Article
Clinical Neurology
Yuanshu Chen, Congcong Liu, Fei Xin, Haochen Zou, Yulan Huang, Jinyu Wang, Jing Dai, Zhili Zou, Stefania Ferraro, Keith M. Kendrick, Bo Zhou, Xiaolei Xu, Benjamin Becker
Summary: Major depression (MDD) and generalized anxiety disorder (GAD) are leading causes of disability globally, with marked interpersonal and social impairments. This study used fMRI to investigate whether MDD and GAD share a neural basis during interpersonal processing. Results suggest that the dlPFC is involved in emotion-specific alteration during interpersonal processing, with depression symptom load positively associated with dlPFC reactivity to sad facial expressions. Dysregulated communication between the amygdala and salience network may be specific to depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Harm J. van Der Horn, Andrew B. Dodd, Tracey V. Wick, Cidney R. Robertson-Benta, Jessica R. Mcquaid, Anne K. Hittson, Josef M. Ling, Vadim Zotev, Sephira G. Ryman, Erik B. Erhardt, John P. Phillips, Richard A. Campbell, Robert E. Sapien, Andrew R. Mayer
Summary: There is an increasing amount of research suggesting that pediatric mild traumatic brain injury (pmTBI) may lead to cerebral pathophysiological processes that extend beyond the usual clinical recovery timeline. This study used fMRI to examine neural processes related to cognitive control in 181 pmTBI patients at sub-acute and early chronic stages post-injury. The results showed alterations in neural functioning during cognitive control up to 4 months post-injury, regardless of clinical recovery.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Yimeng Zeng, Fuxiang Tao, Zaixu Cui, Liyun Wu, Jiahua Xu, Wenshan Dong, Chao Liu, Zhi Yang, Shaozheng Qin
Summary: The study identified two distinct dynamic states of intrinsic connectivity patterns based on BLA and CMA using fMRI and K-means clustering in two groups of young healthy individuals. Higher skin conductance level was found in the integration state compared to the segregation state in another dataset. Additionally, machine learning analysis revealed that the time-varying BLA and CMA intrinsic connectivity patterns had higher predictive values for fluctuations in skin conductance level in the integration state.
Article
Neurosciences
Kun Il Kim, Wi Hoon Jung, Choong-Wan Woo, Hackjin Kim
Summary: This study investigates the individual variability in context-dependent facial expression estimation and its neural circuitry, providing novel insights into the predictive accounts of affective states.
Article
Psychology, Multidisciplinary
Katja Koelkebeck, Jochen Bauer, Thomas Suslow, Patricia Ohrmann
Summary: This case report describes a male patient with right amygdala damage and an ASD. He displayed a non-response of the amygdala to fearful faces and tended to misinterpret fearful expressions. Moreover, a non-reactivity of both amygdalae to emotional facial expressions at an implicit processing level was revealed.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Immunology
Johnna R. Swartz, Angelica F. Carranza, Annchen R. Knodt, Michael R. Irwin, Camelia E. Hostinar
Summary: This study examined the association between peripheral inflammation and amygdala activity and connectivity in adolescents. The results showed that peripheral inflammation was associated with increased amygdala activity to emotional face stimuli and reduced connectivity with occipital and parietal regions. These findings enhance our understanding of the relationship between peripheral inflammation and neural response to emotional faces in adolescents.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Neurosciences
Florence Steiner, Natalia Fernandez, Joris Dietziker, Philipp Stampfli, Erich Seifritz, Anton Rey, Sascha Fruhholz
Summary: Affective speech communication involves decoding of affect information in the cortico-limbic brain systems. Previous research neglected the social nature of affective communication and underestimated its real-time adaptive dynamics. Using real-time neuroimaging, we found that live adaptive affective speech is acoustically distinct, adaptive, and individualized, and makes more efficient use of neural affect decoding mechanisms.
