Article
Neurosciences
Weihao Zheng, Leilei Zhao, Zhiyong Zhao, Tingting Liu, Bin Hu, Dan Wu
Summary: In this study, the development of the thalamus in pre-term and full-term infants was investigated using high-angular resolution diffusion MRI data. The results showed that the lateral thalamus exhibited greater expansion and fiber integrity compared to the medial part. The development of thalamic connections to the frontal cortex was found to be delayed compared to other thalamocortical connections, and functional partitions of thalamic subdivisions developed in a lateral-to-medial pattern. These findings provide insights into the developmental characteristics of the thalamus during the perinatal period.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Andrew Gaddis, Daniel E. Lidstone, Mary Beth Nebel, Roland R. Griffiths, Stewart H. Mostofsky, Amanda F. Mejia, Frederick S. Barrett
Summary: This study used a novel analysis method to investigate the effects of psilocybin on thalamic functional organization and connectivity. The results showed that psilocybin primarily affected the mediodorsal and pulvinar nuclei in the thalamus, leading to decreased connectivity with visual and default mode networks.
Article
Behavioral Sciences
Hilary Toulmin, Jonathan O'Muircheartaigh, Serena J. Counsell, Shona Falconer, Andrew Chew, Christian F. Beckmann, A. David Edwards
Summary: Preterm infants are at high risk of long-term motor and neurocognitive deficits. Structural MRI at birth does not accurately predict outcomes, suggesting the importance of thalamocortical connections in neurocognitive development during the perinatal period.
Article
Chemistry, Multidisciplinary
Nur Hayati Jasmin, May Zaw Thin, Robert D. Johnson, Laurence H. Jackson, Thomas A. Roberts, Anna L. David, Mark F. Lythgoe, Philip C. Yang, Sean M. Davidson, Patrizia Camelliti, Daniel J. Stuckey
Summary: The study investigates the use of manganese as an imaging biomarker of myocardial viability and the potential application of MEMRI in early diagnosis and treatment. Experimental results confirm the safety of manganese and demonstrate that MEMRI can provide quantitative information on myocardial viability earlier.
Article
Biology
Haruka Sato, Jun Hatakeyama, Takuji Iwasato, Kimi Araki, Nobuhiko Yamamoto, Kenji Shimamura
Summary: This study identifies a factor called VGF, derived from the thalamus, that is crucial for maintaining the proper number of layer 4 neurons in the sensory cortices. This process is important for the further maturation of the primary somatosensory area, such as the formation of barrel fields through neuronal activity-dependent mechanisms.
Article
Neurosciences
Yassine Taoudi-Benchekroun, Daan Christiaens, Irina Grigorescu, Oliver Gale-Grant, Andreas Schuh, Maximilian Pietsch, Andrew Chew, Nicholas Harper, Shona Falconer, Tanya Poppe, Emer Hughes, Jana Hutter, Anthony N. Price, J-Donald Tournier, Lucilio Cordero-Grande, Serena J. Counsell, Daniel Rueckert, Tomoki Arichi, Joseph Hajnal, A. David Edwards, Maria Deprez, Dafnis Batalle
Summary: This study used machine learning methods to analyze structural connectomes of neonates and predict demographic and neurodevelopmental characteristics. The results demonstrate that a neural substrate of brain maturation with implications for future neurodevelopment can be detected from the neonatal connectome.
Article
Computer Science, Theory & Methods
Pu Wang, Zheng Yan, Kai Zeng
Summary: This paper proposes a multi-stage authentication and attack tracing scheme based on backscatter communication, which enhances authentication security for both static and mobile devices by utilizing physical spatial information. BCAuth is capable of determining the number of attackers and localizing their positions, and also introduces a reciprocal channel-based re-authentication method for mobile devices.
IEEE TRANSACTIONS ON INFORMATION FORENSICS AND SECURITY
(2022)
Article
Neurosciences
Sherry Jingjing Wu, Elaine Sevier, Deepanjali Dwivedi, Giuseppe-Antonio Saldi, Ariel Hairston, Sabrina Yu, Lydia Abbott, Da Hae Choi, Mia Sherer, Yanjie Qiu, Ashwini Shinde, Mackenzie Lenahan, Daniella Rizzo, Qing Xu, Irving Barrera, Vipin Kumar, Giovanni Marrero, Alvar Pronneke, Shuhan Huang, Klas Kullander, David A. Stafford, Evan Macosko, Fei Chen, Bernardo Rudy, Gord Fishell
Summary: Cardinal classes of cortical interneurons provide a simplified understanding of diversity, but more detailed investigation is needed for subtypes such as somatostatin interneurons. This study reveals that different subtypes of somatostatin interneurons have unique laminar organization and axonal projection patterns, and form cell-type-specific cortical circuits.
