Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: A preliminary study

We measured brain metabolites in the medial prefrontal cortex of 19 schizophrenic patients and 18 healthy controls by 3T proton magnetic resonance spectroscopy (H-1 MRS). and examined the relationship between prefrontal cortex-related neurocognitive functions and brain metabolites In the medial prefrontal cortex The patients with schizophrenia exhibited deficits oil the verbal fluency, Wisconsin card sorting test (WCST). trail making rest, Stroop test and digit span distraction test (DSDT). but not on the Iowa gambling test The patients showed statistical significant changes in the ratio of glutamine/glutamate. the ratio of N-acetyl-1-aspartate (NAA)/glycerophosphorylcholine plus phosphorylcholine (GPC + PC) and the levels of taurine in the medial prefrontal cortex compared with normal controls Furthermore, We found significant correlations h of the ratio of glutamine/glutamate with WCST and DSDT scores the ratio of NAA/(GPC + PC) with verbal fluency and WCST scores, and the levels of taurine with scores on the Snoop test and Trail making test A among the participants The ratios of NAA/(GPC + PC) and (GPC + PC)/(Cr + PCr) had significant relationships with the duration of untreated psychosis of the schizophrenic patients The glutamine/glutamate ratio and levels of taurine were significantly related to the duration of Illness of the patients These data Suggest that specific metabolites of the medial prefrontal cortex are associated with the neurocognitive deficits In schizophrenia (C) 2009 Elseviei Inc All rights reserved.