Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Sook Kim, Hyun-Hae Cho, Ji-Yeon Shin, Sook-Hyun Park, Yu-Sun Min, Byunggeon Park, Jihoon Hong, Seo Young Park, Myong-Hun Hahm, Moon Jung Hwang, So Mi Lee
Summary: The study investigates the predictability of synthetic relaxometry for neurodevelopmental outcomes in premature infants and evaluates the performance of combining relaxation times with clinical variables or qualitative MRI abnormalities. The results show that prolonged T1-frontal/parietal and T2-parietal periventricular white matter, moderate-to-severe white matter abnormality, and bronchopulmonary dysplasia are significantly associated with moderate/severe disability. The combination of clinical variables and T1-parietal PVWM or MRI finding and T1-frontal PVWM improves prediction compared to individual models.
EUROPEAN RADIOLOGY
(2023)
Article
Neurosciences
Ke Song, Yong Wang, Mei-Xia Ren, Jiao Li, Ting Su, Si-Yi Chen, Yi Shao, Ya-Li Lv
Summary: Using resting-state functional connectivity, this study found abnormal neural activities in specific brain regions of patients with optic neuritis, with significant changes in rsFC, longFCD, and IFCD values, which may help identify the specific mechanism of change in brain function in ON.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Yang Liu, Hui-Qun Fu, Yan Wu, Zun-Shu Du, Bo-Ran Li, Xin Gao, Guan-Wen Lin, Shu-Yi Yang, Tian-Long Wang
Summary: Resting-state functional magnetic resonance imaging (rs-fMRI) is a promising method for studying brain function, typically performed on anesthetized animals. This study found that different anesthesia methods in aged rats can lead to variations in functional connectivity in different brain regions. Isoflurane anesthesia may be a suitable substitute for Isoflurane + Dexmedetomidine anesthesia in default mode network studies, depending on the regions of interest.
CHINESE MEDICAL JOURNAL
(2021)
Article
Neurosciences
Jianing Hao, Xintao Hu, Liting Wang, Lei Guo, Junwei Han
Summary: The study suggests that the human cerebellum is involved in a wide range of cognitive tasks beyond traditional motor control and can be divided into distinct functional subregions. By utilizing a naturalistic paradigm of fMRI, the research successfully identified different subregions of the cerebellum, providing an alternative template for exploring neural activities in naturalistic environments.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Clinical Neurology
Nathan T. Cohen, Hua Xie, Taha Gholipour, William D. Gaillard
Summary: This article summarizes the evidence to date on the network basis of FCD-related epilepsy, and highlights the potential applications of rsfMRI in the diagnosis and treatment of FCD-related epilepsy. Numerous studies have shown a global disruption of cortical functional networks in FCD-related epilepsy, and the underlying pathological subtypes of FCD influence overall functional network patterns.
Article
Neurosciences
Yan Xu, Xing Zhang, Ziliang Xiang, Qing Wang, Xinfei Huang, Tao Liu, Zhaoxu Yang, Yun Chen, Jianguo Xue, Jianhuai Chen, Jie Yang
Summary: This study investigated the brain functional connectivity of premature ejaculation patients using functional magnetic resonance imaging, finding a close relationship between emotional stability and functional connectivity in brain regions. Increased connectivity between the left amygdala and left medial superior frontal gyrus may reflect a compensatory cortical control mechanism that stabilizes emotions in premature ejaculation patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Youwon Shin, Yoonho Nam, Taehoon Shin, Jin Wook Choi, Jang Hoon Lee, Da Eun Jung, Jiseon Lim, Hyun Gi Kim
