Article
Neurosciences
Yixiang Mao, Conan Chen, Maryam Falahpour, Kelly H. MacNiven, Gary Heit, Vivek Sharma, Konstantinos Alataris, Thomas T. Liu
Summary: The study found that high-frequency sub-threshold taVNS can lead to sustained effects on the rsFC of brain regions involved in interoception and processing of pain in a cohort of healthy subjects, laying the foundation for future rsfMRI studies of high-frequency sub-threshold taVNS in clinical populations.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Esmeralda Hidalgo-Lopez, Isabel Noachtar, Belinda Pletzer
Summary: This study investigated the influence of anti-androgenic and progestin on the resting state functional connectivity (rs-FC) between the anterior cingulate cortex (ACC) and amygdala, while controlling for the androgenicity of progestin. The results showed that regardless of the androgenicity of progestin, rs-FC between the amygdala and frontal areas, as well as between ACC and temporoparietal areas, decreased with longer duration of HC use. However, the type of progestin had different effects on the gray matter volume of the left ACC and the connectivity between bilateral ACC and the right inferior frontal gyrus.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Tianyue Wang, Yongyi Ye, Shumei Li, Guihua Jiang
Summary: The aim of this study was to explore changes in the connectivity pattern between the anterior cingulate cortex (ACC) and voxels from the whole brain in chronic insomnia (CI). Using region of interest (ROI)-based functional connectivity, a two-sample t-test was performed on individual FC correlation maps from 57 CI patients and 46 healthy controls. The results showed increased connectivity between the ACC and the right middle frontal gyrus, with decreased connectivity between the ACC and the bilateral precuneus gyrus in CI patients compared to healthy controls. The decreased connectivity was positively correlated with Self-Rating Anxiety Scale (SAS) scores.
Article
Neurosciences
Raquel Pestana Araujo, Patricia Figueiredo, Joana Pinto, Pedro Vilela, Isabel Pavao Martins, Raquel Gil-Gouveia
Summary: This study found that there are alterations in brain connectivity during migraine attacks, specifically decreased connectivity between the sensorimotor network and the posterior insula. These changes in connectivity may be associated with the perception of pain and heightened sensitivity to stimuli experienced by migraine patients.
Article
Psychiatry
Rui Yan, Ji Ting Geng, Ying Hong Huang, Hao Wen Zou, Xu Miao Wang, Yi Xia, Shuai Zhao, Zhi Lu Chen, Hongliang Zhou, Yu Chen, Zhi Jian Yao, Jia Bo Shi, Qing Lu
Summary: This study found significant differences in functional connectivity between insular subregions and other brain regions in SD patients compared to NSD patients, which may be related to cognitive impairment in SD patients. Additionally, there were no significant differences in functional connectivity between bilateral posterior insula and any brain regions among the SD, NSD, and HC groups.
Article
Immunology
Johnna R. Swartz, Angelica F. Carranza, Laura M. Tully, Annchen R. Knodt, Janina Jiang, Michael R. Irwin, Camelia E. Hostinar
Summary: The study found associations between peripheral inflammation and adolescent brain connectivity, with higher TNF-α levels linked to changes in neural network connections. Associations with IL-6 and CRP were not significant, suggesting that inflammation may have unique effects on brain connectivity during adolescence.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Yangyang Wang, Xuhong Yang, Lifei Xiao, Wenchao Li, Xianhao Huo, Chaofan Wang, Mei Li, Tao Sun
Summary: Sleep deprivation is a significant cause of cognitive impairment. This study investigated the relationship between functional connectivity of anterior insular subregions and cognitive impairment following total sleep deprivation. The results suggest that altered functional connectivity in these subregions may serve as a neuroimaging biomarker for cognitive impairment after sleep deprivation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neuroimaging
Tianyi Zhang, Qingze Zeng, Kaicheng Li, Xiaocao Liu, Yanv Fu, Tiantian Qiu, Peiyu Huang, Xiao Luo, Zhirong Liu, Guoping Peng
Summary: Smoking is a modifiable risk factor for Alzheimer's disease, and the insula plays a crucial role in both smoking and cognition. However, the effects of smoking on insula-related networks in cognitively normal controls (CN) and mild cognitive impairment (MCI) patients are still unknown.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Clinical Neurology
Woojin Kweon, Kyung Hwa Lee, Sang Ho Choi, Jiyoon Shin, Mincheol Seo, Jeong Eun Jeon, Ha Young Lee, Chowon Park, Sun-Young Kim, Jong Won Kim, Jun Hyuk Chang, Yu Jin Lee
Summary: This study investigated alterations in resting-state functional connectivity and hyperarousal biomarkers in patients with chronic insomnia disorder (CID), compared with good sleepers (GS). The results showed that patients with CID exhibited decreased RSFC between the right amygdala (R.AMG) and left supramarginal gyrus (L.SMG), as well as increased RSFC between the left aINS and bilateral lateral prefrontal cortex. The negative correlation between R.AMG-L.SMG RSFC and EEG beta power suggests daytime hyperarousal in individuals with insomnia.
