Article
Neurosciences
Alexander Goettker, Karl R. Gegenfurtner
Summary: The close relationship between eye movements and visual processing has led to recent studies focusing on interactions and shared signals between saccades and pursuit eye movements, highlighting multiple interactions and synergies in oculomotor control and visual perception.
Article
Neurosciences
Natela M. Shanidze, Zachary Lively, Rachel Lee, Preeti Verghese
Summary: Macular degeneration (MD) leads to variability in the direction of saccades during pursuit, making them less appropriately directed. PRL eccentricity significantly correlates with an increase in saccades in non-target directions.
Article
Neurosciences
Terence L. Tyson, Erin E. Flynn-Evans, Leland S. Stone
Summary: This study aims to investigate the effects of acute and chronic sleep loss, low-dose alcohol, and caffeine on saccade-pursuit coordination. The results show that low-dose alcohol and acute sleep loss have different effects on compensating for tracking deficits, while chronic sleep loss and caffeine-mitigated acute sleep loss show smaller pursuit deficits but remain altered in saccadic behavior.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Ophthalmology
Kevin Parisot, Steeve Zozor, Anne Guerin-Dugue, Ronald Phlypo, Alan Chauvin
Summary: Human ocular pursuit movements can be generated and measured at small amplitudes, referred to as micro-pursuits in this article. These micro-pursuits exhibit correlation between gaze direction and target trajectory, influenced by the nature of the stimulus and task demands. The study suggests that manipulation of stimulus target motion, task, and/or the nature of the stimulus may play a role in the generation of micro-pursuits.
Article
Clinical Neurology
Simon Henin, Anita Shankar, Helen Borges, Adeen Flinker, Werner Doyle, Daniel Friedman, Orrin Devinsky, Gyorgy Buzsaki, Anli Liu
Summary: The spatiotemporal characteristics of cortical high-gamma activity, hippocampal ripple activity, and interictal epileptiform discharges have a significant impact on memory performance during an associative memory task, particularly in the hippocampal region. Interictal epileptiform discharges may impair associative memory by disrupting physiological activity, making them a promising therapeutic target for memory remediation in patients with epilepsy.
Article
Clinical Neurology
Masaki Sonoda, Robert Rothermel, Alanna Carlson, Jeong-Won Jeong, Min-Hee Lee, Takahiro Hayashi, Aimee F. Luat, Sandeep Sood, Eishi Asano
Summary: This prospective study showed that intracranially recorded spectral responses can predict neuropsychological outcomes after epilepsy surgery. The researchers found that high gamma augmentation was associated with a decline in core language scores and expressive language index, while low gamma augmentation and alpha/beta attenuation independently predicted a decline in core language scores. They also developed a machine learning model that accurately predicted patients with postoperative language decline. This study is important for improving neuropsychological predictions in patients undergoing epilepsy surgery.
Article
Neurosciences
Nadine Schenke, Paul Eling, Thomas Duning, Helmut Hildebrandt
Summary: Patients with hemispatial neglect show multiple oculomotor deficits. Modulation of superior colliculus (SC) activity via monocular eye patching does not improve eye movements to the contralesional side of space. These findings suggest that SC activity may have an impact on ocular performance.
BRAIN AND COGNITION
(2023)
Article
Neurosciences
Ji-Won Kim, Katja E. Brueckner, Celina Badenius, Wolfgang Hamel, Miriam Schaper, Michel Le van Quyen, Elisa K. El-Allawy-Zielke, Stefan R. G. Stodieck, Jonas M. Hebel, Michael Lanz
Summary: This study aimed to examine the pathological effect of a mesial temporal seizure onset zone (SOZ) on the response to faces in the amygdala and other structures of the temporal lobe. The results showed that a mesial temporal SOZ impaired the response to faces in the amygdala, fusiform gyrus, and parahippocampal gyrus. Additionally, the response to faces in the hippocampus was impaired in both patients with and without a mesial temporal SOZ. These findings provide further evidence for face processing deficits in patients with a mesial temporal SOZ and highlight the role of the amygdala in this impairment.
