Article
Behavioral Sciences
T. Stoica, L. K. Knight, F. Naaz, S. C. Patton, B. E. Depue
Summary: Despite women reporting higher negative affect, both genders had similar suppression success. Differences were found in the FC patterns of men and women, with women showing stronger FC within the cingulo-opercular network and men exhibiting stronger FC within posterior regions of the ventral attention network during regulation of negative emotion.
Article
Neurosciences
Po-Han Kung, Christopher G. Davey, Ben J. Harrison, Alec J. Jamieson, Kim L. Felmingham, Trevor Steward
Summary: The study found that adolescents with depression showed weaker inhibitory modulation during cognitive reappraisal, which was predictive of individual diagnostic status. Post-treatment depression remission was associated with weaker excitatory connectivity between the ventromedial prefrontal cortex and amygdala at baseline.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Macia Buades-Rotger, Martin Gottlich, Ronja Weiblen, Pauline Petereit, Thomas Scheidt, Brian G. Keevil, Ulrike M. Kraemer
Summary: The study shows that lower-ranking teams are more likely to commit fouls in soccer, ice hockey, and basketball men's leagues, which is consistent with the findings in laboratory experiments. Neuroimaging research reveals the potential neural basis of status-dependent aggressive behavior.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2021)
Article
Neurosciences
Ally Dworetsky, Benjamin A. Seitzman, Babatunde Adeyemo, Maital Neta, Rebecca S. Coalson, Steven E. Petersen, Caterina Gratton
Summary: Recent studies have focused on individual differences in the functional network organization of the human brain and have utilized this information to probabilistically map common functional systems for improved group analyses. While these functional systems exhibit core regions, they vary in their higher-variability components and demonstrate good replication across datasets.
Article
Neurosciences
Wi Hoon Jung, Tae Young Lee, Minah Kim, Junhee Lee, Sanghoon Oh, Silvia Kyungjin Lho, Sun-Young Moon, Jun Soo Kwon
Summary: The study found that females were more sensitive to BIS compared to males, and they showed increased functional connectivity between the ventromedial prefrontal cortex (vmPFC) seed and posterior parietal areas. This functional connectivity mediated the impact of sex on BIS sensitivity. The results may have implications for psychiatric disorders such as depression and anxiety, which have a higher incidence in females.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2022)
Article
Neurosciences
Heini Saarimaki, Enrico Glerean, Dmitry Smirnov, Henri Mynttinen, Iiro P. Jaaskelainen, Mikko Sams, Lauri Nummenmaa
Summary: The study utilized functional magnetic resonance imaging data and pattern recognition techniques to analyze the impact of emotional states on brain functional connectivity. The results indicate that different emotional states exhibit differences in large-scale connectivity patterns, particularly within the default mode system.
Article
Neurosciences
Rotem Dan, Marta Weinstock, Gadi Goelman
Summary: This study investigated the brain's functional network organization during experiences of sadness, amusement, and neutral states elicited by movies. The results suggest that sadness is associated with higher modular integration and increased connectivity of cognitive control networks. Furthermore, individual similarity in both the functional connectome and emotional report was found to be dependent on sex.
Article
Immunology
Johnna R. Swartz, Angelica F. Carranza, Annchen R. Knodt, Michael R. Irwin, Camelia E. Hostinar
Summary: This study examined the association between peripheral inflammation and amygdala activity and connectivity in adolescents. The results showed that peripheral inflammation was associated with increased amygdala activity to emotional face stimuli and reduced connectivity with occipital and parietal regions. These findings enhance our understanding of the relationship between peripheral inflammation and neural response to emotional faces in adolescents.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Psychology, Clinical
Alec J. Jamieson, Ben J. Harrison, Christopher G. Davey
Summary: This study investigated alterations in brain connectivity associated with depression, finding that depressed patients showed reduced inhibition and excitation during processing of sad and fearful expressions. Treatment response was associated with connectivity between the amygdala and prefrontal cortex.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Neurosciences
Alec J. Jamieson, Christopher G. Davey, Ben J. Harrison
Summary: This study examined effective connectivity in the processing of sad and fearful facial expressions, finding greater positive connectivity from the amygdala to dlPFC associated with both expressions, and greater negative connectivity from vmPFC to amygdala specifically during the processing of fearful expressions. Additionally, greater connectivity from the amygdala to dlPFC was found when processing fearful faces compared to sad faces.
