Article
Cell Biology
Yvette Bohraus, Hellmut Merkle, Nikos K. Logothetis, Jozien Goense
Summary: Blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD fMRI) is biased towards large veins on the cortical surface, while cerebral metabolic rate of oxygen (ACMRO2) may better reflect neural cortical function. This study examines the validity of the calibrated BOLD model for measuring functional CMRO2 at high resolution and demonstrates the feasibility of laminar ACMRO2 measurement, providing a meaningful metric of laminar functional metabolism.
Article
Neurosciences
Zhaoxia Qin, Huai-Bin Liang, Muwei Li, Yue Hu, Jing Wu, Yuan Qiao, Jian-Ren Liu, Xiaoxia Du
Summary: This study found decreased functional connections between white matter bundles and gray matter regions in migraine patients, which may contribute to disrupted functional connectivity in the pain processing pathway. These findings suggest that functional and connectivity abnormalities in cortical regions are not limited to gray matter regions but are associated with abnormalities in white matter tracts.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Physics, Multidisciplinary
Maria Guidi, Giovanni Giulietti, Emma Biondetti, Richard Wise, Federico Giove
Summary: Neurovascular alterations play a key role in many brain diseases and can be effectively observed and measured using MRI techniques. The current MRI sequences provide reliable markers for vascular dysfunction, but further research is needed to observe vascular changes at a finer scale.
FRONTIERS IN PHYSICS
(2023)
Article
Neurosciences
Sebastian C. Schneider, Mario E. Archila-Melendez, Jens Goettler, Stephan Kaczmarz, Benedikt Zott, Josef Priller, Michael Kallmayer, Claus Zimmer, Christian Sorg, Christine Preibisch
Summary: By studying asymptomatic patients with arterial stenosis and healthy controls, this study demonstrates a negative association between homotopic BOLD-FC and capillary transit time heterogeneity (CTH) differences, suggesting that increasing CTH differences lead to BOLD-FC reductions. Simulations also show that increasing CTH corresponds to broadened and delayed CBF responses to ongoing neuronal activity.
Article
Neurosciences
Sangcheon Choi, Hang Zeng, Yi Chen, Filip Sobczak, Chunqi Qian, Xin Yu
Summary: This study developed a multislice line-scanning fMRI method to investigate laminar-specific information flow across cortical regions in different brain states. The findings revealed the presence of trial-specific intra- and inter-laminar functional connectivity in both evoked and resting conditions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Bin Guo, Fugen Zhou, Muwei Li, John C. Gore, Zhaohua Ding
Summary: This study aimed to explore the relationship between BOLD signals in white matter and tissue metabolism, finding that BOLD signals are directly related to metabolic demand and engagement with cortical processing. These findings suggest that BOLD signals in white matter should be incorporated into more comprehensive models of brain function.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Neurosciences
Sebastian C. Schneider, Stephan Kaczmarz, Jens Goettler, Jan Kufer, Benedikt Zott, Josef Priller, Michael Kallmayer, Claus Zimmer, Christian Sorg, Christine Preibisch
Summary: This study investigates and compares different hemodynamic-vascular processes and their impact on BOLD-FC in healthy controls and patients with ICAS. The results suggest that systemic perfusion delays have a stronger influence on BOLD-FC than impairments in local neurovascular coupling.
Review
Radiology, Nuclear Medicine & Medical Imaging
Dengrong Jiang, Hanzhang Lu
Summary: This article reviews the emerging MRI-based techniques for measuring oxygen extraction fraction (OEF) in the human brain. OEF is an important physiological parameter in brain function and metabolism. Compared to other methods, MRI techniques are non-invasive, radiation-free, and more widely available.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Physiology
Larissa McKetton, Kevin Sam, Julien Poublanc, Adrian P. Crawley, Olivia Sobczyk, Lakshmikumar Venkatraghavan, James Duffin, Joseph A. Fisher, David J. Mikulis
Summary: This study examines the effect of variability in PaCO2 on the pattern of rs-fMRI connectivity. The findings suggest that fluctuations in PETCO2 during normal breathing can lead to changes in cerebral functional connections and affect the synchronization of BOLD signals.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Yuhua Yu, Caterina Gratton, Derek M. Smith
Summary: While correlations in the BOLD fMRI signal are widely used to capture functional connectivity and its changes across contexts, its interpretation is often ambiguous. Here, a new metric called communication change is proposed to estimate the contribution of nonlocal network input to FC changes across different contexts. It is demonstrated that network input plays a significant role in task-induced FC change and the proposed communication change can effectively track the local coupling in task context-induced change and discriminate specific task types.
