Article
Neurosciences
Lindsay J. Agostinelli, Scott C. Seaman, Clifford B. Saper, Dustin P. Fykstra, Marco M. Hefti, Timothy R. Koscik, Brian J. Dlouhy, Alexander G. Bassuk
Summary: Researchers report a study that combines high-resolution MRI and detailed histology to study the impact of neurologic disease on specific cell groups in the human brainstem and cerebellum. These findings are crucial for understanding and diagnosing brainstem lesions.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Agoston Patthy, Janos Murai, Janos Hanics, Anna Pinter, Peter Zahola, Tomas G. M. Hokfelt, Tibor Harkany, Alan Alpar
Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder for which an effective therapy has yet to be found. Research suggests that early damage to the ascending monoaminergic system in the brainstem may be an early sign and potential trigger of AD. In addition, cortical malfunction and local neurohistopathology are also related to the progression of AD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Patsorn Wichit, Sekh Thanprasertsuk, Onanong Phokaewvarangkul, Roongroj Bhidayasiri, Saknan Bongsebandhu-Phubhakdi
Summary: The study found that PD patients had higher plasma norepinephrine levels but lower epinephrine and serotonin levels compared to control subjects. Additionally, PD patients showed a significantly higher HVA/DA ratio and lower VMA/NE ratio. The levels of different monoamines were associated with clinical profiles in PD patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cell Biology
Diego Baronio, Yu-Chia Chen, Pertti Panula
Summary: Deficiency of monoamine oxidase (MAO) and imbalanced levels of brain monoamines are associated with developmental delay, neuropsychiatric disorders, and aggressive behavior. This study introduces a novel genetic model using zebrafish to study the effects of mao loss of function. The results demonstrate alterations in neurotransmitter systems, expression of relevant genes, and behavioral changes in mao mutants.
DISEASE MODELS & MECHANISMS
(2022)
Review
Endocrinology & Metabolism
Julian B. Wilson, Ma'ayan Epstein, Briana Lopez, Amira K. Brown, Kabirullah Lutfy, Theodore C. Friedman
Summary: Type 2 diabetes mellitus (T2DM) and depression are significant public health and socioeconomic issues, with high co-occurrence rates. This review explores how T2DM and depression interact through shared molecular pathways, affecting brain structure, function, and reward. Treating the symptoms of T2DM without addressing these underlying pathways may not be effective, and targeting immune system, stress circuit, melatonin, and other alterations could offer more promising approaches.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Elizabeth K. Wood, Natalia Gabrielle, Jacob Hunter, Andrea N. Skowbo, Melanie L. Schwandt, Stephen G. Lindell, Christina S. Barr, Stephen J. Suomi, J. Dee Higley
Summary: Studies show that parental absence early in life can have negative effects on the developing central nervous system, particularly on monoamine systems. Furthermore, genotype can also affect the concentrations of these neurotransmitters.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Robert Lalonde, Catherine Strazielle
Summary: The function of the Agtpbp1 gene has been mainly studied through the analysis of Agtpbp1(pcd) mutant mice, which exhibit cerebellar degeneration and changes in neurotransmitter concentrations, leading to cerebellar ataxia and other behavioral deficits. Similar neuropathogical and behavioral profiles have been observed in human subjects with biallelic variants of AGTPBP1.
Article
Medicine, Research & Experimental
Daniela Muresan, Septimiu Voidazan, Andreea Salcudean, Cristina Raluca Bodo, Iosif Gabos Grecu
Summary: This study aimed to evaluate the effectiveness of bioresonance therapy in improving the severity of recurrent depressive disorder. Results showed that bioresonance therapy was more effective than selective serotonin reuptake inhibitor medication in reducing the severity of depression in patients with moderate and mild episodes.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Genetics & Heredity
Robert Lalonde, Catherine Strazielle
Summary: The function of the HERC1 gene, mainly studied through mutant mice and subjects with variants, includes regulating cerebellar Purkinje cells, synaptic vesicles, climbing fiber projections, and alpha-motoneuron projections. The resulting phenotypes involve cerebellar ataxia, motor coordination loss, muscle weakness, and spatial deficits.