Article
Neurosciences
Limin Peng, Zhiguo Luo, Ling-Li Zeng, Chenping Hou, Hui Shen, Zongtan Zhou, Dewen Hu
Summary: This study developed a brain parcellation method based on dynamic functional connectivity and created a new functional brain atlas. The atlas can reveal finer functional boundaries that static methods may overlook, and shows good agreement with cytoarchitectonic areas and task activation maps.
Article
Neurosciences
Xiao-Min Xu, Jian Wang, Richard Salvi, Li-Jie Liu, Yu-Chen Chen, Gao-Jun Teng
Summary: The study aimed to investigate the effects of noise-induced cochlear hearing loss on the central nervous system during the early stage and identify the neural substrate for aberrant patterns mediating noise-related anxiety/depression. Rats were exposed to broad band noise to induce hearing loss. Behavioral tests and resting-state fMRI were conducted to evaluate emotional conditions and aberrant neural activity. Functional connectivity analysis revealed widespread reductions in functional connectivity in rats with noise exposure compared to control groups, suggesting an acoustic-causing network for anxiety and depression related to noise exposure.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Computer Science, Artificial Intelligence
Mingliang Wang, Jiashuang Huang, Mingxia Liu, Daoqiang Zhang
Summary: This study proposes a temporal dynamics learning (TDL) method for network-based brain disease identification using rs-fMRI time-series data. By integrating network feature extraction and classifier training into a unified framework, it addresses the issues of previous studies paying less attention to the evolution of global network structures over time and treating feature extraction and training as separate tasks.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Anna Todeva-Radneva, Sevdalina Kandilarova, Rositsa Paunova, Drozdstoy Stoyanov, Tina Zdravkova, Ronald Sladky
Summary: This study aimed to explore possible differences in whole-brain functional connectivity in patients with major depressive disorder (MDD), bipolar disorder (BD), and healthy controls (HC). The results showed increased connectivity in certain brain regions in the BD group compared to the HC group, while the MDD group showed enhanced connectivity in different regions. These findings suggest that these connectivity patterns may serve as potential diagnostic biomarkers for MDD and BD.
Article
Neurosciences
Jung-Hoon Kim, Josepheen De Asis-Cruz, Kushal Kapse, Catherine Limperopoulos
Summary: The reliability and robustness of rs-fcMRI depend on minimizing the influence of head motion on brain signals. This study examined the impact of head motion on newborn brain connectivity using a large dataset. The findings revealed that head motion significantly affected connectivity, with specific effects observed in sensory-related and default mode networks. Implementing a motion correction strategy helped reduce the confounding effects of head motion on neonatal rs-fcMRI.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Luoyao Pang, Huidi Li, Quanying Liu, Yue-Jia Luo, Dean Mobbs, Haiyan Wu
Summary: Motivated dishonesty is a common social behavior that varies among individuals. This study explores the relationship between brain networks and dishonesty using resting-state functional magnetic resonance imaging (rsfMRI), and demonstrates the ability to predict dishonest behavior through a model based on functional connectivity.
Article
Behavioral Sciences
Theo Andriot, Patrick Ohnmacht, Patrik Vuilleumier, Gabriel Thorens, Yasser Khazaal, Nathalie Ginovart, Tomas Ros
Summary: Current research indicates that long-term cannabis use can lead to cognitive deficits and widespread changes in brain activity. This study investigated the electrophysiological and behavioral correlates of cannabis dependence and found that patients with cannabis use disorder had higher levels of alpha rhythm and lower attentional performance compared to nonusers.
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2022)
Article
Pediatrics
Vanessa Siffredi, Maria Chiara Liverani, Lorena G. A. Freitas, D. Tadros, Y. Farouj, Cristina Borradori Tolsa, Dimitri Van de Ville, Petra Susan Hueppi, Russia Ha-Vinh Leuchter
Summary: This study investigated the association between brain functional connectivity and behavioural outcomes in children born very preterm. The results showed that the spatial organization and dynamic features of brain activity were comparable between preterm and full-term children. However, there were differences in the association between dynamic functional connectivity parameters and socio-emotional abilities between the two groups. These findings suggest a link between the maturational delay of functional architecture and socio-emotional abilities in very preterm children.