NETWORK NEUROSCIENCE
(2023)
Article
Neurosciences
Valeria Vazquez-Trejo, Binyam Nardos, Bradley L. Schlaggar, Damien A. Fair, Oscar Miranda-Dominguez
Summary: Task-based fMRI has improved our understanding of brain functioning, but traditional analyses ignore dynamic connectivity between brain regions. This study used connectotyping to analyze fMRI data from a word vs. pseudoword decision task and found significant differences in dynamic connectivity patterns between brain regions involved in cognitive task control, memory retrieval, and semantic processing.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Sayan Nag, Kamil Uludag
Summary: Functional MRI (fMRI) is used to indirectly measure neuronal activity. In this study, a novel approach combining physiologically informed DCM with recurrent units is proposed and validated for determining dynamic effective connectivity between brain areas during complex cognitive tasks. The simulation results demonstrate the accurate prediction and distinction of fMRI BOLD responses and effective connectivity time-courses, highlighting the effectiveness of the proposed approach.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Jennifer A. Cummings, Benjamin Sipes, Daniel H. Mathalon, Ashish Raj
Summary: Understanding how complex dynamic activity propagates over a static structural network is an important question in neuroscience. Previous research has shown that linear graph-theoretic models can predict functional connectivity as well as non-linear neural simulations, with the advantage of lower computational cost. In this study, we propose a simple model that relates the eigenvalues of the structural connectivity and functional networks using the Gamma function, providing a reliable prediction of functional connectivity with a single model parameter. We also investigate the impact of local activity diffusion and long-range interhemispheric connectivity on the structure-function model, and find that accounting for these latent variables improves the prediction of functional connectivity, which are often excluded from traditional diffusion tensor imaging (DTI) methods.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Shuai Wang, Samuel Planton, Valerie Chanoine, Julien Sein, Jean-Luc Anton, Bruno Nazarian, Anne-Sophie Dubarry, Christophe Pallier, Chotiga Pattamadilok
Summary: The left ventral occipito-temporal cortex plays a crucial role in reading and also responds to speech input, serving as an interface connecting different brain regions and sub-networks during speech processing. Its functional role varies depending on the context and the quality of speech signal and task difficulty.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Ahmed A. Khalil, Ayse C. Tanritanir, Ulrike Grittner, Evgeniya Kirilina, Arno Villringer, Jochen B. Fiebach, Ralf Mekle
Summary: In this study, the reproducibility of BOLD delay was assessed in 136 subjects with normal cerebral perfusion. The highest reproducibility was observed in the posterior cerebral artery territory. Overall, BOLD delay showed good reproducibility, but caution should be exercised when interpreting longitudinal BOLD delay changes that are either very small or located in certain brain regions.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Qihong Zou, Shuqin Zhou, Jing Xu, Zihui Su, Yuezhen Li, Yundong Ma, Hongqiang Sun, Changwei W. Wu, Jia-Hong Gao
Article
Clinical Neurology
Fan-Chi Hsiao, Pei-Jung Tsai, Changwei W. Wu, Chien-Ming Yang, Timothy Joseph Lane, Hsin-Chien Lee, Ling-Chun Chen, We-Kang Lee, Lu-Hsin Lu, Yu-Zu Wu
Article
Mathematical & Computational Biology
Ai-Ling Hsu, Ping Hou, Jason M. Johnson, Changwei W. Wu, Kyle R. Noll, Sujit S. Prabhu, Sherise D. Ferguson, Vinodh A. Kumar, Donald F. Schomer, John D. Hazle, Jyh-Horng Chen, Ho-Ling Liu
