resolution of information for studying the physiological effects of voluntary wheel running activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Neurosciences
Kyeong Jin Yoon, Suhong Park, Seung Hee Kwak, Hyo Youl Moon
Summary: Anxiety disorders are commonly diagnosed psychological conditions that are often treated with drugs, but these medications can have side effects. Exercise is an effective treatment for anxiety, and it has been found to release extracellular vesicles (EVs) that may help reduce anxiety. Research suggests that exercise-derived EVs may have anti-anxiety effects.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Immunology
Kiersten S. Scott, Brandon Chelette, Chinenye Chidomere, A. Phillip West, Robert Dantzer
Summary: Cisplatin decreases energy-consuming activities but not energy-procuring activities unless they require a choice between options differing in their cost-benefit ratio. The physical dimension of fatigue is more likely to develop in cisplatin-treated individuals than the motivational dimension of fatigue.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Multidisciplinary Sciences
Annika Reuser, Kristin Wenzel, Stephan B. Felix, Marcus Doerr, Martin Bahls, Stephanie Koenemann
Summary: This article introduces a method that combines radiotelemetry system and running wheels to determine spontaneous cage activity and voluntary exercise levels of individual animals in group-housed rodents. A software tool is developed for fast and reliable data analysis. This method can be used to study the benefits of physical activity and the impact of therapeutic interventions on animal behavior.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Behavioral Sciences
Kyle A. Sullivan, Corena V. Grant, Kelley R. Jordan, Selina S. Vickery, Leah M. Pyter
Summary: The study found that exercise helps faster recovery from paclitaxel-induced weight loss and deficits in melanocortin signaling, but did not alleviate fatigue or inflammation. Body mass recovery was associated with the wheel running-induced recovery of body composition and associated peripheral circulating hormones.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Ahmad Mohammad, Michael S. Finch, Jacob Sweezey-Munroe, Rebecca E. K. MacPherson
Summary: This study found that voluntary exercise can prevent the increase in BACE1 activity and maintain memory recall in ovariectomized female mice. This may provide a method of slowing the progression of Alzheimer's disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Behavioral Sciences
Katsuya Nakano, Hitomi Nakazawa, Qiang He, Junsuke Uwada, Takeshi Kiyoi, Takaharu Ishibashi, Takayoshi Masuoka
Summary: Recent clinical studies suggest a close association between dry eye and psychiatric disorders. This study investigates the depressive-like behavior in two mouse models of dry eye and the potential benefits of voluntary wheel-running in alleviating depressive states induced by dry eye.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Immunology
Kiersten Scott, Thien Trong Phan, Nabila Boukelmoune, Cobi J. Heijnen, Robert Dantzer
Summary: Chronic restraint stress affects the behavior of mice, specifically their voluntary wheel running but not working for food. This indicates a dissociation between energy demanding and energy procuring activities, possibly due to adaptive response to mitochondrial dysfunction caused by chronic restraint stress.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Medicine, Research & Experimental
Ling Zhang, Wenyu Zou, Yongyan Hu, Honghua Wu, Ying Gao, Junqing Zhang, Jia Zheng
Summary: Maternal overnutrition increases offspring's susceptibility to metabolic diseases, while maternal exercise can improve glucose metabolism. However, the underlying mechanism of intergenerational effects of maternal exercise on glucose metabolism benefits is not fully understood.
Article
Cell Biology
Yukiko Kitase, Julian A. Vallejo, Sarah L. Dallas, Yixia Xie, Mark Dallas, LeAnn Tiede-Lewis, David Moore, Anthony Meljanac, Corrine Kumar, Carrie Zhao, Jennifer Rosser, Marco Brotto, Mark L. Johnson, Ziyue Liu, Michael J. Wacker, Lynda Bonewald
Summary: Exercise can delay aging and have beneficial effects on the musculoskeletal system. High body weight is more protective for muscle and bone health, while exercise can increase muscle size and function, and reduce muscle loss. The combination of exercise and high body weight has the best effect on muscle and bone health.
