Article
Clinical Neurology
Daniel Ontaneda, Praneeta C. Raza, Kedar R. Mahajan, Douglas L. Arnold, Michael G. Dwyer, Susan A. Gauthier, Douglas N. Greve, Daniel M. Harrison, Roland G. Henry, David K. B. Li, Caterina Mainero, Wayne Moore, Sridar Narayanan, Jiwon Oh, Raihaan Patel, Daniel Pelletier, Alexander Rauscher, William D. Rooney, Nancy L. Sicotte, Roger Tam, Daniel S. Reich, Christina J. Azevedo
Summary: Multiple sclerosis is not only a white matter disease, but also involves grey matter injury, especially in deep grey matter regions. The deep grey matter is uniquely suited for studying the mechanisms and clinical relevance of tissue injury in multiple sclerosis using magnetic resonance techniques. MRI characterization of deep grey matter properties has potential as clinical trial end points for neurodegenerative aspects of multiple sclerosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ingrid Anne Lie, Emma Kerklingh, Kristin Wesnes, David R. van Nederpelt, Iman Brouwer, Oivind Torkildsen, Kjell-Morten Myhr, Frederik Barkhof, Lars Bo, Hugo Vrenken
Summary: This study aimed to determine whether reliable brain atrophy measures can be obtained from post-contrast 3D T1-weighted images using FreeSurfer in patients with multiple sclerosis (MS). The results showed excellent consistency between measures obtained from pre- and post-contrast images, suggesting the possibility of extracting reliable brain atrophy measurements. However, there were systematic differences in absolute values between pre- and post-contrast images, indicating the need for further investigation into potential systematic effects.
EUROPEAN RADIOLOGY
(2022)
Article
Neuroimaging
Alexandra de Sitter, Jessica Burggraaff, Fabian Bartel, Miklos Palotai, Yaou Liu, Jorge Simoes, Serena Ruggieri, Katharina Schregel, Stefan Ropele, Maria A. Rocca, Claudio Gasperini, Antonio Gallo, Menno M. Schoonheim, Michael Amann, Marios Yiannakas, Deborah Pareto, Mike P. Wattjes, Jaume Sastre-Garriga, Ludwig Kappos, Massimo Filippi, Christian Enzinger, Jette Frederiksen, Bernard Uitdehaag, Charles R. G. Guttmann, Frederik Barkhof, Hugo Vrenken
Summary: This study successfully established a standardized protocol for manual delineations of deep grey matter structures, demonstrating good reliability among different raters. The fast-semi-automated segmentation approach FASTSURF showed high accuracy in reproducing complete segmentations of deep grey matter based on sparse delineations.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Rosa Cortese, Marco Battaglini, Maria Pia Sormani, Ludovico Luchetti, Giordano Gentile, Maira Inderyas, Nektaria Alexandri, Nicola De Stefano
Summary: This study found that treatment with cladribine 3.5 mg/kg can significantly reduce grey matter (GM) atrophy in patients with relapsing multiple sclerosis (MS) compared to placebo, after a short period of pseudoatrophy. The study also suggests that GM damage is relevant in MS and may have important implications for physical and cognitive disability progression.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neuroimaging
Jessica Burggraaff, Yao Liu, Juan C. Prieto, Jorge Simoes, Alexandra de Sitter, Serena Ruggieri, Iman Brouwer, Birgit Lissenberg-Witte, Mara A. Rocca, Paola Valsasina, Stefan Ropele, Claudio Gasperini, Antonio Gallo, Deborah Pareto, Jaume Sastre-Garriga, Christian Enzinger, Massimo Filippi, Nicola De Stefano, Olga Ciccarelli, Hanneke E. Hulst, Mike P. Wattjes, Frederik Barkhof, Bernard M. J. Uitdehaag, Hugo Vrenken, Charles R. G. Guttmann
Summary: Thalamus atrophy has been consistently associated with cognitive decline in multiple sclerosis (MS), and both manual and automated segmentation methods demonstrate this correlation. However, there may be a proportional bias in smaller thalami, and the choice of MRI vendor can also impact the findings.
NEUROIMAGE-CLINICAL
(2021)
Article
Behavioral Sciences
Marja Niiranen, Juha Koikkalainen, Jyrki Lotjonen, Tuomas Selander, Antti Cajanus, Paivi Hartikainen, Sakari Simula, Ritva Vanninen, Anne M. Remes
Summary: This study found differences in brain structures between benign relapsing-remitting multiple sclerosis (BRRMS) and aggressive relapsing-remitting multiple sclerosis (ARRMS), with thalamic volume being the most prominent differentiating measure. In addition, the validation of automated quantification of corpus callosum index (CCI) provides an applicable MRI biomarker to detect brain atrophy in multiple sclerosis.
