Article
Acoustics
Jia-hui Yan, K. A. I. LI, Yi-lun Ge, W. E. N. LI, Pu-zhi Wang, H. O. N. G. Jin, Jin-ru Zhang, J. I. N. G. Chen, F. E. N. Wang, Ya-ping Yang, Ying-chun Zhang, D. A. N. LI, Cheng-jie Mao, Chun-feng Liu
Summary: This study aimed to investigate the predictive performance of quantitative substantia nigra (SN) evaluations using transcranial sonography for levodopa dyskinesia (LID) in Parkinson's disease (PD). The study found that the total hyperechogenic area of the SN was associated with LID. A model combining clinical features and the hyperechogenic area of the SN showed better efficiency in predicting LID development.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Neurosciences
Pilar Alvarez Jerez, Jose Luis Alcantud, Lucia de los Reyes-Ramirez, Anni Moore, Clara Ruz, Francisco Vives Montero, Noela Rodriguez-Losada, Prabhjyot Saini, Ziv Gan-Or, Chelsea X. Alvarado, Mary B. Makarious, Kimberley J. Billingsley, Cornelis Blauwendraat, Alastair J. Noyce, Andrew B. Singleton, Raquel Duran, Sara Bandres-Ciga
Summary: This study aimed to explore the genetic and genomic connection between neurodegeneration with brain iron accumulation (NBIA) and Parkinson's Disease (PD). Screening for known and rare pathogenic mutations in genes linked to NBIA in PD cases and controls, four NBIA variants were associated with PD risk. However, no enrichment of heterozygous variants in NBIA-related genes risk was identified in PD cases versus controls. Overall, the study suggests that NBIA and PD may be separate molecular entities.
NPJ PARKINSONS DISEASE
(2023)
Article
Acoustics
Xin Yu Fu, Ying Chun Zhang, Chang Wei Ding, Ping Zhao, Qing Yuan Liu, Min Yang, Cai Shan Wang, Xiao Fang Chen, Ying Zhang, Yu Jing Sheng, Pan Mao, Cheng Jie Mao, Chun Feng Liu
Summary: This study explored the asymmetry of bilateral substantia nigra hyperechogenicity (SN+) and its relationship with clinical features in Parkinson's disease (PD). The findings revealed that SN+ asymmetry could reflect the asymmetrical characteristics of PD, and the dynamic change in SN+ asymmetry might indicate a dynamic change in motor asymmetry in PD patients.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Nicolas Louarn, Paul Kauv, Laurent Capelle, Karima Mokhtari, Emmanuel Itti
Summary: This case demonstrates the additional value of F-18-DOPA PET in combination with multimodal MRI to differentiate between low and high-grade gliomas.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liesbeth Reneman, Marieke van der Pluijm, Anouk Schrantee, Elsmarieke van de Giessen
Summary: The dopamine system in the brain plays a crucial role in various neurologic and psychiatric disorders, with PET and SPECT being used to visualize and measure different aspects of the system. New developments in MR imaging offer alternative ways to assess the dopamine system, with techniques like phMRI and NM-MRI showing promise for clinical application.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Review
Behavioral Sciences
Fumihiko Ueno, Yusuke Iwata, Shinichiro Nakajima, Fernando Caravaggio, Jose M. Rubio, Guillermo Horga, Clifford M. Cassidy, Edgardo Torres-Carmona, Vincenzo de Luca, Sakiko Tsugawa, Shiori Honda, Sho Moriguchi, Yoshihiro Noda, Philip Gerretsen, Ariel Graff-Guerrero
Summary: This study found that patients with schizophrenia have increased levels of neuromelanin in the substantia nigra, suggesting that it may serve as a potential biomarker for stratifying schizophrenia.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Goldfarb, Alex Iep, Mohammad Bilal Chawki, Loc Nguyen, Francois Lun, Amer-Adam Al Najjar Carpentier, Anne de Recondo, Jerome Blin, Valerie Bourdinaud, Ludovic Morin, Harisoa Andriatsiferana, Andre Ferreira, Anne Marie Deschiens, Vincent Brulon, Claude Comtat, Vincent Lebon, Florent L. Besson