Article
Neurosciences
Anusha Mohan, Alison Luckey, Nathan Weisz, Sven Vanneste
Summary: Tinnitus may result from predictive coding issues, with patients potentially being more sensitive to auditory stimuli unrelated to tinnitus characteristics. In individuals with minimal or no hearing loss, a more top-down subtype of tinnitus driven by maladaptive changes in the auditory predictive coding network may exist. Empirical evidence suggests the presence of maladaptive changes in hierarchical predictive coding network in a subgroup of tinnitus patients with minimal to no hearing loss.
Article
Clinical Neurology
Valentina Kitchigina, Liubov Shubina
Summary: The dentate gyrus (DG) is crucial for navigation and memory. The oscillatory activity of DG circuits plays an important role in cognition. Disturbances in DG rhythms during temporal lobe epilepsy (TLE) may serve as a diagnostic marker for the disease.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Elisa Tatti, Alberto Cacciola, Federico Carrara, Adalgisa Luciani, Angelo Quartarone, M. Felice Ghilardi
Summary: Previous research has shown that movements are accompanied by modulation of EEG activity. This study found that gamma ERS amplitude decreases after movement practice and rest, while connectivity patterns also decrease. Despite the amplitude reduction, gamma waves are still able to adapt to movement velocity.
Article
Engineering, Biomedical
Carolina Migliorelli, Sergio Romero, Alejandro Bachiller, Javier Aparicio, Joan F. Alonso, Miguel A. Mananas, Victoria San Antonio-Arce
Summary: This study introduces a novel modeling approach to differentiate pathological and physiological ripples in the ripple band, improving the delineation of the epileptogenic zone (EZ). Individual models are found to be more appropriate than a traditional whole-population approach, with significant differences in pathological ripple rates inside and outside the seizure onset zone. This individual Gaussian mixture model (GMM) approach enhances ripple classification and helps in investigating the interaction of epileptogenic and propagation networks.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Psychiatry
Muhammad Ummear Raza, Deepshila Gautam, Dakota Rorie, Digavalli Sivarao
Summary: This study found that clozapine and haloperidol have different effects on local gamma synchrony induced by 40 Hz click trains. Clozapine significantly enhanced gamma synchrony by accelerating gamma phase resetting, reducing background gamma, and improving phase precision and signal power. On the other hand, haloperidol only had modest improvements in gamma synchrony without accelerating phase resetting. These observations provide a neurophysiological basis for the unique profile of clozapine and can help in identifying new drug candidates for treatment-resistant schizophrenia.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Respiratory System
Devine Jackson, Joshua Walum, Priyanka Banerjee, Brandon W. Lewis, Y. S. Prakash, Venkatachalem Sathish, Zhaohui Xu, Rodney D. Britt
Summary: In this study, the effects of TNF alpha and IFN gamma on corticosteroid sensitivity in pediatric airway smooth muscle tissue were investigated. The results showed that TNF alpha had a greater impact on gene expression compared to IFN gamma, and the combined effects of TNF alpha and IFN gamma enhanced the expression of pro-inflammatory genes and pathways related to asthma pathogenesis. These findings highlight the importance of Th1-associated cytokines in promoting inflammation and hypercontractility in severe asthma.
