Article
Neurosciences
Dimitrios G. Gkotsoulias, Roland Mueller, Carsten Jaeger, Torsten Schlumm, Toralf Mildner, Cornelius Eichner, Andre Pampel, Jennifer Jaffe, Tobias Graessle, Niklas Alsleben, Jingjia Chen, Catherine Crockford, Roman Wittig, Chunlei Liu, Harald E. Moeller
Summary: Uncovering brain-tissue microstructure, including axonal characteristics, is a major focus in neuroimaging research. This study proposes a novel phase-based methodology, called high angular resolution susceptibility imaging (HARSI), to estimate orientation distribution functions (ODFs). Results show that HARSI can provide information on whole-brain fiber architecture and potentially offer complementary microstructural information compared to high angular resolution diffusion imaging (HARDI) techniques.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gian Franco Piredda, Tom Hilbert, Erick Jorge Canales-Rodriguez, Marco Pizzolato, Constantin von Deuster, Reto Meuli, Josef Pfeuffer, Alessandro Daducci, Jean-Philippe Thiran, Tobias Kober
Summary: This study investigates the acceleration of multi-echo T2 acquisitions for whole-brain myelin water fraction (MWF) mapping using a CAIPIRINHA undersampling technique. The results suggest that the implemented multi-echo GRASE sequence has the potential to be a promising alternative to the time-consuming MESE acquisitions, allowing for whole-brain MWF mapping in a clinically acceptable time frame with high resolution.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wen-Tung Wang, Ningzhi Li, Ioannis Papageorgiou, Leighton Chan, Dzung L. Pham, John A. Butman
Summary: The objective of this study was to evaluate the effectiveness of an accelerated 3D segmented echo planar imaging susceptibility-weighted imaging (segEPI SWI) in detecting cerebral microhemorrhages (CMBs) in traumatic brain injury (TBI). The results showed that segEPI SWI was comparable to the traditional 3D gradient echo SWI (GRE SWI) in CMB counts and diffuse axonal injury (DAI) diagnosis. Therefore, segEPI SWI has the potential to replace GRE SWI, especially in time-critical situations.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maarten Naeyaert, Jan Aelterman, Johan Van Audekerke, Vladimir Golkov, Daniel Cremers, Aleksandra Pizurica, Jan Sijbers, Marleen Verhoye
Summary: The study aims to use compressed sensing to accelerate fast spin echo (FSE) imaging for acquiring a high angular resolution diffusion Imaging (HARDI) data set in a time comparable to EPI. Results showed that apparent fiber density and complexity metric had minor differences with q-space undersampling, but deteriorated with k-space undersampling.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christoph A. Rettenmeier, Danilo Maziero, V. Andrew Stenger
Summary: 3D REPI is a novel 3D radial echo planar imaging sequence for fMRI, providing flexible, rapid, and motion-robust sampling with improved image quality and sampling characteristics for brain activation maps. Sliding window reconstruction was used for BOLD fMRI experiments, demonstrating the ability to correct for rigid motion.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongyun Huang, Mi Zhou, Tong Gong, Yuting Wang
Summary: This study investigated the feasibility of high-resolution readout-segmented echo-planar imaging (rs-EPI) with simultaneous multislice (SMS) imaging to predict well-differentiated rectal cancer. The high-resolution rs-EPI showed better image quality, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and more stable apparent diffusion coefficient (ADC) measurements compared to conventional rs-EPI. The pretreatment ADC on high-resolution rs-EPI could discriminate well-differentiated rectal cancer with a sensitivity of 0.768.
