Article
Behavioral Sciences
Yu-Ruei Lin, Chia-Hsing Chi, Yu -Ling Chang
Summary: Amnestic mild cognitive impairment (aMCI) is a risk factor for dementia due to Alzheimer's disease. Patients with aMCI perform poorly on both detail and gist memory tests compared to cognitively normal older adults, and this performance gap persists over time. Additionally, multisensory encoding improves memory performance in patients with aMCI. Overall, the findings suggest that detail and gist memory decay differently, with a longer lasting group gap in gist memory. Multisensory encoding effectively reduces or overcomes the gaps between time intervals and within groups, especially for gist memory.
Article
Neurosciences
Isabella Hoi Kei Leung, Kathryn Mary Broadhouse, Loren Mowszowski, Haley M. LaMonica, Jake Robert Palmer, Ian B. Hickie, Sharon L. Naismith, Shantel Leigh Duffy
Summary: This study revealed that older adults with non-amnestic MCI and a history of depression showed larger or relatively preserved right CA1 volumes, which were associated with better verbal encoding and memory retention. Participants taking antidepressants had significantly larger hippocampal subiculum and right hippocampal body volumes, as well as better performance on memory tasks. These findings emphasize the impact of depression history and antidepressant use on hippocampal structure and memory function in non-amnestic MCI.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Immunology
Erin E. Sundermann, Mark W. Bondi, Laura M. Campbell, Ben Gouaux, Raeanne C. Moore, Virawudh Soontornniyomkij, David J. Moore
Summary: This study aimed to distinguish aMCI from HAND in PWH using a neuropsychological method, finding a higher prevalence of high aMCI risk in the HAND group, with beta-amyloid pathology being associated with high aMCI risk, while phospho-Tau pathology did not differ by aMCI classification.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Neurosciences
Maryam Noroozian, Reza Kormi-Nouri, Lars Nyberg, Jonas Persson
Summary: This study investigated the impact of motor involvement ability on brain structure during memory encoding. Results showed that individuals with low or declining ability to benefit from motor involvement during memory encoding had smaller gray matter volume in regions critical for memory and motor functions, as well as altered white matter integrity. Furthermore, the type of dopamine-regulating genes was also associated with motor involvement ability.
Article
Geriatrics & Gerontology
Benoit Jobin, Benjamin Boller, Johannes Frasnelli
Summary: One major challenge in diagnosing AD is to improve the specificity of early diagnosis. This study found that individuals with cognitive decline exhibited cerebral atrophy in central olfactory processing areas, especially in olfactory, piriform cortex, amygdala, entorhinal cortex, and left hippocampus regions, compared to other groups. Furthermore, atrophy in the left hippocampus olfactory region was associated with episodic memory performance.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Geriatrics & Gerontology
Kevin T. Jones, Courtney L. Gallen, Avery E. Ostrand, Julio C. Rojas, Peter Wais, James Rini, Brandon Chan, Argentina Lario Lago, Adam Boxer, Min Zhao, Adam Gazzaley, Theodore P. Zanto
Summary: The study explores the feasibility and potential effects of noninvasive neurostimulation for amnestic mild cognitive impairment (aMCI), suggesting that gamma transcranial alternating current stimulation (tACS) may improve episodic memory in aMCI patients by modulating connectivity and excitability within an episodic memory network.
NEUROBIOLOGY OF AGING
(2023)
Review
Medicine, General & Internal
Giulia Marselli, Francesca Favieri, Maria Casagrande
Summary: Mild cognitive impairment (MCI) is a syndrome characterized by a decline in cognitive performance that exceeds what is expected for an individual based on their age and education level, but does not significantly interfere with daily activities. Previous studies have mainly focused on memory in the analysis of MCI and more severe cases of dementia. Autobiographical memory (AM), a specific memory system, has been extensively studied in Alzheimer's disease, but its impairment in MCI is still controversial.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Tamir Eisenstein, Galit Yogev-Seligmann, Elissa Ash, Nir Giladi, Haggai Sharon, Irit Shapira-Lichter, Shikma Nachman, Talma Hendler, Yulia Lerner
Summary: This study suggests that maximal aerobic capacity (MAC) may be associated with hippocampal-related cognitive reserve in aMCI patients by altering the relationship between hippocampal-related structural deterioration and cognitive function. Additionally, MAC is found to be associated with increased capacity to recruit neural resources during increased cognitive demands.
