Article
Engineering, Multidisciplinary
Ali Daher, Stephen Payne
Summary: Models of micro-circulatory blood flow in the brain can help understand cerebrovascular diseases. These models need to account for structural modifications, blood flow patterns, and impairment in autoregulatory response. An upscaling approach is needed to validate the model against clinical MRI data, while maintaining relevant anatomical connections. The developed hybrid multiscale model accurately characterizes dynamic flow and autoregulation in the microvasculature at improved computational efficiency.
APPLIED MATHEMATICAL MODELLING
(2023)
Article
Engineering, Biomedical
Weifeng Huang, Chen Hua, Yan Guo, Wenwei Gao, Yingchuan Li, Yuanyi Zheng
Summary: The status of cerebral perfusion and its restoration level are crucial in the prognosis and clinical decision making of neurosurgical diseases. Traditional methods for evaluating cerebral perfusion and restoration, such as CT, MR, and ICP monitoring, are facing contradictions due to their inability to measure cerebral reperfusion in microvasculature level accurately. In this study, a new non-invasive imaging method using ultrasonography and super-resolution reconstruction algorithm was developed, which showed precise distribution of microvasculature in deep cerebral regions with high resolution. This method can provide efficient and accurate diagnosis of cerebral perfusion and facilitate early-stage evaluation of neurofunctional restoration.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2023)
Article
Endocrinology & Metabolism
DongKyu Lee, Thuy Thi Le, Geun Ho Im, Seong-Gi Kim
Summary: Non-invasive hypoxia BOLD-MRI approach is viable for perfusion mapping of rodents, and it provides highly correlated perfusion metrics.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peiying Liu, Gongkai Liu, Marco C. Pinho, Zixuan Lin, Binu P. Thomas, Melissa Rundle, Denise C. Park, Judy Huang, Babu G. Welch, Hanzhang Lu
Summary: The study optimized and evaluated a resting-state BOLD functional MRI technique to measure cerebrovascular reactivity and demonstrated its relationship to neurosurgical treatment. The results showed that the technique provided a task-free method to assess cerebrovascular reserve and depicted the treatment effect of revascularization surgery in patients with Moyamoya disease, comparable to the reference standard of CO2 inhalation MRI.
Article
Endocrinology & Metabolism
Yuying Guan, Yakun Gu, Haitao Shao, Wei Ma, Gaifen Li, Mengyuan Guo, Qianqian Shao, Yuning Li, Yingxia Liu, Chaoyu Wang, Zhengming Tian, Jia Liu, Xunming Ji
Summary: Ischemic stroke causes neurological damage due to blood vessel occlusion. This study found that intermittent hypoxia significantly improves cerebrovascular microcirculation and prevents ischemic stroke, while continuous hypoxia has no such effects.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Peripheral Vascular Disease
Ali Daher, Stephen Payne
Summary: Cerebrovascular diseases are a major cause of sickness and death in humans. Abnormalities in dynamic cerebral autoregulation (dCA) are associated with many of these diseases. This study proposes a simple framework for modeling dCA in the microvasculature using a vessel-driven network model, which can incorporate the actual connectivity and anatomy of the vasculature, investigate changes in vessel calibre and morphology, and link model parameters to the actual network physiology.
