Article
Gastroenterology & Hepatology
Ming-Wun Wong, Chih-Hsun Yi, Tso-Tsai Liu, Wei-Yi Lei, Jui-Sheng Hung, Chao-Zong Liu, Chien-Lin Chen
Summary: This study investigated the effects of sildenafil on secondary peristalsis using HRM and found that sildenafil reduces the success rate and vigor of secondary peristalsis, similar to its effects on primary peristalsis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Rebekah Jaung, Chris Varghese, Anthony Y. Lin, Niranchan Paskaranandavadivel, Peng Du, David Rowbotham, Phil Dinning, Gregory O'Grady, Ian Bissett
Summary: In the first high-resolution colonic manometry study of patients with diverticular disease, there was no evidence found for increased manometric pressures or greater colonic activity in diverticulosis patients. Post-meal, patients with diverticulosis had shorter distance of propagation in both descending and sigmoid colon, indicating potential differences in colonic activity compared to healthy controls.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Hui Su, Amanda J. Krause, Melina Masihi, Jacqueline Prescott, Alex Decorrevont, Emma Germond, Dave Karasik, Wenjun Kou, John E. Pandolfino, Dustin A. Carlson
Summary: This study investigated a comprehensive HRM testing protocol on 30 healthy asymptomatic volunteers, reporting normal values and findings. Isolated abnormalities of IRP and contractile parameters were observed in 80% of subjects, while all subjects also displayed normal features.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Chien-Lin Chen, Ming-Wun Wong, Jui-Sheng Hung, Shu-Wei Liang, Tso-Tsai Liu, Chih-Hsun Yi, Lin Lin, William C. Orr, Wei-Yi Lei
Summary: The study investigated the effects of acute administration of codeine on primary and secondary peristalsis in healthy adults. Results showed that codeine increased the relaxation pressure and frequency of secondary peristalsis, while also affecting primary peristalsis by increasing relaxation pressure and shortening distal latency. This suggests that opioids like codeine can impact both primary and secondary peristalsis in the esophagus.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Anh D. Nguyen, Ashton Ellison, Chanakyaram A. Reddy, Roseann Mendoza, Eitan Podgaetz, Marc A. Ward, Rhonda F. Souza, Stuart J. Spechler, Vani J. A. Konda
Summary: This case series demonstrates that treatments targeting spastic secondary contractions identified by FLIP panometry can result in symptomatic improvement in patients with no obstructive disorder and no diagnostic motility disorder on HRM. In such patients, we have identified the novel HRM finding of mid-vertical pressurization, which might be the manometric manifestation of spasm limited to the mid-esophagus.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Shu-Wei Liang, Jui-Sheng Hung, Ming-Wun Wong, Tso-Tsai Liu, Chih-Hsun Yi, Lin Lin, William C. Orr, Chien-Lin Chen
Summary: Intraluminal infusion of menthol reduces upper esophageal sphincter basal pressure and inhibits the frequency of secondary peristalsis. Although menthol modulates esophageal peristalsis, it does not alter other esophageal motility characteristics significantly.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Jasper Pannemans, Tim Vanuytsel, Ans Pauwels, Nathalie Rommel, Heiko De Schepper, Tze J. Lam, Alexander Thys, Jan Tack
Summary: Colonic high-resolution manometry (HRM) is a novel diagnostic method used in chronic constipation. This study aimed to determine agreement for motor pattern identification with HRM, and results showed substantial or high interobserver agreement for most motor patterns, supporting its use in clinical and research settings.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Wenjun Kou, Galal Osama Galal, Matthew William Klug, Vladislav Mukhin, Dustin A. Carlson, Mozziyar Etemadi, Peter J. Kahrilas, John E. Pandolfino
Summary: This study developed and evaluated a deep learning AI model for automatic classification of swallow types based on raw HRM data. The model achieved high accuracies in training/validation/test datasets and accurately classified peristalsis at study level. The misclassifications were mainly adjacent categories, indicating the need for further refinement and incorporation of overall manometric diagnoses in future work.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Tso-Tsai Liu, Jen-Hung Wang, Chih-Hsun Yi, Jui-Sheng Hung, Ming-Wun Wong, Chandra Prakash Gyawali, Chien-Lin Chen
Summary: The study found significant defects in the triggering of secondary peristalsis in GERD patients, particularly those with IEM. This can be characterized by HRM to show differences in esophageal secondary peristalsis between patients with and without IEM.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Computer Science, Interdisciplinary Applications
Niranchan Paskaranandavadivel, Anthony Y. Lin, Leo K. Cheng, Ian Bissett, Andrew Lowe, John Arkwright, Saeed Mollaee, Phil G. Dinning, Gregory O'Grady
Summary: An automated system was developed to identify propagating contractions in cHRM recordings, showing reliability and accuracy. The system was found to be effective and efficient, significantly reducing analysis time compared to manual identification.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2021)
Article
Gastroenterology & Hepatology
David O. Prichard, Jeffrey Fetzer
Summary: This study suggests that constipated men and women exhibit different recto-anal pressure patterns, with women being more prone to defecatory disorders and men being more likely to have abnormal balloon expulsion tests. These findings are independent of sex-specific physiological differences.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Cameron I. I. Wells, James A. A. Penfold, Nira Paskaranandavadivel, David Rowbotham, Peng Du, Sean Seo, Armen Gharibans, Ian P. P. Bissett, Greg O'Grady
Summary: This study used high-resolution manometry to evaluate distal colonic motility after right-sided colectomy. The results showed that hyperactive cyclic motor patterns emerged in the distal colon after surgery, occupying 81.8% of the recording. These patterns gradually resolved during the first 4 postoperative days. Other abnormal repetitive hyperactive patterns may contribute to prolonged ileus development.