PEDIATRIC RESEARCH
(2023)
Article
Neurosciences
Philippe Voruz, Alexandre Cionca, Isabele Jacot de Alcantara, Anthony Nuber-Champier, Gilles Allali, Lamyae Benzakour, Patrice H. Lalive, Karl O. Lovblad, Olivia Braillard, Mayssam Nehme, Matteo Coen, Jacques Serratrice, Jean-Luc Reny, Jerome Pugin, Idris Guessous, Radek Ptak, Basile N. Landis, Dan Adler, Alessandra Griffa, Dimitri Van De Ville, Frederic Assal, Julie A. Peron
Summary: The neuropsychological deficits and brain damage following SARS-CoV-2 infection have been investigated in this study. 116 patients with different disease severities were tested for neuropsychological performance, olfactory function, completed questionnaires, and underwent functional magnetic resonance imaging. Severe patients showed poorer verbal episodic memory, while moderate patients had reduced mental flexibility. Neuroimaging revealed different patterns of functional brain connectivity alterations. The severity of the infection in the acute phase predicted the neuropsychological performance six to nine months later. SARS-CoV-2 infection causes long-term memory and executive dysfunctions related to functional brain connectivity alterations.
HUMAN BRAIN MAPPING
(2023)
Meeting Abstract
Clinical Neurology
Cyprien A. Rivier, Maria G. Preti, Pierre Nicolo, Dimitri Van De Ville, Adrian G. Guggisberg, Elvira Pirondini
Article
Neuroimaging
Thomas A. W. Bolton, Dimitri Van De Ville, Jean Regis, Tatiana Witjas, Nadine Girard, Marc Levivier, Constantin Tuleasca
Summary: In this study, the morphometric underpinnings of variability in essential tremor (ET) were explored. It was found that ET patients had higher variance in surface area in the left lingual and caudal anterior cingulate cortices, and lower variance in mean curvature in the right superior temporal cortex, pars triangularis, left supramarginal gyrus, and bilateral paracentral gyrus. The study also identified clinical characteristics associated with the heterogeneity of ET, such as head tremor and impairments in daily life activities.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Gelareh Mohammadi, Dimitri Van De Ville, Patrik Vuilleumier
Summary: Despite lacking a scientific consensus, emotions are generally believed to involve modifications in the mind, body, and behavior. This study used a data-driven approach to decompose a wide range of emotions into core processes and identify their neural organization in the brain. Results showed coordinated activity across brain networks associated with different component processes, shedding light on the functional architecture of human affective experiences.
Article
Neurosciences
Thomas A. W. Bolton, Dimitri Van De Ville, Enrico Amico, Maria G. Preti, Raphael Liegeois
Summary: Moving from association to causal analysis of neuroimaging data is crucial to advance our understanding of brain function. An arrow-of-time (AoT)-sensitive metric is introduced to capture the intensity of causal effects in multivariate time series of high-resolution functional neuroimaging data. Causal effects underlying brain function are found to be more distinctly localized in space and time than functional activity or connectivity, allowing for tracing neural pathways recruited in different conditions. Overall, a mapping of the causal brain is provided, challenging the association paradigm of brain function.
HUMAN BRAIN MAPPING
(2023)
Article
Engineering, Electrical & Electronic
Selin Aviyente, Alejandro F. Frangi, Erik Meijering, Arrate Munoz-Barrutia, Michael Liebling, Dimitri Van de Ville, Jean-Christophe Olivo-Marin, Jelena Kovacevic, Michael Unser
Summary: The Bio Image and Signal Processing (BISP) Technical Committee (TC) of the IEEE Signal Processing Society (SPS) promotes activities in the field of biomedical image and signal processing. It focuses on areas such as medical and biological imaging, digital pathology, molecular imaging, microscopy, computational imaging, and image analysis. It also includes physiological signal processing, computational biology, and bioinformatics.