Review
Neurosciences
Fatemeh S. N. Mahani, Aref Kalantari, Gereon R. Fink, Mathias Hoehn, Markus Aswendt
Summary: Recent developments in rodent brain imaging have facilitated the analysis of functional and structural connections at the whole brain level. However, the relationship between structural and functional networks remains uncertain. This review systematically investigates existing experimental studies in rodents that explore both structural and functional network measures using in vivo imaging techniques. The results suggest a spatial and temporal disconnection between structural and functional networks during brain diseases, although more research is needed to draw definitive conclusions.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Zifei Liang, Tanzil Mahmud Arefin, Choong H. Lee, Jiangyang Zhang
Summary: Diffusion MRI (dMRI) tractography is the only non-invasive tool for mapping macroscopic structural connectivity. This study demonstrated that a deep learning network trained on mesoscopic tract-tracing data can improve the estimation of fiber orientation distributions (FODs) in mouse brain dMRI data, leading to enhanced specificity in tractography results without compromising sensitivity.
Article
Neurosciences
Petra Bencurova, Hanne Laakso, Raimo A. Salo, Ekaterina Paasonen, Eppu Manninen, Jaakko Paasonen, Shalom Michaeli, Silvia Mangia, Martin Bares, Milan Brazdil, Hana Kubova, Olli Grohn
Summary: TLE progression distorts white matter development in the immature brain, peaking around postnatal day 28 and followed by substantial recovery in adulthood. This developmental delay may give rise to cognitive and behavioral comorbidities typical for early-onset TLE.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Zhiyong Zhao, Lei Zhang, Wanrong Luo, Zuozhen Cao, Qinfeng Zhu, Xueqian Kong, Keqing Zhu, Jing Zhang, Dan Wu
Summary: This study used high-resolution dMRI to investigate the microstructural characteristics of the anterior hippocampus in patients with Alzheimer's disease (AD). The results showed significant variability in microstructural features across different layers and subfields, and these features were associated with protein deposition in AD patients' anterior hippocampus.
HUMAN BRAIN MAPPING
(2023)
Article
Chemistry, Multidisciplinary
V. J. Mane, S. B. Kale, S. B. Ubale, V. C. Lokhande, C. D. Lokhande
Summary: This study prepared Ag-doped MnO2/GO composite thin films using the SILAR method, which exhibited high specific surface area and excellent electro-chemical performance with a maximum specific capacitance of 877 F g(-1) and capacity retention of 94.57% in the electrolyte. The flexible solid state symmetric supercapacitor device showed good cycling stability and electro-chemical performance with a specific capacitance of 164 F g(-1) and capacitive retention of 94% after 10,000 cycles.
MATERIALS TODAY CHEMISTRY
(2021)
Article
Neurosciences
Kahori Kita, Shinichi Furuya, Rieko Osu, Takashi Sakamoto, Takashi Hanakawa
Summary: The study suggests that abnormal cerebellar activity and cerebello-cortical connectivity may play a role in the neuropathophysiology of musician's dystonia. Pianists with FTSD showed greater activation of the right cerebellum during the task, and those who reported dystonic symptoms demonstrated greater cerebellar activation, indicating a link between cerebellar activity and overt dystonic symptoms. Additionally, there were differences in the task-related effective connectivity between the right cerebellum and left premotor/somatosensory cortex between dystonic and healthy pianists.
Article
Multidisciplinary Sciences
Shelei Pan, Peter H. Yang, Dakota DeFreitas, Sruthi Ramagiri, Peter O. Bayguinov, Carl D. Hacker, Abraham Z. Snyder, Jackson Wilborn, Hengbo Huang, Gretchen M. Koller, Dhvanii K. Raval, Grace L. Halupnik, Sanja Sviben, Samuel Achilefu, Rui Tang, Gabriel Haller, James D. Quirk, James A. J. Fitzpatrick, Prabagaran Esakky, Jennifer M. Strahle
Summary: The authors used gold nanoparticle enhanced X-ray microtomography to map CSF distribution in post-natal rodents and described particle size-dependent CSF pathways that transport CSF into the brain parenchyma of rodents.
