期刊
NEUROIMAGE
卷 47, 期 4, 页码 1506-1513出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2009.05.045
关键词
Scanner drift; Registration; Brain atrophy; Boundary shift integral; Alzheimer's disease
资金
- Alzheimer's Disease Neuroimaging Initiative (ADNI) [U01 AG024904]
- National Institute on Aging
- National institute of Biomedical Imaging and Bioengineering (NIBIB)
- Pfizer Inc.
- Wyeth Research
- Bristol-Myers Squibb
- Eli Lilly and Company
- GIaxoSmithKline
- Merck Co. Inc.
- AstraZeneca AB
- Novartis Pharmaceuticals Corporation
- Alzheimer's Association
- Eisai Global Clinical Development
- Elan Corporation plc
- Forest Laboratories
- Institute for the Study of Aging
- Department of Health's NIHR Biomedical Research Centres
- The Dementia Research Centre is an Alzheimer's Research Trust Co-ordinating centre
- TSB [M1638A]
- Alzheimer's Research Trust (UK) Research Fellowship
- MRC (UK)
- MRC [G0601846] Funding Source: UKRI
- Alzheimers Research UK [ART-RF2007-1] Funding Source: researchfish
- Medical Research Council [G0601846] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10123] Funding Source: researchfish
Rates of brain atrophy derived from serial magnetic resonance (MR) studies may be used to assess therapies for Alzheimer's disease (AD). These measures may be confounded by changes in scanner voxel sizes. For this reason, the Alzheimer's Disease Neuroimaging Initiative (ADNI) included the imaging of a geometric phantom with every scan. This study compares voxel scaling correction using a phantom with correction using a 9 degrees of freedom (9DOF) registration algorithm. We took 129 pairs of baseline and 1-year repeat scans, and calculated the volume scaling correction, previously measured using the phantom. We used the registration algorithm to quantify any residual scaling errors, and found the algorithm to be unbiased, with no significant (p=0.97) difference between control (n=79) and AD subjects (n=50), but with a mean (SD) absolute volume change of 0.20 (0.20) % due to linear scalings. 9DOF registration was shown to be comparable to geometric phantom correction in terms of the effect on atrophy measurement and unbiased with respect to disease status. These results suggest that the additional expense and logistic effort of scanning a phantom with every patient scan can be avoided by registration-based scaling correction. Furthermore, based upon the atrophy rates in the AD subjects in this study, sample size requirements would be approximately 10-12% lower with (either) correction for voxel scaling than if no correction was used. (C) 2009 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据