Article
Biochemical Research Methods
David A. Feinberg, Alexander J. S. Beckett, An T. Vu, Jason Stockmann, Laurentius Huber, Samantha Ma, Sinyeob Ahn, Kawin Setsompop, Xiaozhi Cao, Suhyung Park, Chunlei Liu, Lawrence L. Wald, Jonathan R. Polimeni, Azma Mareyam, Bernhard Gruber, Ruediger Stirnberg, Congyu Liao, Essa Yacoub, Mathias Davids, Paul Bell, Elmar Rummert, Michael Koehler, Andreas Potthast, Ignacio Gonzalez-Insua, Stefan Stocker, Shajan Gunamony, Peter Dietz
Summary: To increase granularity in human neuroimaging science, a next-generation 7 Tesla magnetic resonance imaging scanner was designed and built. It implemented several hardware advancements to improve spatial resolution, image signal-to-noise ratio, and reduce acquisition time.
Article
Chemistry, Multidisciplinary
Tian He, Zhenfeng Pang, Yu Yin, Huadong Xue, Yichuan Pang, Haixin Song, Jianhua Li, Ruiliang Bai, An Qin, Xueqian Kong
Summary: Recent developments in MR instruments and techniques have made it possible to acquire anatomical and physiological information from compact, mineralized cortical bone tissues despite its poor H-1 signals. This study conducted the first MR research on cortical bones under an ultrahigh magnetic field of 14 T. The results show the multi-exponential decays of H-1 signals with three characteristic T-2 or T-2* values, and the spatial resolution achieved by ultrahigh-field MR imaging allows for the differentiation of soft and organic compartments in bone tissues.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jacco A. de Zwart, Peter van Gelderen, Jeff H. Duyn
Summary: The study investigated the practical resolution limits of perfusion-weighted fMRI in human visual stimulation experiments. Results showed that at high resolution, perfusion-weighted fMRI had lower sensitivity than BOLD, potentially compromising the detection of visual activation.
MAGNETIC RESONANCE IMAGING
(2021)
Article
Endocrinology & Metabolism
Wouter Schellekens, Alex A. Bhogal, Emiel C. A. Roefs, Mario G. Baez-Yanez, Jeroen C. W. Siero, Natalia Petridou
Summary: Ultra-high field functional magnetic resonance imaging (fMRI) provides high spatial resolution for measuring neuronal activity at the scale of cortical layers. The current study investigates the influence of different vascular compartments on laminar BOLD fMRI using hypercapnic and hyperoxic breathing conditions. The results show that all venous vascular and micro-vascular compartments have comparable maximum signal intensities, but the capacity for vessel dilation is larger for venous vascular compartments. This study suggests that differences in dilation properties between macro- and micro-vascular compartments may contribute to BOLD signal differences across cortical depth.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neurosciences
Thomas T. Liu, Bochao Li, Brice Fernandez, Suchandrima Banerjee
Summary: In multi-echo fMRI research, tSNR and dCNR are two important metrics for evaluating performance. The study identified three main patterns of weight dependence for these metrics, namely tSNR-robust regime, dCNR-robust regime, and within-type robust regime.
