Article
Chemistry, Physical
Sang Gu Ji, Haesol Kim, Woong Hee Lee, Hyung-Suk Oh, Chang Hyuck Choi
Summary: Carbon materials are commonly used as supporting substrates for electrocatalysis due to their high conductivity and chemical inertness. Understanding and preventing corrosion are crucial for long-lasting electrocatalysis. Real-time monitoring of CO2 evolution by DEMS provides valuable information about carbon corrosion, and using CO as a corrosion marker allows successful monitoring of corrosion in both acidic and alkaline media. Corrosion in alkaline media is qualitatively similar to that in acidic media but is quantitatively alleviated.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Psychology, Developmental
Carolina Badke D'Andrea, Jeanette K. Kenley, David F. Montez, Amy E. Mirro, Ryland L. Miller, Eric A. Earl, Jonathan M. Koller, Sooyeon Sung, Essa Yacoub, Jed T. Elison, Damien A. Fair, Nico U. F. Dosenbach, Cynthia E. Rogers, Christopher D. Smyser, Deanna J. Greene
Summary: Imaging the infant brain with MRI has improved our understanding of early neurodevelopment. However, head motion during MRI acquisition is detrimental to both functional and structural MRI scan quality. Providing MRI technicians with real-time motion estimates via FIRMM software can help obtain high-quality, low motion fMRI data in infants. The addition of FIRMM significantly increased the amount of usable fMRI data acquired per infant, demonstrating its value for research and clinical infant neuroimaging.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2022)
Article
Biology
Ziqi Yu, Xiaoyang Han, Wenjing Xu, Jie Zhang, Carsten Marr, Dinggang Shen, Tingying Peng, Xiao-Yong Zhang, Jianfeng Feng
Summary: This study proposes a domain-adaptive and semi-supervised deep neural network called Brain Extraction Net (BEN) for extracting brain tissues across species, MRI modalities, and MR scanners. Compared to conventional toolboxes, BEN demonstrates superior robustness, accuracy, and generalizability.
Article
Chemistry, Multidisciplinary
Jinping Tang, Li Song, Han Xie, Jinyu Zhu, Wei Li, Guangyang Xu, Linjun Cai, Xiao Xia Han
Summary: The study demonstrates the potential of SERRS for monitoring the interaction between mitochondria and endoplasmic reticula in apoptosis. SERRS allows for label-free, in situ, and real-time monitoring of ROS formation and cytochrome c release, providing a novel strategy for cancer treatment.
Review
Biophysics
Nathalie Just
Summary: H-1-fMRS in the human brain is a valuable technique to evaluate and quantify metabolic responses to localized brain activity, providing insights into brain functioning and connectivity. Understanding healthy brain metabolism during tasks is crucial for detecting and characterizing neurochemical changes associated with neurological disorders, while new techniques like optogenetics may offer more specificity in investigating brain cell populations and molecular changes.
NMR IN BIOMEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Yi Zhao, Kai-Qi Jin, Jing-Du Li, Kai-Kai Sheng, Wei-Hua Huang, Yan-Ling Liu
Summary: The development of flexible and stretchable electronics has revolutionized biosensor techniques for probing biological systems. Flexible and stretchable electrochemical sensors (FSECSs) enable the in situ quantification of biochemical molecules in different biological entities due to their exceptional sensitivity, fast response, and easy miniaturization. This review discusses the key developments in electrode fabrication and FSECSs functionalization, as well as their applications in exploring the chemical information from different biological entities. Current challenges and future opportunities for FSECSs are also highlighted.
ADVANCED MATERIALS
(2023)
Article
Biochemical Research Methods
Samuel Dulay, Lourdes Rivas, Laura Pla, Sergio Berdun, Elisenda Eixarch, Eduard Gratacos, Miriam Illa, Monica Mir, Josep Samitier
Summary: Novel micro-implantable multiparametric electrochemical sensors were developed for real-time monitoring of ischemia in fetal tissues and blood vessels. The sensors demonstrated high sensitivity in detecting oxygen and pH changes during ischemic conditions, showing potential for future medical applications in fetal monitoring.
