Article
Gastroenterology & Hepatology
Xiu-Cai Fang, Wen-Juan Fan, Douglas D. Drossman, Shao-Mei Han, Mei-Yun Ke
Summary: This study compared bowel symptoms and psychosocial features in IBS patients diagnosed with Rome III criteria with abdominal discomfort, abdominal pain, and pain & discomfort. The results showed that IBS patients with abdominal discomfort have similar bowel symptoms and psychosocial features to those with abdominal pain.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Kevin Vervier, Stephen Moss, Nitin Kumar, Anne Adoum, Meg Barne, Hilary Browne, Arthur Kaser, Christopher J. Kiely, B. Anne Neville, Nina Powell, Tim Raine, Mark D. Stares, Ana Zhu, Juan De la Revilla Negro, Trevor D. Lawley, Miles Parkes
Summary: Reducing FODMAPs can be beneficial for IBS, with 50% of cases showing a 'pathogenic' gut microbial signature that improved with a low FODMAP diet. IBSP cases demonstrated enhanced clinical responsiveness to the dietary therapy, indicating that microbiota signatures could serve as biomarkers for guiding IBS treatment and investigating pathogenic mechanisms.
Review
Pediatrics
Robyn Rexwinkel, Arine M. Vlieger, Miguel Saps, Merit M. Tabbers, Marc A. Benninga
Summary: Disorders of the gut-brain interaction have a negative impact on quality of life and socio-economic burden. The understanding and guidelines for the treatment of functional abdominal pain disorders in children are lacking, making their management challenging. It is important to make an accurate diagnosis of irritable bowel syndrome or functional abdominal pain-not otherwise specified in children with chronic abdominal pain to prevent unnecessary referrals and costs.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
Pr. Benoit Coffin, Henri Duboc
Summary: Persistent abdominal pain is a challenging condition often misdiagnosed as functional disorders. This article provides an update on less well-known causes of abdominal pain and their diagnosis and management.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Pharmacology & Pharmacy
Michael Camilleri, Saam Dilmaghani
Summary: This narrative review provides an update on current approaches for the treatment of pain, global symptoms, or relief in irritable bowel syndrome (IBS). The review evaluates medications, dietary interventions, fecal microbial transplantation (FMT), electrical approaches, and behavioral therapies. The evidence suggests only modest benefit in global IBS symptoms and pain relief. A future approach involving validated biomarkers could individualize treatment and improve outcomes.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Congzhen Wang, Xiucai Fang
Summary: Irritable bowel syndrome (IBS) and functional dyspepsia (FD) are common functional gastrointestinal disorders that often overlap with each other. The pathogenesis of these disorders is complex, involving various factors, with limited studies focusing on the inflammatory mechanism in patients with overlap syndrome of IBS-FD.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Letter
Gastroenterology & Hepatology
Cong Dai, Yu-Hong Huang, Min Jiang
Summary: This article is connected to the papers of Marasco et al. To access these papers, visit and
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Nutrition & Dietetics
Chiara Ricci, Fernando Rizzello, Maria Chiara Valerii, Enzo Spisni, Paolo Gionchetti, Silvia Turroni, Marco Candela, Federica D'Amico, Renato Spigarelli, Irene Bellocchio, Giovanni Marasco, Giovanni Barbara
Summary: Geraniol, an acyclic monoterpene alcohol, has demonstrated anti-inflammatory and antimicrobial properties and positive effects on gut microbiota in IBS patients. In this study, IBS patients treated with a low-absorbable geraniol food supplement (LAGS) showed a significant reduction in IBS symptoms severity score compared to placebo. Geraniol administration also resulted in changes in gut microbiota composition, with a decrease in Oscillospira and an increase in Faecalibacterium. The findings suggest that LAGS is effective in treating overall IBS symptoms and improving gut microbiota profile, particularly in the IBS mixed subtype.
