Article
Cell Biology
Junqiu Jia, Lili Zheng, Lei Ye, Jian Chen, Shu Shu, Siyi Xu, Xinyu Bao, Shengnan Xia, Renyuan Liu, Yun Xu, Meijuan Zhang
Summary: Ischemic stroke leads to white matter damage and neurological deficits. In this study, the characteristics of white matter injury and repair after stroke were investigated using a mouse stroke model. The researchers found that white matter damage was most severe on Day 7 after the stroke, and gradually recovered from Day 7 to Day 30. They also discovered that CD11c(+) microglia play critical roles in white matter repair and functional recovery after stroke. These findings suggest that spontaneous white matter repair occurs after ischemic stroke, with CD11c(+) microglia being key players in this restorative process.
CELL DEATH & DISEASE
(2023)
Article
Endocrinology & Metabolism
Lingling Liu, Henan Liu, Zhiming Zhen, Yalan Zheng, Xiaoyue Zhou, Esther Raithel, Jiang Du, Yan Hu, Wei Chen, Xiaofei Hu
Summary: This study compared the effects of long-walking and regular daily physical training on knee joint injuries and cartilage structure in freshmen students. The results showed that the long-walking group had significantly higher injury to the medial meniscus and anterior cruciate ligament, joint effusion, and bone marrow edema compared to the baseline and daily groups. Moreover, the injury to the lateral meniscus was significantly worse in the long-walking group compared to the baseline group but was significantly better in the daily group compared to the baseline group. Knee cartilage volume was significantly increased in specific areas in both groups.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anneloes de Boer, Anita A. Harteveld, Bjorn Stemkens, Peter J. Blankestijn, Clemens Bos, Suzanne L. Franklin, Martijn Froeling, Jaap A. Joles, Marianne C. Verhaar, Nico van den Berg, Hans Hoogduin, Tim Leiner
Summary: The study assessed the intrasubject test-retest repeatability of renal MRI measurements in 19 healthy subjects, with most MRI measures showing good repeatability below 13%, except for perfusion fraction and perfusion as measured by DCE, which were above 13%.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Oncology
Alistair D. R. Grey, Rebecca Scott, Bina Shah, Peter Acher, Sidath Liyanage, Menelaos Pavlou, Rumana Omar, Frank Chinegwundoh, Prasad Patki, Taimur T. Shah, Sami Hamid, Maneesh Ghei, Kayleigh Gilbert, Diane Campbell, Chris Brew-Graves, Nimalan Arumainayagam, Alex Chapman, Laura McLeavy, Angeliki Karatziou, Zayneb Alsaadi, Tom Collins, Alex Freeman, David Eldred-Evans, Mariana Bertoncelli-Tanaka, Henry Tam, Navin Ramachandran, Sanjeev Madaan, Mathias Winkler, Manit Arya, Mark Emberton, Hashim U. Ahmed
Summary: Multiparametric ultrasound has slightly lower ability to detect clinically significant prostate cancer compared to multiparametric MRI, but it would result in more patients being referred for a biopsy. For patients at risk of prostate cancer who cannot undergo multiparametric MRI, multiparametric ultrasound can be considered as the first test.
Article
Biophysics
Camilla W. Rasmussen, Nikolaj Bogh, Sabrina K. Bech, Thomas H. Thorsen, Esben S. S. Hansen, Lotte B. Bertelsen, Christoffer Laustsen
Summary: Chronic kidney disease has significant implications for health and mortality, and there is a need for a noninvasive method to assess kidney fibrosis. This study explores the potential of a multiparametric MRI protocol, including sodium imaging, in assessing fibrosis. The results suggest that sodium imaging can partially predict fibrosis but its application in kidney disease remains uncertain.
NMR IN BIOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jia Sun, Xin Meng, Di Huang, Zipeng Gong, Chunhua Liu, Ting Liu, Jie Pan, Yuan Lu, Lin Zheng
Summary: The study revealed that the pharmacokinetic behavior and tissue distribution characteristics of the four major active components of CA were altered under the pathological state of functional dyspepsia, providing an experimental basis for the role of CA in treating functional dyspepsia.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Kun Cheng, Qi Duan, Jianxing Hu, Chenxi Li, Xiaoxiao Ma, Xiangbing Bian, Caohui Duan, Yongqin Xiong, Jiaji Lin, Haoxuan Lu, Linlin Deng, Ze Li, Mengting Wei, Jinhao Lyu, Ling Chen, Xin Lou
Summary: This study aimed to evaluate the diagnostic value of ultrahigh-field MRI for brain tumors. The results showed that 7T MRI can provide better visualization of brain tumor details and increase tumor detail diagnostic confidence.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Oncology
Leonhard Gruber, Christian Kremser, Bettina Zelger, Anton Schwabegger, Ena Josip, Dietmar Dammerer, Martin Thaler, Benjamin Henninger
Summary: This study aimed to differentiate between benign and atypical lipomatous tumors using MRI features and develop a scoring system. Several single MRI features were found to have significant diagnostic value, and a multiparametric approach may support radiologists in the identification of lipomatous tumors for further histological assessment.