Summary: The study aimed to compare the diagnostic performance of the rabbit visual pattern with the EANM/SNMMI-endorsed pattern for diagnosing parkinsonian syndromes in PET/MRI. The PET images of 129 patients were reviewed by 5 experienced readers using two visual methods (EANM/SNMMI criteria and the rabbit shape of the striate) independently. The results showed no statistical difference between the two methods, indicating that the rabbit visual pattern is comparable to the current reference procedure.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Health Care Sciences & Services
Niels Bergsland, Laura Pelizzari, Maria Marcella Lagana, Sonia Di Tella, Federica Rossetto, Raffaello Nemni, Mario Clerici, Francesca Baglio
Summary: This study demonstrates robust and clinically meaningful associations between substantia nigra microstructure and Parkinson's disease, particularly showing a significant correlation between axial diffusivity in SNpc and UPDRS III scores in PD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ramon Martinez-Mamol, Rosina Giordano-Santini, Eva Kaulich, Ann-Na Cho, Magdalena Przybyla, Md Asrafuzzaman Riyadh, Emilija Robinson, Keng Yih Chew, Rumelo Amor, Frederic A. Meunier, Giuseppe Balistreri, Kirsty R. Short, Yazi D. Ke, Lars M. Ittner, Massimo A. Hilliard
Summary: Viruses, including SARS-CoV-2, can infect the brain and cause severe neurological symptoms through the fusion of neurons and glia. This fusion is mediated by the viral fusogen and leads to the formation of multicellular syncytia, as well as the spread of molecules and organelles. Furthermore, the fusion severely compromises neuronal activity. These findings contribute to our understanding of the mechanisms by which viruses affect the nervous system and cause neuropathology.
Article
Cell Biology
Jacob K. Sterling, Tae-In Kam, Samyuktha Guttha, Hyejin Park, Bailey Baumann, Amir A.Mehrabani-Tabari, Hannah Schultz, Brandon Anderson, Ahab Alnemri, Shih-Ching Chou, Juan C. Troncoso, Valina L. Dawson, Ted M. Dawson, Joshua L. Dunaief
Summary: The aggregation and accumulation of a-synuclein drive neurodegeneration in Parkinson's disease (PD). Microglia activated by misfolded a-synuclein release interleukin 6 (IL-6), which induces changes in neuronal iron transcriptome and leads to cellular iron accumulation. The IL-6-mediated cellular iron sequestration response (CISR) contributes to synuclein-induced neurodegeneration in PD patients.
Article
Oncology
Hiroyuki Tatekawa, Akifumi Hagiwara, Hiroyuki Uetani, Shadfar Bahri, Catalina Raymond, Albert Lai, Timothy F. Cloughesy, Phioanh L. Nghiemphu, Linda M. Liau, Whitney B. Pope, Noriko Salamon, Benjamin M. Ellingson
Summary: The study developed a voxel-wise clustering method using multiparametric MRI and FDOPA PET images to classify the IDH status of gliomas, achieving successful visualization of associations between multiparametric imaging values and high classification performance. Machine learning approach may improve understanding of prioritizing multiparametric imaging for classifying IDH status.
Article
Clinical Neurology
Semra Smajic, Cesar A. Prada-Medina, Zied Landoulsi, Jenny Ghelfi, Sylvie Delcambre, Carola Dietrich, Javier Jarazo, Jana Henck, Saranya Balachandran, Sinthuja Pachchek, Christopher M. Morris, Paul Antony, Bernd Timmermann, Sascha Sauer, Sandro L. Pereira, Jens C. Schwamborn, Patrick May, Anne Gruenewald, Malte Spielmann
Summary: In this study, the contribution of different cell types to Parkinson's disease pathology was investigated using single-nuclei RNA sequencing. The results revealed a disease-specific neuronal cell cluster and changes in glial cells, as well as the enrichment of Parkinson's disease risk genes. These findings highlight the importance of inflammatory signaling and immunomodulatory treatments in Parkinson's disease.
