Article
Multidisciplinary Sciences
Simeng Zhang, Yoshiaki Tanaka, Asuka Ishihara, Akiko Uchizawa, Insung Park, Kaito Iwayama, Hitomi Ogata, Katsuhiko Yajima, Naomi Omi, Makoto Satoh, Masashi Yanagisawa, Hiroyuki Sagayama, Kumpei Tokuyama
Summary: Research shows that the metabolic process during sleep is influenced by various factors such as gender, age, and metabolic inflexibility. The changes in respiratory quotient during sleep could reflect individual differences in metabolism.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Aditi Pophale, Kazumichi Shimizu, Tomoyuki Mano, Teresa L. Iglesias, Kerry Martin, Makoto Hiroi, Keishu Asada, Paulette Garcia Andaluz, Thi Thu Van Dinh, Leenoy Meshulam, Sam Reiter
Summary: Octopuses exhibit two stages of sleep, quiet sleep and active sleep. Active sleep is characterized by body movements and changes in skin patterning similar to wakefulness. Quiet sleep is characterized by brain activity and specific brain regions resembling mammalian sleep, suggesting convergent features of complex cognition.
Article
Clinical Neurology
Jonas Beck, Erna Loretz, Bjorn Rasch
Summary: The study found that activating the concept of relaxation during sleep can extend the time spent in slow-wave sleep, increase power in the slow-wave activity band, and improve sleep quality and subjective alertness.
Article
Clinical Neurology
Jonas Beck, Erna Loretz, Bjoern Rasch
Summary: Our study found that activating the concept of relaxation during sleep can increase time spent in slow-wave sleep, improve sleep quality, eliminate asymmetrical sleep depth, and increase subjective alertness.
Article
Biology
Stefan M. Lemke, Dhakshin S. Ramanathan, David Darevksy, Daniel Egert, Joshua D. Berke, Karunesh Ganguly
Summary: The strength of cortical connectivity to the striatum influences the balance between behavioral variability and stability, with plasticity in corticostriatal connectivity being essential for learning to consistently produce skilled actions. This plasticity appears to occur during non-rapid-eye-movement (NREM) sleep, shaping cross-area coupling required for skill learning.
Article
Mathematical & Computational Biology
Irina Gaynanova, Naresh Punjabi, Ciprian Crainiceanu
Summary: We propose a multilevel functional Beta model to analyze continuous blood glucose monitoring data in patients with type 2 diabetes mellitus. The model estimates subject-specific blood glucose levels, quantifies within- and between-subject variability, and provides interpretable parameters for blood glucose dynamics. The model results are validated through simulations and by studying the association with hemoglobin A1c, the gold standard for assessing glucose control in diabetes.
Article
Multidisciplinary Sciences
Hio-Been Han, Bowon Kim, Youngsoo Kim, Yong Jeong, Jee Hyun Choi
Summary: This work presents an EEG dataset collected from nine mice during sleep deprivation, including continuous recordings of frontal and parietal EEG data and accelerometer data. The dataset can be used to compare mouse and human HD-EEG, track oscillatory activities of sleep EEG under different conditions, and investigate cortical traveling waves in the mouse brain. Additionally, Python code for basic analyses is provided.
Article
Meteorology & Atmospheric Sciences
S. Kalisch, H. -Y. Chun
Summary: This study investigated the role of stratospheric gravity waves (GWs) in the Northern Hemisphere during the sudden stratospheric warming (SSW) event of 2009. Analysis of NASA satellite instrument data showed prominent GW activity in Labrador Peninsula and southern Greenland prior to the onset of the warming event. Planetary waves peaked in amplitude between mid-January and January 24.
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES
(2021)
Editorial Material
Endocrinology & Metabolism
Melissa A. Linden, Susan J. Burke, Humza A. Pirzadah, Tai-Yu Huang, Heidi M. Batdorf, Walid K. Mohammed, Katarina A. Jones, Sujoy Ghosh, Shawn R. Campagna, J. Jason Collier, Robert C. Noland
Summary: Glucocorticoid therapy can cause iatrogenic diabetes, and activating lipolysis plays a crucial role in its development. Inhibiting lipolysis can reduce glucocorticoid-induced obesity and hyperglycemia. The role of lipolysis differs between skeletal muscle and liver.