Article
Neurosciences
Margot Thiaucourt, Polina Shabes, Natalie Schloss, Markus Sack, Ulf Baumgaertner, Christian Schmahl, Gabriele Ende
Article
Clinical Neurology
Alexander Sartorius, Traute Demirakca, Andreas Boehringer, Christian Clemm von Hohenberg, Suna Su Aksay, Jan Malte Bumb, Laura Kranaster, Thomas Nickl-Jockschat, Michael Groezinger, Philipp A. Thomann, Robert Christian Wolf, Peter Zwanzger, Udo Dannlowski, Ronny Redlich, Maxim Zavorotnyy, Rebecca Zoellner, Isabel Methfessel, Matthias Besse, David Zilles, Gabriele Ende
Article
Neurosciences
Mark Mikkelsen, Daniel L. Rimbault, Peter B. Barker, Pallab K. Bhattacharyya, Maiken K. Brix, Pieter F. Buur, Kim M. Cecil, Kimberly L. Chan, David Y-T Chen, Alexander R. Craven, Koen Cuypers, Michael Dacko, Niall W. Duncan, Ulrike Dydak, David A. Edmondson, Gabriele Ende, Lars Ersland, Megan A. Forbes, Fei Gao, Ian Greenhouse, Ashley D. Harris, Naying He, Stefanie Heba, Nigel Hoggard, Tun-Wei Hsu, Jacobus F. A. Jansen, Alayar Kangarlu, Thomas Lange, R. Marc Lebel, Yan Li, Chien-Yuan E. Lin, Jy-Kang Liou, Jiing-Feng Lirng, Feng Liu, Joanna R. Long, Ruoyun Ma, Celine Maes, Marta Moreno-Ortega, Scott O. Murray, Sean Noah, Ralph Noeske, Michael D. Noseworthy, Georg Oeltzschner, Eric C. Porges, James J. Prisciandaro, Nicolaas A. J. Puts, Timothy P. L. Roberts, Markus Sack, Napapon Sailasuta, Muhammad G. Saleh, Michael-Paul Schallmo, Nicholas Simard, Diederick Stoffers, Stephan P. Swinnen, Martin Tegenthoff, Peter Truong, Guangbin Wang, Iain D. Wilkinsons, Hans-Joerg Wittsack, Adam J. Woods, Hongmin Xu, Fuhua Yan, Chencheng Zhang, Vadim Zipunnikov, Helge J. Zoellner, Richard A. E. Edden
Review
Psychiatry
L. Kuhlwilm, C. Schoenfeldt-Lecuona, M. Gahr, B. J. Connemann, F. Keller, A. Sartorius
ACTA PSYCHIATRICA SCANDINAVICA
(2020)
Article
Clinical Neurology
Alexander Sartorius, Juliane Beuschlein, Dmitry Remennik, Anna-Maria Pfeifer, Sebastian Karl, Jan Malte Bumb, Suna Su Aksay, Laura Kranaster, Christoph Janke
Summary: Ketofol may be a beneficial option for improved anaesthesia in ECT, offering advantages with reduced doses. Higher propofol doses are associated with poorer seizure quality, while recovery time is primarily influenced by age rather than ketamine dosage.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Letter
Behavioral Sciences
Alexander Sartorius, Charles H. Kellner, Sebastian Karl
Letter
Biochemistry & Molecular Biology
Alexander Sartorius
MOLECULAR PSYCHIATRY
(2022)
Letter
Biochemistry & Molecular Biology
David Zilles-Wegner, Charles H. Kellner, Alexander Sartorius
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Laurens Winkelmeier, Carla Filosa, Renee Hartig, Max Scheller, Markus Sack, Jonathan R. Reinwald, Robert Becker, David Wolf, Martin Fungisai Gerchen, Alexander Sartorius, Andreas Meyer-Lindenberg, Wolfgang Weber-Fahr, Christian Clemm von Hohenberg, Eleonora Russo, Wolfgang Kelsch
Summary: The authors used a hierarchical approach to investigate brain mechanisms for history informed updating of future predictions. Through behavioral modeling, systems fMRI, and cellular coding, they identified the circuits responsible for cognition and revealed the contributions of different brain areas in olfactory reinforcement learning. The findings validate the use of a cross-scale approach in understanding higher cognitive functions in rodents.
NATURE COMMUNICATIONS
(2022)
Letter
Biochemistry & Molecular Biology
Alexander Sartorius, Sebastian Karl, David Zilles-Wegner
MOLECULAR PSYCHIATRY
(2022)
Article
Behavioral Sciences
Jana Plemper, Alexander Sartorius, Sebastian Karl
Summary: This study retrospectively analyzed dose adjustments in 472 patients undergoing ECT and found that dose increased over the course of ECT treatment, especially in geriatric patients. The results indicate that attention should be paid to decreasing seizure quality and adjusting dose accordingly, particularly in older patients, to ensure high efficacy throughout the course of treatment.
Article
Neurosciences
Karen M. Ryan, Paul Smyth, Gordon Blackshields, Laura Kranaster, Alexander Sartorius, Orla Sheils, Declan M. McLoughlin
Summary: MiRNA expression changes in the hippocampus were examined using next-generation sequencing technology during electroconvulsive stimulation in rats. Six miRNAs were found to be significantly differentially expressed, and some of these miRNAs were also altered in patients with depression receiving medication treatment. These findings may provide insights into the mechanism of action of electroconvulsive therapy and the neurobiology of depression.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Miklos Argyelan, Zhi-De Deng, Olga Therese Ousdal, Leif Oltedal, Brian Angulo, Mate Baradits, Andrew J. Spitzberg, Ute Kessler, Alexander Sartorius, Annemiek Dols, Katherine L. Narr, Randall Espinoza, Jeroen A. van Waarde, Indira Tendolkar, Philip van Eijndhoven, Guido A. van Wingen, Akihiro Takamiya, Taishiro Kishimoto, Martin B. Jorgensen, Anders Jorgensen, Olaf B. Paulson, Antoine Yrondi, Patrice Peran, Carles Soriano-Mas, Narcis Cardoner, Marta Cano, Linda van Diermen, Didier Schrijvers, Jean-Baptiste Belge, Louise Emsell, Filip Bouckaert, Mathieu Vandenbulcke, Maximilian Kiebs, Rene Hurlemann, Peter C. R. Mulders, Ronny Redlich, Udo Dannlowski, Kavakbasi Erhan, Michael D. Kritzer, Kristen K. Ellard, Joan A. Camprodon, Georgios Petrides, Anil K. Malhotra, Christopher C. Abbott
Summary: Neurostimulation is a common treatment option for major depression, and this study found that electroconvulsive therapy has similar neuronal underpinnings to a causal depression network. The expression of this pattern was correlated with clinical outcomes, suggesting that optimizing modulation of this network could improve the effectiveness of neurostimulation in depression.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Annegret Krause-Utz, Ezgi Erol, Athina Brousianou, Sylvia Cackowski, Christian Paret, Gabriele Ende, Bernet Elzinga
BORDERLINE PERSONALITY DISORDER AND EMOTION DYSREGULATION
(2019)
Meeting Abstract
Psychology, Biological
Jenny Zaehringer, Christine Jennen-Steinmetz, Christian Schmahl, Gabriele Ende, Christian Paret
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.