BRAIN AND BEHAVIOR
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Loredana Storelli, Elisabetta Pagani, Patrizia Pantano, Claudia Piervincenzi, Gioacchino Tedeschi, Antonio Gallo, Nicola De Stefano, Marco Battaglini, Maria A. Rocca, Massimo Filippi, INNI Network
Summary: This study compared different methods for measuring whole-brain and gray matter atrophy using the INNI dataset, and found that SPM-v12 and Jim-v8 software showed significant agreement in assessing gray matter volumes and atrophy progression.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Dumitru Ciolac, Gabriel Gonzalez-Escamilla, Yaroslav Winter, Nico Melzer, Felix Luessi, Angela Radetz, Vinzenz Fleischer, Stanislav A. Groppa, Michael Kirsch, Stefan Bittner, Frauke Zipp, Muthuraman Muthuraman, Sven G. Meuth, Matthias Grothe, Sergiu Groppa
Summary: In patients with epilepsy, multiple sclerosis patients have larger lesion volumes in the hippocampus, mesiotemporal cortex, and amygdala, smaller cortical volumes, and higher network topology compared to healthy subjects. The volume of the hippocampus can be used to differentiate patients with epilepsy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Serena Ruggieri, Maria Petracca, Laura De Giglio, Francesca De Luca, Costanza Gianni, Flavia Gurreri, Nikolaos Petsas, Silvia Tommasin, Carlo Pozzilli, Patrizia Pantano
Summary: The study found that brain and spinal cord atrophy in multiple sclerosis have a significant impact on disability worsening. The presence of both brain and spinal cord atrophy is the strongest correlate of disability progression over time, while isolated spinal cord atrophy also leads to disability worsening.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Jenny A. Nij Bijvank, Sam N. Hof, Stefanos E. Prouskas, Menno M. Schoonheim, Bernard M. J. Uitdehaag, Laurentius J. van Rijn, Axel Petzold
Summary: Double-step saccades can serve as a robust metric for evaluating clinical, cognitive, and visual functioning, as well as global and local grey matter atrophy in multiple sclerosis, making it a potential new outcome measure for remyelination trials.
Article
Clinical Neurology
Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Deborah Pareto, Alex Rovira, Jaume Sastre-Garriga, Piotr Sowa, Einar A. Hogestol, Hanne F. Harbo, Barbara Bellenberg, Carsten Lukas, Serena Ruggieri, Claudio Gasperini, Tomas Uher, Manuela Vaneckova, Stefan Bittner, Ahmed E. Othman, Sara Collorone, Ahmed T. Toosy, Sven G. Meuth, Frauke Zipp, Frederik Barkhof, Olga Ciccarelli, Sergiu Groppa
Summary: This study investigated the prognostic value of longitudinal structural networks in predicting 5-year Expanded Disability Status Scale (EDSS) progression in relapsing-remitting multiple sclerosis (RRMS) patients. The study found that changes in network degree and global efficiency can predict disability accumulation independent of disease activity, and these network measures outperform conventional MRI predictors in predicting EDSS worsening.
Article
Clinical Neurology
Paolo Preziosa, Elisabetta Pagani, Alessandro Meani, Olga Marchesi, Lorenzo Conti, Andrea Falini, Maria A. Rocca, Massimo Filippi
Summary: Using diffusion tensor and neurite orientation dispersion and density imaging (NODDI), this study found that neuro-axonal damage and loss of microarchitecture integrity in focal WM lesions, NAWM, and GM contribute to cognitive impairment in MS.
JOURNAL OF NEUROLOGY
(2023)
Article
Behavioral Sciences
Juichi Fujimori, Kazuo Fujihara, Mike Wattjes, Ichiro Nakashima
Summary: The study found that cortical gray matter thickness reduction patterns in multiple sclerosis (MS) patients are mainly characterized by the degree of temporal lobe cortical atrophy, which may start in the relapsing-remitting phase. As the disease progresses, neurodegenerative changes in the temporal pole region may accelerate in the progressive phase.
BRAIN AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Peiyuan Zhao, Xihong Liu, Yunqian Wang, Xinyan Zhang, Han Wang, Xiaodan Du, Zhixin Du, Liping Yang, Junlin Hou
Summary: This study investigated the gray matter lesion-related genes in multiple sclerosis (MS) and identified TLR9, CCL5, CXCL8, and PDGFRB as potential biomarkers for gray matter injuries in MS. A reliable prediction model was established, and gene enrichment analysis revealed their association with cell adhesion molecules, cytokine-cytokine receptor interaction, and the JAK-STAT signaling pathway. These findings provide guidance for therapeutic intervention in MS.