Article
Neurosciences
Zhongyan Shi, Bo Jiang, Tiantian Liu, Li Wang, Guangying Pei, Dingjie Suo, Jian Zhang, Shintaro Funahashi, Jinglong Wu, Tianyi Yan
Summary: Individual-level cortical segmentation can provide additional individual information compared to group-level mapping studies in Parkinson's disease (PD). Functional connectivity analysis at the individual level is beneficial for clinical markers and treatment prediction. The study identified individualized functional connectivity between the visual network and sensorimotor network as a potential marker for estimating motor symptom severity in early-stage PD.
Article
Psychology, Clinical
Hanne Lie Kjaerstad, Julian Macoveanu, Gitte Moos Knudsen, Sophia Frangou, K. Luan Phan, Maj Vinberg, Lars Vedel Kessing, Kamilla Woznica Miskowiak
Summary: This study compared the neural responses during voluntary down-regulation of negative emotions in bipolar disorder patients, their unaffected first-degree relatives, and healthy controls. The results showed hypo-activity in the prefrontal cortex and deficient connectivity between the prefrontal cortex and amygdala in patients and their relatives, indicating impaired emotion regulation. This study highlights the importance of understanding aberrant emotion regulation in bipolar disorder.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Danielle L. Kurtina, Gregory Scott, Henry Hebron, Anne C. Skeldon, Ines R. Violante
Summary: This study investigates how different cognitive demands influence brain state dynamics and whether these dynamics relate to cognitive ability. Using fMRI data, the researchers identified shared, recurrent, global brain states in participants performing various cognitive tasks. The results suggest that the brain reconfigures in response to cognitive demands, and the relationships between task, state dynamics, and cognitive ability are contextual.
Review
Neurosciences
Raphael Underwood, Eva Tolmeijer, Johannes Wibroe, Emmanuelle Peters, Liam Mason
Summary: Existing models of emotion processing mainly rely on brain activation data, but assumptions about network connectivity need to be integrated. Studies on effective connectivity reveal context-dependent dynamic modulatory relationships, challenging purely top-down regulatory models.
Article
Neurosciences
Gidon Levakov, Joshua Faskowitz, Galia Avidan, Olaf Sporns
Summary: Connectome embedding (CE) creates compact vectorized representations of brain nodes capturing their context in the global network topology, defining nodes context as random walks on the brain graph representing a generative model of diffusive communication around nodes. By extending the framework to explore individual differences, CE shows improved structural to functional connectivity mapping at both group and subject levels, capturing age-related differences and predicting age and intelligence with higher accuracy compared to using structural and functional connectivity alone.
Article
Clinical Neurology
Katrina Moore, Rhian Convery, Martina Bocchetta, Mollie Neason, David M. Cash, Caroline Greaves, Lucy L. Russell, Mica T. M. Clarke, Georgia Peakman, John van Swieten, Lize Jiskoot, Fermin Moreno, Myriam Barandiaran, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Marie-Claire Dore, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Hans-Otto Karnath, Rik Vandenberghe, Alexandre de Mendonca, Carolina Maruta, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris Butler, Alex Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Jason D. Warren, Jonathan D. Rohrer, Martin N. Rossor, Nick C. Fox, Ione O. C. Woollacott, Rachelle Shafei, Carolin Heller, Rita Guerreiro, Jose Bras, David L. Thomas, Jennifer Nicholas, Simon Mead, Lieke Meeter, Jessica Panman, Janne Papma, Rick van Minkelen, Yolande Pijnenburg, Begona Indakoetxea, Alazne Gabilondo, Mikel Tainta, Maria de Arriba, Ana Gorostidi, Miren Zulaica, Jorge Villanua, Zigor Diaz, Sergi Borrego-Ecija, Jaume Olives, Albert Llado, Mircea Balasa, Anna Antonell, Nuria Bargallo, Enrico Premi, Maura Cosseddu, Stefano Gazzina, Alessandro Padovani, Roberto Gasparotti, Silvana Archetti, Sandra Black, Sara Mitchell, Ekaterina Rogaeva, Morris Freedman, Ron Keren, David Tang-Wa, Linn Oijerstedt, Christin Andersson, Vesna Jelic, Hakan Thonberg, Andrea Arighi, Chiara Fenoglio, Elio Scarpini, Giorgio Fumagalli, Thomas Cope, Carolyn