Summary: A radiomics approach using MRI images can predict poor psychomotor development in preterm neonates, with white matter analysis playing a key role in the prediction model.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
N. Tuovinen, A. Stefani, T. Mitterling, A. Heidbreder, B. Frauscher, E. R. Gizewski, W. Poewe, B. Hoegl, C. Scherfler
Summary: Patients with restless legs syndrome showed alterations in connectivity within different resting-state networks, with some networks showing increased connectivity and others showing decreased connectivity, corresponding to regions associated with attention, response inhibitory control, and processing of sensory information. Patients on dopaminergic medication displayed increased connectivity between the thalamus and prefrontal regions.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Xin Zhang, Jiayue Liu, Yang Yang, Shijie Zhao, Lei Guo, Junwei Han, Xintao Hu
Summary: The study examined the test-retest reliability of dynamic functional connectivity (dFC) in functional magnetic resonance imaging (fMRI) under natural viewing condition, revealing significantly improved reliability compared to resting state. This suggests that naturalistic paradigms may enhance the study of functional brain networks using fMRI.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Nao-Xin Huang, Zhu-Ling Gao, Jia-Hui Lin, Yan-Juan Lin, Hua-Jun Chen
Summary: Sleep deprivation can alter the stability of the brain's functional architecture and may have implications for various neurocognitive domains.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Lu Chen, Ting Huang, Di Ma, Yu-Chen Chen
Summary: This study used resting-state functional magnetic resonance imaging (fMRI) to investigate the intrinsic functional connectivity (FC) pattern of the default mode network (DMN) in patients with Parkinson's disease (PD). The results showed increased FC between the posterior cingulate cortex (PCC) and other brain regions in PD patients compared to healthy controls (HCs). The increased FC values in the right precuneus were also positively correlated with motor severity in the PD group. These findings suggest that altered connectivity in the DMN may play a crucial role in the cognitive decline observed in PD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Dennis M. Hedderich, Aurore Menegaux, Benita Schmitz-Koep, Rachel Nuttall, Juliana Zimmermann, Sebastian C. Schneider, Josef G. Bauml, Marcel Daamen, Henning Boecker, Marko Wilke, Claus Zimmer, Dieter Wolke, Peter Bartmann, Christian Sorg, Christian Gaser
Summary: The study revealed an elevated BrainAGE in premature-born adults, indicating a potential increased risk for accelerated brain aging in individuals born prematurely.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
Zeyi Wei, Jinhuan Yue, Xiaoling Li, Weiwei Zhao, Danna Cao, Ang Li, Guanhu Yang, Qinhong Zhang
Summary: This study investigated the use of advanced imaging techniques such as structural magnetic resonance imaging (sMRI) and resting-state functional magnetic resonance imaging (rs-fMRI) in understanding and treating vascular cognitive impairment (VCI). The findings from this study provide valuable evidence on the importance of using these techniques for early diagnosis and intervention strategies for VCI, potentially preventing the progression to vascular dementia (VaD).
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Xiaoyi Li, Kai Zhang, Xiao He, Jinyun Zhou, Chentao Jin, Lesang Shen, Yuanxue Gao, Mei Tian, Hong Zhang
Summary: Recent neuroimaging studies have provided insights into the neurobiological processes associated with ASD, with MRI revealing abnormal developmental trajectories, functional MRI highlighting disrupted neural networks, and PET/SPECT imaging indicating metabolic and neurotransmitter abnormalities contributing to aberrant neural circuits in ASD.