Review
Gastroenterology & Hepatology
Iam van Thiel, W. J. de Jonge, R. M. van den Wijngaard
Summary: Although the gut microbiota consists of bacteria, viruses, and fungi, most studies on the microbiota-gut-brain axis in IBS have primarily focused on bacteria due to their higher presence. However, recent research on the intestinal mycobiome in inflammatory bowel disease suggests that the low numbers of fungi and viruses may still have relevance. This review discusses the current IBS mycobiome data and how these findings could relate to previous observations in IBS, as well as identifies questions for future research.
Review
Gastroenterology & Hepatology
Vivek C. Goodoory, Mais Khasawneh, Christopher J. Black, Eamonn M. M. Quigley, Paul Moayyedi, Alexander C. Ford
Summary: This article conducted a meta-analysis to study the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS). The study found that certain combinations of probiotics or strains may be beneficial for IBS, but the certainty of the evidence was low.
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Letter
Gastroenterology & Hepatology
Giovanni Marasco, Marcello Maida, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara
Summary: This article is connected to Marasco et al papers. To view these articles, visit and...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
David Deutsch, Michel Bouchoucha, Julien Uzan, Jean-Jacques Raynaud, Jean-Marc Sabate, Robert Benamouzig
Summary: The severity of abdominal pain is associated with bloating severity in patients with functional bowel disorders, with differences in associations based on gender and specific phenotype. In female patients, severity of abdominal pain is negatively associated with age and positively associated with depression, constipation severity, and diarrhea severity. In male patients, severity of abdominal pain is associated with state anxiety, constipation severity, and diarrhea severity.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Medicine, General & Internal
Mustafa Abdul Karim, Nadeen Al-Baz, Peter M. Haddad, Shuja M. Reagu, Majid Alabdulla
Summary: This case study suggests that buspirone is effective in treating refractory IBS. Further research is needed to evaluate the role of buspirone in IBS management.
Article
Gastroenterology & Hepatology
Giovanni Marasco, Marcello Maida, Cesare Cremon, Maria Raffaella Barbaro, Vincenzo Stanghellini, Giovanni Barbara
Summary: This meta-analysis aimed to estimate the incidence of post-COVID-19 functional dyspepsia (FD) and irritable bowel syndrome (IBS). The analysis found that COVID-19 survivors are at a higher risk of developing IBS compared to controls, while data for FD are inconclusive.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Allergy
Ida Mogensen, Charlotta Flodstrom, Anna Nopp, Erik Melen, Anna Bergstrom, Inger Kull
Article
Pediatrics
Maria Ulnes, Henrik Albrektsson, Ketil Stordal, Robert Saalman, Jonas F. Ludvigsson, Karl Marild
Summary: The aim of this study was to examine the clinical follow up of paediatric coeliac disease and the rate of loss of follow up during childhood. The results showed that 14% of the coeliac patients were lost to follow up after an average of 5.3 years since diagnosis. The patients who were lost to follow up were more often boys and had a slightly longer average disease duration.
Editorial Material
Gastroenterology & Hepatology
Xiaoying Kang, Shengxin Liu, Jonas F. Ludvigsson
Summary: This article is related to the papers by Kang et al. To access these articles, please visit...
