Article
Neurosciences
Yongxin Li, Jianping Wang, Xiao Wang, Qian Chen, Bing Qin, Jiaxu Chen
Summary: The study investigated alterations in thalamus morphology, functional activity, and connectivity in children with GTCS, finding both increased and decreased connectivity variability in thalamo-cortical networks. The dynamic restructuring of pathways connecting the thalamus suggests implications for understanding the neural mechanisms underlying GTCS in children.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Yongxin Li, Yun Ran, Qian Chen
Summary: This study aimed to explore the whole-brain static and dynamic functional connectivity in children with GTCS. The results showed that GTCS patients had weaker static functional connectivity compared to the control group, and the changes in dynamic functional connectivity mainly occurred in State 1. Additionally, the dynamic functional connectivity was significantly correlated with epilepsy duration. These findings revealed the abnormal changes in connectivity strength and temporal properties in children with GTCS, highlighting the differences in static and dynamic functional connectivity in this population.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Mathematics, Interdisciplinary Applications
Gayathri Vivekanandhan, Mahtab Mehrabbeik, Hayder Natiq, Nikhil Pal, Karthikeyan Rajagopal, Sajad Jafari
Summary: This paper investigates the contribution of basal ganglia regions in absence seizures and provides a detailed analysis of the basal ganglia cortex-thalamus (BGCT) model. The study finds that the BGCT model can exhibit chaotic behavior in small regions of the coupling parameter.
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
(2023)
Article
Neurosciences
Nathaniel C. Wright, Peter Y. Borden, Yi Juin Liew, Michael F. Bolus, William M. Stoy, Craig R. Forest, Garrett B. Stanley
Summary: Rapid sensory adaptation is a common phenomenon observed in all sensory systems, yet the mechanistic basis behind it is still poorly understood. Studies on awake mice suggest that cortical adaptation in primary somatosensory cortex is mainly driven by changes in thalamic input timing and differential impacts on cortical excitation and feed forward inhibition. This highlights the significant role of thalamic gating in rapid adaptation of primary sensory cortex.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Monica Betta, Giacomo Handjaras, Andrea Leo, Alessandra Federici, Valentina Farinelli, Emiliano Ricciardi, Francesca Siclari, Stefano Meletti, Daniela Ballotta, Francesca Benuzzi, Giulio Bernardi
Summary: EEG slow waves play a crucial role in regulating essential processes such as learning and sensory disconnection. They may involve complex interactions within and between cortical and subcortical structures. Moreover, simultaneous EEG-fMRI recordings show that slow waves are associated with specific hemodynamic changes in different brain regions.
Article
Clinical Neurology
Ning Sun, Min Liu, Penghong Liu, Aixia Zhang, Chunxia Yang, Zhifen Liu, Jianying Li, Gaizhi Li, Yanfang Wang, Kerang Zhang
Summary: This study aimed to explore the changes in brain structure and function in patients with major depressive disorder (MDD) with and without somatic symptoms. The results showed that the structure and function of the cortical-striatal-thalamic-cortical (CSTC) circuit centered on the thalamus were abnormal in MDD patients with somatic symptoms, which may be the neurobiological basis of somatic symptoms in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Weiping Liao, Zhou Dong, Hong Zhen, Anna Patten, Amitabh Dash, Manoj Malhotra
Summary: The post hoc analysis evaluated the efficacy and safety of adjunctive perampanel in Chinese patients with focal seizures, showing good efficacy in reducing seizure frequency, particularly in focal seizures and generalized tonic-clonic seizures. The safety and tolerability of perampanel were similar between Chinese and non-Chinese patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Psychiatry
Meidan Zu, Lulan Fu, Mingwei Hu, Xiaoyan Cao, Long Wang, Juan Zhang, Ziru Deng, Bensheng Qiu, Yu Wang