Article
Clinical Neurology
Hiroaki Yokote, Yusei Miyazaki, Shuta Toru, Yoichiro Nishida, Takaaki Hattori, Masaaki Niino, Nobuo Sanjo, Takanori Yokota
Summary: The study found that high-efficacy therapy (HET) significantly improves the mid-term prognosis of patients with multiple sclerosis compared to low-efficacy therapy (LET), reducing disease activity and regional brain volume loss.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Ralf Gold, Douglas L. Arnold, Amit Bar-Or, Robert J. Fox, Ludwig Kappos, Oksana Mokliatchouk, Xiaotong Jiang, Jennifer Lyons, Shivani Kapadia, Catherine Miller
Summary: This study assessed the long-term safety and efficacy of dimethyl fumarate (DMF) in multiple sclerosis patients for up to 13 years. The results demonstrate sustained safety and efficacy of DMF treatment, with low annualized relapse rates and a majority of patients showing no disability worsening over the long-term treatment period. This supports the positive benefit-risk profile of DMF for long-term RRMS treatment.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Neuroimaging
Ana L. Manera, Mahsa Dadar, D. Louis Collins, Simon Ducharme
Summary: This study used an automated tool to analyze lateral ventricles and found that ventricular features, particularly the antero-posterior ratio (APR), may be reliable and easy-to-implement markers for the diagnosis of behavioral variant frontotemporal dementia (bvFTD). Differentiating bvFTD from other dementia cohorts achieved a high accuracy using either other ventricular features or just the APR feature alone.
NEUROIMAGE-CLINICAL
(2022)
Article
Neuroimaging
Cassandra Morrison, Mahsa Dadar, Neda Shafiee, Sylvia Villeneuve, D. Louis Collins
Summary: Using different methods to define subjective cognitive decline (SCD) can affect the results of volume differences and cognitive decline findings among cognitively normal older adults in this study.
NEUROIMAGE-CLINICAL
(2022)
Article
Geriatrics & Gerontology
Mahsa Dadar, Ana Laura Manera, Simon Ducharme, D. Louis Collins
Summary: White matter hyperintensities may have a synergistic effect in the neurodegenerative processes of mild cognitive impairment, Alzheimer's dementia, and fronto-temporal dementia, affecting grey matter atrophy and cognition.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
John D. Lewis, Henriette Acosta, Jetro J. Tuulari, Vladimir S. Fonov, D. Louis Collins, Noora M. Scheinin, Satu J. Lehtola, Aylin Rosberg, Kristian Lidauer, Elena Ukharova, Jani Saunavaara, Riitta Parkkola, Tuire Lahdesmaki, Linnea Karlsson, Hasse Karlsson
Summary: The corpus callosum is the largest fiber tract in the human brain, connecting homologous areas of the two cerebral hemispheres. Sex differences exist in the allometric relationships between the size of the corpus callosum and brain size, and these differences are already present in newborns, suggesting that sexual dimorphism in brain lateralization may have prenatal origins.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Jens Kuhle, Tanuja Chitnis, Brenda Banwell, Marc Tardieu, Douglas L. Arnold, Andreea M. Rawlings, Svend S. Geertsen, Alex L. Lublin, Stephane Saubadu, Philippe Truffinet, Ludwig Kappos
Summary: The TERIKIDS study demonstrated that teriflunomide is effective and safe in children with relapsing multiple sclerosis (RMS). Teriflunomide treatment is associated with significantly reduced pNfL levels in children with RMS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Geriatrics & Gerontology
Cassandra Morrison, Mahsa Dadar, Ana L. Manera, D. Louis Collins
Summary: White matter hyperintensities (WMHs) may be an early pathological change in aging. The study examined the influence of race on WMHs and whether these differences are influenced by vascular risk factors. Results showed that vascular risk factors had higher prevalence in Blacks than Whites. After controlling for vascular factors, only the longitudinal parietal WMH group differences remained significant, suggesting that vascular factors contribute to racial group differences observed in WMHs.
