Article
Geriatrics & Gerontology
Emma L. Ducca, Gabriela T. Gomez, Priya Palta, Kevin J. Sullivan, Clifford R. Jack, David S. Knopman, Rebecca F. Gottesman, Jeremy Walston, B. Gwen Windham, Keenan A. Walker
Summary: The study found a strong association between cerebral white matter structure and current and future frailty. Specifically, white matter hyperintensity volume was significantly associated with frailty. However, measures of white matter microstructure were not generally associated with progression from nonfrail to frail status.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Bingxin Zhao, Tengfei Li, Yue Yang, Xifeng Wang, Tianyou Luo, Yue Shan, Ziliang Zhu, Di Xiong, Mads E. Hauberg, Jaroslav Bendl, John F. Fullard, Panagiotis Roussos, Yun Li, Jason L. Stein, Hongtu Zhu
Summary: The study identified common genetic variants influencing white matter microstructure and detected multiple associated loci, some of which were related to brain diseases. Additionally, genetic correlations were observed between white matter microstructure and a wide range of complex traits and diseases.
Review
Endocrinology & Metabolism
Cong Zhou, Jie Li, Man Dong, Liangliang Ping, Hao Lin, Yuxin Wang, Shuting Wang, Shuo Gao, Ge Yu, Yuqi Cheng, Xiufeng Xu
Summary: This meta-analysis examined white matter microstructural alterations in patients with type 2 diabetes mellitus and found reductions in fractional anisotropy in the left inferior network, corpus callosum, and left olfactory cortex. Additionally, a negative correlation was observed between fractional anisotropy in the corpus callosum and BMI in the patient group.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Mia Andreoli, Melissa-Ann Mackie, David Aaby, Matthew C. Tate
Summary: This study investigates the relationship between white matter tract disruption and cognitive deficits in glioma patients using diffusion tensor imaging (DTI). The findings suggest that WM tract disruption predicts cognitive dysfunction in glioma patients, emphasizing the importance of understanding WM tract organization for surgical resection and functional preservation in these patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Neurosciences
Matthew Kiely, Curtis Triebswetter, Luis E. Cortina, Zhaoyuan Gong, Maryam H. Alsameen, Richard G. Spencer, Mustapha Bouhrara
Summary: This study evaluated sex and age-related differences in white matter microstructure using diffusion tensor imaging (DTI) and magnetic resonance imaging (MRI). The results showed that myelin content and axonal density in white matter exhibited nonlinear changes with age, and the posterior white matter regions were more preserved from neurodegeneration compared to anterior regions. Additionally, DTI indices were moderately correlated with myelin content, indicating their sensitivity to other constituents of white matter tissue.
Article
Neurosciences
Jingyi Tang, Yue Xie, Weihua Liao, Youming Zhang, Fangxue Yang, Linmei Zhao, Gaofeng Zhou, Yuanchao Zhang, Hong Jiang, Wu Xing
Summary: Gray matter volume and thickness reductions have been found in SCA3 patients. This study explored cortical gyrification alterations using LGI and FA and found widespread reductions in LGI and white matter FA in SCA3 patients. The abnormalities in gyrification may contribute to the clinical heterogeneity of SCA3 and may be mediated by white matter microstructural abnormalities.
Review
Clinical Neurology
Chengmin Yang, Li Yao, Naici Liu, Wenjing Zhang, Bo Tao, Hengyi Cao, Qiyong Gong, Su Lui
Summary: This study investigated white matter deficits in patients with TS, finding robustly decreased FA in the corpus callosum and right inferior longitudinal fasciculus compared with healthy controls. The results suggest important abnormalities in interhemispheric connections and long association fiber bundles in TS, with future research needed to support these findings with larger sample sizes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Shannon Kelley, John Plass, Andrew R. Bender, Thad A. Polk
Summary: This study investigated age-related white matter differences using fixel-based analysis (FBA). The results revealed that age-related differences in FA were strongly associated with differences in multi-fiber complexity, indicating differences in crossing fibers and individual fiber segments. FBA also provided insights into distinct microstructural changes underlying age-related effects in specific brain regions.