PROGRESS IN NEUROBIOLOGY
(2022)
Review
Neurosciences
Ekaterina Lunkova, Guido Guberman, Alain Ptito, Rajeet Singh Saluja
Summary: This review discusses various imaging methods for concussion, including fMRI, SWI, dMRI, and ASL, highlighting their benefits and drawbacks. A multimodal approach is recommended for a comprehensive understanding of mild traumatic brain injury mechanisms.
HUMAN BRAIN MAPPING
(2021)
Article
Neuroimaging
Moon-Soo Lee, Purnima Anumagalla, Mani N. Pavuluri
Summary: This meta-analysis aimed to understand the brain dysfunction related to emotion and cognition in individuals with PTSD, revealing that individuals with PTSD exhibit overactivation in subcortical regions like the amygdala and striatum when processing emotions. Additionally, underactivation in the anterior cingulate cortex was especially prominent in individuals with PTSD following exposure to emotional stimuli.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neurosciences
Lea Marie Reisch, Martin Wegrzyn, Malena Mielke, Alexandra Mehlmann, Friedrich G. Woermann, Johanna Kissler, Christian G. Bien
Summary: The study suggests that negative stimuli can lead to increased activation in the visual cortex, possibly due to modulating feedback from the amygdala. There are differential effects of left and right amygdala lesions on the visual cortex, with the right amygdala influencing visual processing more broadly and the left amygdala specifically contributing to emotion processing.
HUMAN BRAIN MAPPING
(2022)
Article
Psychology, Biological
Nicola Sambuco
Summary: Recent findings questioned the replicability of fMRI in affective processing studies, suggesting that poor replicability may be due to a lack of emotional engagement. The current study tested the replicability of emotional enhancement using a large sample size, showing that replicability increased with increasing sample size. Importantly, even with relatively small samples, fMRI replicability during emotional compared to neutral scene viewing was good to excellent, indicating the importance of successful emotional engagement in task-related brain regions.
Article
Behavioral Sciences
Naomi B. Fine, Naama Schwartz, Talma Hendler, Tal Gonen, Gal Sheppes
Summary: This study aimed to investigate the association between emotion regulation ability and preference. By conducting neuroimaging tasks and behavioral selection tasks, the researchers found that a decrease in amygdala activity during implementation was associated with a higher preference for using the distraction strategy.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychology, Developmental
Arianna M. Gard, Andrea M. Maxwell, Daniel S. Shaw, Colter Mitchell, Jeanne Brooks-Gunn, Sara S. McLanahan, Erika E. Forbes, Christopher S. Monk, Luke W. Hyde
Summary: Studies suggest that early childhood neighborhood socioeconomic disadvantage has specific and independent effects on amygdala reactivity. These effects remain even when accounting for family-level adversities, highlighting the importance of neighborhood economic resources in brain development.
DEVELOPMENTAL SCIENCE
(2021)
Article
Psychology, Developmental
Jennifer A. Silvers, Bridget L. Callaghan, Michelle VanTieghem, Tricia Choy, Kaitlin O'Sullivan, Nim Tottenham
Summary: Research indicates that adolescents tend to learn fears preferentially through observing their parents, and this learning is associated with emotional traits and neural activity in parents.