DISEASES OF THE COLON & RECTUM
(2023)
Correction
Gastroenterology & Hepatology
Rebekah Jaung, Chris Varghese, Anthony Y. Lin, Niranchan Paskaranandavadivel, Peng Du, David Rowbotham, Phil Dinning, Gregory O'Grady, Ian Bissett
Summary: The article contained an error in the unit used for 'Distance of propagation', which should be in 'cm' instead of 'mm' throughout the manuscript.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Deepika Razia, Amy Trahan, Chengcheng Hu, Luca Giulini, Ross M. Bremner, Sumeet K. Mittal
Summary: The study aimed to investigate the correlation between upright and prone bolus transit time (BTT) on barium esophagography (BE), esophageal peristalsis on high-resolution manometry (HRM), and self-reported dysphagia in patients. The results showed that prone BTT correlated with the proportion of normal esophageal swallows and dysphagia.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Chen Xu, Jiying Cong, Tingting Liu, Chenmeng Jiao, Mingsen Li, Yongjun Yu, Zhao Zhang, Shiwu Zhang, Yuwei Li
Summary: This study utilized high-resolution colonic manometry to evaluate the colonic motility in patients with slow transit constipation (STC). The study found that STC patients had lower occurrence rate and times of high amplitude propagated contraction (HAPC) compared to healthy controls (HCs). The characteristics of HAPC contraction, including length, amplitude, area under the curve (AUC) of pressure wave, and duration, were reduced in STC patients. The study also classified STC patients into four types based on HRCM characteristics and provided treatment recommendations.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Paul T. Heitmann, Reizal Mohd Rosli, Lyn Maslen, Lukasz Wiklendt, Raghu Kumar, Taher I. Omari, David Wattchow, Marcello Costa, Simon J. Brookes, Phil G. Dinning
Summary: This study utilized high-resolution impedance manometry to investigate colonic motor patterns and gas transit in healthy volunteers. Results showed an increase in the prevalence of the 2-8/minute cyclic motor pattern and propagation of impedance events after a meal or gas insufflation. The temporal association between propagating contractions and gas transit supports the hypothesis that the 2-8/minute cyclic motor pattern acts as a physiological brake modulating rectal filling.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Urology & Nephrology
Luke A. Parkinson, Paivi K. Karjalainen, Shayanti Mukherjee, Anthony W. Papageorgiou, Mugdha Kulkarni, John W. Arkwright, Natharnia Young, Jerome A. Werkmeister, Miranda Davies-Tuck, Caroline E. Gargett, Anna Rosamilia
Summary: This study measured the pressure applied to the anterior and posterior vaginal walls in a group of 46 patients using a fiber-optic pressure sensor and found that this correlated with vaginal parity and pelvic organ prolapse (POP). Previous vaginal birth was associated with decreased anterior pressure during pelvic floor muscle contraction (MVC), and women with Stage 2 posterior prolapse had lower MVC pressure in the midvagina compared to those with Stage 0/1. However, no difference was found in resting tissue resistance (RTR) according to previous vaginal birth or stage of prolapse.
NEUROUROLOGY AND URODYNAMICS
(2022)
Review
Surgery
Charles H. Knowles, Phil Dinning, S. Mark Scott, Michael Swash, Stefan de Wachter
Summary: The pathophysiology of fecal incontinence is not solely dependent on barrier mechanisms of fecal containment, but also involves reflex control of rectal contractility. A revised understanding implicates the barrier as a reflex controller of rectal function, providing a better explanation for clinical observations.
ANNALS OF LAPAROSCOPIC AND ENDOSCOPIC SURGERY
(2022)
Article
Gastroenterology & Hepatology
Anthony Y. Lin, Chris Varghese, Niranchan Paskaranandavadivel, Sean Seo, Peng Du, Phil Dinning, Ian P. Bissett, Greg O'Grady
Summary: The rectosigmoid brake was suppressed in patients with faecal incontinence, and sacral neuromodulation (SNM) may exert a therapeutic effect by modulating this rectosigmoid brake.