MOLECULAR METABOLISM
(2023)
Article
Multidisciplinary Sciences
Jelena Skorucak, Bigna K. Boelsterli, Sarah Storz, Sven Leach, Bernhard Schmitt, Georgia Ramantani, Reto Huber
Summary: Slow-wave sleep, a restorative function of sleep, is affected by epileptic discharges in certain pathological conditions. By analyzing a large-scale dataset of pediatric EEG recordings over a 25-year period, our study finds a correlation between the overnight change in slow-wave slope and epileptic spike-wave index, suggesting the impairment of synaptic strength reduction during sleep is spike dependent.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Aerospace
Christina E. Plomariti, Christos A. Frantzidis, Christina Dimitriadou, Maria Velana, Christiane M. Nday, Panteleimon Chriskos, Lycurgus Chatziioannidis, Giorgos Ntakakis, Anna Nikolaidou, Polyxeni T. Gkivogkli, Panagiotis D. Bamidis, Chrysoula Kourtidou-Papadeli
Summary: There is concrete evidence that weightlessness and microgravity may affect sleep quality, but a comprehensive understanding of sleep disorders is lacking. This study proposes a novel, multi-modal, data-driven model for identifying the detrimental factors that are crucial for sleep quality. The results of the study indicate significant functional connectivity alterations within the alpha band and correlations between biomarkers and sleep quality characteristics. The importance of this research lies in its personalized, multi-parametric evaluation of sleep quality to identify disorders before their clinical onset.
Article
Neurosciences
Iyo Koyanagi, Kazuhiro Sonomura, Toshie Naoi, Takaaki Ohnishi, Naoko Kaneko, Kazunobu Sawamoto, Taka-Aki Sato, Masanori Sakaguchi
Summary: The study used a metabolomics approach to investigate memory processing during sleep, revealing significant changes in metabolites in the dentate gyrus of mice during sleep-wake states. Changes in purine metabolism were observed during both sleep and contextual fear memory consolidation, suggesting the importance of purine metabolism in fear memory processing.
Article
Clinical Neurology
Karuna Datta, Hruda Nanda Mallick, Manjari Tripathi, Navdeep Ahuja, K. K. Deepak
Summary: The study aimed to characterize the electrophysiological features of yoga nidra. The findings showed that yoga nidra practice in novices is electrophysiologically an awake state with signs of slow waves locally, resembling local sleep. Additionally, after 2 weeks of practice, participants experienced improved sleep quality and efficiency.
FRONTIERS IN NEUROLOGY
(2022)
Article
Engineering, Civil
Laura Szczyrba, Ryan P. Mulligan, Joshua Humberston, A. Spicer Bak, Jesse McNinch, Peir K. Pufahl
Summary: In this study, X-band radar (XBR) remote sensing, a phase-resolving numerical model (SWASH), and in-situ observations with acoustic wave and current sensors are combined to assess nearshore wave angles. Two new methods of estimating wave angles are developed for comparison between model results and remote sensing observations. The study highlights the importance of understanding wave directions in nearshore areas for sediment transport, morphological change, wave impact forces, and wave power estimates.
COASTAL ENGINEERING
(2023)
Article
Clinical Neurology
John R. McLaren, Yancheng Luo, Hunki Kwon, Wen Shi, Mark A. Kramer, Catherine J. Chu
Summary: Objective: Epileptic encephalopathy with spike-wave activation in sleep (EE-SWAS) is characterized by abundant epileptiform spikes during non-rapid eye movement (NREM) sleep accompanied by cognitive dysfunction. The study aimed to investigate the mechanism of cognitive dysfunction and the effect of high-dose diazepam treatment on spike and spindle activities in patients with EE-SWAS. Methods: EEG data were analyzed to quantify spike and spindle rates before and after treatment. Cognitive response was determined from a chart review. Results: The study found an anti-correlation between spike and spindle rates in patients with EE-SWAS. High-dose diazepam treatment increased spindle rates and decreased spike rates. Patients with cognitive improvement after treatment showed increased spindle rates, duration, and percentage, while those without cognitive improvement did not. Interpretation: These findings confirm thalamocortical disruption in EE-SWAS, provide insights into the mechanism of benzodiazepines in supporting cognitive recovery, and suggest sleep spindles as a potential biomarker for treatment response evaluation in severe epileptic encephalopathies.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Celine Mathey, Caroline Keyzer, Didier Blocklet, Gaetan Van Simaeys, Nicola Trotta, Simon Lacroix, Bernard Corvilain, Serge Goldman, Rodrigo Moreno-Reyes
Summary: This study found that F-18-FCH PET/CT performs better than C-11-MET PET/CT in detecting and localizing abnormal parathyroid tissue in patients with pHPT when Tc-99m-MIBI SPECT results are negative or inconclusive.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Behavioral Sciences
Claire Bar, Delphine Breuillard, Mathieu Kuchenbuch, Melanie Jennesson, Gwenael Le Guyader, Herve Isnard, Anne Rolland, Diane Doummar, Joel Fluss, Alexandra Afenjar, Patrick Berquin, Anne De Saint Martin, Sophie Dupont, Alice Goldenberg, Damien Lederer, Gaetan Lesca, Helene Maurey, Pierre Meyer, Cyril Mignot, Anca Nica, Sylvie Odent, Alice Poisson, Emmanuel Scalais, Tayeb Sekhara, Pascal Vrielynck, Giulia Barcia, Rima Nabbout
Summary: This study aimed to investigate adaptive and behavioral features in patients with KCNB1 encephalopathy, revealing pathological adaptive behavior, attention problems, and autism spectrum disorder risks. The severity of epilepsy predicted behavioral profile severity, highlighting the impact of early-onset epilepsy and gene dysfunction on patients with KCNB1 encephalopathy.