Article
Oncology
Mirjam Gerwing, Emily Hoffmann, Katharina Kronenberg, Uwe Hansen, Max Masthoff, Anne Helfen, Christiane Geyer, Lydia Wachsmuth, Carsten Hoeltke, Bastian Maus, Verena Hoerr, Tobias Kraehling, Lena Hiddessen, Walter Heindel, Uwe Karst, Melanie A. Kimm, Regina Schinner, Michel Eisenblaetter, Cornelius Faber, Moritz Wildgruber
Summary: Multiparametric MRI can non-invasively differentiate the degree of malignancy in breast cancer models by assessing tumor features such as structural composition and endothelial permeability.
FRONTIERS IN ONCOLOGY
(2022)
Article
Plant Sciences
Genbei Wang, Ruijia Hao, Yu Liu, Yu Wang, Shuli Man, Wenyuan Gao
Summary: The study aimed to investigate the metabolism and distribution of Paris polyphylla var yunnanensis saponins in rats. Through LC-MS/MS analysis and various experimental methods, the concentration distribution of metabolites in different tissues and the characteristics of permeability and recovery were determined. The results provided a theoretical basis for the future application of this medicinal plant.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Linhu Ye, Lei Cheng, Yan Deng, Sen Wang, Xinyu Wu, Shuiping Ou, Qi Chang, Xinqian Zhao, Wen Zhou, Jinghua Yu, Zuqiang Wu
Summary: Licorice (Glycyrrhiza uralensis Fisch) is widely used in China as a food and herbal medication. The present study investigated the pharmacokinetic profile of Glycycoumarin (GCM), a major coumarin in licorice, in rats. The results showed that GCM was rapidly absorbed and transformed into its conjugated metabolites, with low bioavailability and widespread distribution in various tissues except the brain.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Raffaello Bonacchi, Alessandro Meani, Elisabetta Pagani, Olga Marchesi, Massimo Filippi, Maria A. Rocca
Summary: This study confirmed the relevance of cerebellar gray matter and connecting structures damage in explaining cognitive dysfunction and physical disability in multiple sclerosis patients. Data-driven MRI clustering analysis can improve our understanding of the correlation between MRI findings and clinical manifestations.
JOURNAL OF NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Wenhao Cheng, Siyang Wu, Zheng Yuan, Weiyu Hu, Xin Yu, Nianxin Kang, Qiutao Wang, Mingying Zhu, Kexin Xia, Wei Yang, Chen Kang, Shuofeng Zhang, Yingfei Li
Summary: Through a multicompound pharmacokinetic analysis, the tissue distribution and excretion characteristics of Radix Polygoni Multiflori (RPM) components were investigated. The findings showed that the active ingredients of RPM were quickly absorbed after oral administration and had high tissue distribution in the liver and kidney. These components were key contributors to the effectiveness and toxicity of RPM on the liver and kidney.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiangjun He, Zhi Zhong, Quan Wang, Zhenmao Jia, Jing Lu, Jianwen Chen, Peiqing Liu
Summary: Cryptotanshinone (CTS), derived from Salvia miltiorrhiza, has shown significant benefits in a rat model of pulmonary fibrosis induced by bleomycin. Pharmacokinetic studies revealed slow absorption, low bioavailability, and a slow clearance rate of CTS. Tissue distribution analysis showed higher exposure of CTS in the lungs and liver.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chengjiang Lin, Donghu Zhang, Shanshan Sun, Yue Shi, Chengda Yan, Jianyang Lin
Summary: The study investigated the pharmacokinetics and tissue distribution of ZCY-15 in rats using a LC-MS/MS method, revealing higher concentrations and lower clearance rates of ZCY-15 in female rats compared to male rats. ZCY-15 was found to pass through the blood-brain barrier and accumulate significantly in the hippocampus.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Neurosciences
Chiara Marzi, Alessandro d'Ambrosio, Stefano Diciotti, Alvino Bisecco, Manuela Altieri, Massimo Filippi, Maria Assunta Rocca, Loredana Storelli, Patrizia Pantano, Silvia Tommasin, Rosa Cortese, Nicola De Stefano, Gioacchino Tedeschi, Antonio Gallo
Summary: This study used machine learning techniques to assess the relationship between brain MRI structural volumes and cognitive deficits in MS patients, and found that damage to gray matter structures is most closely related to cognitive performance.