Timberlake, Timothy Rittman, Christen Shoesmith, Robart Bartha, Rosa Rademakers, Carlo Wilke, Benjamin Bender, Rose Bruffaerts, Philip Van Damme, Mathieu Vandenbulcke, Catarina B. Ferreira, Gabriel Miltenberger, Ana Verdelho, Sonia Afonso, Ricardo Taipa, Paola Caroppo, Giuseppe Di Fede, Giorgio Giaccone, Sara Prioni, Veronica Redaelli, Giacomina Rossi, Pietro Tiraboschi, Diana Duro, Maria Rosario Almeida, Miguel Castelo-Branco, Maria Joao Leitao, Miguel Tabuas-Pereira, Beatriz Santiago, Serge Gauthier, Pedro Rosa-Neto, Michele Veldsman, Toby Flanagan, Catharina Prix, Tobias Hoegen, Elisabeth Wlasich, Sandra Loosli, Sonja Schonecker, Elisa Semler, Sarah Anderl-Straub
Summary: This study investigates semantic cognition in patients with genetic frontotemporal dementia (FTD). The study finds that symptomatic patients scored lower than controls on semantic knowledge, while only late-stage MAPT and C9orf72 mutation carriers scored lower than controls in the presymptomatic groups. Furthermore, the study shows a correlation between mCCT score and brain volume in different regions in different mutation groups.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Psychology, Clinical
Ana Catarino, Jonathan M. Fawcett, Michael P. Ewbank, Sarah Bateup, Ronan Cummins, Valentin Tablan, Andrew D. Blackwell
Summary: This study used a data-driven approach to define depressive states and explore transitions between states in response to cognitive behavioural therapy (CBT). The results identified seven depressive states and showed that patients with cognitive/affective symptoms do not typically transition towards somatic states and vice-versa. Additionally, patients starting in a somatic depressive state are less likely to engage with or improve with therapy.
PSYCHOLOGICAL MEDICINE
(2022)
Letter
Clinical Neurology
Linn Oijerstedt, Christin Andersson, Vesna Jelic, John Cornelis van Swieten, Lize C. Jiskoot, Harro Seelaar, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Matthis Synofzik, Daniela Galimberti, James Benedict Rowe, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonca, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Christopher R. Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Giovanni Frisoni, Roberta Ghidoni, Sandro Sorbi, Jonathan Daniel Rohrer, Caroline Graff
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Carlo Wilke, Selina Reich, John C. van Swieten, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Daniela Galimberti, James B. Rowe, Mario Masellis, Maria C. Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonca, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris R. Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Giovanni Frisoni, Roberta Ghidoni, Sandro Sorbi, Martina Bocchetta, Emily Todd, Jens Kuhle, Christian Barro, Jonathan D. Rohrer, Matthis Synofzik
Summary: This study provides a biomarker cascade for the conversion stage in presymptomatic frontotemporal dementia, using serum neurofilament levels to stratify individuals in different stages and potentially identify those converting to symptomatic disease. The biomarker cascade may pave the way towards a biomarker-based precision medicine approach to genetic FTD.
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Emma L. van der Ende, Esther E. Bron, Jackie M. Poos, Lize C. Jiskoot, Jessica L. Panman, Janne M. Papma, Lieke H. Meeter, Elise G. P. Dopper, Carlo Wilke, Matthis Synofzik, Carolin Heller, Imogen J. Swift, Aitana Sogorb-Esteve, Arabella Bouzigues, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Caroline Graff, Robert Laforce, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, James B. Rowe, Alexandre de Mendonca, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Christopher R. Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Yolande A. L. Pijnenburg, Sandro Sorbi, Henrik Zetterberg, Wiro J. Niessen, Jonathan D. Rohrer, Stefan Klein, John C. van Swieten, Vikram Venkatraghavan, Harro Seelaar
Summary: This study aimed to model the sequence of biomarker abnormalities in genetic frontotemporal dementia and determine the disease stages of patients. The results showed that NPTX2 and neurofilament light chain were the earliest biomarkers to change. This model could help select suitable patients for pharmaceutical trials and improve patient stratification and tracking of therapeutic interventions.