EPILEPSY & BEHAVIOR
(2022)
Article
Genetics & Heredity
Katrine M. Johannesen, Sumaiya Iqbal, Milena Guazzi, Nazanin A. Mohammadi, Eduardo Perez-Palma, Elise Schaefer, Anne De Saint Martin, Marie Therese Abiwarde, Amy McTague, Roser Pons, Amelie Piton, Manju A. Kurian, Gautam Ambegaonkar, Helen Firth, Alba Sanchis-Juan, Marie Deprez, Katrien Jansen, Liesbeth De Waele, Eva H. Briltra, Nienke E. Verbeek, Marjan van Kempen, Walid Fazeli, Pasquale Striano, Federico Zara, Gerhard Visser, Hilde M. H. Braakman, Martin Haeusler, Miriam Elbracht, Ulvi Vaher, Thomas Smol, Johannes R. Lemke, Konrad Platzer, Joanna Kennedy, Karl Martin Klein, Ping Yee Billie Au, Kimberly Smyth, Julie Kaplan, Morgan Thomas, Malin K. Dewenter, Argirios Dinopoulos, Arthur J. Campbell, Dennis Lal, Damien Lederer, Vivian W. Y. Liao, Philip K. Ahring, Rikke S. Moller, Elena Gardella
Summary: This study analyzed a large cohort of individuals with GABRB3 variants to investigate the phenotypic understanding and genotype-phenotype correlations. The results showed a wide spectrum of phenotypes associated with different structural locations of the variants. The genotype-phenotype correlations will aid in genetic counseling and treatment, and future studies may reveal functional differences underlying the phenotypic differences.
GENETICS IN MEDICINE
(2022)
Article
Neurosciences
N. Coquelet, X. De Tiege, L. Roshchupkina, P. Peigneux, S. Goldman, M. Woolrich, V Wens
Summary: Research has shown that there are significant differences in spatial and temporal aspects between microstates and power envelope HMM states. Microstates reflect sharp events of neural synchronization, whereas power envelope HMM states disclose network-level activity with 100-200 ms lifetimes.
Article
Clinical Neurology
Josselin Demas, Mathieu Bourguignon, Xavier De Tiege, Vincent Wens, Nicolas Coquelet, Antonin Rovai, Sandra Bouvier, Rodolphe Bailly, Sylvain Brochard, Mickael Dinomais, Patrick Van Bogaert
Summary: The study developed an electrophysiological marker of proprioceptive spino-cortical tracts integrity in young children with UCP based on corticokinematic coherence (CKC). Results showed that CKC strength was weaker for affected hand movements compared to non-affected hand movements, influenced by the type of lesion, especially in children with cortico-subcortical lesions.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neuroimaging
Dorine Van Dyck, Nicolas Deconinck, Alec Aeby, Simon Baijot, Nicolas Coquelet, Nicola Trotta, Antonin Rovai, Serge Goldman, Charline Urbain, Vincent Wens, Xavier De Tiege
Summary: Children with DCD exhibit increased functional brain connectivity in visual and motor areas, but this enhancement does not impact their coordinated motor and visual perceptual abilities. Additionally, an interhemispheric compensatory process may help DCD children perform visuomotor tasks within the normal range.