Summary: The study aimed to explore the neural substrate differences in the response to antiseizure drugs between seizure-free (SF) and non-seizure-free (NSF) patients with generalized tonic-clonic seizures (GTCS). Through the analysis of amplitude of low-frequency fluctuation (ALFF) in resting-state functional magnetic resonance imaging (rs-fMRI) data, it was found that the NSF group exhibited higher abnormal brain activity in the fusiform gyrus (FG) compared to the SF and healthy control groups. These findings suggest that abnormal brain activity in the FG may play a role in the failure of seizure control in patients with GTCS.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Behavioral Sciences
Neel Fotedar, Guadalupe Fernandez-BacaVaca, Michael Rose, Jonathan P. Miller, Hans O. Lueders
Summary: Objective: This study aimed to investigate the neurophysiology of motor responses elicited by electrical stimulation of the primary motor cortex. Methods: Motor responses were studied in four patients undergoing invasive epilepsy monitoring and functional cortical mapping using surface EMG electrodes. Polygraphic analysis of intracranial EEG and EMG during bilateral tonic-clonic seizures induced by cortical stimulation was performed in two patients. Results: The motor responses were classified as clonic, jittery, and tonic. The electrical cortical stimulation induced different types of clonic responses depending on stimulation frequency and intensity. Bilateral tonic-clonic seizures exhibited unique patterns of intracranial EEG and synchronized EMG bursts. Interpretation: Epileptic activity involving the primary motor cortex can produce a continuum of motor responses ranging from clonic to tonic contractions and bilateral tonic-clonic seizures. This study provides valuable insights into the neurophysiological mechanisms underlying motor responses to electrical stimulation of the primary motor cortex.
EPILEPSY & BEHAVIOR
(2023)
Article
Neurosciences
Yongxin Li, Bing Qin, Qian Chen, Jiaxu Chen
Summary: This study examined the interhemispheric functional connectivity and topological organization within the default-mode network (DMN) in children with generalized tonic-clonic seizures (GTCS). The results showed significant changes in connectivity and organization in the DMN of GTCS patients. Decreased homotopic coordination in the DMN can be used as an effective biomarker to reflect seizure effects and distinguish children with GTCS from typically developing children.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Isabelle Lambert, Nicolas Roehri, Julie Fayerstein, Bernard Giusiano, Bruno Colombet, Christian-George Benar, Fabrice Bartolomei
Summary: This study investigated changes in thalamo-cortical and cortico-cortical connectivity during different sleep stages using stereoelectroencephalography (SEEG) recordings in humans. The results showed stronger connectivity between the thalamus and other brain regions during N2 and REM sleep compared to N3 sleep, while N3 sleep exhibited stronger cortico-cortical connectivity. The thalamus played a driving role in thalamo-insular connectivity during REM sleep.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Lucio M. Schiapparelli, Yi Xie, Pranav Sharma, Daniel B. McClatchy, Yuanhui Ma, John R. Yates III, Anton Maximov, Hollis T. Cline
Summary: Neuronal activity triggers signaling cascades that lead to structural and functional neuronal plasticity, as well as metabolic changes. By quantitatively analyzing the dynamic changes in newly synthesized proteins (NSPs) induced by activity in genetically defined cortical glutamatergic neurons, this study identified downstream mediators of neuronal plasticity.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biology
Jian Carlo Nocon, Howard J. Gritton, Nicholas M. James, Rebecca A. Mount, Zhili Qu, Xue Han, Kamal Sen
Summary: By studying the auditory cortex of mice, it is found that parvalbumin neurons play a critical role in encoding complex scenes through timing-based coding, improving the cortex's ability to process dynamic stimuli and reducing cortical noise, thereby enhancing the representation of dynamic stimuli in complex scenes.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Tingting Yang, Cuihua Yan, Tao Han, Huai Kuanwu, Junji Hu, Yujiao Wu, Yang Jin, Jing Jiang, Wuliu Xue
Summary: This study confirms the efficacy and safety of ZNS as the first additional treatment for focal or sBTCS in Chinese patients, with a high short-term retention rate.