Letter
Clinical Neurology
Annita Christodoulidou, Georgina E. McKenna, Simon T. Holden, James B. Rowe, Thomas E. Cope
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Ece Kocagoncu, David Nesbitt, Tina Emery, Laura E. Hughes, Richard N. Henson, James B. Rowe
Summary: The study focuses on cognitive frailty and compared the structural and neurophysiological properties of cognitively frail adults with Alzheimer’s disease and mild cognitive impairment. The results suggest that cognitive frailty may represent a spectrum of normal aging rather than the onset of Alzheimer’s disease.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maura Malpetti, Sanne S. Kaalund, Kamen A. Tsvetanov, Timothy Rittman, Mayen Briggs, Kieren S. J. Allinson, Luca Passamonti, Negin Holland, P. Simon Jones, Tim D. Fryer, Young T. Hong, Antonina Kouli, W. Richard Bevan-Jones, Elijah Mak, George Savulich, Maria Grazia Spillantini, Franklin Aigbirhio, Caroline H. Williams-Gray, John T. O'Brien, James B. Rowe
Summary: The study found that F-18-flortaucipir PET does not correspond to neuropathologic staging in PSP. The analytic approach seeking to mirror in vivo neuropathology staging with PET-to-autopsy correlational analyses might enable in vivo staging with next-generation tau PET tracers; however, further evidence and comparisons with postmortem data are needed.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Dace Apsvalka, Catarina S. Ferreira, Taylor W. Schmitz, James B. Rowe, Michael C. Anderson
Summary: This study demonstrates that inhibitory control activates the right dorsolateral and ventrolateral prefrontal cortex to suppress diverse content, and these regions play a crucial role in action and thought stopping.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Arabella Bouzigues, Lucy L. Russell, Georgia Peakman, Martina Bocchetta, Caroline Greaves, Rhian S. Convery, Emily Todd, James B. Rowe, Barbara Borroni, Daniela Galimberti, Pietro Tiraboschi, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, John C. van Swieten, Harro Seelaar, Lize Jiskoot, Sandro Sorbi, Chris R. Butler, Caroline Graff, Alexander Gerhard, Tobias Langheinrich, Robert Laforce, Raquel Sanchez-Valle, Alexandre de Mendonca, Fermin Moreno, Matthis Synofzik, Rik Vandenberghe, Simon Ducharme, Isabelle Le Ber, Johannes Levin, Adrian Danek, Markus Otto, Florence Pasquier, Isabel Santana, Jonathan D. Rohrer
Summary: This study finds that MAPT mutation carriers develop early naming impairments likely associated with semantic knowledge deficits, while C9orf72 and GRN mutation carriers can have more widespread brain atrophy.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Thomas E. Cope, Laura E. Hughes, Holly N. Phillips, Natalie E. Adams, Amirhossein Jafarian, David Nesbitt, Moataz Assem, Alexandra Woolgar, John Duncan, James B. Rowe
Summary: The study demonstrates the causal role of the multiple demand (MD) network in automatic auditory change detection, showing that atrophy of any MD node impairs auditory neurophysiological response. Different neurodegenerative syndromes display altered connectivity within the MD network, with evidence of partially effective compensation mechanisms. Damage to any node of the MD network is found to impair top-down control of sensation, providing a common mechanism for impaired change detection across dementia syndromes.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Alessandro Tomassini, Frank H. Hezemans, Rong Ye, Kamen A. Tsvetanov, Noham Wolpe, James B. Rowe
Summary: This study confirms the association between locus coeruleus integrity and response inhibition ability using MRI imaging. It also demonstrates that the connectivity between presupplementary motor area (preSMA) and right inferior frontal gyrus (rIFG) plays a mediating role in this association. These findings suggest that the locus coeruleus noradrenergic system regulates inhibitory control in healthy individuals.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Andrea Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Negin Holland, Tim D. Fryer, John T. O'Brien, James B. Rowe, David K. Menon, Daniel Bor, Emmanuel A. Stamatakis
Summary: This study decomposes neural information into synergistic and redundant components, showing the role of core brain regions in supporting higher cognition and demonstrating that humans leverage synergistic information more than macaques. The study also reveals the distinct roles of redundant and synergistic interactions in neural information processing.
NATURE NEUROSCIENCE
(2022)
Review
Clinical Neurology
Michael C. B. David, Martina Del Giovane, Kathy Y. Liu, Benjamin Gostick, James Benedict Rowe, Imafidon Oboh, Robert Howard, Paresh A. Malhotra
Summary: This study assessed the efficacy of drugs with noradrenergic action in improving cognitive and neuropsychiatric symptoms in Alzheimer's disease. The findings showed a small positive effect on global cognition and a large positive effect on apathy. This suggests that repurposing established noradrenergic drugs may offer effective treatment for certain symptoms in Alzheimer's disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Joseph Giorgio, Ankeet Tanna, Maura Malpetti, Simon R. White, Jingshen Wang, Suzanne Baker, Susan Landau, Tomotaka Tanaka, Christopher Chen, James B. Rowe, John O'Brien, Jurgen Fripp, Michael Breakspear, William Jagust, Zoe Kourtzi
Summary: This study used a two-stage approach to harmonize cognitive data from different cohorts and derive a cross-cohort score for cognitive impairment due to AD. The results showed that the cognitive composites were robust across cohorts and achieved comparable sensitivity to AD-related cognitive decline. This approach offers a simple and effective way for researchers to harmonize and pool cognitive data for the study of cognitive decline in AD.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2023)