FRONTIERS IN NEUROINFORMATICS
(2018)
Article
Clinical Neurology
Fan-Chi Hsiao, Pei-Jung Tsai, Changwei W. Wu, Chien-Ming Yang, Timothy Joseph Lane, Hsin-Chien Lee, Ling-Chun Chen, We-Kang Lee, Lu-Hsin Lu, Yu-Zu Wu
Article
Neuroimaging
Kuo-Lun Huang, Ting-Yu Chang, Meng-Yang Ho, Wei-Hao Chen, Mei-Yu Yeh, Yeu-Jhy Chang, Ho-Fai Wong, Chien-Hung Chang, Chi-Hung Liu, Tsong-Hai Lee, Changwei W. Wu
NEUROIMAGE-CLINICAL
(2018)
Article
Physiology
Pei-Ying S. Chan, Chia-Hsiung Cheng, Yu-Ting Wu, Changwei W. Wu, Ho-Ling A. Liu, Fu-Zen Shaw, Chia-Yih Liu, Paul W. Davenport
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Neurosciences
Feng-Ying Huang, Ai-Ling Hsu, Li-Ming Hsu, Jaw-Shiun Tsai, Chih-Mao Huang, Yi-Ping Chao, Tzung-Jeng Hwang, Changwei W. Wu
FRONTIERS IN HUMAN NEUROSCIENCE
(2019)
Article
Neurosciences
Yi-Chia Kung, Chia-Wei Li, Shuo Chen, Sharon Chia-Ju Chen, Hun-Yi Z. Lo, Timothy J. Lane, Bharat Biswal, Changwei W. Wu, Ching-Po Lin
HUMAN BRAIN MAPPING
(2019)
Article
Clinical Neurology
Changwei W. Wu, Pei-Jung Tsai, Sharon Chia-Ju Chen, Chia-Wei Li, Ai-Ling Hsu, Hong-Yi Wu, Yu-Ting Ko, Pai-Chuan Hung, Chun-Yen Chang, Ching-Po Lin, Timothy J. Lane, Chia-Yuen Chen
SLEEP AND BIOLOGICAL RHYTHMS
(2019)
Article
Multidisciplinary Sciences
Pei-Ying S. Chan, Yu-Ting Wu, Ai-Ling Hsu, Chia-Wei Li, Changwei W. Wu, Andreas von Leupoldt, Shih-Chieh Hsu
SCIENTIFIC REPORTS
(2019)
Article
Neuroimaging
Li-Ming Hsu, Timothy Joseph Lane, Changwei W. Wu, Chien-Yuan Lin, Chi-Bin Yeh, Hung-Wen Kao, Ching-Po Lin
Summary: This study found that Sertraline treatment can restore some brain network connections in MDD patients, but some connections remain impaired. Thalamo-prefrontal connectivity shows moderate predictive power for the effectiveness of Sertraline treatment.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neurosciences
Feng-Ying Huang, Ai-Ling Hsu, Yi-Ping Chao, Chloe Mu-Hsuan Shang, Jaw-Shiun Tsai, Changwei W. Wu
Summary: The study found that mindfulness-based cognitive therapy (MBCT) can enhance emotional regulation among bereaved individuals by reshaping resting-state brain networks, therefore improving their mental well-being.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Ai-Ling Hsu, Chia-Wei Li, Pengmin Qin, Men-Tzung Lo, Changwei W. Wu
Summary: This study used the Hilbert-Huang transform to examine the spectral interactions in resting-state fMRI and revealed differences in these interactions between eye-closed and eye-open conditions.
Review
Neurosciences
Hsuan-Chu Shih, Mu-En Kuo, Changwei W. Wu, Yi-Ping Chao, Hsu-Wen Huang, Chih-Mao Huang
Summary: Maternal and passionate love play crucial roles in reproduction and involve attachment behaviors with high rewards. Neurobiological studies suggest that the coordination of oxytocinergic and vasopressinergic pathways, coupled with the dopaminergic reward system, contribute to the formation and maintenance of maternal and passionate love. A quantitative meta-analysis of human neuroimaging revealed common and dissociable neural substrates associated with maternal and passionate love. The findings suggest that maternal attachment involves cognitive-affective regulation, while romantic love behaviors desire to combine liking and wanting. The ventral tegmental area (VTA) shows functional convergence in both types of human love, indicating a shared neurobiological mechanism with evolutionary roots.
Article
Neurosciences
Tun Jao, Chia-Wei Li, Petra E. Vertes, Changwei Wesley Wu, Sophie Achard, Chao-Hsien Hsieh, Chien-Hui Liou, Jyh-Horng Chen, Edward T. Bullmore
BRAIN CONNECTIVITY
(2016)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.