Article
Neurosciences
Martin Field, Istvan P. Lukacs, Emily Hunter, Richard Stacey, Puneet Plaha, Laurent Livermore, Olaf Ansorge, Peter Somogyi
Summary: The study found that specific types of interneurons in the human neocortex, such as rosehip cells and layer 2-3 innervating cells, exhibit larger tonic GABA(A) receptor currents compared to other interneuron types, potentially allowing for selective modulation of cortical circuitry. Patient parameters like age, seizures, cancer type, and anticonvulsant treatment were also examined for their potential influence on tonic inhibitory currents in human neurons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Mahmoud Koko, Joshua E. Motelow, Kate E. Stanley, Dheeraj R. Bobbili, Ryan S. Dhindsa, Patrick May
Summary: GABRG2 likely plays an important role in familial GGE, while the association of GABAergic signaling gene sets with familial GGE is more prominent than with sporadic GGE.
Article
Endocrinology & Metabolism
Mengyang Xu, Binshi Bo, Mengchao Pei, Yuyan Chen, Christina Y. Shu, Qikai Qin, Lydiane Hirschler, Jan M. Warnking, Emmanuel L. Barbier, Zhiliang Wei, Hanzhang Lu, Peter Herman, Fahmeed Hyder, Zhi-jie Liu, Zhifeng Liang, Garth J. Thompson
Summary: Research utilized a relaxometry-based calibrated fMRI method in mice to map cerebral oxygen metabolism without the need for gas challenges, revealing CMRO2 1.5-2 times higher in awake state compared to anesthetized state. This study confirms the potential of calibrated fMRI in preclinical research.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Endocrinology & Metabolism
Yury Koush, Douglas L. Rothman, Kevin L. Behar, Robin A. de Graaf, Fahmeed Hyder
Summary: Functional magnetic resonance spectroscopy (fMRS) plays a vital role in uncovering metabolic conditions in the brain, particularly in measuring metabolites during task-induced and resting states. By utilizing ultra-high magnetic fields and J-difference editing techniques, fMRS can provide more accurate and reliable quantification. Combining fMRS measurements with fMRI is crucial for understanding normal brain function and neurological and neuropsychiatric disorders.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Biophysics
Abul B. M. Zakaria, Yuegao Huang, Daniel Coman, Sandeep K. Mishra, Jelena M. Mihailovic, Samuel Maritim, Federico A. Rojas-Quijano, Paul Jurek, Garry E. Kiefer, Fahmeed Hyder
Summary: This article describes paramagnetic agents that provide physiological information through two mechanisms in magnetic resonance imaging (MRI) and magnetic resonance spectroscopic imaging (MRSI). MRI utilizing chemical exchange saturation transfer (CEST) can create pH contrast by utilizing the exchangeable protons of the agent. The non-exchangeable protons of the agent can be used to map tissue temperature and/or pH using a method called biosensor imaging of redundant deviation in shifts (BIRDS). In addition, new tetra-amide chelates were synthesized and modified to improve sensor performance.
NMR IN BIOMEDICINE
(2022)
Article
Biophysics
Jelena M. Mihailovic, Yuegao Huang, John J. Walsh, Muhammad H. Khan, Sandeep K. Mishra, Sara Samuels, Fahmeed Hyder, Daniel Coman
Summary: The study explores high-resolution pH imaging in vivo by combining CEST and BIRDS imaging techniques, investigating the impact of temperature on imaging results. Results show that the temperature calibration performed by BIRDS allows for more accurate pH measurement, enabling high-resolution pH imaging.
NMR IN BIOMEDICINE
(2022)
Article
Oncology
Fahmeed Hyder, Muhammad H. Khan
Summary: Acidity and salinity of the extracellular fluid play important roles in regulating cellular functions, especially in cancer. Pioneering imaging of extracellular acidity and salinity holds promise for early cancer diagnosis and tracking therapies.
