Article
Neurosciences
Lin Zhang, Deirdre M. McCarthy, Karen L. Eskow Jaunarajs, Joseph Biederman, Thomas J. Spencer, Pradeep G. Bhide
Summary: The study indicates that the KOR antagonist norbinaltorphimine (norBNI) and methylphenidate can improve attention and working memory in the PNE mouse model by increasing dopamine and noradrenaline release.
Article
Endocrinology & Metabolism
Giovanna Nordio, Rubaida Easmin, Alessio Giacomel, Ottavia Dipasquale, Daniel Martins, Steven Williams, Federico Turkheimer, Oliver Howes, Mattia Veronese, Sameer Jauhar, Maria Rogdaki, Robert McCutcheon, Stephen Kaar, Luke Vano, Grazia Rutigliano, Ilinca Angelescu, Faith Borgan, Enrico D'Ambrosio, Tarik Dahoun, Euitae Kim, Seoyoung Kim, Micheal Bloomfield, Alice Egerton, Arsime Demjaha, Ilaria Bonoldi, Chiara Nosarti, James Maccabe, Philip McGuire, Julian Matthews, Peter S. Talbot
Summary: In this study, a fully automated analytical framework for FDOPA PET neuroimaging data was evaluated. The framework showed good reproducibility and sensitivity to demographic and experimental variables. It represents an effective resource for standardized and robust quantification of dopamine synthesis capacity using FDOPA PET data.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Health Care Sciences & Services
Daniela Senior, Rania Ahmed, Eliz Arnavut, Alexandra Carvalho, Wen Xuan Lee, Kenneth Blum, David E. Komatsu, Michael Hadjiargyrou, Rajendra D. Badgaiyan, Panayotis K. Thanos
Summary: The majority of animal studies on methylphenidate (MP) use methods such as intraperitoneal injections, subcutaneous injections, or the oral gavage route. However, the most clinically relevant route is oral administration. Intraperitoneal injections provide an immediate and maximum dose, but only represent a limited window of the drug's effects. Subcutaneous injections do not accurately reflect oral exposure, and the oral-gavage method has adverse effects and may be stressful for animals. The use of a two-bottle drinking method allows for free consumption of MP and more accurately mirrors human treatment, enabling the study of MP's effects on development, behavior, neurochemistry, and brain function.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Psychology, Developmental
Arianna D. Cascone, Finnegan Calabro, William Foran, Bart Larsen, Tehila Nugiel, Ashley C. Parr, Brenden Tervo-Clemmens, Beatriz Luna, Jessica R. Cohen
Summary: Children with ADHD show impairments in response inhibition, which can be improved by modulating dopamine using rewards or medication like methylphenidate. This study investigates the impact of intrinsic dopamine availability on response inhibition in children with ADHD. The results suggest that higher tissue iron levels in certain brain regions are associated with worse response inhibition in all participants, but also with greater responsiveness to methylphenidate in children with ADHD.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Dimitri Renard, Laurent Collombier, Sabine Laurent-Chabalier, Thibault Mura, Anne Le Floch, Hassan El Fertit, Eric Thouvenot, Jean Sebastien Guillamo
Summary: This study retrospectively analyzed FDOPA-PET scans of 74 patients suspected of primary brain tumors, finding that FDOPA-PET uptake should be interpreted cautiously in patients with low or intermediate SUV values in the lesions.
JOURNAL OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Yu Liu, Changhong Yang, Yingxue Meng, Yonghui Dang, Lin Yang
Summary: This study investigates the potential use of a ketogenic diet (KD) in treating attention deficit hyperactivity disorder (ADHD) by altering gut microbiota. The results indicate that KD can regulate gut microbiota and alleviate behavioral symptoms in ADHD. The findings provide novel insights into the use of KD as an alternative therapy for ADHD.
Article
Psychiatry
Sevim Berrin Inci Izmir, Melis Ipci, Eyup Sabri Ercan
Summary: This study investigated the effects of methylphenidate (MPH) on neurocognitive test scores in individuals with different presentations of attention deficit/hyperactivity disorder (ADHD), as well as the impact of comorbidities on executive function. The results showed that MPH treatment improved neurocognitive test scores in patients with different presentations of ADHD, and the treatment was effective even in the presence of comorbidities.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Biological
Cecilia Mazzetti, Christienne Gonzales Damatac, Emma Sprooten, Niels ter Huurne, Jan K. Buitelaar, Ole Jensen
Summary: This study aimed to identify the white matter tracts that mediate the effect of methylphenidate (MPH) on ADHD patients. The results showed that the anterior thalamic radiation (ATR), superior longitudinal fasciculus (parietal endings) (SLFp), and superior longitudinal fasciculus (temporal endings) (SLFt) were significantly associated with the effects of MPH. In addition, ADHD symptom severity was related to lower fractional anisotropy (FA) within the ATR, and individuals with higher FA in SLFp compared to SLFt exhibited stronger behavioral effects of MPH and beta power modulation.