JOURNAL OF BIOLOGICAL ENGINEERING
(2021)
Article
Endocrinology & Metabolism
Yaoheng Yang, Jinyun Yuan, Rachael L. Field, Dezhuang Ye, Zhongtao Hu, Kevin Xu, Lu Xu, Yan Gong, Yimei Yue, Alexxai V. Kravitz, Michael R. Bruchas, Jianmin Cui, Jonathan R. Brestoff, Hong Chen
Summary: By using ultrasound to activate specific neurons in the hypothalamus, researchers have successfully induced a torpor-like state in rodents, characterized by hypothermia and reduced metabolic rate. This noninvasive technique involves closed-loop feedback control of ultrasound stimulation and automated detection of body temperature. The study identifies TRPM2 as an ultrasound-sensitive ion channel in the hypothalamus preoptic area, and demonstrates the feasibility of ultrasound-induced hypothermia and hypometabolism in non-torpid animals.
Article
Computer Science, Information Systems
Gihyoun Lee, Ji-Su Park, Jungsoo Lee, Jinuk Kim, Young-Jin Jung, Yun-Hee Kim
Summary: OptoNet II is an advanced MATLAB toolbox developed to efficiently analyze brain connectivity and overcome the limitations of its predecessor. Through a finger-tapping task experiment, it effectively demonstrates the impact of tDCS on functional brain region connectivity. This toolbox is a useful tool for researchers conducting cortical connectivity analysis using fNIRS.
Article
Neurosciences
J. R. Garrison, F. Saviola, E. Morgenroth, H. Barker, M. Luhrs, J. S. Simons, C. Fernyhough, P. Allen
Summary: Neurofeedback can modulate mPFC activity and increase cooperation between the FPN and DMN, but its effects on reality monitoring performance are less clear.
Article
Chemistry, Analytical
Marsilea A. Booth, Sally A. N. Gowers, Melinda Hersey, Isabelle C. Samper, Seongjun Park, Polina Anikeeva, Parastoo Hashemi, Molly M. Stevens, Martyn G. Boutelle
Summary: The study explored the potential of polymer fibers as a platform for sensing pH and neurometabolic lactate, successfully detecting transient lactate changes in an in vivo mouse model. The changes in lactate concentration were associated with spreading depolarizations.
ANALYTICAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Clement Brunner, Nielsen Lagumersindez Denis, Karen Gertz, Micheline Grillet, Gabriel Montaldo, Matthias Endres, Alan Urban
Summary: Ischemic stroke causes abrupt neurologic deficits and little is known about early hemodynamic changes in the brain. This study used functional ultrasound imaging to monitor relative cerebral blood volume (rCBV) variations after stroke onset in rats. Two stroke models were compared and a typical hemodynamic pattern was observed, with a drop in rCBV followed by reperfusion of nearby brain regions. The severity and location of the ischemia varied within the groups, with infarcts extending to non-ischemic regions associated with spreading depolarizations.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Electrochemistry
M. G. Strebl, M. P. Bruns, S. Virtanen
Summary: A highly sensitive respirometric method is developed for real-time monitoring of reaction rates involving H-2 and O-2 during electrochemical polarization. The method allows quantification of rates resulting from reactions such as HER, ORR, and OER based on simultaneous monitoring of total pressure and O-2 partial pressure changes. It enables deconvolution of net electric current into cathodic and anodic partial reaction rates and determination of the true metal oxidation rate. The respirometric monitoring approach also distinguishes the rate of O-2 evolution from electrode oxidation processes.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Review
Biotechnology & Applied Microbiology
Maria Grazia Tupone, Michele d'Angelo, Vanessa Castelli, Mariano Catanesi, Elisabetta Benedetti, Annamaria Cimini
Summary: Exploring and developing multifunctional intelligent biomaterials is crucial for improving next-generation therapies in tissue engineering and regenerative medicine. These biomaterials can mimic the in situ microenvironment and provide specialized bioactive signals to regulate the surrounding biological habitat, contributing to wound healing and biomaterial integration. The connection between stem cells and biomaterials can stimulate specific modifications in cell properties and fate, influencing processes such as self-renewal, adhesion, and differentiation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Ryosuke Takegawa, Kei Hayashida, Tai Yin, Rishabh C. Choudhary, Santiago J. Miyara, Houman Khalili, Muhammad Shoaib, Yusuke Endo, Emesto P. Molmenti, Lance B. Becker