RESPIRATORY RESEARCH
(2022)
Article
Clinical Neurology
Dorottya Cserpan, Richard Rosch, Santo Pietro Lo Biundo, Johannes Sarnthein, Georgia Ramantani
Summary: This study aimed to identify the optimal timing within sleep and the minimal data length for sensitive and reproducible high frequency oscillation (HFO) detection. The results showed that the first N3 sleep stage was the most sensitive time window for HFO rate detection, and at least 10 minutes of N3 data intervals were required for reliable measurement of HFO rates.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Oncology
Hamza S. Gorsi, Stephanie A. Toll, Sandeep Sood, Steven Miler, Deniz Altinok, Chandan Kumar-Sinha, Rajen Mody, Maxim Yankelevich
Summary: Posterior fossa ependymomas A have the worst prognosis among all subtypes, but can be targeted with epigenetic modifiers like Vorinostat to improve prognosis by reducing tumor burden.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2022)
Article
Clinical Neurology
Masaki Sonoda, Robert Rothermel, Alanna Carlson, Jeong-Won Jeong, Min-Hee Lee, Takahiro Hayashi, Aimee F. Luat, Sandeep Sood, Eishi Asano
Summary: This prospective study showed that intracranially recorded spectral responses can predict neuropsychological outcomes after epilepsy surgery. The researchers found that high gamma augmentation was associated with a decline in core language scores and expressive language index, while low gamma augmentation and alpha/beta attenuation independently predicted a decline in core language scores. They also developed a machine learning model that accurately predicted patients with postoperative language decline. This study is important for improving neuropsychological predictions in patients undergoing epilepsy surgery.
Article
Clinical Neurology
Nolan B. O'Hara, Min-Hee Lee, Csaba Juhasz, Eishi Asano, Jeong-Won Jeong
Summary: The study aims to determine the structural networks that constrain the propagation of ictal oscillations during epileptic spasm events and compare the observed patterns across patients with successful or unsuccessful surgical outcomes. The results show that the propagation patterns align with the length and FA measures from onset-originating corticocortical pathways, which have important implications for surgical decision-making and expectations of surgical outcomes.
Article
Neurosciences
Kazuki Sakakura, Masaki Sonoda, Takumi Mitsuhashi, Naoto Kuroda, Ethan Firestone, Nolan O'Hara, Hirotaka Iwaki, Min-Hee Lee, Jeong-Won Jeong, Robert Rothermel, Aimee F. Luat, Eishi Asano
Summary: This study investigates the development of neural dynamics for auditory processing, revealing a maturation of an anterior-to-posterior functional division within the superior-temporal gyrus (STG). The findings show that with age, the human STG refines neural dynamics to rapidly detect and subsequently disregard irrelevant auditory signals.
Article
Neurosciences
Takumi Mitsuhashi, Masaki Sonoda, Ethan Firestone, Kazuki Sakakura, Jeong-Won Jeong, Aimee F. Luat, Sandeep Sood, Eishi Asano
Summary: This study investigated the spatiotemporal characteristics and functional significance of rapid, large-scale brain network dynamics during task switching in patients with drug-resistant focal epilepsy. The results demonstrated the presence of high-gamma augmentation during task switch trials, which was more intense than during repeat trials, and the high-gamma amplitude predicted the accuracy of upcoming responses among switch trials.
Article
Oncology
Avanti Gupte, Sandeep Sood, William J. Kupsky, Deniz Altinok, Steven Miller, Sumita Roy, Kanta Bhambhani
Summary: DICER1 syndrome is a rare inherited tumor predisposition syndrome that increases the risk of various malignancies and benign tumors. We report a case of pineal parenchymal tumor of intermediate differentiation with a germline pathogenic variant in the DICER1 gene. The association between pineal parenchymal tumor of intermediate differentiation and DICER1 mutation is rare, with only one recent large molecular study reporting this association. This report expands the tumor spectrum of DICER1 and emphasizes the importance of molecular evaluation in pediatric brain tumors for treatment decisions and long-term surveillance.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2023)
Article
Engineering, Biomedical
