期刊
NEUROIMAGE
卷 47, 期 4, 页码 1608-1619出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2009.05.092
关键词
fMRI; Optical imaging spectroscopy; Biophysical model; Haemodynamics
资金
- MRC [G0601581] Funding Source: UKRI
- Medical Research Council [G0601581] Funding Source: Medline
- NINDS NIH HHS [R01 NS044567-05] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Medical Research Council [G0601581] Funding Source: researchfish
We describe the use of the three dimensional characteristics of the functional magnetic resonance imaging (fMRI) blood oxygenation level dependent (BOLD) and cerebral blood volume (CBV) MRI signal changes to refine a two dimensional optical imaging spectroscopy (OIS) algorithm. The cortical depth profiles of the BOLD and CBV changes following neural activation were used to parameterise a 5-layer heterogeneous tissue model used in the Monte Carlo simulations (MCS) of light transport through tissue in the OIS analysis algorithm. To transform the fMRI BOLD and CBV measurements into deoxy-haemoglobin (Hbr) profiles we inverted an MCS of extra-vascular MR signal attenuation under the assumption that the extra-/intravascular ratio is 2:1 at a magnetic field strength of 3 T. The significant improvement in the quantitative accuracy of haemodynamic measurements using the new heterogeneous tissue model over the original homogeneous tissue model OIS algorithm was demonstrated on new concurrent OIS and fMRI data covering a range of stimulus durations. (C) 2009 Elsevier Inc. All rights reserved.
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