NATURE COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mladen Barbic, Stephen J. Dodd, Hatem ElBidweihy, Neil R. Dilley, Barbara Marcheschi, Alan L. Huston, H. Douglas Morris, Alan P. Koretsky
Summary: Magnetocaloric materials of different purity and composition were demonstrated to act as diverse high contrast ratio switchable MRI contrast agents, showing clear image contrast changes at physiological temperatures and different MRI magnetic field strengths.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Biophysics
Hsu-Lei Lee, Xiaoqing Alice Zhou, Zengmin Li, Kai-Hsiang Chuang
Summary: This study demonstrates the ability of multiband DTI to acquire high-resolution data of the mouse brain, increasing the SNR efficiency and reducing variations in signal, leading to reduced free-water contamination.
NMR IN BIOMEDICINE
(2021)
Article
Neurosciences
Wan Yun Ho, Ira Agrawal, Sheue-Houy Tyan, Emma Sanford, Wei-Tang Chang, Kenneth Lim, Jolynn Ong, Bernice Siu Yan Tan, Aung Aung Kywe Moe, Regina Yu, Peiyan Wong, Greg Tucker-Kellogg, Edward Koo, Kai-Hsiang Chuang, Shuo-Chien Ling
Summary: Research shows that ALS and FTD are two ends of the same disease spectrum, affecting motor and cognitive functions. Mutations in FUS may lead to changes in proteostasis and mitochondrial function, impacting brain structure and connectivity, resulting in cognitive deficits.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Biophysics
Emily Petrus, Galit Saar, Alexia Daoust, Steve Dodd, Alan P. Koretsky
Summary: Contrast agents like manganese ion (Mn2+) enhance MRI contrast due to their paramagnetic properties, and are widely used in imaging healthy and diseased states in animal models. Mn2+ accumulates in high activity brain regions and can compete with zinc (Zn2+) and iron (Fe2+) for uptake into cells. Studies in hippocampal slice cultures have established a hierarchy of agents influencing Mn2+ uptake, helping to understand its entry mechanisms.
NMR IN BIOMEDICINE
(2021)
Article
Neurosciences
Zhiwei Ma, Daniel S. Reich, Sarah Dembling, Jeff H. Duyn, Alan P. Koretsky
Summary: This study developed a two-level outlier detection and screening methodology to characterize individual outliers from the multimodal MRI dataset of more than 15,000 UK Biobank subjects. The study established an unsupervised framework for investigating rare individual imaging phenotypes within a large neuroimaging cohort.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemical Research Methods
Gary Zabow, Stephen Dodd, Alan Koretsky
Summary: Meander-line, or zig-zag, MRI surface coils were found to have poorer than expected field localizations and highly inhomogeneous images due to design based on an invalid approximation. A modified coil design was introduced to correct this issue, improving signal uniformity and eliminating image artifacts. The correction method involved adding a single extra turn of wire, resulting in tighter coil field localization and reduced unwanted signal interference.
JOURNAL OF MAGNETIC RESONANCE
(2021)
Article
Psychiatry
T. Ewais, Lead Psychiatrist, Mater Young Adult Health Centre Brisbane, J. Begun, M. Kenny, K. Hay, Evan Houldin, Kai-Hisang Chuang, M. Tefay, S. Kisely
Summary: The study demonstrated the feasibility and benefits of using MBCT therapy for AYAs with Inflammatory Bowel Disease and comorbid depression. Results showed that the MBCT group had significant advantages in improving depression, stress, mindfulness, and adaptive coping.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Katherine S. Matho, Dhananjay Huilgol, William Galbavy, Miao He, Gukhan Kim, Xu An, Jiangteng Lu, Priscilla Wu, Daniela J. Di Bella, Ashwin S. Shetty, Ramesh Palaniswamy, Joshua Hatfield, Ricardo Raudales, Arun Narasimhan, Eric Gamache, Jesse M. Levine, Jason Tucciarone, Eric Szelenyi, Julie A. Harris, Partha P. Mitra, Pavel Osten, Paola Arlotta, Z. Josh Huang
Summary: The study established genetic strategies and tools to dissect and fate-map subpopulations of pyramidal neurons based on their developmental and molecular programs. Through combinatorial strategies, subsets of pyramidal neurons defined by developmental origin, marker expression, anatomical location, and projection targets can be targeted for viral access. These strategies provide an experimental framework for understanding the hierarchical organization and developmental trajectory of subpopulations of pyramidal neurons.