Yipeng Zhang, Hoyoung Chung, Jacquline P. Ngo, Tonmoy Monsoor, Shaun A. Hussain, Joyce H. Matsumoto, Patricia D. Walshaw, Aria Fallah, Myung Shin Sim, Eishi Asano, Raman Sankar, Richard J. Staba, Jerome Engel, William Speier, Vwani Roychowdhury, Hiroki Nariai
Summary: This study aimed to characterize salient features of physiological high-frequency oscillations (HFOs) using deep learning, and proposed a novel weakly supervised deep learning model for interpreting these features.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Computer Science, Information Systems
Jeong-Won Jeong, Min-Hee Lee, Naoto Kuroda, Kazuki Sakakura, Nolan O'Hara, Csaba Juhasz, Eishi Asano
Summary: The present study investigates the effectiveness of a deep learning neural network for non-invasively localizing the seizure onset zone (SOZ) using multi-modal MRI data that are clinically acquired from children with drug-resistant epilepsy. The proposed MRI marker provided a very large effect size between SOZ and non-SOZ and improved the localization of epileptogenic foci for successful pediatric epilepsy surgery.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Clinical Neurology
Ethan Firestone, Masaki Sonoda, Naoto Kuroda, Kazuki Sakakura, Jeong-Won Jeong, Min-Hee Lee, Keiko Wada, Yutaro Takayama, Keiya Iijima, Masaki Iwasaki, Tomoyuki Miyazaki, Eishi Asano
Summary: This study investigated the effects of sevoflurane anesthesia on intraoperative epilepsy biomarkers, including high-frequency oscillation (HFO) effective connectivity (EC). The results showed that HFO EC increased with increasing sevoflurane concentration, particularly in epileptogenic sites. The classification ability of HFO EC was optimized at a sevoflurane concentration of 2 MAC. The HFO EC could be visualized on major white matter tracts using diffusion-weighted imaging and dynamic tractography. These findings support the hypothesis that sevoflurane-activated HFO biomarkers may help localize the epileptogenic zone during surgery.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Behavioral Sciences
Shin-ichiro Osawa, Kyoko Suzuki, Eishi Asano, Kazushi Ukishiro, Dai Agari, Kazuo Kakinuma, Ryuzaburo Kochi, Kazutaka Jin, Nobukazu Nakasato, Teiji Tominaga
Summary: This article presents the findings of an electrical stimulation experiment, which reveals the involvement of the medial surface of the non-dominant hemisphere in subjective auditory perception, influenced by the context of the condition. The study shows that the patient perceived sounds as higher when she had greater control over the situation, while perceiving them as lower when her eyes were closed.
Article
Neurosciences
Yu Kitazawa, Masaki Sonoda, Kazuki Sakakura, Takumi Mitsuhashi, Ethan Firestone, Riyo Ueda, Toshimune Kambara, Hirotaka Iwaki, Aimee F. Luat, Neena I. Marupudi, Sandeep Sood, Eishi Asano
Summary: We developed normative brain atlases that demonstrate millisecond-level connectivity dynamics in white matter for object recognition and speech production. Using electrocorticographic data from 1,114 non-epileptic intracranial electrodes, we identified functional connectivity enhancements during naming tasks and observed task-specific connectivity patterns.
Article
Clinical Neurology
Hiroya Ono, Masaki Sonoda, Kazuki Sakakura, Yu Kitazawa, Takumi Mitsuhashi, Ethan Firestone, Jeong-Won Jeong, Aimee F. Luat, Neena Marupudi, Sandeep Sood, Eishi Asano
Summary: Using a whole-brain level movie atlas, researchers clarified the white matter dynamic circuitry of alpha waves and high-gamma activity in response to eye movements. They found significant changes in brain connectivity patterns before and after eye closure, indicating the involvement of extensive white matter networks. These findings contribute to a better understanding of the functional integrity of brain networks and the effects of eye movements on cognitive neuroscience research.
BRAIN COMMUNICATIONS
(2023)
Review
Clinical Neurology
Neena I. Marupudi, Breanne Reisen, Arlene Rozzelle, Sandeep Sood
Summary: Over the past 30 years, advancements in endoscopic technology and interest in the benefits of minimally invasive approaches have made them a part of standard care for craniosynostosis treatment. This review discusses the development and adoption of endoscopic-assisted strip craniectomy procedures, highlighting the comparison of outcomes between traditional and endoscopic-assisted techniques for different craniosynostosis diagnoses.
JOURNAL OF PEDIATRIC NEUROSCIENCES
(2022)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.