ABDOMINAL RADIOLOGY
(2023)
Article
Neurosciences
Zijing Dong, Fuyixue Wang, Kwok-Shing Chan, Timothy G. Reese, Berkin Bilgic, Jose P. Marques, Kawin Setsompop
Summary: The study introduces a fast imaging technique called variable flip angle Echo Planar Time-Resolved Imaging (vFA-EPTI) for multi-echo myelin water imaging, achieving significant reduction in acquisition time while ensuring high accuracy. The method utilizes efficient readout, optimized encoding, and joint subspace reconstruction, as well as a method to estimate off-resonance field changes for high-quality reconstruction. Experimental results demonstrate the ability of the method to produce high-quality myelin water imaging data at different resolutions and field strengths.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jesse K. Sandberg, Victoria A. Young, Ali B. Syed, Jianmin Yuan, Yuxin Hu, Christopher Sandino, Anne Menini, Brian Hargreaves, Shreyas Vasanawala
Summary: This study compared the performance of near-silent and distortion-free DWI (DW-SD) with standard echo-planar DWI (DW-EPI) in pediatric extremity MRI. The results showed that DW-SD provided similar ADC values and improved image quality compared to DW-EPI in bone marrow, muscle, and lesions. DW-SD was rated significantly better than DW-EPI across all comparative variables.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huiqiao Xie, Yang Lei, Tonghe Wang, Justin Roper, Anees H. Dhabaan, Jeffrey D. Bradley, Tian Liu, Hui Mao, Xiaofeng Yang
Summary: The proposed method using self-supervised parallel CycleGANs to synthesize high-resolution MR images shows feasibility in shortening MR acquisition time in clinical practices. Through qualitative and quantitative evaluations, the method demonstrates good performance in generating HR MR images.
Article
Neurosciences
Fuyixue Wang, Zijing Dong, Lawrence L. Wald, Jonathan R. Polimeni, Kawin Setsompop
Summary: The study extended a distortion/blurring-free multi-shot EPI technique to cortical-depth dependent SE-fMRI to improve neuronal specificity while limiting T-2' contamination, demonstrating the robustness of the proposed technique for high specificity SE-BOLD fMRI.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jos J. M. Westenberg, Hans C. Assen, Pieter J. den Boogaard, Jelle J. Goeman, Hicham Saaid, Jason Voorneveld, Johan Bosch, Sasa Kenjeres, Tom Claessens, Pankaj Garg, Marc Kouwenhoven, Hildo J. Lamb
Summary: Velocity and flow rates are inaccurate for 4DEPI with EPI factor 5 when flow is parallel to the readout or blip phase-encoding gradient. However, mean differences in flow rate, voxel-based speed, and spatio-temporal median speed were acceptable (<= 10%) when comparing 4DEPI to 4DGRE for intracardiac flow in healthy volunteers.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Medicine, General & Internal
Marco Wiesmueller, Wolfgang Wuest, Angelika Mennecke, Matthias Stefan May, Rafael Heiss, Tobit Fuehres, Rolf Janka, Michael Uder, Arnd Doerfler, Frederik Bernd Laun
Summary: This study compares the diagnostic performance and image quality of different DWI techniques for cholesteatoma detection. The results show that topupDWI and tseDWI have higher sensitivity, while rsDWI has lower specificity and image quality.
Article
Clinical Neurology
John Conklin, Matthew P. Frosch, Shibani S. Mukerji, Otto Rapalino, Mary D. Maher, Pamela W. Schaefer, Michael H. Lev, R. G. Gonzalez, Sudeshna Das, Samantha N. Champion, Colin Magdamo, Pritha Sen, G. Kyle Harrold, Haitham Alabsi, Erica Normandin, Bennett Shaw, Jacob E. Lemieux, Pardis C. Sabeti, John A. Branda, Emery N. Brown, M. Brandon Westover, Susie Y. Huang, Brian L. Edlow
Summary: In patients with severe COVID-19, microvascular brain lesions, characterized by punctate SWI lesions, are commonly found in the subcortical and deep white matter. These lesions are associated with widespread microvascular injury, indicating a risk for hemorrhagic and ischemic lesions in the brain.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Renjie Yang, Yujie Zou, Weiyin (Vivian) Liu, Changsheng Liu, Zhi Wen, Liang Li, Chenyu Sun, Min Hu, Yunfei Zha
Summary: This study investigated the diagnostic performance of high-resolution single-shot fast spin-echo (SSFSE) imaging with deep learning (DL) reconstruction algorithm on follicle counting. The results showed that SSFSE-DL images had better image quality and higher repeatability and reproducibility compared to SSFSE and FSE images.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tetsuro Kaga, Yoshifumi Noda, Takayuki Mori, Nobuyuki Kawai, Hirota Takano, Kimihiro Kajita, Masami Yoneyama, Yuta Akamine, Hiroki Kato, Fuminori Hyodo, Masayuki Matsuo
Summary: This study found that EPICS-DWI showed better image quality and higher ADC values compared with PI-DWI in MRI of the abdomen, indicating superior performance.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Anatomy & Morphology