Article
Multidisciplinary Sciences
Xiaoqing Alice Zhou, Daniel G. Blackmore, Junjie Zhuo, Fatima A. Nasrallah, XuanVinh To, Nyoman D. Kurniawan, Alison Carlisle, King-Year Vien, Kai-Hsiang Chuang, Tianzi Jiang, Perry F. Bartlett
Summary: The improvement in hippocampal-based learning in aged mice following physical exercise is due to enhanced DG connectivity, particularly the strengthening of specific connections, and is dependent on neurogenesis. These changes in circuitry are crucial for the cognitive improvements resulting from physical activity.
Article
Multidisciplinary Sciences
Kai-Hsiang Chuang, Pei-Huan Wu, Zengmin Li, Kang-Hsing Fan, Jun-Cheng Weng
Summary: This study developed a deep learning network based on generative adversarial networks (GAN) to automatically correct coil inhomogeneity and extract the brain from different image contrasts without user intervention. Using various quantitative indices, it was shown that this method achieved high similarity to the reference target and had consistent performance across different datasets. These results highlight the potential of deep networks to integrate different postprocessing methods and adapt to different image contrasts.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Li Liu, Steve Dodd, Ryan D. Hunt, Nikorn Pothayee, Tatjana Atanasijevic, Nadia Bouraoud, Dragan Maric, E. Ashley Moseman, Selamawit Gossa, Dorian B. McGavern, Alan P. Koretsky
Summary: This study introduces a novel MRI-based method for monitoring pathology and immunity in the brain. Using a murine model, the authors identify small cerebral microbleeds as an early pathological event associated with viral entry, and show that virus-specific CD8+ T cells can reduce these microbleeds. These findings highlight the importance of MRI in detecting early pathological events and the therapeutic potential of antiviral T cells in CNS infections.
Article
Geriatrics & Gerontology
Xiaoqing Alice Zhou, Grace Ngiam, Lei Qian, Kornraviya Sankorrakul, Elizabeth J. Coulson, Kai-Hsiang Chuang
Summary: Degeneration of cholinergic neurons in the basal forebrain (BF) is a contributing factor to cognitive impairment. However, the volume changes measured by structural MRI in the BF do not directly reflect the changes in cholinergic neurons.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
Matthew B. Pomrenze, Daniel F. Cardozo Pinto, Peter A. Neumann, Pierre Llorach, Jason M. Tucciarone, Wade Morishita, Neir Eshel, Boris D. Heifets, Robert C. Malenka
Summary: Social isolation plays a major role in the current opioid addiction crisis. Research shows that sociability deficits during opioid withdrawal are linked to the activation of kappa opioid receptors in the nucleus accumbens. Blocking the release of dynorphin from dorsal raphe neurons prevents these deficits, while optogenetic activation of these neurons reproduces sociability decreases. Deleting KORs from serotonin neurons prevents sociability deficits, but not from NAc neurons or dopamine neurons.
Article
Neurosciences
Joanes Grandjean, Gabriel Desrosiers-Gregoire, Cynthia Anckaerts, Diego Angeles-Valdez, Fadi Ayad, David A. Barriere, Ines Blockx, Aleksandra Bortel, Margaret Broadwater, Beatriz M. Cardoso, Marina Celestine, Jorge E. Chavez-Negrete, Sangcheon Choi, Emma Christiaen, Perrin Clavijo, Luis Colon-Perez, Samuel Cramer, Tolomeo Daniele, Elaine Dempsey, Yujian Diao, Arno Doelemeyer, David Dopfel, Lenka Dvorakova, Claudia Falfan-Melgoza, Francisca F. Fernandes, Caitlin F. Fowler, Antonio Fuentes-Ibanez, Clement Garin, Eveline Gelderman, Carla E. M. Golden, Chao C. G. Guo, Marloes J. A. G. Henckens, Lauren A. Hennessy, Peter Herman, Nita Hofwijks, Corey Horien, Tudor M. Ionescu, Jolyon Jones, Johannes