Article
Clinical Neurology
Sha Zhu, Yaxi Wang, Yinyin Jiang, Ruxin Gu, Min Zhong, Xu Jiang, Bo Shen, Jun Zhu, Jun Yan, Yang Pan, Li Zhang
Summary: This study aimed to explore the relationship between substantia nigra hyperechogenicity (SNH) and the clinical features of Parkinson's disease (PD). The results showed that SNH was significantly correlated with activities of daily living and gait impairment in Chinese patients with PD, suggesting the formation of SNH might be a dynamic biomarker reflecting disease severity.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Neurosciences
Cui Liu, Nan-Wei Kang, Ying Wang, Yan Xue, Xin-Yi Chen, Lei Chen
Summary: The present study investigated the effects of apelin on the spontaneous firing activity of nigral dopaminergic neurons and found that it may serve as a neuroprotective factor in Parkinson's disease.
Article
Neurosciences
Cui Liu, Nan-Wei Kang, Ying Wang, Yan Xue, Xin-Yi Chen, Lei Chen
Summary: The neuropeptide apelin modulates the firing activity of nigral dopaminergic neurons and may serve as a neuroprotective factor in Parkinson's disease.
Article
Clinical Neurology
Ulf Jensen-Kondering, Nils G. Margraf, Caroline Weiler, Walter Maetzler, Justina Dargvainiene, Kim Falk, Sarah Philippen, Thorsten Bartsch, Charlotte Flueh, Christoph Roecken, Bettina Moeller, Georg Royl, Alexander Neumann, Norbert Brueggemann, Benjamin Roeben, Claudia Schulte, Benjamin Bender, Daniela Berg, Gregor Kuhlenbaeumer
Summary: This study compared the clinical, radiological, and cerebrospinal fluid marker data of patients with CAA, MLH, AD, and healthy controls. The results showed that cSS was more common in CAA, and MLH with cSS was associated with ICH. The concentrations of cerebrospinal fluid markers differed among the groups.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Bernd Leplow, Daniela Renftle, Mareike Thomas, Katja Michaelis, Susanne Solbrig, Walter Maetzler, Daniela Berg, Inga Liepelt-Scarfone
Summary: Impulse control disorders (ICD) frequently occur in Parkinson's disease (PD), not always as a direct consequence of medication. This study investigated premorbid personality traits and behavioral characteristics in non-demented PD patients with self-reported symptoms of ICD (PD-srICD). It was found that patients with PD-srICD had similarities with substance use disorder patients, and thorough psychological diagnostics are recommended.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Neurosciences
Gabrielle Todd, Caroline D. Rae, Janet L. Taylor, Nigel C. Rogasch, Jane E. Butler, Michael Hayes, Robert A. Wilcox, Simon C. Gandevia, Karl Aoun, Adrian Esterman, Simon J. G. Lewis, Julie M. Hall, Elie Matar, Jana Godau, Daniela Berg, Christian Plewnia, Anna-Katharina Von Thaler, Clarence Chiang, Kay L. Double
Summary: Research has found that increased thickness of the substantia nigra in healthy older adults may be associated with changes in excitability of motor cortical circuitry. This finding has important implications for understanding brain changes in healthy older adults at risk of Parkinson's disease.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Clinical Neurology