Article
Neurosciences
Mattia Veronese, Barbara Santangelo, Sameer Jauhar, Enrico D'Ambrosio, Arsime Demjaha, Hugh Salimbeni, Jin Huajie, Paul McCrone, Federico Turkheimer, Oliver Howes
Summary: The study evaluated the potential of [F-18]FDOPA PET imaging to identify non-responders to antipsychotic treatment using linear and non-linear machine learning analyses and found good test-retest reproducibility and predictive power in distinguishing responders from non-responders. The economic analysis indicated potential healthcare cost savings by using [F-18]FDOPA PET to fast-track treatment-resistant patients to clozapine. Overall, the findings suggest that [F-18]FDOPA PET dopamine imaging has the potential to serve as a biomarker to guide treatment choice for patients with schizophrenia.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Darwin Contreras, Ricardo Pina, Claudia Carvallo, Felipe Godoy, Gonzalo Ugarte, Marc Zeise, Carlos Rozas, Bernardo Morales
Summary: This study demonstrates that methylphenidate can restore behavioral impairments and neuroplasticity in an ADHD mouse model induced by prenatal nicotine exposure. The restoration is achieved through changes in AMPAR subunit composition and distribution, as well as the maturation of dendritic spines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Clinical
William E. Pelham, Amy R. Altszuler, Brittany M. Merrill, Joseph S. Raiker, Fiona L. Macphee, Marcela Ramos, Elizabeth M. Gnagy, Andrew R. Greiner, Erika K. Coles, Carol M. Connor, Christopher J. Lonigan, Lisa Burger, Anne S. Morrow, Xin Zhao, James M. Swanson, James G. Waxmonsky, William E. Pelham
Summary: This study evaluated the impact of stimulant medication on the acquisition of academic material in children with ADHD in a classroom setting. The results showed that medication had positive effects on students' seatwork productivity and classroom behavior, but did not improve their learning of new academic material.
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
(2022)
Article
Psychology, Developmental
Ann C. Childress, Henry C. Foehl, Jeffrey H. Newcorn, Stephen Faraone, Benjamin Levinson, Akwete L. Adjei
Summary: The study on the long-term safety and symptom control of extended-release methylphenidate in children aged 4 to <6 years showed that most treatment-emergent adverse events were of mild or moderate severity, weight and height z scores as well as obesity rates decreased significantly, with insomnia reported in 9% and hypertension in 6.7%, while ADHD symptom control was maintained.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anna Goujon, Gabriel Pop, Julien Hissier, Benjamin Moreau, Xavier Palard-Novello
Summary: A 53-year-old man with chronic kidney failure underwent F-18-FDOPA PET/CT scan for a mass located on the right spermatic cord. Previous pathological analysis of CT-guided biopsies suggested paraganglioma or metastatic lesion of pheochromocytoma. Serum normetanephrine and serum metanephrine values were elevated, but could be explained by the chronic kidney failure. PET/CT images showed intense F-18-FDOPA uptake of the mass without any other pathological findings, suggesting the diagnosis of paraganglioma. Pathological examination of surgical specimen confirmed the diagnosis of paraganglioma of the spermatic cord, which is exceptional.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Medicine, General & Internal
Antoine Girard, Pierre-Jean Le Reste, Alice Metais, Nibras Chaboub, Anne Devillers, Herve Saint-Jalmes, Florence Le Jeune, Xavier Palard-Novello
Summary: The study evaluated the value of FDOPA PET kinetic parameters for tumor grading in newly diagnosed gliomas with neuronavigation-guided biopsies as reference. Results showed that kinetic parameters (K1, k2, TTP) were significantly higher for high-grade gliomas compared to low-grade gliomas, with higher AUC values for kinetic parameters compared to static parameters. This suggests that FDOPA PET/CT kinetic parameters have additional value for grading newly diagnosed gliomas.