Alessio Fracasso, Anna Gaglianese, Mariska J. Vansteensel, Erik J. Aarnoutse, Nick F. Ramsey, Serge O. Dumoulin, Natalia Petridou
Summary: This study found that positive blood oxygenation level-dependent (BOLD) responses are correlated with high-frequency band (HFB) responses in electrodes responding to visual stimulation, while negative BOLD responses are associated with an absence of HFB power responses and an unexpected decrease in alpha power responses.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Computer Science, Interdisciplinary Applications
Kees M. van Hespen, Hugo J. Kuijf, Jeroen Hendrikse, Peter R. Luijten, Jaco J. M. Zwanenburg
Summary: 4D phase contrast magnetic resonance imaging (PC-MRI) is able to visualize and quantify cerebral blood flow, with software allowing for measurements like lumen area pulsatility index (aPI) and blood flow velocity pulsatility index (vPI). The study introduced software for measuring aPI and vPI from 4D PC-MRI, validated against 2D PC-MRI results for internal carotid arteries. The measurements from 4D PC-MRI were comparable to those from 2D PC-MRI, indicating the potential for accurately capturing arterial variations and aiding in identifying changes in arterial stiffness.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rick J. Tuijl, Ynte M. Ruigrok, Lennart J. Geurts, Irene C. Schaaf, Geert Jan Biessels, Gabriel J. E. Rinkel, Birgitta K. Velthuis, Jaco J. M. Zwanenburg
Summary: This study found that increased pulsatility and decreased distensibility along the internal carotid artery (ICA) are associated with intracranial ICA calcification (iICAC) in patients with cerebral small vessel disease (cSVD), which may contribute to the development of cSVD.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tine Arts, Laurien P. Onkenhout, Raquel P. Amier, Rob van der Geest, Thijs van Harten, Jaap Kappelle, Sanne Kuipers, Matthijs J. P. van Osch, Ed T. van Bavel, Geert Jan Biessels, Jaco J. M. Zwanenburg
Summary: This study aimed to investigate flow pulsatility damping between the M1 segment of the middle cerebral artery (M1) and the small perforating arteries using magnetic resonance imaging. The results showed that pulse pressure (PP) and aortic pulse wave velocity (PWV) were significantly positively correlated to M1 velocity pulsatility.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Clinical Neurology
V. Perosa, T. Arts, A. Assmann, H. Mattern, O. Speck, J. Oltmer, H. -J. Heinze, E. Duezel, S. Schreiber, J. J. M. Zwanenburg
Summary: Age may be the driving factor for altered cerebral small vessel hemodynamics. This study also associates cerebral small vessel disease with blood flow characteristics in the basal ganglia region.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jacob-Jan Sloots, Martijn Froeling, Geert Jan Biessels, Jaco J. M. Zwanenburg
Summary: The variation of apparent diffusion coefficient in brain tissue is likely mainly due to physiology, although tissue deformation can cause artificial ADC variations.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Clinical Neurology
Wilmar M. T. Jolink, Susanne J. van Veluw, Jaco J. M. Zwanenburg, Annemieke J. M. Rozemuller, Wim van Hecke, Matthew P. Frosch, Brian J. Bacskai, Gabriel J. E. Rinkel, Steven M. Greenberg, Catharina J. M. Klijn
Summary: In this study, the histopathological features of cerebral microinfarcts (CMIs) and cerebral microbleeds (CMBs) in patients with spontaneous intracerebral hemorrhage (ICH) caused by different vasculopathies were investigated. The results suggest shared pathophysiological mechanisms in lobar and non-lobar ICH caused by different vasculopathies.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Clinical Neurology
Hilde van den Brink, Anna Kopczak, Tine Arts, Laurien Onkenhout, Jeroen C. W. Siero, Jaco J. M. Zwanenburg, Sandra Hein, Mathias Huebner, Benno Gesierich, Marco Duering, Michael S. Stringer, Jeroen Hendrikse, Joanna M. Wardlaw, Anne Joutel, Martin Dichgans, Geert Jan Biessels
Summary: This study used advanced 7T-MRI techniques to investigate cerebral small vessel function in CADASIL patients, revealing abnormalities in multiple aspects of small vessel function, indicating increased arteriolar stiffness and regional abnormalities in reactivity, particularly related to white matter injury. These findings provide novel markers for mechanistic and intervention studies on cSVD.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
R. J. van Tuijl, Y. M. Ruigrok, M. E. H. Ophelders, I. N. Vos, I. C. van der Schaaf, J. J. M. Zwanenburg, B. K. Velthuis
Summary: This study evaluated the relationship between A1-diameter asymmetry and blood flow asymmetry and defined a hemodynamically significant cut-off value for A1-diameter asymmetry.