Eva-Juliane Vollstedt, Susen Schaake, Katja Lohmann, Shalini Padmanabhan, Alexis Brice, Suzanne Lesage, Christelle Tesson, Marie Vidailhet, Isabel Wurster, Faycel Hentati, Anat Mirelman, Nir Giladi, Karen Marder, Cheryl Waters, Stanley Fahn, Meike Kasten, Norbert Bruggemann, Max Borsche, Tatiana Foroud, Eduardo Tolosa, Alicia Garrido, Grazia Annesi, Monica Gagliardi, Maria Bozi, Leonidas Stefanis, Joaquim J. Ferreira, Leonor Correia Guedes, Micol Avenali, Simona Petrucci, Lorraine Clark, Ekaterina Y. Fedotova, Natalya Y. Abramycheva, Victoria Alvarez, Manuel Menendez-Gonzalez, Silvia Jesus Maestre, Pilar Gomez-Garre, Pablo Mir, Andrea Carmine Belin, Caroline Ran, Chin-Hsien Lin, Ming-Che Kuo, David Crosiers, Zbigniew K. Wszolek, Owen A. Ross, Joseph Jankovic, Kenya Nishioka, Manabu Funayama, Jordi Clarimon, Caroline H. Williams-Gray, Marta Camacho, Mario Cornejo-Olivas, Luis Torres-Ramirez, Yih-Ru Wu, Guey-Jen Lee-Chen, Ana Morgadinho, Teeratorn Pulkes, Pichet Termsarasab, Daniela Berg, Gregor Kuhlenbaumer, Andrea A. Kuhn, Friederike Borngraeber, Giuseppe de Michele, Anna De Rosa, Alexander Zimprich, Andreas Puschmann, George D. Mellick, Jolanta Dorszewska, Jonathan Carr, Rosangela Ferese, Stefano Gambardella, Bruce Chase, Katerina Markopoulou, Wataru Satake, Tatsushi Toda, Malco Rossi, Marcelo Merello, Timothy Lynch, Diana A. Olszewska, Shen-Yang Lim, Azlina Ahmad-Annuar, Ai Huey Tan, Bashayer Al-Mubarak, Hasmet Hanagasi, Dariusz Koziorowski, Sibel Ertan, Gencer Genc, Patricia de Carvalho Aguiar, Melinda Barkhuizen, Marcia M. G. Pimentel, Rachel Saunders-Pullman, Bart van de Warrenburg, Susan Bressman, Mathias Toft, Silke Appel-Cresswell, Anthony E. Lang, Matej Skorvanek, Agnita J. W. Boon, Rejko Kruger, Esther M. Sammler, Vitor Tumas, Bao-Rong Zhang, Gaetan Garraux, Sun Ju Chung, Yun Joong Kim, Juliane Winkelmann, Carolyn M. Sue, Eng-King Tan, Joana Damasio, Peter Klivenyi, Vladimir S. Kostic, David Arkadir, Mika Martikainen, Vanderci Borges, Jens Michael Hertz, Laura Brighina, Mariana Spitz, Oksana Suchowersky, Olaf Riess, Parimal Das, Brit Mollenhauer, Emilia M. Gatto, Maria Skaalum Petersen, Nobutaka Hattori, Ruey-Meei Wu, Sergey N. Illarioshkin, Enza Maria Valente, Jan O. Aasly, Anna Aasly, Roy N. Alcalay, Avner Thaler, Matthew J. Farrer, Kathrin Brockmann, Jean-Christophe Corvol, Christine Klein
Summary: Through a worldwide online survey, we established an international cohort of individuals with PD-linked variants, providing harmonized and quality-controlled clinical and genetic data for each participant and promoting collaboration among researchers in the field of monogenic PD.
MOVEMENT DISORDERS
(2023)
Article
Medicine, General & Internal
Constanze Stolz-Klingenberg, Claudia Buenzen, Marie Coors, Charlotte Flueh, Klarissa Hanja Stuerner, Kai Wehkamp, Marla L. Clayman, Fueloep Scheibler, Jens Ulrich Rueffer, Wiebke Schuettig, Leonie Sundmacher, Daniela Berg, Friedemann Geiger
Summary: SHARE TO CARE (S2C) is a comprehensive program aimed at promoting shared decision making (SDM). It has been successfully implemented at the University Hospital Schleswig-Holstein in Kiel, Germany, and among general practitioners in the Federal State of Bremen. The results of the implementation showed an increase in patients' perceived involvement in medical decision making.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Letter
Clinical Neurology
Gunther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Anastasia Kuzkina, Celine Panzer, Aline Seger, Daniela Schmitt, Jonas Roessle, Sebastian R. Schreglmann, Henrike Knacke, Elena Salabasidou, Antonia Kohl, Elisabeth Sittig, Michael Barbe, Daniela Berg, Jens Volkmann, Claudia Sommer, Wolfgang H. Oertel, Eva Schaeffer, Michael Sommerauer, Annette Janzen, Kathrin Doppler
Summary: The study assessed the use of RT-QuIC method to detect alpha-synuclein aggregation in skin biopsy samples of iRBD patients. It was found that 97.4% of iRBD patients, 87.2% of PD patients, and 13% of controls showed aggregation of alpha-synuclein. RT-QuIC was more sensitive but less specific compared to immunohistochemistry.