NEUROBIOLOGY OF AGING
(2023)
Article
Neurosciences
Bastien Caba, Alexandre Cafaro, Aurelien Lombard, Douglas L. Arnold, Colm Elliott, Dawei Liu, Xiaotong Jiang, Arie Gafson, Elizabeth Fisher, Shibeshih Mitiku Belachew, Nikos Paragios
Summary: In this study, a novel machine learning approach is developed for the automatic detection of acute multiple sclerosis (MS) lesions using single-timepoint non-contrast T1- and T2-weighted brain MRI. By using image inpainting, the MRI input data is supplemented, and a multi-objective statistical ranking module and ensemble classifier are used for analysis, leading to the identification of a compact textural signature characterizing the lesion phenotype. Our method achieves a balanced accuracy in the range of 74.3-74.6% on fully external validation cohorts for the patch-level task of acute versus chronic MS lesion classification.
Article
Geriatrics & Gerontology
Cassandra Morrison, Mahsa Dadar, Sylvia Villeneuve, Simon Ducharme, D. Louis Collins
Summary: Increased age and cognitive impairment are associated with an increase in cerebrovascular pathology. Different methods of classifying subjective cognitive decline (SCD) result in different white matter hyperintensities (WMHs) burden between those with SCD and those without SCD. The various methods used to define SCD may reflect different types of underlying pathologies.
Article
Clinical Neurology
Colm Elliott, David A. Rudko, Douglas L. Arnold, Dumitru Fetco, Ahmed M. Elkady, David Araujo, Bing Zhu, Arie Gafson, Zhe Tian, Shibeshih Belachew, Daniel P. Bradley, Elizabeth Fisher
Summary: This study aimed to assess the lesion-level concordance between paramagnetic rim lesions (PRLs) and slowly expanding lesions (SELs) in chronic active lesions (CALs) of multiple sclerosis (MS), and to characterize changes in brain tissue integrity in CALs. The results showed that co-localization of PRLs and SELs was associated with rapid expansion and worsening of microstructural damage over time, and both SELs with and without co-localization with PRLs showed ongoing tissue damage. Therefore, the coexistence of PRLs and SELs is associated with severe accumulation of tissue damage.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Multidisciplinary Sciences
Victoria Madge, Vladimir S. Fonov, Yiming Xiao, Lucy Zou, Courtney Jackson, Ronald B. Postuma, Alain Dagher, Edward A. Fon, D. Louis Collins
Summary: Parkinson's disease (PD) is a complex neurodegenerative disorder that affects various brain regions. This study presents MRI templates created from multiple contrast MRI modalities, including T1w, T2*w, T1-T2* fusion, R2*, T2w, PDw, FLAIR, susceptibility-weighted imaging, and neuromelanin-sensitive MRI. The templates were created from PD patients and healthy controls, and the dataset is publicly available on the NIST MNI Repository and NITRC.
Article
Neurosciences
John D. Lewis, Vladimir S. Fonov, D. Louis Collins
Summary: This study examines the impact of blood-flow artifacts on the registration of T1-weighted data to a template using data from the Autism Brain Imaging Data Exchange. By identifying and partially removing blood-flow artifacts, we found that registering deblooded data to a template resulted in significantly higher similarity values compared to registering original data. This highlights the potential serious impact of blood-flow artifacts on data processing that relies on template registration.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Elisa Colato, Ferran Prados, Jonathan Stutters, Alessia Bianchi, Sridar Narayanan, Douglas L. Arnold, Claudia Wheeler-Kingshott, Frederik Barkhof, Olga Ciccarelli, Declan T. Chard, Arman Eshaghi
Summary: Network-based measures of white and grey matter damage can predict disability progression and cognitive worsening in multiple sclerosis (MS). This study has important implications for identifying patients at risk of disease worsening and for stratifying cohorts in treatment trials.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Barry A. Singer, Douglas L. Arnold, Jelena Drulovic, Mark S. Freedman, Ralf Gold, Mark Gudesblatt, Elzbieta Jasinska, Christopher C. Laganke, Robert T. Naismith, Donald Negroski, Jiwon Oh, Miguel Angel Hernandez Perez, Krzysztof Selmaj, Florian Then Bergh, Annette Wundes, Tjalf Ziemssen, Wanda Castro-Borrero, Hailu Chen, Seth Levin, Matthew Scaramozza, Sai L. Shankar, Ting Wang, Sibyl Wray
Summary: DRF was generally well tolerated over 2 years, with few discontinuations due to AEs; radiological measures indicated decreased disease activity from baseline. These outcomes support DRF as a treatment option in patients with RRMS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Alfie Wearn, Lars Lau Raket, D. Louis Collins, R. Nathan Spreng
Summary: Early detection of Alzheimer's disease is crucial for preventive treatment strategies. Texture analysis of the hippocampus can detect microstructural changes before cognitive impairment occurs, providing additional information beyond hippocampal volume for predicting future cognitive decline.
BRAIN COMMUNICATIONS
(2023)