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Yajuan Wang, Yingshuang Wang, Lihong Bu, Shaoyang Wang, Xinhui Xie, Fuchun Lin, Zheman Xiao
Summary: This study examines the differences in resting-state functional connectivity (rsFC) between migraine and tension-type headache patients, focusing on brain regions associated with cognition and emotion. The results demonstrate that rsFC alterations in the amygdala and hippocampus with the occipital lobe can be effective in distinguishing patients with migraine from patients with tension-type headaches.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Statistics & Probability
Kuang-Yao Lee, Dingjue Ji, Lexin Li, Todd Constable, Hongyu Zhao
Summary: Graphical modeling of multivariate functional data is important in various applications. In this article, we propose a new conditional graphical model that takes into account the effects of external variables on graph structure, and introduce new linear operators to extend existing methods.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Neurosciences
Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Koundal, Maysam Z. Pedram, Lucia A. Torres-Fernandez, Kristian Haendler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao, Bettina Jux, Andre M. M. Sousa, Fuchen Liu, Suel-Kee Kim, Mingfeng Li, Yiying Yang, Yutaka Takeo, Alvaro Duque, Carol Nelson-Williams, Yonghyun Ha, Kartiga Selvaganesan, Stephanie M. Robert, Amrita K. Singh, Garrett Allington, Charuta G. Furey, Andrew T. Timberlake, Benjamin C. Reeves, Hannah Smith, Ashley Dunbar, Tyrone DeSpenza, June Goto, Arnaud Marlier, Andres Moreno-De-Luca, Xin Yu, William E. Butler, Bob S. Carter, Evelyn M. R. Lake, R. Todd Constable, Pasko Rakic, Haifan Lin, Engin Deniz, Helene Benveniste, Nikhil S. Malvankar, Juvianee Estrada-Veras, Christopher A. Walsh, Seth L. Alper, Joachim L. Schultze, Katrin Paeschke, Angelika Doetzlhofer, F. Gregory Wulczyn, Sheng Chih Jin, Richard P. Lifton, Nenad Sestan, Waldemar Kolanus, Kristopher T. Kahle
Summary: This study reveals a neuroprogenitor-based genetic subtype of human hydrocephalus with defective neurogenesis and altered brain-fluid biomechanics. By analyzing genomic and transcriptomic data of 483 patients with congenital hydrocephalus, the study identifies a group of risk genes that converge in embryonic neuroepithelial stem cells. Mutations in these genes lead to premature neuroepithelial cell differentiation and reduced neurogenesis, resulting in the development of hydrocephalus. This research highlights the importance of precisely regulated neuroepithelial cell fate for normal brain-CSF biomechanics and provides insights into the genetic mechanisms behind hydrocephalus.
NATURE NEUROSCIENCE
(2022)
Article
Psychology, Biological
Kwangsun Yoo, Monica D. Rosenberg, Young Hye Kwon, Qi Lin, Emily W. Avery, Dustin Sheinost, R. Todd Constable, Marvin M. Chun
Summary: This study introduces a model that predicts a person's overall attentional functioning using functional magnetic resonance imaging data and demonstrates its generalization across multiple datasets.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Neurosciences
Kwangsun Yoo, Monica D. Rosenberg, Young Hye Kwon, Dustin Scheinost, R. Todd Constable, Marvin M. Chun
Summary: This study presents a novel method that models the brain's functional reorganization in response to specific task goals. The method accurately generates task-related connectomes from task-free connectomes and amplifies behaviorally relevant individual differences. Additionally, the study reveals how the brain reorganizes between different cognitive states.
Article
Clinical Neurology
Lejla Colic, Alexis Clark, Anjali Sankar, Durga J. Rathi, Danielle A. Goldman, Jihoon A. Kim, Luca M. Villa, E. Kale Edmiston, Elizabeth T. C. Lippard, Brian Pittman, R. Todd Constable, Carolyn M. Mazure, Hilary P. Blumberg
Summary: This study investigated the relationships among gender, childhood maltreatment, hippocampus and prefrontal gray matter structure, and clinical features in bipolar disorder (BD). The findings demonstrated significant gender-related effects of childhood maltreatment on frontotemporal structure and clinical features of BD, providing novel perspectives on the gendered effects of childhood maltreatment in BD.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Kangjoo Lee, Corey Horien, David O'Connor, Bronwen Garand-Sheridan, Fuyuze Tokoglu, Dustin Scheinost, Evelyn M. R. Lake, R. Todd Constable
Summary: This study investigates the impact of arousal levels indexed by pupil area on the integration of large-scale brain networks using simultaneous resting state functional magnetic resonance imaging (fMRI) and pupillometry. The results show a decrease in between-network integration and inter-subject variability at low arousal compared to high arousal, with differences occurring across regions of multiple brain networks. State-dependent changes in network integration within hub regions suggest a brain state transition characterized by global synchronization and reduced network overlaps. Arousal modulation has a brain-wide impact on high-level between-network communications. Additionally, changes in fMRI signal correlation structures and the choice of global signal regression can influence conclusions when studying arousal modulations.