Review
Radiology, Nuclear Medicine & Medical Imaging
Tomohisa Okada, Koji Fujimoto, Yasutaka Fushimi, Thai Akasaka, Dinh H. D. Thuy, Atsushi Shima, Nobukatsu Sawamoto, Naoya Oishi, Zhilin Zhang, Takeshi Funaki, Yuji Nakamoto, Toshiya Murai, Susumu Miyamoto, Ryosuke Takahashi, Tadashi Isa
Summary: Neuroimaging using the 7-Tesla human magnetic resonance system has gained popularity for its high signal-to-noise and contrast-to-noise ratios, providing high-resolution acquisitions and better contrast for detecting brain disorders. It allows for the measurement of a greater number of neurochemicals and visualization of small structures that are difficult to observe at lower magnetic field strengths.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Clinical Neurology
Valeria Barletta, Elena Herranz, Constantina A. Treaba, Ambica Mehndiratta, Russell Ouellette, Gabriel Mangeat, Tobias Granberg, Jacob A. Sloane, Eric C. Klawiter, Julien Cohen-Adad, Caterina Mainero
Summary: Cortical demyelination in early stages of multiple sclerosis can be detected by a novel quantitative MRI technique known as CME mapping, which shows microstructural changes related to myelin content and is more sensitive than NODDI. These changes observed in the cortex are associated with cognitive performance.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Yuka Donoshita, Uk-Su Choi, Hiroshi Ban, Ikuhiro Kida
Summary: Olfaction could be an early marker of neurodegenerative diseases. This study used 7-Tesla fMRI to assess olfactory function in the human brain and found that the piriform cortex is mainly associated with subjective odor intensity, while the posterior orbitofrontal cortex is involved in discriminating the subjective hedonic tone of the odorant.
Article
Neurosciences
Adrian W. Gilmore, Anna M. Agron, Estefania Gonzalez-Araya, Stephen J. Gotts, Alex Martin
Summary: In recent years, there has been an increasing use of multi-echo fMRI designs in cognitive neuroscience. Acquiring multiple echoes provides various benefits such as increased contrast-to-noise ratio, reduced signal dropout and thermal noise, as well as the identification of nuisance signal components in BOLD data. However, the use of multi-echo acquisitions also comes with increased data processing complexity and potential trade-offs in temporal and spatial resolution. This study reexamines a multi-echo dataset and demonstrates the practical benefits of multi-echo denoising in a naturalistic memory paradigm, specifically in understanding hippocampal activity during autobiographical recall.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Sriranga Kashyap, Dimo Ivanov, Martin Havlicek, Laurentius Huber, Benedikt A. Poser, Kamil Uludag
Summary: Laminar fMRI at ultra-high magnetic field strength is typically carried out using the Blood Oxygenation Level-Dependent (BOLD) contrast, but the spatial specificity is limited due to signals from veins. Alternatively, regional changes in perfusion can be measured accurately using Arterial Spin Labelling (ASL) MRI. In this study, isotropic sub-millimetre spatial resolution functional perfusion images were obtained using Flow-sensitive Alternating Inversion Recovery (FAIR) ASL with a 3D-EPI readout at 7 T, showing consistent perfusion and BOLD profiles. The results suggest caution is needed when interpreting BOLD signal laminar profiles as direct representation of neuronal activity distribution in the cortex.
Article
Engineering, Biomedical
Assunta Ciarlo, Andrea G. Russo, Sara Ponticorvo, Francesco di Salle, Michael Luhrs, Rainer Goebel, Fabrizio Esposito
Summary: This study assessed the performance of semantic rt-fMRI-NF in multiple subjects and sessions, showing that subjects can successfully modulate and maintain a target mental state when guided by rt-RSA derived feedback.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Dilsa Cemre Akkoc Altinok, Ravichandran Rajkumar, Dominik Niessen, Hasan Sbaihat, Margo Kersey, N. Jon Shah, Tanja Veselinovic, Irene Neuner
Summary: Despite previous studies, there is still a lack of information on the common neurobiological basis of resilience and personality traits at the level of the large resting-state networks. Using ultra-high-field 7T-MRI, this study found that the salience network (SN) plays a significant role in both resilience and personality traits, while the default mode network (DMN) is closely associated with resilience. Additionally, the degree centrality (DC) in the central executive network (CEN) emerged as a significant moderator for the correlations between resilience and neuroticism and extraversion traits.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Fuyixue Wang, Zijing Dong, Lawrence L. Wald, Jonathan R. Polimeni, Kawin Setsompop
Summary: The study extended a distortion/blurring-free multi-shot EPI technique to cortical-depth dependent SE-fMRI to improve neuronal specificity while limiting T-2' contamination, demonstrating the robustness of the proposed technique for high specificity SE-BOLD fMRI.