TRANSLATIONAL ONCOLOGY
(2022)
Review
Endocrinology & Metabolism
J. Jean Chen, Biranavan Uthayakumar, Fahmeed Hyder
Summary: Recent studies have shown that gas-free calibrated fMRI can effectively measure the cerebral metabolic rate of oxygen consumption (CMRO2) and have potential clinical applications. This review highlights the technological advances in gas-free calibrated fMRI experiments and their impact on neurological and neurodegenerative disease research.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Clinical Neurology
Patrick D. Lyden, Francesca Bosetti, Marcio A. Diniz, Andre Rogatko, James Koenig, Jessica Lamb, Karisma A. Nagarkatti, Ryan P. Cabeen, David C. Hess, Pradip K. Kamat, Mohammad B. Khan, Kristofer Wood, Krishnan Dhandapani, Ali S. Arbab, Enrique C. Leira, Anil K. Chauhan, Nirav Dhanesha, Rakesh B. Patel, Mariia Kumskova, Daniel Thedens, Andreia Morais, Takahiko Imai, Tao Qin, Cenk Ayata, Ligia S. B. Boisserand, Alison L. Herman, Hannah E. Beatty, Sofia E. Velazquez, Sebastian Diaz-Perez, Basavaraju G. Sanganahalli, Jelena M. Mihailovic, Fahmeed Hyder, Lauren H. Sansing, Raymond C. Koehler, Steven Lannon, Yanrong Shi, Senthilkumar S. Karuppagounder, Adnan Bibic, Kazi Akhter, Jaroslaw Aronowski, Louise D. McCullough, Anjali Chauhan, Andrew Goh
Summary: Cerebral ischemia and reperfusion lead to neurological disabilities, and developing successful stroke treatments has been challenging. The Stroke Preclinical Assessment Network (SPAN) aims to reduce bias in treatment selection for clinical studies by rigorously assessing candidate treatments across multiple research laboratories. The first stage of SPAN successfully implemented standardized procedures, randomization, and blinded assessment. Subsequent stages will evaluate candidate treatments using aged animals and animals with comorbid conditions.
Article
Medicine, General & Internal
Miao Zhang, Qikai Qin, Shuning Zhang, Wei Liu, Hongping Meng, Mengyang Xu, Xinyun Huang, Xiaozhu Lin, Mu Lin, Peter Herman, Fahmeed Hyder, Raymond C. Stevens, Zheng Wang, Biao Li, Garth J. Thompson
Summary: For patients with temporal lobe epilepsy, OGI imaging during inter-ictal period shows higher values on the same side as the epileptic focus compared to the opposite side. OGI results agree with invasive electrophysiology, providing promising insights into metabolic changes in epilepsy.
Article
Neurosciences
Yuguo Yu, Adil Akif, Peter Herman, Miao Cao, Douglas L. Rothman, Richard E. Carson, Divyansh Agarwal, Alan C. Evans, Fahmeed Hyder
Summary: This study establishes a digital 3D atlas of cortical energy based on the energetic costs of different cortical regions. The atlas is validated using glucose oxidation measurements and reveals heterogeneous activity rates across cortical regions. The distribution of synaptic connections plays a crucial role in cortical energetics. Additionally, some cortical areas act as hubs with higher metabolic rates and synaptic density. The open-source BrainEnergyAtlas provides a granular framework for exploring design principles in energy-constrained human cortical circuits.
Article
Neurosciences
D. O'Connor, F. Mandino, X. Shen, C. Horien, X. Ge, P. Herman, F. Hyder, M. Crair, X. Papademetris, E. M. R. Lake, R. T. Constable
Summary: To improve the translation from the laboratory to the clinic, it is essential to have bidirectional knowledge flow between animal models and humans. This study presents a new pipeline for the preprocessing of wide-field optical fluorescence imaging data, along with functional connectivity and graph theory analyses inspired by recent work in human neuroimaging. The results demonstrate the usefulness of these approaches in quantifying differences between wakefulness states and cell populations, aiding translational neuroscience efforts.