Article
Multidisciplinary Sciences
Yonghyun Ha, Kartiga Selvaganesan, Baosong Wu, Kasey Hancock, Charles Rogers, Sajad Hosseinnezhadian, Gigi Galiana, R. Todd Constable
Summary: At low field MRI, the long recovery time of the RF coil results in long rising and ring-down times for the square pulse, causing distortion of the applied sinc pulse. By using the Q-factor to calculate the rising and ring-down times, the RF square pulse can be compensated with additional square pulses. A series of square pulses are applied to continuously changing amplitude of the sinc pulse. The number and amplitude of the square pulses are calculated. Experimental results show that sinc pulses can be compensated using a series of square pulses, with smoother application to the RF coil with more pulses.
Article
Neurosciences
John Bero, Yang Li, Aviral Kumar, Colin Humphries, Snehesh Nag, Heungyeol Lee, Woo Young Ahn, Sowon Hahn, Robert Todd Constable, Hackjin Kim, Daeyeol Lee
Summary: This study examined the interaction between myelination, cortical thickness, and resting-state functional connectivity in children aged 10 to 15. The results showed higher correlations among these measures in sensory-motor cortical areas compared to association cortical areas. These correlations were stable and not influenced by age-related changes in each measure, and regional variations reflected the hierarchy of cortical information processing.
HUMAN BRAIN MAPPING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhiying Zhao, Gigi Galiana, Cristofer Zillo, Terry Camarro, Maolin Qiu, Xenophon Papademetris, Michelle Hampson
Summary: This article introduces a software tool called HALO, which actively aligns the head position between different MRI sessions. Through evaluation in experiments, it is shown that HALO can help subjects align their head position with the desired position of the initial session, ensuring data quality consistency.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Meeting Abstract
Clinical Neurology
Ece Eldem, Shubham Misra, Terence Quinn, Lucas Driskell, Alice Perez, Carmen Carrion, Todd Constable, Joseph Schindler, Yize Zhao, Jason Sico, Jason D. Hinman, Heather Allore, Swathi Kiran, Jubin Abutalebi, Jean-Marie Annoni, Nishant K. Mishra
Article
Chemistry, Multidisciplinary
Sandeep K. Mishra, Peter Herman, Michael Crair, R. Todd Constable, John J. Walsh, Adil Akif, Justus V. Verhagen, Fahmeed Hyder
Summary: In this study, magnetic protein nanoparticles (MPNPs) with fluorescent dye (f-MPNPs) were successfully synthesized for optical cerebrovascular imaging without losing the properties of positive magnetic resonance imaging (MRI) contrast. In vivo experiments on mice showed that f-MPNPs provided detailed microvascular contrast enhancement with fast clearance and no toxic effects.
Article
Multidisciplinary Sciences
Abigail S. Greene, Xilin Shen, Stephanie Noble, Corey Horien, C. Alice Hahn, Jagriti Arora, Fuyuze Tokoglu, Marisa N. Spann, Carmen Carrion, Daniel S. Barron, Gerard Sanacora, Vinod H. Srihari, Scott W. Woods, Dustin Scheinost, R. Todd Constable
Summary: Individual differences in brain functional organization manifest a range of traits, symptoms, and behaviors. Predictive models linking brain activity to phenotype highlight the failure of models in different individuals, showing reliable and phenotype-specific failures that generalize across datasets.
Article
Clinical Neurology
Mubbahsir Sheikh, Mohamad Koubeissi, R. Todd Constable, Dennis D. Spencer, Rafeed Alkawadri
Summary: This is the first known case of profound illusionary time dilation caused by electrical cortical stimulation. The study found that stimulation of certain brain regions can alter time perception. This finding may have potential benefits for conditions involving impaired time perception.
EPILEPTIC DISORDERS
(2022)
Meeting Abstract
Neurosciences
Yihong Zhao, Martin Paulus, Kara Bagot, R. Todd Constable, Marc Potenza
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Neurosciences
Danielle Goldman, Anjali Sankar, Lejla Colic, Luca M. Villa, Jihoon A. Kim, Brian Pittman, R. Todd Constable, Dustin Scheinost, Hilary P. Blumberg
BIOLOGICAL PSYCHIATRY
(2022)