Article
Geriatrics & Gerontology
Nena Lejko, Shankar Tumati, Esther M. Opmeer, Jan-Bernard C. Marsman, Fransje E. Reesink, Peter P. De Deyn, Andre Aleman, Branislava Curcic-Blake
Summary: The impaired planning ability in individuals with amnestic mild cognitive impairment (aMCI) is associated with lower activation in a diffuse cortico-thalamic network. Higher planning-related activity is related to better memory performance.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Neuroimaging
Peyton L. Delgorio, Lucy V. Hiscox, Grace McIlvain, Mary K. Kramer, Alexa M. Diano, Kyra E. Twohy, Alexis A. Merritt, Matthew D. J. McGarry, Hillary Schwarb, Ana M. Daugherty, James M. Ellison, Alyssa M. Lanzi, Matthew L. Cohen, Christopher R. Martens, Curtis L. Johnson
Summary: Hippocampal subfields (HCsf) are brain regions important for memory function and are vulnerable in amnestic mild cognitive impairment (aMCI), a preclinical stage of Alzheimer's disease. Magnetic resonance elastography (MRE) can detect viscoelastic mechanical properties of HCsf tissue, showing that aMCI affects the tissue integrity in CA1-CA2 and DG-CA3 subfields. Including HCsf stiffness in a logistic regression improves classification of aMCI beyond volume measures alone. Lower DG-CA3 stiffness predicts aMCI status regardless of volume, highlighting the benefit of using MRE to detect subtle pathological changes in aMCI.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Anni Richter, Joram Soch, Jasmin M. Kizilirmak, Larissa Fischer, Hartmut Schutze, Anne Assmann, Gusalija Behnisch, Hannah Feldhoff, Lea Knopf, Matthias Raschick, Annika Schult, Constanze I. Seidenbecher, Renat Yakupov, Emrah Duezel, Bjorn H. Schott
Summary: In this study, we investigated the associations between two single-value scores and brain function and cognitive changes in middle-aged and older adults. The results showed that these scores were related to memory recall performance and one of the scores also correlated with brain gray matter and other neuropsychological measures. This suggests that single-value scores of memory-related fMRI provide valuable information about network dysfunction in individuals and age-related cognitive decline.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Joram Soch, Anni Richter, Hartmut Schuetze, Jasmin M. Kizilirmak, Anne Assmann, Gusalija Behnisch, Hannah Feldhoff, Larissa Fischer, Julius Heil, Lea Knopf, Christian Merkel, Matthias Raschick, Clara-Johanna Schietke, Annika Schult, Constanze Seidenbecher, Renat Yakupov, Gabriel Ziegler, Jens Wiltfang, Emrah Duezel, Bjoern H. Schott
Summary: As older adults, especially those at risk for dementia, show declines in memory performance, fMRI can be used to detect alterations in memory network activity. The FADE and FADE-SAME scores are developed as potential biomarkers for successful aging and are correlated with behavioral measures of cognitive aging.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Yaonan Zheng, Tao Li, Teng Xie, Ying Zhang, Ying Liu, Xiangzhu Zeng, Zhijiang Wang, Luchun Wang, Huizi Li, Yuhan Xie, Xiaozhen Lv, Jing Wang, Xin Yu, Huali Wang
Summary: This study reveals that memory binding deficit in aMCI patients is primarily manifested in the encoding phase, which is associated with volumetric losses in the left inferior temporal gyrus.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Yi Zhu, Yaxin Gao, Chuan Guo, Ming Qi, Ming Xiao, Han Wu, Jinhui Ma, Qian Zhong, Hongyuan Ding, Qiumin Zhou, Nawab Ali, Li Zhou, Qin Zhang, Ting Wu, Wei Wang, Cuiyun Sun, Lehana Thabane, Ling Zhang, Tong Wang
Summary: This study demonstrates that aerobic dance can increase the right and total hippocampal volumes and improve episodic memory in elderly individuals with amnestic mild cognitive impairment (aMCI).