JOURNAL OF NEURORADIOLOGY
(2023)
Article
Mechanics
S. Scarsoglio, A. Saglietto, F. Tripoli, J. J. M. Zwanenburg, G. J. Biessels, G. M. De Ferrari, M. Anselmino, L. Ridolfi
Summary: Atrial fibrillation (AF) is a common cardiac arrhythmia that increases the risk of dementia and cognitive decline. This study uses computational fluid dynamics analysis and high-resolution magnetic resonance imaging to investigate the effects of AF on the hemodynamics of lenticulostriate arteries (LSAs). The results show that AF leads to reduced wall shear stress and flow velocity in the LSAs, indicating an increased risk of atherosclerosis and thrombosis.
Article
Neuroimaging
Fariba Karimi, Esra Neufeld, Arya Fallahi, Andrea Boraschi, Jaco J. M. Zwanenburg, Andreas Spiegelberg, Vartan Kurtcuoglu, Niels Kuster
Summary: Monitoring intracranial pressure (ICP) and craniospinal compliance (CC) is important in craniospinal disease treatment. Current methods are invasive and cannot provide continuous CC monitoring. This study proposes a non-invasive CC surrogate using impedance changes caused by dynamic exchange of blood and cerebrospinal fluid.
NEUROIMAGE-CLINICAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Geert Jan Biessels, G. Johan Amelink, Jaco J. M. Zwanenburg
Summary: This study used a novel 3D strain tensor imaging (STI) method to assess brain tissue deformations caused by heartbeat and respiration. The findings showed that craniotomy leads to widespread deformation abnormalities in the brain tissue, which can be detected at the individual patient level.
MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rick J. van Tuijl, Stanley D. T. Pham, Ynte M. Ruigrok, Geert Jan Biessels, Birgitta K. Velthuis, Jaco J. M. Zwanenburg
Summary: This study assessed the test-retest reliability of 3T MRI blood flow velocity measurements in perforating arteries in the BG. The results showed high reliability of the measurements. The measurement uncertainty is mainly affected by scanner and physiological noise, rather than planning.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. Saglietto, S. Scarsoglio, F. Tripoli, J. J. M. Zwanenburg, G. J. Biessels, L. Ridolfi, G. M. De Ferrari, M. Anselmino
EUROPEAN HEART JOURNAL
(2022)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Rick J. van Tuijl, Iris N. Vos, Ynte M. Ruigrok, Irene C. van der Schaaf, Birgitta K. Velthuis, Jaco J. M. Zwanenburg
Summary: This study found a relationship between asymmetry in the A1 segment and changes in blood flow in the internal carotid artery and middle cerebral artery. Increased asymmetry was associated with increased blood flow.
MEDICAL IMAGING 2022: BIOMEDICAL APPLICATIONS IN MOLECULAR, STRUCTURAL, AND FUNCTIONAL IMAGING
(2022)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.