MICROVASCULAR RESEARCH
(2023)
Article
Endocrinology & Metabolism
Maryam Anzabi, Baoqiang Li, Hui Wang, Sreekanth Kura, Sava Sakadzi, David Boas, Leif Ostergaard, Cenk Ayata
Summary: The study found that in the process of SD in the mouse cortex, the blood flow in capillaries started to drop several seconds before the constriction of pial arterioles, indicating that the origin of the hemodynamic response is in the capillary bed.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Ottavia Dipasquale, Alexander Cohen, Daniel Martins, Fernando Zelaya, Federico Turkheimer, Mattia Veronese, Mitul A. Mehta, Steven C. R. Williams, Baolian Yang, Suchandrima Banerjee, Yang Wang
Summary: The Receptor-enriched analysis of functional connectivity by targets (REACT) combines molecular information on neurotransmitter distribution density with functional MRI (fMRI) data, providing a biological basis for analyzing functional connectivity (FC) in the human brain. This study applied REACT to simultaneous ASL/BOLD resting-state fMRI data and compared the FC maps of both modalities. The results showed robust spatial patterns of molecular-enriched FC for ASL and BOLD, moderate similarity between the two modalities, and comparable reproducibility for most molecular-enriched functional networks.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Aocai Yang, Hangwei Zhuang, Lei Du, Bing Liu, Kuan Lv, Jixin Luan, Pianpian Hu, Feng Chen, Kai Wu, Ni Shu, Amir Shmuel, Guolin Ma, Yi Wang
Summary: This study evaluated the whole-brain pattern of oxygen extraction fraction (OEF), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen consumption (CMRO2) perturbation in Alzheimer's disease (AD) and investigated the relationship between regional cerebral oxygen metabolism and global cognition. The results showed that CBF and CMRO2 values significantly decreased in certain brain regions in AD patients. Moreover, there was a positive correlation between CBF and CMRO2 values in the hippocampus and cognitive status. The findings suggest that CMRO2 may serve as a potential biomarker for AD and CMRO2 in the hippocampus may be useful for monitoring cognitive impairment.
Article
Multidisciplinary Sciences
Peiying Liu, Zachary Baker, Yue C. Li, Yang G. Li, Jiadi Xu, Denise J. Park, Babu E. Welch, Marco Pinho, Jay Pillai, Argye Hillis, Susumu Mori, Hanzhang Lu
Summary: CVR-MRICloud is a cloud-based CVR processing pipeline that enables automated processing of CVR MRI data. It includes steps such as extraction of CO2 curve, alignment with BOLD time course, and computation of CVR value, as well as standard image processing steps. This technology has potential applications in cerebrovascular diseases.
Article
Behavioral Sciences
Vita Cardinale, Traute Demirakca, Tobias Gradinger, Markus Sack, Matthias Ruf, Nikolaus Kleindienst, Marius Schmitz, Christian Schmahl, Ulf Baumgaertner, Gabriele Ende
Summary: ASL is a functional neuroimaging technique that has been used to investigate acute pain states, offering advantages for low-frequency designs. A study found that ASL can sensitively detect brain activation in healthy controls following mechanical painful stimulation, indicating its potential for studying acute pain in a single event paradigm.
BRAIN AND BEHAVIOR
(2022)
Editorial Material
Biology
Anusha Mishra, Catherine N. Hall, Clare Howarth, Ralph D. Freeman
Summary: Functional neuroimaging using MRI relies on measuring blood oxygen level-dependent (BOLD) signals to infer underlying neuronal activity, but accurate interpretation depends on a full understanding of neurovascular coupling and other mechanisms.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Neurosciences
Maniselvan Kuppusamy, Matteo Ottolini, Swapnil K. Sonkusare
Summary: TRP channels play a crucial role in regulating cerebrovascular contractility and cerebral blood flow, with potential implications in maintaining blood-brain barrier integrity. They exert their effects through cell membrane depolarization or by serving as a Ca2+ influx pathway, and their activity in endothelial cells and astrocytes can impact blood-brain barrier function.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Wenyi Li, Jiwei Jiang, Xinying Zou, Yuan Zhang, Mengfan Sun, Ziyan Jia, Wei Li, Jun Xu