Kaesser, Eugene Kim, Henriette Lambers, Alberto Lazari, Sung-Ho Lee, Amanda Lillywhite, Yikang Liu, Yanyan Y. Liu, Alejandra Lopez-Castro, Xavier Lopez-Gil, Zilu Ma, Eilidh MacNicol, Dan Madularu, Francesca Mandino, Sabina Marciano, Matthew J. McAuslan, Patrick McCunn, Alison McIntosh, Xianzong Meng, Lisa Meyer-Baese, Stephan Missault, Federico Moro, Daphne M. P. Naessens, Laura J. Nava-Gomez, Hiroi Nonaka, Juan J. Ortiz, Jaakko Paasonen, Lore M. Peeters, Mickael Pereira, Pablo D. Perez, Marjory Pompilus, Malcolm Prior, Rustam Rakhmatullin, Henning M. Reimann, Jonathan Reinwald, Rodrigo Triana Del Rio, Alejandro Rivera-Olvera, Daniel Ruiz-Perez, Gabriele Russo, Tobias J. Rutten, Rie Ryoke, Markus Sack, Piergiorgio Salvan, Basavaraju G. Sanganahalli, Aileen Schroeter, Bhedita J. Seewoo, Erwan Selingue, Aline Seuwen, Bowen Shi, Nikoloz Sirmpilatze, Joanna A. Smith, Corrie Smith, Filip Sobczak, Petteri J. Stenroos, Milou Straathof, Sandra Strobelt, Akira Sumiyoshi, Kengo Takahashi, Maria E. Torres-Garcia, Raul Tudela, Monica van den Berg, Kajo van der Marel, Aran T. B. van Hout, Roberta Vertullo, Benjamin Vidal, Roel M. Vrooman, Victora X. Wang, Isabel Wank, David J. G. Watson, Ting Yin, Yongzhi Zhang, Stefan Zurbruegg, Sophie Achard, Sarael Alcauter, Dorothee P. Auer, Emmanuel L. Barbier, Juergen Baudewig, Christian F. Beckmann, Nicolau Beckmann, Guillaume J. P. C. Becq, Erwin L. A. Blezer, Radu Bolbos, Susann Boretius, Sandrine Bouvard, Eike Budinger, Joseph D. Buxbaum, Diana Cash, Victoria Chapman, Kai-Hsiang Chuang, Luisa Ciobanu, Bram F. Coolen, Jeffrey W. Dalley, Marc Dhenain, Rick M. Dijkhuizen, Oscar Esteban, Cornelius Faber, Marcelo Febo, Kirk W. Feindel, Gianluigi Forloni, Jeremie Fouquet, Eduardo A. Garza-Villarreal, Natalia Gass, Jeffrey C. Glennon, Alessandro Gozzi, Olli Grohn, Andrew Harkin, Arend Heerschap, Xavier Helluy, Kristina Herfert, Arnd Heuser, Judith R. Homberg, Danielle J. Houwing, Fahmeed Hyder, Giovanna Diletta Ielacqua, Ileana O. Jelescu, Heidi Johansen-Berg, Gen Kaneko, Ryuta Kawashima, Shella D. Keilholz, Georgios A. Keliris, Clare Kelly, Christian Kerskens, Jibran Y. Khokhar, Peter C. Kind, Jean-Baptiste Langlois, Jason P. Lerch, Monica A. Lopez-Hidalgo, Denise Manahan-Vaughan, Fabien Marchand, Rogier B. Mars, Gerardo Marsella, Edoardo Micotti, Emma Munoz-Moreno, Jamie Near, Thoralf Niendorf, Willem M. Otte, Patricia Pais-Roldan, Wen-Ju Pan, Roberto A. Prado-Alcala, Gina L. Quirarte, Jennifer Rodger, Tim Rosenow, Cassandra Sampaio-Baptista, Alexander Sartorius, Stephen J. Sawiak, Tom W. J. Scheenen, Noam Shemesh, Yen-Yu Ian Shih, Amir Shmuel, Guadalupe Soria, Ron Stoop, Garth J. Thompson, Sally M. Till, Nick Todd, Annemie van der Linden, Annette van der Toorn, Geralda A. F. van Tilborg, Christian Vanhove, Andor Veltien, Marleen Verhoye, Lydia Wachsmuth, Wolfgang Weber-Fahr, Patricia Wenk, Xin Yu, Valerio Zerbi, Nanyin Zhang, Baogui B. Zhang, Luc Zimmer, Gabriel A. Devenyi, M. Mallar Chakravarty, Andreas Hess
Summary: Task-free functional connectivity in animal models is an important tool for studying connectivity phenomena. However, the lack of standardized protocols and analysis methods hampers result comparison and integration. In this study, the authors developed a standardized protocol, called StandardRat, for rat functional magnetic resonance imaging (fMRI) acquisition and analysis, which enhances the detection of functional connectivity patterns and promotes cooperation in neuroscience research.
NATURE NEUROSCIENCE
(2023)
Meeting Abstract
Neurosciences
Neir Eshel, Gavin Touponse, Allan Wang, Amber Osterman, Amei Shank, Alexa Groome, Lara Taniguchi, Daniel Cardozo Pinto, Jason Tucciarone, Brandon Bentzley, Robert Malenka
NEUROPSYCHOPHARMACOLOGY
(2022)