Article
Behavioral Sciences
Gerly Tamm, Kairi Kreegipuu, Jaanus Harro
Summary: This study aimed to describe the interaction between platelet MAO activity and COMT Val158Met genotype in visual working memory updating. The results suggest that the effect of COMT Val158Met on updating efficiency depends on the level of platelet MAO activity.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Qin Ru, Qi Xiong, Xiang Tian, Congyue Xu, Can Li, Lin Chen, Yuxiang Wu
Summary: This study investigated the therapeutic effect and mechanism of a candidate Chinese herbal medicine (CCHM) on methamphetamine (METH) addiction using network pharmacology and molecular docking methods. The results showed that CCHM effectively inhibited METH-induced conditioned place preference (CPP) behaviors in mice and identified several key targets and active ingredients.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Alessandro Alunni, Constance Pierre, Jorge Torres-Paz, Natacha Clairet, Auriane Langlume, Marie Pavie, Thomas Escoffier-Pirouelle, Michael Leblanc, Maryline Blin, Sylvie Retaux
Summary: The function of MAO has multiple effects on brain development in Astyanax mexicanus, including regulation of serotonin and proliferation of cells. Moreover, serotonergic neurons in the hypothalamus and raphe exhibit different responses to loss of mao function.
DEVELOPMENT GROWTH & DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Gisela Andrea Camacho-Hernandez, Andrea Casiraghi, Deborah Rudin, Dino Luethi, Therese C. Ku, Daryl A. Guthrie, Valentina Straniero, Ermanno Valoti, Gerhard J. Schutz, Harald H. Sitte, Amy Hauck Newman
Summary: The study used fluorescent ligands to investigate the function and distribution of monoamine transporters. By extending SAR for nisoxetine and talopram, high affinity rhodamine-labeled fluorescent probes were identified for the norepinephrine transporter (NET). Nisoxetine-based fluorescent probe 6 showed high binding affinity for NET and stained both NET and SERT in transporter-expressing cells at low concentrations.
RSC MEDICINAL CHEMISTRY
(2021)
Article
Neurosciences
Asmaa S. Shahat, Wafaa A. Hassan, Wael M. El-Sayed
Summary: Hyperthyroidism has detrimental effects on neurotransmitters, oxidative homeostasis, apoptosis, and DNA damage in various regions of the brain. Supplementation with N-acetylcysteine and safranal can mitigate these effects by improving the antioxidant status of the brain.
NUTRITIONAL NEUROSCIENCE
(2022)
Review
Cardiac & Cardiovascular Systems
Anna Calvi, Ilaria Fischetti, Ignazio Verzicco, Martino Belvederi Murri, Stamatula Zanetidou, Riccardo Volpi, Pietro Coghi, Stefano Tedeschi, Mario Amore, Aderville Cabassi
Summary: Patients with depression who take antidepressant medication may have an increased risk of developing hypertension. Different types of antidepressants have varying effects on blood pressure, with selective serotonin reuptake inhibitors being the safest class, while dopamine-norepinephrine reuptake inhibitors may lead to blood pressure increases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Engineering, Biomedical
Meena M. Makary, Hani M. Bu-Omer, Ramy S. Soliman, Kyungmo Park, Yasser M. Kadah
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2018)
Article
Neurosciences
Andrew H. Song, Aaron Kucyi, Vitaly Napadow, Emery N. Brown, Marco L. Loggia, Oluwaseun Akeju
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Roberta Sclocco, Florian Beissner, Marta Bianciardi, Jonathan R. Polimeni, Vitaly Napadow