Summary: This study aimed to investigate the potential risk factors and cerebral perfusion in patients with subjective cognitive decline (SCD). The results showed that family history of dementia and higher cerebral blood flow in the left parahippocampal gyrus were independently associated with SCD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Zsuzsanna Mihaly, Lilla Istvan, Cecilia Czako, Fruzsina Benyo, Sarolta Borzsak, Andrea Varga, Rita Magyar-Stang, Peter Vince Banga, Agnes Elo, Robert Debreczeni, Illes Kovacs, Peter Sotonyi
Summary: The Circle of Willis (CoW) is the main collateral system and its morphological variants are more common in patients with severe carotid artery stenosis. Optical coherence tomography angiography (OCTA) can be used to evaluate changes in cerebral vascular perfusion by imaging retinal blood flow. This study found that patient age and CoW morphology were associated with superficial capillary vessel density (VD), and retinal blood flow significantly improved after carotid endarterectomy (CEA). Measuring retinal blood flow may be an important indicator of collateral cerebrovascular circulation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
A. Andre, M. Rongieres, J. -M. Laffosse, R. Pailhe, F. Lauwers, J. -L. Grolleau
ANNALES DE CHIRURGIE PLASTIQUE ESTHETIQUE
(2015)
Article
Pediatrics
A. de Berall, F. Lauwers, E. Noirrit Esclassan, V. Woisard Bassols, B. Gardini, P. Galinier
ARCHIVES DE PEDIATRIE
(2015)
Article
Surgery
Florian Nadon, Benoit Chaput, Jean Perisse, Ambre de Berail, Frederic Lauwers, Raphael Lopez
JOURNAL OF CRANIOFACIAL SURGERY
(2015)
Article
Dentistry, Oral Surgery & Medicine
B. Lerhe, S. Alshehri, F. Delanoe, F. Lauwers, R. Lopez
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2016)
Article
Surgery
Stephane Bruneau, Jean-Marc Foletti, Samuel Muller Camille Vercasson, Frederic Lauwers, Laurent Guyot
PLASTIC AND RECONSTRUCTIVE SURGERY
(2016)
Article
Clinical Neurology
Pierre Brandicourt, Franck Delanoe, Franck-Emmanuel Roux, Florian Jalbert, David Brauge, Frederic Lauwers
WORLD NEUROSURGERY
(2017)
Article
Clinical Neurology
Franck-Emmanuel Roux, Cheng Ngiep Ou, Ratha Soum, James Gollogly, Imene Djidjeli, Frederic Lauwers
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2018)
Article
Dentistry, Oral Surgery & Medicine
F. Boutault, Z. Cavallier, F. Lauwers, A. Prevost
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2018)
Article
Otorhinolaryngology
Mathieu Marx, Frank Risi, Bernard Escude, Irfan Durmo, Christopher James, Frederic Lauwers, Olivier Deguine, Bernard Fraysse
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2014)
Article
Dentistry, Oral Surgery & Medicine
F. Jalbert, S. Boetto, F. Nadon, F. Lauwers, E. Schmidt, R. Lopez
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2014)
Review
Surgery
L. Chanel, J. -L. Grolleau, F. Lauwers, A. Andre
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2014)
Article
Orthopedics
Etienne Cavaignac, Regis Pailhe, Jerome Murgier, Nicolas Reina, Frederic Lauwers, Philippe Chiron
Article
Peripheral Vascular Disease
Sylvie Lorthois, Frederic Lauwers, Francis Cassot
MICROVASCULAR RESEARCH
(2014)
Article
Physiology
Amy F. Smith, Vincent Doyeux, Maxime Berg, Myriam Peyrounette, Mohammad Haft-Javaherian, Anne-Edith Larue, John H. Slater, Frederic Lauwers, Pablo Blinder, Philbert Tsai, David Weinfeld, Chris B. Schaffer, Nozomi Nishimura, Yohan Davit, Sylvie Lorthois
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Orthopedics
Pierre Laumonerie, Laurent Blasco, Meagan E. Tibbo, Kerezoudis Panagiotis, Olivier Fernandes, Frederic Lauwers, Nicolas Bonnevialle, Pierre Mansat, Xavier Ohl
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2019)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.