DEVELOPMENTAL SCIENCE
(2021)
Article
Medicine, General & Internal
Lara Pankatz, Philine Rojczyk, Johanna Seitz-Holland, Sylvain Bouix, Leonard B. Jung, Tim L. T. Wiegand, Elena M. Bonke, Nico Sollmann, Elisabeth Kaufmann, Holly Carrington, Twishi Puri, Yogesh Rathi, Michael J. Coleman, Ofer Pasternak, Mark S. George, Thomas W. Mcallister, Ross Zafonte, Murray B. Stein, Christine E. Marx, Martha E. Shenton, Inga K. Koerte
Summary: This study analyzed diffusion and structural MRI data of 278 participants with and without military background, and found microstructural alterations at the gray matter/white matter boundary of the brain after mild traumatic brain injury (mTBI) that were associated with post-concussive symptom severity, functional, and cognitive impairment. These findings suggest that microstructural changes at the gray matter/white matter boundary may be sensitive markers of adverse long-term outcomes following mTBI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychology, Clinical
Daniel M. Stout, Katia M. Harle, Sonya B. Norman, Alan N. Simmons, Andrea D. Spadoni
Summary: Data-driven subtyping of comorbid PTSD/AUD patients identified a subgroup associated with improvement in PTSD symptoms, characterized by specific connectivity patterns. These findings provide insights into the neural mechanisms underlying the efficacy of individual psychotherapy.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Anesthesiology
Tiffany Toor, Emily Murphy, Alan N. Simmons, Sarah Palyo, Sara C. Librodo, Irina A. Strigo
Summary: The United States is facing a crisis due to high rates of chronic pain, opioid use disorder, and overdose deaths. While craving is a core symptom of addiction, its role in prescription opioid use among patients with chronic pain is not well understood. Understanding the degree to which craving should be considered in patients with chronic pain is critical for developing effective interventions to support patients in reducing their opioid use.
Article
Neuroimaging
Alison Myoraku, Adam Lang, Charles T. Taylor, R. Scott Mackin, Dieter J. Meyerhoff, Susanne Mueller, Irina A. Strigo, Duygu Tosun
Summary: The study found that differences in brain morphology between MDD patients and healthy controls are dependent on age and brain region, with significant age-by-group interactions in the lateral orbital frontal gyrus and insular subregions, making these regions potential targets for future longitudinal studies of MDD.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Daniel M. Stout, Alan N. Simmons, Caroline M. Nievergelt, Nilima Biswas, Adam X. Maihofer, Victoria B. Risbrough, Dewleen G. Baker
Summary: Identification of biomarkers for psychiatric disorders is challenging. Using multi-set canonical correlation analysis, this study found distinct physiological and biological phenotypes associated with different symptom clusters. The findings support the potential of mCCA to reveal important psychiatric symptom biomarkers.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Imanuel Lerman, Ruth Klaming, Andrea Spadoni, Dewleen G. Baker, Alan N. Simmons
Summary: The study found that transcutaneous cervical nVNS has valence-specific effects on reaction time and response patterns in healthy individuals during fMRI anticipation tasks, enhancing responsiveness to negatively valenced images and diminishing responsiveness to positively valenced images.
Article
Neurosciences
Sara H. Timtim, Alan N. Simmons, Chelsea Hays, Irina Strigo, Scott Sorg, Ronald Ellis, John R. Keltner
Summary: In this study, the authors examined white matter microstructure in HIV patients with distal sensory polyneuropathy (HIV-DSP). They found that severity of neuropathy was associated with decreased white matter integrity along certain pathways, suggesting cortical white matter degeneration and cingulum degeneration.
JOURNAL OF NEUROVIROLOGY
(2022)
Correction
Neurosciences
Daniel M. Stout, Alan. N. Simmons, Caroline M. Nievergelt, Arpi Minassian, Nilima Biswas, Adam X. Maihofer, Victoria B. Risbrough, Dewleen G. Baker
NEUROPSYCHOPHARMACOLOGY
(2022)
Editorial Material
Neurosciences
Alan N. Simmons, Irina A. Strigo