HUMAN BRAIN MAPPING
(2023)
Review
Clinical Neurology
Massimo Filippi, Paolo Preziosa, Douglas L. Arnold, Frederik Barkhof, Daniel M. Harrison, Pietro Maggi, Caterina Mainero, Xavier Montalban, Elia Sechi, Brian G. Weinshenker, Maria A. Rocca
Summary: The use of MRI in the diagnosis of MS has evolved considerably, with the introduction of the 2017 McDonald criteria and new MRI markers. Artificial intelligence tools may complement human assessment in improving diagnosis and patient classification.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Paolo Preziosa, Maria A. Rocca, Elisabetta Pagani, Paola Valsasina, Maria Pia Amato, Giampaolo Brichetto, Nicolo Bruschi, Jeremy Chataway, Nancy D. Chiaravalloti, Gary Cutter, Ulrik Dalgas, John DeLuca, Rachel Farrell, Peter Feys, Jennifer Freeman, Matilde Inglese, Alessandro Meani, Cecilia Meza, Robert W. Motl, Amber Salter, Brian M. Sandroff, Anthony Feinstein, Massimo Filippi
Summary: The study explores the associations among fatigue, dual-task performance and structural and functional abnormalities of frontal cortico-subcortical network in progressive multiple sclerosis (PMS). The results indicate that both structural and functional abnormalities contribute to fatigue and worse dual-task performance in PMS, with different patterns according to the presence of fatigue.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Monica Margoni, Elisabetta Pagani, Paolo Preziosa, Mor Gueye, Matteo Azzimonti, Maria A. Rocca, Massimo Filippi
Summary: This study used multimodal MRI to investigate the regional distribution of different pathological processes in the brain white and gray matter of relapse-onset multiple sclerosis (MS) patients. The results showed that compared to healthy controls, relapsing-remitting MS (RRMS) patients exhibited white matter, deep gray matter, and cortical atrophy, as well as significantly lower MTR and T1w/T2w ratio in periventricular and infratentorial white matter, deep gray matter, and several cortical areas. Secondary progressive MS (SPMS) patients showed more severe deep gray matter and widespread cortical atrophy, lower MTR of periventricular white matter, deep gray matter, and cerebellum, lower T1w/T2w ratio of fronto-temporal white matter regions, lower ICV_f of some fronto-tempo-occipital white matter and cortical areas, and increased QSM and T1w/T2w ratio in the pallidum.
JOURNAL OF NEUROLOGY
(2023)
Correction
Clinical Neurology
Chiara Zanetta, Maria A. Rocca, Alessandro Meani, Vittorio Martinelli, Laura Ferre, Lucia Moiola, Massimo Filippi
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nicolo Tedone, Paolo Preziosa, Alessandro Meani, Elisabetta Pagani, Carmen Vizzino, Massimo Filippi, Maria A. Rocca
Summary: In this study, the researchers investigated whether the regional distribution of white matter lesions, normal-appearing white matter microstructural abnormalities, and gray matter atrophy contribute differently to cognitive performance in MS patients based on their sex. The study found that in female MS patients, the association between white matter lesions and microstructural abnormalities with cognitive performance, especially global cognition, is stronger. In contrast, male MS patients showed worse performance on verbal memory tasks.