Article
Clinical Neurology
Melanie A. Matyi, Jeffrey M. Spielberg
Summary: Deficits in negative emotion differentiation are associated with mental health outcomes, but the processes underlying individual differences in negative emotion differentiation are poorly understood. This study examines the relationship between white matter microstructure and negative emotion differentiation, providing insights into its component processes and its link to brain structure.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Guorui Zhao, Way K. W. Lau, Chanyu Wang, Haifeng Yan, Chichen Zhang, Kangguang Lin, Shijun Qiu, Ruiwang Huang, Ruibin Zhang
Summary: Schizophrenia and bipolar disorder share similarities in terms of brain white matter structure abnormalities, but also have disorder-specific abnormalities. Schizophrenia patients show more extensive white matter alterations compared to bipolar disorder cases, which may be the pathophysiological basis for the clinical continuity of both disorders.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Neurosciences
Alexandrine Morand, Shailendra Segobin, Gregory Lecouvey, Julie Gonneaud, Francis Eustache, Geraldine Rauchs, Beatrice Desgranges
Summary: This study found that older participants had lower gray matter volumes in several brain areas, but these did not correlate with TBPM performance. On the other hand, a decline in white matter integrity was correlated with TBPM performance, indicating a disconnection process that occurs in aging and contributes to cognitive decline.
Article
Clinical Neurology
Bo Wang, Haotian Wang, Zhidong Cen, Jiachen Yuan, Dehao Yang, Xinhui Chen, Fei Xie, Lebo Wang, Sheng Wu, Zhiyuan Ouyang, Yu-Feng Zang, Wei Luo
Summary: This study investigated white matter structural changes in patients with familial cortical myoclonic tremor with epilepsy (FCMTE) and their relationship with clinical and electrophysiological features. The results showed widespread reductions in white matter values in FCMTE patients, including in the commissural, projection, and association fibers. Increased white matter volume was found in the right cerebellum and sagittal stratum, while decreased values were detected in the sagittal stratum. Furthermore, there was a positive correlation between the volume of the right cerebellum and somatosensory-evoked potential amplitude.
Article
Immunology
Kalen J. Petersen, Jeremy Strain, Sarah Cooley, Florin Vaida, Beau M. Ances
Summary: Older persons with HIV may experience changes in brain white matter similar to accelerated aging, with viral load and comorbidities playing a role in this process. These changes in white matter can contribute to cognitive impairment.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Arashk Mallahzadeh, Mahan Shafie, Mahdi Tahvilian, Mohammad Sadeghi, Golsa Moslemian, Pouria Barzin, Maryam Bemanalizadeh, Mahsa Mayeli, Mohammad Hadi Aarabi
Summary: Using diffusion MRI connectometry, this study found that the integrity of white matter in certain tracts is associated with behavioral activation and inhibition, expanding our knowledge of the neural networks associated with risk-taking and reward-seeking behaviors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Masahiro Fujino, Keita Watanabe, Yoshinori Yamakawa
Summary: This study explores the relationship between the entire brain structure and spiritual growth using neuroimaging-derived measures. The results show that there is no significant correlation between gray matter volume and spiritual growth, but there is a positive correlation between white matter integrity and spiritual growth.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Chemistry, Medicinal
Brandon M. Taoka, Wen-Lian Wu, Jinsong Hao, Martin Dolmaski, Hongwu Wang, Dorthy Levorse, Peter Orth, Lynn A. Hyde, Brad Smith, Maria S. Michener, Matthew E. Kennedy, Eric M. Parker, Jared N. Cumming
Summary: This paper explores the structure-activity relationships of novel fluoroalkyl substituents at the C2 position of iminothiazine dioxide beta secretase inhibitors, highlighting the impact of reduced amidine basicity on Pgp, cell potency, and efficacy in preclinical in vivo animal models. The findings provide valuable insights into the mechanisms of action of these inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Neurosciences
Valeria Elisa Contarino, Silvia Siggillino, Andrea Arighi, Elisa Scola, Giorgio Giulio Fumagalli, Giorgio Conte, Emanuela Rotondo, Daniela Galimberti, Anna Margherita Pietroboni, Tiziana Carandini, Alexander Leemans, Anna Maria Bianchi, Fabio Maria Triulzi