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Nynke A. Groenewold, Janna Marie Bas-Hoogendam, Alyssa R. Amod, Max A. Laansma, Laura S. Van Velzen, Moji Aghajani, Kevin Hilbert, Hyuntaek Oh, Ramiro Salas, Andrea P. Jackowski, Pedro M. Pan, Giovanni A. Salum, James R. Blair, Karina S. Blair, Joy Hirsch, Spiro P. Pantazatos, Franklin R. Schneier, Ardesheer Talati, Karin Roelofs, Inge Volman, Laura Blanco-Hinojo, Narcis Cardoner, Jesus Pujol, Katja Beesdo-Baum, Christopher R. K. Ching, Sophia Thomopoulos, Andreas Jansen, Tilo Kircher, Axel Krug, Igor Nenadic, Frederike Stein, Udo Dannlowski, Dominik Grotegerd, Hannah Lemke, Susanne Meinert, Alexandra Winter, Michael Erb, Benjamin Kreifelts, Qiyong Gong, Su Lui, Fei Zhu, Benson Mwangi, Jair C. Soares, Mon-Ju Wu, Ali Bayram, Mesut Canli, Rasit Tukel, P. Michiel Westenberg, Alexandre Heeren, Henk R. Cremers, David Hofmann, Thomas Straube, Alexander G. G. Doruyter, Christine Lochner, Jutta Peterburs, Marie-Jose Van Tol, Raquel E. Gur, Antonia N. Kaczkurkin, Bart Larsen, Theodore D. Satterthwaite, Courtney A. Filippi, Andrea L. Gold, Anita Harrewijn, Andre Zugman, Robin Buelow, Hans J. Grabe, Henry Voelzke, Katharina Wittfeld, Joscha Boehnlein, Katharina Dohm, Harald Kugel, Elisabeth Schrammen, Peter Zwanzger, Elisabeth J. Leehr, Lisa Sindermann, Tali M. Ball, Gregory A. Fonzo, Martin P. Paulus, Alan Simmons, Murray B. Stein, Heide Klumpp, K. Luan Phan, Tomas Furmark, Kristoffer N. T. Mansson, Amirhossein Manzouri, Suzanne N. Avery, Jennifer Urbano Blackford, Jacqueline A. Clauss, Brandee Feola, Jennifer C. Harper, Chad M. Sylvester, Ulrike Lueken, Dick J. Veltman, Anderson M. Winkler, Neda Jahanshad, Daniel S. Pine, Paul M. Thompson, Dan J. Stein, Nic J. A. Van der Wee
Summary: Limited convergence exists in neuroimaging investigations of subcortical brain region volumes in social anxiety disorder (SAD). Variations in methodological approaches and sample selection based on age and clinical characteristics may contribute to inconsistent findings. A global mega-analysis initiated by the ENIGMA-Anxiety Working Group revealed subtle volumetric alterations in subcortical regions in SAD patients. Differences were found in putamen and pallidum volumes, with additional factors such as comorbid anxiety disorders and age of SAD onset influencing these volumetric differences.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Sergio Garcia Guerra, Andrea Spadoni, Jennifer Mitchell, Irina A. Strigo
Summary: This study investigates the interaction between opioidergic and dopaminergic processing in the human brain during pain-related experiences using radioligand studies. The results show that there is a functional overlap between opioid and dopamine activations in most regions, but also some unique activation areas.
Article
Psychology, Developmental
Katia M. Harle, Tiffany C. Ho, Colm G. Connolly, Alan Simmons, Tony T. Yang
Summary: Unforeseen obstacles disrupting reward seeking behavior can lead to negative affect in adolescents, potentially contributing to the development of depression. However, the neurocognitive mechanisms underlying this impact on reward processing in adolescent depression have not been characterized. This study uses neuroimaging and a novel paradigm to examine how incidental action obstruction affects reward-based decision making. Rating: 7 out of 10.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Biographical-Item
Neurosciences
Anders Blomqvist, Henry C. Evrard, Jonathan O. Dostrovsky, Irina A. Strigo, Wilfrid Jaenig
Summary: Bud Craig, an exceptional neuroscientist, made unique contributions to the fields of pain and interoception. His research challenged major dogmas and provided powerful explanations for central pain and subjective awareness of feelings, significantly impacting our understanding of consciousness.
NATURE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Irina A. Strigo, Andrea D. Spadoni, Alan N. Simmons
Summary: Our study identified three subgroups with different functional connectivity patterns, despite similar demographic and diagnostic characteristics. These findings suggest the existence of neurobiologically dissociable biotypes with different mechanisms for managing pain and trauma, which may have implications for tailored interventions targeting specific neurological systems.
FRONTIERS IN PAIN RESEARCH
(2022)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.