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Xiaomei Zhong, Ben Chen, Le Hou, Qiang Wang, Meiling Liu, Mingfeng Yang, Min Zhang, Huarong Zhou, Zhangying Wu, Si Zhang, Gaohong Lin, Yuping Ning
Summary: This study aimed to compare temporal variability in the spontaneous fluctuations of activity and connectivity between amnestic MCI (aMCI) and nonamnestic MCI (naMCI). The results showed that both aMCI and naMCI patients exhibited abnormal brain activity and connectivity. The variability in dALFF, dReHo, and hippocampal dFC was different between aMCI and naMCI patients and was associated with cognitive scores. The dReHo of the superior parietal lobule and dFC of the hippocampus-cerebellum contributed to the memory heterogeneity of MCI subtypes.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Olin Janssen, Willemijn J. Jansen, Stephanie J. B. Vos, Merce Boada, Lucilla Parnetti, Tomasz Gabryelewicz, Tormod Fladby, Jose Luis Molinuevo, Sylvia Villeneuve, Jakub Hort, Stephane Epelbaum, Alberto Lleo, Sebastiaan Engelborghs, Wiesje M. van der Flier, Susan Landau, Julius Popp, Anders Wallin, Philip Scheltens, Marcel Olde Rikkert, Peter J. Snyder, Chris Rowe, Gael Chetelat, Agustin Ruiz, Marta Marquie, Elena Chipi, Steffen Wolfsgruber, Michael Heneka, Henning Boecker, Oliver Peters, Jonas Jarholm, Lorena Rami, Adria Tort-Merino, Alexa Pichet Binette, Judes Poirier, Pedro Rosa-Neto, Jiri Cerman, Bruno Dubois, Marc Teichmann, Daniel Alcolea, Juan Fortea, M. Belen Sanchez-Saudinos, Jarith Ebenau, Cornelia Pocnet, Marie Eckerstrom, Louisa Thompson, Victor Villemagne, Rachel Buckley, Samantha Burnham, Marion Delarue, Yvonne Freund-Levi, Asa K. Wallin, Inez Ramakers, Magda Tsolaki, Hilkka Soininen, Harald Hampel, Luiza Spiru, Betty Tijms, Rik Ossenkoppele, Frans R. J. Verhey, Frank Jessen, Pieter Jelle Visser
Summary: In addition to age, setting, and APOE ε4 carriership, specific characteristics of subjective cognitive decline may aid in identifying individuals with amyloid positivity.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Ines Moulinet, Brigitte Landeau, Edelweiss Touron, Vincent De La Sayette, Beatrice Desgranges, Denis Vivien, Natalie Marchant, Geraldine Poisnel, Gael Chetelat
Summary: The study found that depressive symptoms decrease with age, while anxiety symptoms only increase in women. Higher anxiety symptoms are associated with lower gray matter volume and glucose metabolism, with an interaction of sex in this relationship, which is significant only in women. Longitudinally, only low baseline gray matter volume predicts an increase in anxiety symptoms over time.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Jean-Claude Baron, Ulf Jensen-Kondering, Simona Sacco, Sacha Posener, Joseph Benzakoun, Johan Pallud, Catherine Oppenheim, Pascale Varlet, Guillaume Turc
Summary: Lobar hematomas are common and have high mortality and morbidity. Distinguishing between hypertensive arteriolopathy (HA) and cerebral amyloid angiopathy (CAA) is important. Current diagnostic criteria for probable CAA have limitations, and new imaging biomarkers are proposed to improve diagnosis. Testing clinical-radiological biomarkers for positive diagnosis of HA in lobar hematomas is also suggested.
JOURNAL OF NEUROLOGY
(2023)
Correction
Clinical Neurology
Jean-Claude Baron, Ulf Jensen-Kondering, Simona Sacco, Sacha Posener, Joseph Benzakoun, Johan Pallud, Catherine Oppenheim, Pascale Varlet, Guillaume Turc
JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Jean-Claude Baron
Article
Psychology, Clinical
Florence Requier, Anne Sophia Hendy, Marco Schlosser, Harriet Demnitz-King, Tim Whitfield, Gael Chetelat, Olga Klimecki, Antoine Lutz, Natalie L. Marchant, Fabienne Collette
Summary: This study aimed to assess the association between dispositional mindfulness (or more generally trait meditation capacities) and cognition in older adults. The results showed a positive relationship between the "deconstructive capacity" associated with self-inquiry and downregulation of maladaptive affective schemes, and global cognition in healthy aging. However, it remains unclear to what extent explicit training in meditation positively influences these capacities and whether these changes contribute to better cognition in aging.