Summary: This study investigates the alterations in superficial white matter (SWM) in Alzheimer's disease (AD) and non-AD neurodegenerative dementia (ND), and explores the relationship with cerebrospinal fluid (CSF) biomarkers and clinical data. The findings suggest that widespread SWM alterations occur in both AD and non-AD ND, and AD shows more severe alterations in the parietal SWM. These alterations are strongly linked to both cognitive decline and diagnostic CSF biomarkers.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Anouk S. Verschuur, Vivian Boswinkel, Chantal M. W. Tax, Jochen A. C. van Osch, Ingrid M. Nijholt, Cornelis H. Slump, Linda S. de Vries, Gerda van Wezel-Meijler, Alexander Leemans, Martijn F. Boomsma
Summary: This study aimed to apply and evaluate an intensity-based interpolation technique for segmentation of motion-affected neonatal brain MRI. The results showed that interpolation can effectively improve the segmentation of scans with motion artifacts and reduce the percentage of discarded scans.
JOURNAL OF NEUROIMAGING
(2022)
Article
Medicine, General & Internal
Takashi Tarumi, Neena R. Patel, Tsubasa Tomoto, Evan Pasha, Ayaz M. Khan, Kayla Kostroske, Jonathan Riley, Cynthia D. Tinajero, Ciwen Wang, Linda S. Hynan, Karen M. Rodrigue, Kristen M. Kennedy, Denise C. Park, Rong Zhang
Summary: This study investigated the effects of a 1-year aerobic exercise intervention on cognitive function, brain volume, and cortical thickness in sedentary older adults. The results showed that both aerobic exercise and stretching interventions improved cognitive performance, but did not prevent age-related brain volume loss. Improvements in cardiorespiratory fitness were positively correlated with cognitive performance and regional cortical thickness.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Neurosciences
Xi Chen, Melissa M. Rundle, Kristen M. Kennedy, William Moore, Denise C. Park
Summary: Neuroimaging research has found two different patterns of brain activation in successful cognitive aging - maintenance of youth-like activity and compensatory novel recruitment. This study investigated these patterns in individuals who resisted age-related cognitive decline over four years. The results showed that successful agers exhibited high subsequent memory effect until very old age, while average agers had reduced subsequent memory effect starting in young-old age. Additionally, successful agers showed additional recruitment in prefrontal clusters in young-old age. This study provides evidence of the neural mechanisms underlying successful cognitive aging.
Article
Anatomy & Morphology
Szabolcs David, Lucy L. Brown, Anneriet M. Heemskerk, Elaine Aron, Alexander Leemans, Arthur Aron
Summary: This study found subtle axonal microarchitectural differences in specific brain regions associated with sensory processing sensitivity (SPS), further deepening the understanding of SPS. The results suggest that heightened sensory processing in individuals with SPS may be influenced by the microstructure of white matter in specific cortical regions.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Endocrinology & Metabolism
Tsubasa Tomoto, Aryan Verma, Kayla Kostroske, Takashi Tarumi, Neena R. Patel, Evan P. Pasha, Jonathan Riley, Cynthia D. Tinajero, Linda S. Hynan, Karen M. Rodrigue, Kristen M. Kennedy, Denise C. Park, Rong Zhang
Summary: This study found that one-year progressive, moderate-to-vigorous aerobic exercise training has positive effects on cerebral blood flow, central arterial stiffness, and cognitive performance. In cognitively normal older adults, aerobic exercise training increased cerebral blood flow, decreased carotid arterial stiffness and cerebrovascular resistance, and was associated with improved memory function.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Biophysics
Ernst Christiaanse, Patrik O. O. Wyss, Anke Scheel-Sailer, Angela Frotzler, Dirk Lehnick, Rajeev K. K. Verma, Markus F. F. Berger, Alexander Leemans, Alberto De Luca
Summary: The study investigates the variability and reliability of diffusion kurtosis imaging (DKI) metrics in brain tissues outside white matter using an advanced estimation called mean kurtosis (MK)-Curve. The MK-Curve corrected DKI metrics showed good to excellent agreement in white and gray matter at 3 T, except for two metrics derived from DKI. This study highlights the importance of using a correction method to improve the reliability of DKI metrics.