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Guenther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
MOVEMENT DISORDERS
(2023)
Article
Multidisciplinary Sciences
Meemansa Sood, Ulrike Suenkel, Anna-Katharina von Thaler, Helena U. U. Zacharias, Kathrin Brockmann, Gerhard W. Eschweiler, Walter Maetzler, Daniela Berg, Holger Froehlich, Sebastian Heinzel
Summary: Parkinson's disease (PD) has a long prodromal phase with many markers indicating an increased risk prior to clinical diagnosis. Current prediction models lack consideration of interdependencies between predictors and differentiation by subtypes, and may be limited by confounding factors and restricted data access. Using AI and a Bayesian network, we analyzed data from 1178 healthy individuals and 24 incident PD cases to quantify marker interdependencies and generate synthetic profiles. We identified robust interdependencies and demonstrated the usefulness of AI in modeling and understanding PD markers.
Article
Clinical Neurology
Stephan Greten, Florian Wegner, Ida Jensen, Lea Krey, Sophia Rogozinski, Meret Fehring, Johanne Heine, Johanna Doll-Lee, Monika Poetter-Nerger, Molly Zeitzschel, Keno Hagena, David J. Pedrosa, Carsten Eggers, Katrin Buerk, Claudia Trenkwalder, Inga Claus, Tobias Warnecke, Patrick Suess, Juergen Winkler, Doreen Gruber, Florin Gandor, Daniela Berg, Steffen Paschen, Joseph Classen, Elmar H. Pinkhardt, Jan Kassubek, Wolfgang H. Jost, Lars Toenges, Andrea A. Kuehn, Johannes Schwarz, Oliver Peters, Eman Dashti, Josef Priller, Eike J. Spruth, Patricia Krause, Annika Spottke, Anja Schneider, Aline Beyle, Okka Kimmich, Markus Donix, Robert Haussmann, Moritz Brandt, Elisabeth Dinter, Jens Wiltfang, Bjoern H. Schott, Inga Zerr, Mathias Baehr, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Endy Weidinger, Johannes Levin, Sabrina Katzdobler, Emrah Duezel, Wenzel Glanz, Stefan Teipel, Ingo Kilimann, Johannes Prudlo, Thomas Gasser, Kathrin Brockmann, Daniel C. Hoffmann, Thomas Klockgether, Olaf Krause, Johannes Heck, Guenter U. Hoeglinger, Martin Klietz
Summary: This study explored the pattern of comorbidities and co-medication in PSP patients. It found that PSP patients have a higher prevalence of cardiovascular diseases and diabetes, and they receive a greater number of drugs, leading to a higher prevalence of polypharmacy.
JOURNAL OF NEUROLOGY
(2023)
Article
Psychology, Multidisciplinary
Lydia Kastner, Ulrike Suenkel, Gerhard W. Eschweiler, Theresa Dankowski, Anna-Katharina von Thaler, Christian Mychajliw, Kathrin Brockmann, Walter Maetzler, Daniela Berg, Andreas J. Fallgatter, Sebastian Heinzel, Ansgar Thiel
Summary: Older age is a major risk factor for severe COVID-19. In 2020, there was a broad political debate on whether older adults need special protection and isolation to minimize their risk of SARS-CoV-2 infection. However, isolation may also have indirect negative psychological or physical consequences depending on individual coping strategies and personality traits.
FRONTIERS IN PSYCHOLOGY
(2023)
Meeting Abstract
Clinical Neurology
R. Yilmaz, R. Wolke, N. Puls, M. Sorgun, G. Deuschl, D. Berg, N. Margraf
MOVEMENT DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
C. Zatti, A. Pilotto, A. Rizzardi, M. Catania, L. Purin, M. Pasolini, C. Hansen, R. Romijnders, E. Schaeffer, A. Galbiati, L. Ferini Strambi, D. Berg, W. Maetzler, A. Padovani
MOVEMENT DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
A. Kluge, E. Schaeffer, K. Brockmann, C. Schulte, C. Deuschle, J. Bunk, W. Maetzler, D. Berg
MOVEMENT DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
I. Liepelt-Scarfone, M. Bode, S. Solbrig, K. Brockmann, W. Maetzler, I. Wurster, M. Timmers, D. Berg, S. Becker
MOVEMENT DISORDERS
(2023)