Article
Neurosciences
Huan Wang, Xiaoxiao Wang, Yanming Wang, Du Zhang, Yan Yang, Yifeng Zhou, Benshen Qiu, Peng Zhang
Summary: There is increasing evidence that functional magnetic resonance imaging (fMRI) can detect blood-oxygen-level-dependent (BOLD) activity in the white matter (WM). However, the functional relevance and significance of WM BOLD signals are still controversial. In this study, 7T BOLD fMRI was used to investigate the fine-scale functional organizations of visual WM bundles, revealing clear contralateral retinotopic organizations and over-representations of the central visual field.
Review
Radiology, Nuclear Medicine & Medical Imaging
Tanja Platt, Mark E. Ladd, Daniel Paech
Summary: Ultrahigh magnetic fields, referred to as UHFs with B-0 >= 7T, offer higher signal-to-noise and contrast-to-noise ratios. While they provide advantages in resolving structures and visualizing physiological/pathophysiological effects, challenges such as inhomogeneities and higher energy deposition in the human body exist. This review discusses the advantages, challenges, and promising clinical applications of UHF.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan Orzada, Thomas M. Fiedler, Harald H. Quick, Mark E. Ladd
Summary: This study proposes an iterative expansion method of an existing algorithm, gradually reducing the number of virtual observation points to improve the speed of online monitoring and pulse design, and evaluates it on different simulated arrays. The new algorithm significantly reduces the number of virtual observation points and compression time, with speed-up factors of up to 2.5.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Biophysics
Thomas M. Fiedler, Stephan Orzada, Martina Floeser, Stefan H. G. Rietsch, Harald H. Quick, Mark E. Ladd, Andreas K. Bitz
Summary: This study investigates the performance of integrated RF transmit arrays with high channel counts for body imaging at 7 T, optimizing the position and number of transmit elements. Results show that integrated multiring arrays can generate homogeneous B-1(+) field distributions for large FOVs, especially for coronal/sagittal slices, enabling body imaging at 7 T with a clinical workflow.
NMR IN BIOMEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan Orzada, Thomas M. Fiedler, Harald H. Quick, Mark E. Ladd
Summary: Two post-processing algorithms are introduced in this study to enhance previously compressed VOP sets by reducing overestimation and identifying redundant VOPs respectively.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Biochemical Research Methods
Julien Cohen-Adad, Eva Alonso-Ortiz, Mihael Abramovic, Carina Arneitz, Nicole Atcheson, Laura Barlow, Robert L. Barry, Markus Barth, Marco Battiston, Christian Buechel, Matthew Budde, Virginie Callot, Anna J. E. Combes, Benjamin De Leener, Maxime Descoteaux, Paulo Loureiro de Sousa, Marek Dostal, Julien Doyon, Adam Dvorak, Falk Eippert, Karla R. Epperson, Kevin S. Epperson, Patrick Freund, Juergen Finsterbusch, Alexandru Foias, Michela Fratini, Issei Fukunaga, Claudia A. M. Gandini Wheeler-Kingshott, Giancarlo Germani, Guillaume Gilbert, Federico Giove, Charley Gros, Francesco Grussu, Akifumi Hagiwara, Pierre-Gilles Henry, Tomas Horak, Masaaki Hori, James Joers, Kouhei Kamiya, Haleh Karbasforoushan, Milos Kerkovsky, Ali Khatibi, Joo-Won Kim, Nawal Kinany, Hagen Kitzler, Shannon Kolind, Yazhuo Kong, Petr Kudlicka, Paul Kuntke, Nyoman D. Kurniawan, Slawomir Kusmia, Rene Labounek, Maria Marcella Lagana, Cornelia Laule, Christine S. Law, Christophe Lenglet, Tobias Leutritz, Yaou Liu, Sara Llufriu, Sean Mackey, Eloy Martinez-Heras, Loan Mattera, Igor Nestrasil, Kristin P. O'Grady, Nico Papinutto, Daniel Papp, Deborah Pareto, Todd B. Parrish, Anna Pichiecchio, Ferran Prados, Alex Rovira, Marc J. Ruitenberg, Rebecca S. Samson, Giovanni Savini, Maryam Seif, Alan C. Seifert, Alex K. Smith, Seth A. Smith, Zachary A. Smith, Elisabeth Solana, Yuichi Suzuki, George Tackley, Alexandra Tinnermann, Jan Valosek, Dimitri Van De Ville, Marios C. Yiannakas, Kenneth A. Weber, Nikolaus Weiskopf, Richard G. Wise, Patrik O. Wyss, Junqian Xu
Summary: The study introduces a harmonized quantitative MRI protocol called the spine generic protocol to address challenges in quantitative spinal cord imaging. The protocol provides guidance for assessing spinal cord structure and has been validated in 260 healthy subjects.