NEUROIMAGE-CLINICAL
(2022)
Letter
Clinical Neurology
Audrey Van Hecke, Andrea Nebbioso, Roberto Santalucia, Justine Vermeiren, Xavier De Tiege, Antoine Nonclercq, Patrick Van Bogaert, Alec Aeby
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Florian Destoky, Julie Bertels, Maxime Niesen, Vincent Wens, Marc Vander Ghinst, Antonin Rovai, Nicola Trotta, Marie Lallier, Xavier De Tiege, Mathieu Bourguignon
Summary: The study found altered neural basis of speech perception in children with dyslexia in different auditory conditions. These alterations are associated with reduced reading level, suggesting they are driven by reduced reading experience rather than a cause of dyslexia. Additionally, in severe dyslexia, altered lateralization of phrasal speech is related to impaired rapid automatized naming ability.
Article
Radiology, Nuclear Medicine & Medical Imaging
Odile Feys, Pierre Corvilain, Alec Aeby, Claudine Sculier, Niall Holmes, Matthew Brookes, Serge Goldman, Vincent Wens, Xavier De Tiege, Florence Christiaens
Summary: This study compared the effectiveness of cryogenic and on-scalp MEG in detecting and localizing focal interictal epileptiform discharges (IEDs) in children with epilepsy. The results showed that on-scalp MEG had higher IED amplitudes and signal-to-noise ratios compared to cryogenic MEG, and the localization value was similar between the two modalities.
Article
Oncology
Corentin Martens, Antonin Rovai, Daniele Bonatto, Thierry Metens, Olivier Debeir, Christine Decaestecker, Serge Goldman, Gaetan Van Simaeys
Summary: This research proposed a deep learning-based approach to address problems in glioma growth models. By training deep neural networks, it is possible to reconstruct the cell-density distribution of the tumor and accurately evaluate model parameters. This approach has significant potential application value for glioma characterization and therapy planning.
Editorial Material
Clinical Neurology
Odile Feys, Pierre Corvilain, Audrey Van Hecke, Claudine Sculier, Estelle Rikir, Benjamin Legros, Nicolas Gaspard, Gil Leurquin-Sterk, Niall Holmes, Matthew Brookes, Serge Goldman, Vincent Wens, Xavier De Tiege
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Dorine Van Dyck, Nicolas Deconinck, Alec Aeby, Simon Baijot, Nicolas Coquelet, Xavier De Tiege, Charline Urbain
Summary: This study investigated the procedural learning deficit hypothesis in children with Developmental Coordination Disorder (DCD) and found that children with DCD have reduced sequence learning skills compared to typically developing children. However, both groups were able to discriminate between sequential and random trials, indicating similar abilities in this aspect. This finding highlights the importance of considering the overall functioning of the child when assessing learning skills in patients.
CHILD NEUROPSYCHOLOGY
(2023)
Article
Immunology
Sophie Henrard, Nicola Trotta, Antonin Rovai, Tim Coolen, Hichem Slama, Julie Bertels, Delphine Puttaert, Jean-Christophe Goffard, Jean-Paul Van Vooren, Serge Goldman, Xavier De Tiege
Summary: This study investigated the brain structure and metabolism of young European men with HIV, including recreational drug use. The results showed that cognitive impairments in these individuals were mainly attributed to recreational drug use rather than HIV itself.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Neurosciences
Maxime Niesen, Mathieu Bourguignon, Julie Bertels, Marc Vander Ghinst, Vincent Wens, Serge Goldman, Xavier De Tiege
Summary: Children have more difficulty perceiving speech in noise than adults, which may be related to an immature processing of linguistic elements. A study was conducted to evaluate the impact of noise on the cortical tracking of intelligible speech in school-aged children and adults. The results showed that children had lower cortical tracking for linguistic units without noise compared to adults, and in the presence of noise, adults increased cortical tracking of words while children did not, indicating an immature tracking of lexical units in children.
Article
Psychology, Developmental
Julie Bertels, Maxime Niesen, Florian Destoky, Tim Coolen, Marc Vander Ghinst, Vincent Wens, Antonin Rovai, Nicola Trotta, Martijn Baart, Nicola Molinaro, Xavier De Tiege, Mathieu Bourguignon
Summary: Humans' ability to understand speech in noise develops with age through multiple processes. Using MEG, researchers studied cortical oscillations in 144 participants (aged 5-27 years) to understand how they track phrasal and syllabic structures in connected speech mixed with different types of noise. The study found that while the extraction of prosodic cues from clear speech remains stable during development, its maintenance in a multi-talker background matures rapidly up to age 9 and is associated with speech comprehension. The study also found that the extraction of subtler information provided by syllables matures at age 9, but its maintenance in noisy backgrounds progressively matures until adulthood.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