Article
Geriatrics & Gerontology
Line S. Reitlo, Jelena M. Mihailovic, Dorthe Stensvold, Ulrik Wisloff, Fahmeed Hyder, Asta Kristine Haberg
Summary: The study aimed to investigate the differences in hippocampal metabolites for neuronal viability and cell membrane density between older adults performing supervised exercise and those following national physical activity guidelines. The results showed that supervised exercise led to lower NAA/Cr levels in the hippocampal body compared to following guidelines. Higher training intensity was associated with lower Cho/Cr levels in the hippocampal body. Lower NAA/Cr levels were associated with poorer psychological health and slightly higher cognitive scores. Following national guidelines and not training at the highest intensity level resulted in the best neurochemical profile in the hippocampus at 3 years.
Article
Biochemistry & Molecular Biology
Mauro DiNuzzo, Gerald A. Dienel, Kevin L. Behar, Ognen A. Petroff, Helene Benveniste, Fahmeed Hyder, Federico Giove, Shalom Michaeli, Silvia Mangia, Suzana Herculano-Houzel, Douglas L. Rothman
Summary: During brain activation, cerebral blood flow increases more than cerebral metabolic rate of oxygen consumption, resulting in blood hyperoxygenation. The high neurovascular coupling constant in the brain is maintained to support mitochondrial ATP production and maintain homeostasis of pH, pCO2, and pO2. The optimal values of the neurovascular coupling constant and oxygen extraction fraction (OEF) are remarkably similar to their experimental values.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Cell Biology
Patrick D. Lyden, Marcio A. Diniz, Francesca Bosetti, Jessica Lamb, Karisma A. Nagarkatti, Andre Rogatko, Sungjin Kim, Ryan P. Cabeen, James I. Koenig, Kazi Akhter, Ali S. Arbab, Brooklyn D. Avery, Hannah E. Beatty, Adnan Bibic, Suyi Cao, Ligia Simoes Braga Boisserand, Angel Chamorro, Anjali Chauhan, Sebastian Diaz-Perez, Krishnan Dhandapani, Nirav Dhanesha, Andrew Goh, Alison L. Herman, Fahmeed Hyder, Takahiko Imai, Conor W. Johnson, Mohammad B. Khan, Pradip Kamat, Senthilkumar S. Karuppagounder, Mariia Kumskova, Jelena M. Mihailovic, Joseph B. Mandeville, Andreia Morais, Rakesh B. Patel, Basavaraju G. Sanganahalli, Cameron Smith, Yanrong Shi, Brijesh Sutariya, Daniel Thedens, Tao Qin, Sofia E. Velazquez, Jaroslaw Aronowski, Cenk Ayata, Anil K. Chauhan, Enrique C. Leira, David C. Hess, Raymond C. Koehler, Louise D. Mccullough, Lauren H. Sansing
Summary: Human diseases can be modeled in animals for preclinical assessment of new clinical interventions, but recent failures in clinical trials have raised concerns about the value of preclinical assessment. To address this issue, we established the Stroke Preclinical Assessment Network (SPAN) and conducted a rigorous, multi-laboratory trial to evaluate candidate stroke treatments. By following a common protocol, six independent research laboratories enrolled 2615 animals and achieved full data completion and comprehensive animal tracking.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Ryan P. Cabeen, Joseph Mandeville, Fahmeed Hyder, Basavaraju G. Sanganahalli, Daniel R. Thedens, Ali S. Arbab, Shuning Huang, Adnan Bibic, Erendiz Tarakci, Jelena Mihailovic, Andreia Morais, Jessica Lamb, Karisma Nagarkatti, Arthur W. Toga, Patrick Lyden, Cenk Ayata
Summary: This study developed a pipeline for image-based stroke outcome quantification to improve the assessment quality and scalability of potential therapeutic interventions in rodent models. By analyzing multi-parameter MRI data, including measures of lesion extent and longitudinal changes, the study revealed the overall effects and long-term variations of stroke injury. The validated method may serve as a promising resource for future preclinical studies.
2023 IEEE 20TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING, ISBI
(2023)