IEEE SIGNAL PROCESSING MAGAZINE
(2023)
Article
Clinical Neurology
Giorgia G. Evangelista, Philip Egger, Julia Bruegger, Elena Beanato, Philipp J. Koch, Martino Ceroni, Lisa Fleury, Andeol Cadic-Melchior, Nathalie H. Meyer, Diego de Leon Rodriguez, Gabriel Girard, Bertrand Leger, Jean-Luc Turlan, Andreas Muehl, Philippe Vuadens, Jan Adolphsen, Caroline E. Jagella, Christophe Constantin, Vincent Alvarez, Diego San Millan, Christophe Bonvin, Takuya Morishita, Maximilian J. Wessel, Dimitri Van De Ville, Friedhelm C. Hummel
Summary: This study investigates the correlation between brain network connectivity and deficits in different domains in stroke patients. It finds that attentional deficits are more sensitive to disruption of coordinated networks, while motor deficits are more sensitive to disruption of localized networks. This study is of great importance for understanding stroke mechanisms.
Article
Psychiatry
Farnaz Delavari, Halima Rafi, Corrado Sandini, Ryan J. Murray, Caren Latreche, Dimitri Van De Ville, Stephan Eliez
Summary: This study investigates the functional connectivity of amygdala subdivisions in patients with 22q11.2DS and finds that dysfunction in the amygdala is associated with positive psychotic symptoms and impaired tolerance to stress. These findings suggest that amygdala dysfunction may be a neurobiological basis for psychosis.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Behavioral Sciences
Luigi F. Saccaro, Julian Gaviria, Dimitri Van De Ville, Camille Piguet
Summary: This study found that there are differences in the dynamic functional connectivity (dFC) of the hippocampus in bipolar disorder (BD) patients compared to healthy controls. The bilateral hippocampal dFC with the somatomotor networks (SMN) was reduced in BD, while the dFC between the left hippocampus and the midcingulo-insular salience system (SN) was higher. The dFC between the bilateral hippocampus and the default mode network (DMN) correlated with depression scores in BD. Pathological hyperconnectivity between the DMN, SMN, and frontoparietal network (FPN) was also modulated by depression scores in BD. Overall, this study provides insights into the neural architecture underlying BD and suggests that dFC markers may improve detection and treatment of BD patients.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
N. Kinany, A. Khatibi, O. Lungu, J. Finsterbusch, C. Buechel, V. Marchand-Pauvert, D. Van De Ville, S. Vahdat, J. Doyon
Summary: Mapping neural patterns is crucial in understanding human behavior. However, most neuroimaging research has neglected the role of the spinal cord in shaping behavior. To address this, we propose a data-driven approach using coactivation patterns to reveal the dynamics of cerebro-spinal signals and demonstrate its relevance in motor sequence learning.
Article
Neurosciences
Elenor Morgenroth, Laura Vilaclara, Michal Muszynski, Julian Gaviria, Patrik Vuilleumier, Dimitri Van De Ville
Summary: Film functional magnetic resonance imaging (fMRI) has become popular in many areas of neuroscience, but the field of affective neuroscience has been slower to adopt this approach. This article discusses the advantages of using film fMRI for emotion research and provides a general guide for conducting such studies. It gives an overview of emotion theories and how they inform experimental design choices, and discusses the use of films as experimental paradigms for eliciting emotions and the process of annotating them. The article also compares film fMRI to other fMRI approaches and summarizes the results of previous studies on the advantages of film fMRI. It includes an overview of state-of-the-art analysis techniques, including methods that probe neurodynamics, as well as the limitations of using film fMRI to study emotion.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
David R. Samson, Alice Clerget, Noor Abbas, Jeffrey Senese, Mallika S. Sarma, Sheina Lew-Levy, Ibrahim A. Mabulla, Audax Z. P. Mabulla, Valchy Miegakanda, Francesca Borghese, Pauline Henckaerts, Sophie Schwartz, Virginie Sterpenich, Lee T. Gettler, Adam Boyette, Alyssa N. Crittenden, Lampros Perogamvros
Summary: This study compares dream content between cross-cultural populations and finds that dreams in forager groups may serve a more effective emotion regulation function due to their strong social norms and high interpersonal support.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Sebastian Baez-Lugo, Yacila Deza-Araujo, Christel Maradan, Fabienne Collette, Antoine Lutz, Natalie L. Marchant, Gael Chetelat, Patrik Vuilleumier, Olga Klimecki
Summary: Basic emotional functions appear intact in older adults, but their response to and recovery from negative social events are not well understood. The researchers used a 'task-rest' paradigm and functional MRI to investigate the neural dynamics of empathy-related functions in older adults. They found that emotional elicitation during the task enhanced resting-state connectivity between the default mode network and amygdala in older adults, and this connectivity was associated with higher anxiety, rumination, and negative thoughts.