Article
Multidisciplinary Sciences
Meena M. Makary, Jeungchan Lee, Eunyoung Lee, Seulgi Eun, Jieun Kim, Geon-Ho Jahng, Kiok Kim, You-Suk Youn, Jun-Hwan Lee, Kyungmo Park
SCIENTIFIC REPORTS
(2018)
Article
Medicine, Research & Experimental
Koh-Woon Kim, Kyungmo Park, Hi-Joon Park, Geon-Ho Jahng, Dae-Jean Jo, Jae-Heung Cho, Eun-Mo Song, Woo-Chul Shin, Ye-Ji Yoon, Soo-Jeon Kim, Seulgi Eun, Mi-Yeon Song
Review
Oncology
Nhan Do, Robert Grossman, Theodore Feldman, Nathanael Fillmore, Danne Elbers, David Tuck, Rupali Dhond, Luis Selva, Frank Meng, Michael Fitzsimons, Samuel Ajjarapu, Siamack Ayandeh, Robert Hall, Stephanie Do, Mary Brophy
SEMINARS IN ONCOLOGY
(2019)
Article
Neurosciences
Jeungchan Lee, Seulgi Eun, Jieun Kim, Jun-Hwan Lee, Kyungmo Park
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Suk-tak Chan, Karleyton C. Evans, Tian-yue Song, Juliette Selb, Andre van der Kouwe, Bruce R. Rosen, Yong-ping Zheng, Andrew Ahn, Kenneth K. Kwong
Article
Multidisciplinary Sciences
Seulgi Eun, Jeungchan Lee, Eun-Mo Song, Alexandra De Rosa, Jun-Hwan Lee, Kyungmo Park
Article
Multidisciplinary Sciences
Suk-tak Chan, Karleyton C. Evans, Tian-yue Song, Juliette Selb, Andre van der Kouwe, Bruce R. Rosen, Yong-ping Zheng, Andrew C. Ahn, Kenneth K. Kwong
Article
Multidisciplinary Sciences
Westyn Branch-Elliman, Ryan Ferguson, Gheorghe Doros, Patricia Woods, Sarah Leatherman, Judith Strymish, Rupak Datta, Rekha Goswami, Matthew D. Jankowich, Nishant R. Shah, Thomas H. Taylor, Sarah T. Page, Sara J. Schiller, Colleen Shannon, Cynthia Hau, Maura Flynn, Erika Holmberg, Karen Visnaw, Rupali Dhond, Mary Brophy, Paul A. Monach
Summary: This pragmatic, embedded, adaptive trial aimed to measure the effectiveness of the subcutaneous anti-IL-6R antibody sarilumab in COVID-19 patients. However, adding sarilumab to evolving standard of care did not show additional benefit. The trial was stopped early due to safety concerns, but it provided valuable information for the treatment of hospitalized COVID-19 patients with subcutaneous IL-6R inhibition.
Article
Health Care Sciences & Services
Rupali Dhond, Danne Elbers, Nilla Majahalme, Svitlana Dipietro, Sergey Goryachev, Ryan Acher, Sarah Leatherman, Tori Anglin-Foote, Qingzhu Liu, Shaoyu Su, Ramana Seerapu, Robert Hall, Ryan Ferguson, Mary T. Brophy, Jeff Ferraro, Scott L. DuVall, Nhan Do
Summary: The article introduces ProjectFlow, a flexible clinical research workflow management application developed to meet the needs of point-of-care research, and describes its application in the DCP and RePOP projects; ProjectFlow has successfully managed the research processes of thousands of patients and demonstrated the importance of flexible workflow management tools for clinical research.
Article
Neuroimaging
Wei Shen, Yiheng Tu, Randy L. Gollob, Ana Ortiz, Vitaly Napadow, Siyi Yu, Georgia Wilson, Joel Park, Courtney Lang, Minyoung Jung, Jessica Gerber, Ishtiaq Mawla, Suk-Tak Chan, Ajay D. Wasan, Robert R. Edwards, Ted Kaptchuk, Shasha Li, Bruce Rosen, Jian Kong
NEUROIMAGE-CLINICAL
(2019)
Article
Health Care Sciences & Services
Melat Gebre, Anna Woodbury, Vitaly Napadow, Venkatagiri Krishnamurthy, Lisa C. Krishnamurthy, Roman Sniecinski, Bruce Crosson
JMIR RESEARCH PROTOCOLS
(2018)
Article
Medicine, Research & Experimental
Xue-Jun Kong, Jun Liu, Jing Li, Kenneth Kwong, Madelyn Koh, Piyawat Sukijthamapan, Jason J. Guo, Zhenyu Jim Sun, Yiqing Song
PILOT AND FEASIBILITY STUDIES
(2020)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.