FRONTIERS IN MEDICINE
(2021)
Article
Clinical Neurology
Mathieu Di Miceli, Adesina Omoloye, Benjamin Gronier
Summary: This study demonstrated that the combination of methylphenidate and a dopamine D-2 receptor antagonist has long-lasting effects on midbrain dopamine neurons, mediated by glutamatergic-dependent mechanisms.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Leonie Lampe, Sebastian Niehaus, Hans-Juergen Huppertz, Alberto Merola, Janis Reinelt, Karsten Mueller, Sarah Anderl-Straub, Klaus Fassbender, Klaus Fliessbach, Holger Jahn, Johannes Kornhuber, Martin Lauer, Johannes Prudlo, Anja Schneider, Matthis Synofzik, Adrian Danek, Janine Diehl-Schmid, Markus Otto, Arno Villringer, Karl Egger, Elke Hattingen, Rudiger Hilker-Roggendorf, Alfons Schnitzler, Martin Sudmeyer, Wolfgang Oertel, Jan Kassubek, Gunter Hoeglinger, Matthias L. Schroeter
Summary: This study compared several machine learning methods for the classification of neurodegenerative diseases based on structural magnetic resonance imaging. The results showed that the neural network performed the best and most consistently, while the ensemble learning methods or support vector machine had better performance for smaller classes.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Oncology
Abdalla Ibrahim, Bruno Barufaldi, Turkey Refaee, Telmo M. Silva Filho, Raymond J. Acciavatti, Zohaib Salahuddin, Roland Hustinx, Felix M. Mottaghy, Andrew D. A. Maidment, Philippe Lambin
Summary: This study quantified the effects of variations in imaging parameters on the reproducibility of handcrafted radiomic features (HRFs) and developed a score to objectively assess the number of reproducible HRFs in different scenarios. The score can be used to determine the inclusion of data acquired differently and evaluate the generalizability of radiomic signatures.
Editorial Material
Clinical Neurology
Jan Kassubek
Article
Clinical Neurology
Florian Philipp Raber, Florian Vincent Gmeiner, Jens Dreyhaupt, Armin Wolf, Albert Christian Ludolph, Jens Ulrich Werner, Jan Kassubek, Katharina Althaus
Summary: This study aimed to investigate the feasibility, efficacy, and safety of intravenous thrombolysis (IVT) in functionally blind patients with non-arteritic central retinal artery occlusion (NA-CRAO). The results showed that early IVT therapy within 4.5 hours of symptom onset might be a potential treatment option for NA-CRAO. MRI should be performed in all patients for optimized treatment and secondary stroke prevention.
JOURNAL OF NEUROLOGY
(2023)
Article
Oncology
Cornelis M. de Mooij, Thiemo J. A. van Nijnatten, Briete Goorts, Loes F. S. Kooreman, Isabel W. M. Raymakers, Silke P. L. van Meijl, Maaike de Boer, Kristien B. M. I. Keymeulen, Joachim E. Wildberger, Felix M. Mottaghy, Marc B. I. Lobbes, Marjolein L. Smidt
Summary: This study investigated the feasibility of sequential hybrid [18F]FDG PET/MRI in predicting the treatment response in breast cancer patients undergoing neoadjuvant chemo(targeted) therapy. The qualitative or quantitative evaluation of PET/MRI after therapy was found to be unreliable in predicting the response of the primary tumor and axillary lymph nodes. However, combining the relative decrease in PET and MR imaging variables halfway through therapy improved the diagnostic accuracy, especially for predicting the response of axillary lymph nodes. These findings suggest that sequential hybrid [18F]FDG PET/MRI may have complementary value in the early prediction of treatment response in breast cancer.
Review
Clinical Neurology
Martin Regensburger, Chi Wang Ip, Zacharias Kohl, Christoph Schrader, Peter P. Urban, Jan Kassubek, Wolfgang H. Jost
Summary: Inhibitors of monoamine oxidase B (MAO-B) and catechol-O-methyltransferase (COMT) are important strategies in Parkinson's disease treatment. Several drugs have been available on the market for more than a decade, while others have been approved more recently. Various post-authorization studies have provided comprehensive data on their use and characteristics in real-life clinical practice. This article summarizes the current knowledge on these medications and discusses their clinical value in Parkinson's disease, as well as practical considerations and ongoing studies.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Hans-Peter Mueller, Anna Behler, Maximilian Muench, Johannes Dorst, Albert C. C. Ludolph, Jan Kassubek
Summary: This study investigates the association between the sequential alteration pattern and disease severity in patients with ALS using diffusion tensor imaging (DTI). The results show that the progression of white matter alterations across tracts is associated with clinical disease severity, suggesting the use of staging-based DTI as a technical marker for disease progression.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Wolfgang Becker, Anna Behler, Olga Vintonyak, Jan Kassubek
Summary: The characteristics of microsaccades and square wave jerks (SWJs) have been found to follow common patterns in different neurodegenerative disorders. The amplitude of microsaccades is related to the frequency of SWJ-like patterns. This suggests that there are differences in microsaccade characteristics between different diseases, possibly due to different underlying mechanisms.