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Gastroenterology & Hepatology
Hannes Hagstroem, Jonas F. F. Ludvigsson
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Xiaoying Kang, Shengxin Liu, Bjorn Roelstraete, Hamed Khalili, Jonas F. Ludvigsson
Summary: This study examined the association between type 1 diabetes (T1D) and microscopic colitis (MC). The results showed that the prevalence of T1D was almost 80% higher in MC patients compared to the general population. This association may be related to the consumption of medications associated with MC onset.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Haley M. Zylberberg, Benjamin Lebwohl, Bjorn Roelstraete, Jonas Soederling, Olof Stephansson, Peter H. R. Green, Jonas F. Ludvigsson
Summary: This study aimed to investigate the risk of cardiac birth defects in infants born to mothers with celiac disease (CeD). The results showed no statistically significant association between maternal CeD and the risk of any or cardiac birth defects in the offspring, compared to the general population and non-affected siblings.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Fahim Ebrahimi, Tracey G. Simon, Hannes Hagstrom, Jonas Soderling, Axel Wester, Bjorn Roelstraete, Jonas F. Ludvigsson
Summary: Patients with biopsy-proven NAFLD have a significantly higher risk of developing severe infections requiring hospitalization compared to the general population and their siblings. The risk of infection increases with the severity of NAFLD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Jonas F. Ludvigsson
Article
Surgery
Andreas Wallhuss, Johan Ottosson, Yang Cao, Ellen Andersson, Daniel Bergemalm, Carl Eriksson, Ola Olen, Eva Szabo, Erik Stenberg
Summary: This study aimed to evaluate the safety and effectiveness of bariatric surgery in obese patients with inflammatory bowel disease. The results showed that sleeve gastrectomy was a safe and effective option for weight loss in patients with both Crohn's disease and ulcerative colitis, while Roux-en-Y gastric bypass was associated with a higher risk of postoperative complications in patients with ulcerative colitis.
Review
Behavioral Sciences
Erland Axelsson, Dorian Kern, Erik Hedman-Lagerlof, Perjohan Lindfors, Josefin Palmgren, Hugo Hesser, Erik Andersson, Robert Johansson, Ola Olen, Marianne Bonnert, Maria Lalouni, Brjann Ljotsson
Summary: This systematic review and meta-analysis examined the effects of various psychological treatments on irritable bowel syndrome (IBS). The results showed that exposure therapy and hypnotherapy had significant additional effects compared to attention controls. Exposure therapy was found to be a particularly promising treatment for IBS.
COGNITIVE BEHAVIOUR THERAPY
(2023)
Article
Public, Environmental & Occupational Health
Patrik Nasr, Erik von Seth, Raphaela Mayerhofer, Nelson Ndegwa, Jonas F. F. Ludvigsson, Hannes Hagstrom
Summary: The incidence rates of non-alcoholic fatty liver disease, alcohol-related cirrhosis, unspecified liver cirrhosis, and liver malignancies have increased in Sweden over the last 15 years. There has also been an increase in mortality rates for several liver diseases. Significant disparities across sex and geographical regions need to be considered when allocating healthcare resources.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fahim Ebrahimi, Tracey G. Simon, Hannes Hagstrom, Jiangwei Sun, David Bergman, Anders Forss, Bjorn Roelstraete, Lars Engstrand, Jonas F. Ludvigsson
Summary: Antibiotic use may increase the risk of developing nonalcoholic fatty liver disease (NAFLD), especially in individuals without metabolic syndrome. Fluoroquinolones were found to have the highest risk, and the associations remained robust in sibling comparisons.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Bjorn Roelstraete, Emma Svennberg, Jonas Halfvarson, Johan Sundstrom, Anders Forss, Ola Olen, Jonas F. Ludvigsson
Summary: This study found that patients with inflammatory bowel disease (IBD) have an increased risk of developing arrhythmias. This increased risk persists even 25 years after the diagnosis of IBD.
Article
Allergy
M. B. Gea Kiewiet, Christian Lupinek, Susanne Vrtala, Sandra Wieser, Alexandra Baar, Renata Kiss, Inger Kull, Erik Melen, Magnus Wickman, Daniela Porta, Davide Gori, Ulrike Gehring, Rob Aalberse, Jordi Sunyer, Marie Standl, Joachim Heinrich, Dagmar Waiblinger, John Wright, Josep M. Anto, Jean Bousquet, Marianne van Hage, Rudolf Valenta
Summary: The study analyzed the IgE sensitization profiles in more than 2800 children from different regions of Europe and found regional, exposome- and climate-dependent differences in molecular IgE-reactivity profiles. These findings provide the basis for precision medicine-based approaches for allergy treatment and prevention.
Letter
Gastroenterology & Hepatology
Kyle Staller, Jonas F. Ludvigsson
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)