Correction
Multidisciplinary Sciences
Julien Cohen-Adad, Eva Alonso-Ortiz, Mihael Abramovic, Carina Arneitz, Nicole Atcheson, Laura Barlow, Robert L. Barry, Markus Barth, Marco Battiston, Christian Buchel, Matthew Budde, Virginie Callot, Anna J. E. Combes, Benjamin De Leener, Maxime Descoteaux, Paulo Loureiro de Sousa, Marek Dostal, Julien Doyon, Adam Dvorak, Falk Eippert, Karla R. Epperson, Kevin S. Epperson, Patrick Freund, Jurgen Finsterbusch, Alexandru Foias, Michela Fratini, Issei Fukunaga, Claudia A. M. Gandini Wheeler-Kingshott, Giancarlo Germani, Guillaume Gilbert, Federico Giove, Charley Gros, Francesco Grussu, Akifumi Hagiwara, Pierre-Gilles Henry, Tomas Horak, Masaaki Hori, James Joers, Kouhei Kamiya, Haleh Karbasforoushan, Milos Kerkovsky, Ali Khatibi, Joo-Won Kim, Nawal Kinany, Hagen H. Kitzler, Shannon Kolind, Yazhuo Kong, Petr Kudlicka, Paul Kuntke, Nyoman D. Kurniawan, Slawomir Kusmia, Rene Labounek, Maria Marcella Lagana, Cornelia Laule, Christine S. Law, Christophe Lenglet, Tobias Leutritz, Yaou Liu, Sara Llufriu, Sean Mackey, Eloy Martinez-Heras, Loan Mattera, Igor Nestrasil, Kristin P. O'Grady, Nico Papinutto, Daniel Papp, Deborah Pareto, Todd B. Parrish, Anna Pichiecchio, Ferran Prados, Alex Rovira, Marc J. Ruitenberg, Rebecca S. Samson, Giovanni Savini, Maryam Seif, Alan C. Seifert, Alex K. Smith, Seth A. Smith, Zachary A. Smith, Elisabeth Solana, Y. Suzuki, George Tackley, Alexandra Tinnermann, Jan Valosek, Dimitri van de Ville, Marios C. Yiannakas, Kenneth A. Weber, Nikolaus Weiskopf, Richard G. Wise, Patrik O. Wyss, Junqian Xu
Article
Multidisciplinary Sciences
Julien Cohen-Adad, Eva Alonso-Ortiz, Mihael Abramovic, Carina Arneitz, Nicole Atcheson, Laura Barlow, Robert L. Barry, Markus Barth, Marco Battiston, Christian Buchel, Matthew Budde, Virginie Callot, Anna J. E. Combes, Benjamin De Leener, Maxime Descoteaux, Paulo Loureiro de Sousa, Marek Dostal, Julien Doyon, Adam Dvorak, Falk Eippert, Karla R. Epperson, Kevin S. Epperson, Patrick Freund, Jurgen Finsterbusch, Alexandru Foias, Michela Fratini, Issei Fukunaga, Claudia A. M. Gandini Wheeler-Kingshott, Giancarlo Germani, Guillaume Gilbert, Federico Giove, Charley Gros, Francesco Grussu, Akifumi Hagiwara, Pierre-Gilles Henry, Tomas Horak, Masaaki Hori, James Joers, Kouhei Kamiya, Haleh Karbasforoushan, Milos Kerkovsky, Ali Khatibi, Joo-Won Kim, Nawal Kinany, Hagen H. Kitzler, Shannon Kolind, Yazhuo Kong, Petr Kudlicka, Paul Kuntke, Nyoman D. Kurniawan, Slawomir Kusmia, Rene Labounek, Maria Marcella Lagana, Cornelia Laule, Christine S. Law, Christophe Lenglet, Tobias Leutritz, Yaou Liu, Sara Llufriu, Sean Mackey, Eloy Martinez-Heras, Loan Mattera, Igor Nestrasil, Kristin P. O'Grady, Nico Papinutto, Daniel Papp, Deborah Pareto, Todd B. Parrish, Anna Pichiecchio, Ferran Prados, Alex Rovira, Marc J. Ruitenberg, Rebecca S. Samson, Giovanni Savini, Maryam Seif, Alan C. Seifert, Alex K. Smith, Seth A. Smith, Zachary A. Smith, Elisabeth Solana, Y. Suzuki, George Tackley, Alexandra Tinnermann, Jan Valosek, Dimitri van de Ville, Marios C. Yiannakas, Kenneth A. . Weber, Nikolaus Weiskopf, Richard G. Wise, Patrik O. Wyss, Junqian Xu