EXPERIMENTAL BRAIN RESEARCH
(2023)
Article
Cell Biology
Amelie Heesch, Lars Ortmanns, Jochen Maurer, Elmar Stickeler, Sabri E. M. Sahnoun, Felix M. Mottaghy, Agnieszka Morgenroth
Summary: Recent studies have shown that PSMA expression on TNBC cells and adjacent endothelial cells may serve as a new target for therapy. This study analyzed the expression of PSMA and its isoforms in TNBC cells, BCSCs, and tumor-associated endothelial cells. The results demonstrated that PSMA was highly expressed in TNBC cell lines and its isoforms were predominantly found in BCSCs. In addition, tumor-conditioned media had a significant pro-angiogenic effect and all TNBC cell lines induced PSMA expression in HUVEC. These findings suggest the potential of PSMA-targeted therapy in TNBC.
Article
Genetics & Heredity
Sarah Jesse, Hans-Peter Mueller, Hans-Juergen Huppertz, Stephanie Andres, Albert C. Ludolph, Michael Schoen, Tobias M. Boeckers, Jan Kassubek
Summary: Alterations of CSF markers in Phelan-McDermid syndrome patients were found to be correlated with structural connectivity losses. These findings have important implications for further clinical diagnostics and basic research.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Review
Oncology
Karl-Josef Langen, Norbert Galldiks, Joerg Mauler, Martin Kocher, Christian Peter Filss, Gabriele Stoffels, Claudia Regio Brambilla, Carina Stegmayr, Antje Willuweit, Wieland Alexander Worthoff, Nadim Jon Shah, Christoph Lerche, Felix Manuel Mottaghy, Philipp Lohmann
Summary: Advanced MRI methods and PET using radiolabelled amino acids provide valuable additional information for brain tumour diagnostics. While the hybrid PET/MRI has allowed for the convergence of these methods, simultaneous imaging has limited relevance in clinical neuro-oncology. A multimodal approach that combines PET and MRI shows promising improvement in the diagnosis of cerebral gliomas.
Article
Clinical Neurology
Franz Marxreiter, Vera Lambrecht, Angelika Mennecke, Jannis Hanspach, Jelena Jukic, Martin Regensburger, Juergen Herrler, Alexander German, Jan Kassubek, Georg Groen, Hans-Peter Mueller, Frederik B. Laun, Arnd Doerfler, Juergen Winkler, Manuel A. Schmidt
Summary: Quantitative susceptibility mapping (QSM) on high-field MRI shows excellent diagnostic accuracy in the differential diagnosis of Parkinson's disease (PD) and multiple system atrophy (MSA). Particularly, putaminal susceptibility measures on ultra-high-field MRI can distinguish MSA patients from PD patients, allowing for an early and sensitive diagnosis of MSA.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Anna Behler, Hans-Peter Mueller, Albert C. C. Ludolph, Jan Kassubek
Summary: Diffusion tensor imaging (DTI) can be used to visualize white matter alterations in patients with amyotrophic lateral sclerosis (ALS), and machine learning (ML) models based on DTI parameters offer new opportunities for ALS diagnosis and patient stratification. To capture the full range of neuropathological signatures, DTI can be combined with other modalities, such as T1w 3-D MRI, in ML models. Standardized DTI protocols and multi-center collaborations are needed to validate multimodal DTI biomarkers for ALS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Jan Kassubek, Fabrizio Stocchi, Ernest Balaguer Martinez, Rajesh Pahwa, William Ondo, Yi Zhang, Alyssa Bowling, Eric Pappert, Stuart Isaacson, Stacy Wu
Summary: Most patients with Parkinson's disease were able to optimize the dosage of sublingual apomorphine at home and find their optimal dosage.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Neuroimaging
Maximilian Wiesenfarth, Hans-Juergen Huppertz, Johannes Dorst, Dorothee Lule, Albert C. Ludolph, Hans-Peter Mueller, Jan Kassubek
Summary: This study explores the MRI characteristics of C9orf72-associated ALS and finds significant alterations in both white matter and gray matter in the early stages of the disease.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.