MOLECULAR PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Giovanni Napoli, Martina Rubin, Gianni Cutillo, Paride Schito, Tommaso Russo, Angelo Quattrini, Massimo Filippi, Nilo Riva
Summary: This study summarizes four cases of amyotrophic lateral sclerosis (ALS) patients with Tako-Tsubo syndrome (TTS) and reviews the relevant literature, revealing the association between ALS and TTS. Among these cases, one ALS patient developed TTS during hospitalization, and three additional cases with ALS-TTS were identified retrospectively. The study found that cardiovascular autonomic dysfunction in ALS is especially pronounced in cases with bulbar involvement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Loredana Storelli, Elisabetta Pagani, Martina Rubin, Monica Margoni, Massimo Filippi, Maria A. A. Rocca
Summary: This study developed an accurate and easily implementable method for automatic choroid plexus segmentation in multiple sclerosis using T1-weighted and FLAIR MRI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Teuta Domi, Paride Schito, Giacomo Sferruzza, Tommaso Russo, Laura Pozzi, Federica Agosta, Paola Carrera, Nilo Riva, Massimo Filippi, Angelo Quattrini, Yuri Matteo Falzone
Summary: This study aims to outline the clinical features of SOD1-ALS patients by comparing them to patients without ALS major gene variants and patients with variants in other major ALS genes. Defining the SOD1-ALS phenotype can assist clinicians in identifying patients who should be prioritized for genetic testing.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Massimo Filippi, Camilla Cividini, Silvia Basaia, Edoardo G. G. Spinelli, Veronica Castelnovo, Michela Leocadi, Elisa Canu, Federica Agosta
Summary: This study aimed to evaluate the impact of aging on the functional connectivity of pivotal regions in the human brain connectome and to examine whether these effects influence the overall functional and structural changes of the brain. By analyzing functional connectivity and cortical thinning data, it was found that aging leads to changes in functional connectivity of key regions and affects the structural alterations of specific brain regions.
MOLECULAR PSYCHIATRY
(2023)
Review
Psychiatry
Monica Margoni, Paolo Preziosa, Maria A. A. Rocca, Massimo Filippi
Summary: Neuropsychiatric abnormalities in multiple sclerosis (MS) can be categorized into mood, affect, and behavior disorders and abnormalities affecting cognition. These manifestations have a significant impact on patients' quality of life and treatment adherence, especially in progressive and more severe forms of the disease. The pathogenesis of these manifestations is not fully understood yet, but brain structural and functional abnormalities observed with MRI, along with genetic and immunologic factors, play important roles. However, these symptoms are often overlooked in clinical practice, and the efficacy of available treatments is limited due to multiple underlying mechanisms and methodological limitations. A better evaluation and understanding of these manifestations may lead to the development of personalized treatment strategies.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Clinical Neurology
M. Petracca, A. Carotenuto, C. Scandurra, M. Moccia, L. Rosa, S. Arena, A. Ianniello, A. Nozzolillo, M. Turrini, L. M. Streito, G. Abbadessa, M. Cellerino, S. Bucello, E. Ferraro, M. Mattioli, A. Chiodi, M. Inglese, S. Bonavita, M. Clerico, C. Cordioli, L. Moiola, F. Patti, L. Lavorgna, M. Filippi, G. Borriello, E. D. Amico, C. Pozzilli, V. Brescia Morra, R. Lanzillo
Summary: This study investigated the impact of different cut-offs in the MSISQ-19 on the prevalence of sexual dysfunction (SD) and associated risk factors in people with MS. Depending on the chosen cut-off, 45% to 54% of individuals with MS reported SD. SD defined as an MSISQ-19 score >30 was associated with age, cognition, and anxiety, while SD defined as a score >3 on any MSISQ-19 item was associated with motor disability and cognition. These findings highlight the importance of considering the chosen cut-off when planning studies and interpreting data.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Audiology & Speech-Language Pathology
Roberto Teggi, Bruno Colombo, Iacopo Cangiano, Omar Gatti, Mario Bussi, Massimo Filippi
Summary: Meniere's disease and vestibular migraine (VM) are two common inner ear disorders. Recurrent Vestibular Symptoms-Not Otherwise Specified (RVS-NOS) refers to patients who experience recurring episodes of vertigo but do not fulfill the criteria for either disease. This study aimed to compare RVS-NOS with VM in terms of clinical history, bedside examination, and family history. The findings showed similarities between the two disorders, including age of onset, duration of attacks, motion sickness, and family history. However, some aspects suggest that RVS-NOS may be a heterogeneous disorder.
AUDIOLOGY RESEARCH
(2023)
Article
Clinical Neurology
Loredana Storelli, Elisabetta Pagani, Patrizia Pantano, Antonio Gallo, Nicola De Stefano, Maria A. Rocca, Massimo Filippi
Summary: The use of FSL-MIST multimodal segmentation method improves the robustness of results and enables better detection of small variations in thalamic volumes.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Meeting Abstract
Clinical Neurology
S. Chatfield, L. Connolly, J. Freeman, A. Salter, M. P. Amato, G. Brichetto, J. Chataway, N. D. Chiaravalloti, G. Cutter, J. DeLuca, U. Dalgas, R. Farrell, P. Feys, M. Inglese, C. Meza, N. B. Moore, R. W. Motl, M. A. Rocca, B. M. Sandroff, A. Feinstein
MULTIPLE SCLEROSIS JOURNAL
(2023)