Summary: The paper introduces a spine generic quantitative MRI protocol and presents normative values and statistics generated from datasets across multiple centers, demonstrating high reproducibility of the protocol. This will support the development of accessible and reproducible quantitative MRI in the spinal cord.
Correction
Multidisciplinary Sciences
Julien Cohen-Adad, Eva Alonso-Ortiz, Mihael Abramovic, Carina Arneitz, Nicole Atcheson, Laura Barlow, Robert L. Barry, Markus Barth, Marco Battiston, Christian Buchel, Matthew Budde, Virginie Callot, Anna J. E. Combes, Benjamin De Leener, Maxime Descoteaux, Paulo Loureiro de Sousa, Marek Dostal, Julien Doyon, Adam Dvorak, Falk Eippert, Karla R. Epperson, Kevin S. Epperson, Patrick Freund, Jurgen Finsterbusch, Alexandru Foias, Michela Fratini, Issei Fukunaga, Claudia A. M. Gandini Wheeler-Kingshott, Giancarlo Germani, Guillaume Gilbert, Federico Giove, Charley Gros, Francesco Grussu, Akifumi Hagiwara, Pierre-Gilles Henry, Tomas Horak, Masaaki Hori, James Joers, Kouhei Kamiya, Haleh Karbasforoushan, Milos Kerkovsky, Ali Khatibi, Joo-Won Kim, Nawal Kinany, Hagen H. Kitzler, Shannon Kolind, Yazhuo Kong, Petr Kudlicka, Paul Kuntke, Nyoman D. Kurniawan, Slawomir Kusmia, Rene Labounek, Maria Marcella Lagana, Cornelia Laule, Christine S. Law, Christophe Lenglet, Tobias Leutritz, Yaou Liu, Sara Llufriu, Sean Mackey, Eloy Martinez-Heras, Loan Mattera, Igor Nestrasil, Kristin P. O'Grady, Nico Papinutto, Daniel Papp, Deborah Pareto, Todd B. Parrish, Anna Pichiecchio, Ferran Prados, Alex Rovira, Marc J. Ruitenberg, Rebecca S. Samson, Giovanni Savini, Maryam Seif, Alan C. Seifert, Alex K. Smith, Seth A. Smith, Zachary A. Smith, Elisabeth Solana, Y. Suzuki, George Tackley, Alexandra Tinnermann, Jan Valosek, Dimitri Van de Ville, Marios C. Yiannakas, Kenneth A. Weber, Nikolaus Weiskopf, Richard G. Wise, Patrik O. Wyss, Junqian Xu
Correction
Radiology, Nuclear Medicine & Medical Imaging
Najat Salameh, David G. Norris, Andrew Webb
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Biophysics
Thomas M. Fiedler, Stephan Orzada, Martina Floeser, Stefan H. G. Rietsch, Simon Schmidt, Jonathan K. Stelter, Marco Wittrich, Harald H. Quick, Andreas K. Bitz, Mark E. Ladd
Summary: This study evaluated the performance of an integrated body-imaging array for 7 T with 32 RF channels, compared to a clinical 3 T body coil. The results showed that in some cases, achieving similar B-1(+) homogeneity at 7 T may require higher SAR or lower duty cycle.