Article
Clinical Neurology
Antoine Garnier-Crussard, Francois Cotton, Pierre Krolak-Salmon, Gael Chetelat
Summary: White matter hyperintensities (WMH) are vascular lesions frequently seen in older adults, but recent evidence suggests that non-vascular mechanisms, particularly in Alzheimer's disease (AD), may also contribute to WMH. This alternative hypothesis is supported by arguments from neuropathology, neuroimaging, fluid biomarkers, and genetics. The underlying mechanisms of AD-related WMH, such as neurodegeneration or neuroinflammation, are discussed, as well as the implications for AD diagnosis and management. Testing this hypothesis and addressing remaining challenges can improve personalized care for patients.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Diana I. Bocancea, Anna L. Svenningsson, Anna C. van Loenhoud, Colin Groot, Frederik Barkhof, Olof Strandberg, Ruben Smith, Renaud La Joie, Howard J. Rosen, Michael J. Pontecorvo, Gil D. Rabinovici, Wiesje M. van der Flier, Oskar Hansson, Rik Ossenkoppele
Summary: The mechanisms of resilience against tau pathology in Alzheimer's disease spectrum are not well understood. This longitudinal study investigates the factors that contribute to cognitive and brain resilience against tau pathology and finds that education is the most important determinant of resilience. However, resilience may be depleted in advanced stages of the disease.
Article
Clinical Neurology
Elizabeth Kuhn, Audrey Perrotin, Renaud La Joie, Edelweiss Touron, Sophie Dautricourt, Matthieu Vanhoutte, Denis Vivien, Vincent de La Sayette, Gael Chetelat
Summary: This study aimed to assess the association between informant-reported subjective memory decline and Alzheimer disease biomarkers. The results showed a strong correlation between the informant report and higher amyloid deposition as well as lower cognitive performance in patients with mild cognitive impairment.
Review
Clinical Neurology
Sacha Posener, Ghazi Hmeydia, Joseph Benzakoun, Catherine Oppenheim, Jean-Claude Baron, Guillaume Turc
Summary: This systematic review and meta-analysis examined the prevalence, associated factors, and presumed causes of remote diffusion-weighted imaging lesions (RDWILs) in patients with spontaneous intracerebral hemorrhage (ICH). The results showed that RDWILs were detected in approximately 25% of acute ICH patients and were associated with neuroimaging features of microangiopathy, atrial fibrillation, clinical severity, elevated blood pressure, ICH volume, and the presence of subarachnoid or intraventricular hemorrhage. RDWILs were also associated with poor functional outcome at 3 months. Further studies are needed to investigate the impact of specific ICH treatment strategies on reducing RDWILs and improving outcomes.
Letter
Clinical Neurology
Antoine Garnier-Crussard, Gael Chetelat
ALZHEIMERS & DEMENTIA
(2023)
Review
Endocrinology & Metabolism
Adrien ter Schiphorst, Guillaume Turc, Wagih Ben Hassen, Catherine Oppenheim, Jean-Claude Baron
Summary: The reported incidence of impaired microvascular reperfusion (IMR) after complete recanalization varies widely, possibly due to differences in definitions, operational definitions, and consideration of alternative causes. Based on a systematic review, IMR after true complete recanalization appears relatively rare, and reported incidence depends on the definitions used and consideration of confounding factors.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Cell Biology
Sebastian Baez-Lugo, Yacila Deza-Araujo, Christel Maradan, Fabienne Collette, Antoine Lutz, Natalie L. Marchant, Gael Chetelat, Patrik Vuilleumier, Olga Klimecki
Summary: Basic emotional functions appear intact in older adults, but their response to and recovery from negative social events are not well understood. The researchers used a 'task-rest' paradigm and functional MRI to investigate the neural dynamics of empathy-related functions in older adults. They found that emotional elicitation during the task enhanced resting-state connectivity between the default mode network and amygdala in older adults, and this connectivity was associated with higher anxiety, rumination, and negative thoughts.
Article
Cell Biology
Valentin Ourry, Stephane Rehel, Claire Andre, Alison Mary, Leo Paly, Marion Delarue, Florence Requier, Anne Hendy, Fabienne Collette, Natalie L. Marchant, Francesca Felisatti, Cassandre Palix, Denis Vivien, Vincent de la Sayette, Gael Chetelat, Julie Gonneaud, Geraldine Rauchs
Summary: Sleep, especially slow wave sleep, plays a crucial role in cognitive functioning, but it is reduced in older adults. Cognitive reserve (CR) may modulate the impact of sleep on cognition. This study found that individuals with higher CR were able to maintain cognitive performance despite lower amounts of slow wave sleep, suggesting that CR may protect against age-related sleep changes on cognition.