NMR IN BIOMEDICINE
(2023)
Article
Multidisciplinary Sciences
Justyna A. Dobrowolska Zakaria, Randall J. Bateman, Monika Lysakowska, Ammaarah Khatri, Dinorah Jean-Gilles, Matthew E. Kennedy, Robert Vassar
Summary: This paper presents a method for measuring the metabolism of sAPP beta and sAPP alpha in humans using stable isotope labeling kinetics, immunoprecipitation, and liquid chromatography/tandem mass spectrometry. The method allows for a comprehensive study of these analytes and could provide novel insights into the pathophysiological mechanisms of Alzheimer's disease.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
David A. Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Gunaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A. Piesvaux, Karin M. Otte, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
Summary: This article describes the optimization process of a novel LRRK2 inhibitor for the treatment of Parkinson's disease. By combining structure-based drug design with cross-coupling technologies, a unique motif with extraordinary potency and favorable CNS drug-like properties was discovered. The lead compound showed exceptional on-target potency, selectivity, and brain exposure, making it a promising candidate for preclinical studies.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Neurosciences
Joseph P. Hennessee, Christina E. Webb, Xi Chen, Kristen M. Kennedy, Gagan S. Wig, Denise C. Park
Summary: There is a debate about the significance of additional fMRI-measured activity in the right prefrontal cortex in older adults and whether it enhances cognition. A study with 461 adults aged 20-89 found that higher left-lateralization in the prefrontal cortex was associated with better cognitive performance in middle-aged adults, while lower laterality scores were associated with better cognition in older adults. These findings have important implications for current theories of neurocognitive aging.
Article
Clinical Neurology
M. Yuan, Kristen M. Kennedy
Summary: This study used geospatial tools and landmarks to assess environmental complexity and predict cognitive status. The results showed that street length, circuity, and points of interest were associated with dementia. Therefore, environmental complexity plays an important role in the development of Alzheimer's disease.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Stephan A. Muller, Merav D. Shmueli, Xiao Feng, Johanna Tushaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler
Summary: In this study, the researchers identified SEZ6 and gp130/IL6ST as physiological substrates of BACE1 in non-human-primate cerebrospinal fluid. They also found a reduction of gp130 in human CSF from a clinical trial with a BACE inhibitor and in plasma of BACE1-deficient mice. These findings provide insights into the relationship between BACE1 and gp130 in neuronal signaling and survival.
MOLECULAR NEURODEGENERATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrey Zhylka, Alexander Leemans, Josien P. W. Pluim, Alberto De Luca
Summary: Multi-level Fiber Tractography (MLFT) is a novel algorithm that reconstructs fiber pathways by progressively considering previously unused fiber orientations. It has been evaluated on synthetic and in vivo data and shown to achieve a comparable radial extent of reconstruction to conventional methods while preserving topography better.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Neuroimaging
Joanne P. M. Kenney, Laura Milena Rueda-Delgado, Erik O. Hanlon, Lee Jollans, Ian Kelleher, Colm Healy, Niamh Dooley, Conor McCandless, Thomas Frodl, Alexander Leemans, Catherine Lebel, Robert Whelan, Mary Cannon
Summary: Accurate markers of psychiatric illness are important for predicting disease course. This study used machine learning to investigate neuroanatomical markers of subclinical psychotic experiences (PEs) in early and later adolescence. Neuroimaging data classified adolescents with PEs at 11-13 years and 18-20 years, but not at 14-16 years. Left frontal regions were top classifiers for 11-13 years-old adolescents with PEs, while those with future PEs at 18-20 years were best distinguished based on specific brain regions.
NEUROIMAGE-CLINICAL
(2022)