NMR IN BIOMEDICINE
(2022)
Article
Neurosciences
Rene Scheeringa, Mathilde Bonnefond, Tim van Mourik, Ole Jensen, David G. Norris, Peter J. Koopmans
Summary: We analyzed EEG and fMRI data and found that beta and alpha oscillations are related to laminar-specific fMRI connectivity, while gamma oscillations are not. The decrease in beta power is associated with an increase in deep-to-deep layer coupling between brain regions and an increase in deep/middle-to-superficial layer connectivity within brain regions. On the other hand, the decrease in alpha power is related to reduced connectivity between deep and superficial layers within brain regions. These findings suggest that different frequency bands are involved in different feedback-related neural processes in laminar-specific fMRI-based connectivity.
Article
Clinical Neurology
Jeryn Chang, Thomas B. Shaw, Cory J. Holdom, Pamela A. McCombe, Robert D. Henderson, Jurgen Fripp, Markus Barth, Christine C. Guo, Shyuan T. Ngo, Frederik J. Steyn
Summary: This study found that lower hypothalamic volume is associated with lower and higher BMI in ALS patients, unlike AD patients and controls. Hypothalamic volume is not related to loss of appetite or hypermetabolism. In ALS patients, lower hypothalamic volume with lower BMI is associated with weight loss and earlier death.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan Orzada, Safi Akash, Thomas M. Fiedler, Fabian J. Kratzer, Mark E. Ladd
Summary: This study aims to investigate the relationship between the number of channels and the computational burden for SAR calculation using virtual observation point-based SAR compression. The results show that the number of virtual observation points increases with the number of channels, and the computational burden increases exponentially with the number of channels. Therefore, it is necessary to use the best compression algorithms when dealing with high channel counts.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Computer Science, Artificial Intelligence
Francesco Cognolato, Kieran O'Brien, Jin Jin, Simon Robinson, Frederik B. Laun, Markus Barth, Steffen Bollmann
Summary: Deep learning based Quantitative Susceptibility Mapping (QSM) has shown great potential, but current methods lack data consistency and often result in error propagation. We developed a new framework, NeXtQSM, that solves the QSM problem jointly and overcomes these limitations.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chia-Yin Wu, Jin Jin, Carl Dixon, Donald Maillet, Markus Barth, Martijn A. Cloos
Summary: Replacing standard excitation pulses with parallel transmit pulses can improve the efficiency of velocity selective labeling.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Neurosciences
Beata Bachrata, Steffen Bollmann, Jin Jin, Monique Tourell, Assunta Dal -Bianco, Siegfried Trattnig, Markus Barth, Stefan Ropele, Christian Enzinger, Simon Daniel Robinson
Summary: Quantitative Susceptibility Mapping (QSM) has the potential to provide additional insights into neurological diseases. We propose an ultra-fast acquisition method based on three orthogonal 2D simultaneous multislice EPI scans, which can generate high-resolution data in a short time. This method can be used to acquire QSM without additional imaging time.