Summary: Clinical studies have shown that the timing of decline in regional cerebral oxygen saturation (rSO(2)) after cardiac arrest and cardiopulmonary resuscitation can predict neurological outcomes. This study investigated the relationship between the timing of rSO(2) decline and brain injury severity in a rat model of cardiac arrest. The results suggest that the timing of rSO(2) decline can serve as a predictor of good neurological outcomes after cardiac arrest and cardiopulmonary resuscitation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
John Kealy, Sean Commins, John P. Lowry
Article
Multidisciplinary Sciences
Alison S. Walker, Guilherme Neves, Federico Grillo, Rachel E. Jackson, Mark Rigby, Cian O'Donnell, Andrew S. Lowe, Gema Vizcay-Barrena, Roland A. Fleck, Juan Burrone
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Chemistry, Analytical
Keeley L. Baker, Fiachra B. Bolger, John P. Lowry
SENSORS AND ACTUATORS B-CHEMICAL
(2017)
Article
Optics
Zhengyuan Tang, Sinead J. Barton, Tomas E. Ward, John P. Lowry, Michelle M. Doran, Hugh J. Byrne, Bryan M. Hennelly
Article
Biochemical Research Methods
J. J. O'Connor, K. M. O'Boyle, J. P. Lowry
JOURNAL OF NEUROSCIENCE METHODS
(2018)
Article
Chemistry, Analytical
Keeley L. Baker, Fiachra B. Bolger, Michelle M. Doran, John P. Lowry
Article
Psychiatry
Joao Lima, Trevor Sharp, David M. Bannerman, Stephen B. McHugh
TRANSLATIONAL PSYCHIATRY
(2019)
Article
Neurosciences
John Kealy, Carol Murray, Eadaoin W. Griffin, Ana Belen Lopez-Rodriguez, Daire Healy, Lucas Silva Tortorelli, John P. Lowry, Leiv Otto Watne, Colm Cunningham
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Giuseppe P. Gava, Stephen B. McHugh, Laura Lefevre, Vitor Lopes-dos-Santos, Stephanie Trouche, Mohamady El-Gaby, Simon R. Schultz, David Dupret
Summary: By investigating the topology of neuronal co-activity in the mouse hippocampus network, researchers found that high-activity principal cells form the core of memories, while low-activity cells join co-activity motifs across different operational axes. This organizational principle reveals continuous integration and interaction of hippocampal memories. Gava et al. explore how new associative memories integrate into the network and restructure neural patterns representing prior memories from a graph theoretical perspective.
NATURE NEUROSCIENCE
(2021)
Article
Chemistry, Analytical
Kobi P. Bermingham, Michelle M. Doran, Fiachra B. Bolger, John P. Lowry
Summary: The performance optimization of a polymer/enzyme composite biosensor for monitoring glutamate was conducted in vitro. The biosensor displayed appropriate sensitivity, stability, and biocompatibility, and reliably detected glutamate in neurological monitoring. Implantation experiments in rats demonstrated stable recording and reliable detection of physiological changes in glutamate in response to behavioral/neuronal activation.
ANALYTICA CHIMICA ACTA
(2022)
Article
Neurosciences
Stephen B. McHugh, Vitor Lopes-dos-Santos, Giuseppe P. Gava, Katja Hartwich, Shu K. E. Tam, David M. Bannerman, David Dupret
Summary: The study reveals the crucial role of adult-born granule cells (abDGCs) in controlling the information processing in the hippocampus by promoting sparser population firing and enhancing responses to novel stimuli.
NATURE NEUROSCIENCE
(2022)
Article
Chemistry, Analytical
Gama Theophile Gnahore, Jack L. Kelly, Saidhbhe L. O'Riordan, Fiachra B. Bolger, Michelle M. Doran, Michelle Sands, John P. Lowry
ANALYTICAL METHODS
(2020)
Article
Behavioral Sciences
John Kealy, Rachel Bennett, Barbara Woods, John P. Lowry
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Developmental Biology
Karli Montague, Andrew S. Lowe, Ana Uzquiano, Athene Knu Fer, Marc Astick, Stephen R. Price, Sarah Guthrie
Article
Chemistry, Analytical
Saidhbhe L. O'Riordan, John P. Lowry
ANALYTICAL METHODS
(2017)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.