COLORECTAL DISEASE
(2022)
Review
Gastroenterology & Hepatology
Hannah M. E. Evans-Barns, Melissa Y. Tien, Misel Trajanovska, Mark Safe, John M. Hutson, Phil G. Dinning, Sebastian K. King
Summary: This systematic review evaluated the available evidence on post-operative colonic motility in children with anorectal malformations and assessed the equipment and protocols used for colonic manometry in this cohort. The review found limited evidence on post-operative colonic motility and a lack of high-resolution manometry results. Future research should focus on standardized manometry protocols and robust reporting of surgical characteristics, bowel function, and manometric outcomes.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Sport Sciences
Stephanie K. Gaskell, Rebecca Burgell, Lukasz Wiklendt, Phil Dinning, Ricardo J. S. Costa
Summary: This study showed that running for 2 hours at 60% V?O2max in hot ambient conditions can affect gastric myoelectrical activity and orocecal transit time, leading to increased gastrointestinal symptoms incidence and severity in hot conditions.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2022)
Article
Gastroenterology & Hepatology
Paul T. Heitmann, Lauren Keightley, Lukasz Wiklendt, David A. Wattchow, Simon S. J. Brookes, Nicholas J. Spencer, Marcello Costa, Phil G. Dinning
Summary: This study aimed to describe the effects of loperamide on neuromuscular function in the human colon. The findings suggest that loperamide primarily alters colonic function by acting on inhibitory motor neurons or alternative non-opioid receptor pathways.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Physiology
Stephanie K. Gaskell, Rebecca Burgell, Lukasz Wiklendt, Phil G. Dinning, Ricardo J. S. Costa
Summary: The study aimed to determine the impact of exercise duration on gastrointestinal functional responses and symptoms. It found that exercise is associated with changes in gastric myoelectrical activity, leading to a reduction in gastric motility and slower gastric transit time. This may explain the high incidence and severity of exercise-associated gastrointestinal symptoms.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Wai Ping Yew, Adam Humenick, Bao Nan Chen, David A. Wattchow, Marcello Costa, Phil G. Dinning, Simon J. H. Brookes
Summary: Ex vivo intracellular recordings and dye fills, combined with immunohistochemistry, are used to analyze the enteric nervous system of laboratory animals. Treatment with a collagenase/neutral protease mix improves recording success and reduces damage. Most dye-filled myenteric neurons are uni-axonal, and there is a low correlation between morphology and electrophysiology. Neurons immunoreactive for nitric oxide synthase are more excitable and distinctive grooves on the neuron surface may represent preferential sites of synaptic inputs.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Neurosciences
Michaela E. Johnson, Adam Humenick, Rochelle A. Peterson, Marcello Costa, David A. Wattchow, Tiong Cheng Sia, Phil G. Dinning, Simon J. H. Brookes
Summary: Ascending nerves in the human colon can be distinguished using GLUT1 labelling combined with NF200.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Physiology
David J. J. Smolilo, Timothy J. J. Hibberd, Marcello Costa, Phil G. G. Dinning, Lauren J. J. Keightley, Dayan De Fontgalland, David A. Wattchow, Nick J. J. Spencer
Summary: The speed of pellet propulsion in the isolated guinea pig distal colon in vitro is higher than in vivo measurements, suggesting inhibitory mechanisms from outside the gut. The study aimed to investigate the effects of sympathetic nerve stimulation on different motor behaviors of the distal colon. Results showed that electrical stimulation of colonic nerves inhibited transient neural events (TNEs) and pellet propulsion, while significant inhibition of colonic motor complexes (CMCs) required higher frequencies of stimulation. The findings suggest differential sensitivities to sympathetic input among distinct neurogenic motor behaviors of the colon and raise the possibility of paradoxical effects of CMCs on pellet movement suppression in vivo.
PHYSIOLOGICAL REPORTS
(2023)
Review
Medicine, General & Internal
Hannah M. E. Evans-Barns, Melissa Y. Tien, Misel Trajanovska, Mark Safe, John M. Hutson, Phil G. Dinning, Sebastian K. King
Summary: Despite surgical correction, long-term bowel dysfunction can occur in children with anorectal malformations, including fecal incontinence and evacuation disorders. Anorectal manometry is commonly used to assess anorectal function in this population, but there is a lack of standardized protocols and interpretation. This systematic review evaluated existing data on anorectal manometry results in children following anorectal malformation repair and highlighted the need for standardized protocols to enhance comparability and clinical relevance.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Hannah M. E. Evans-Barns, Liesel Porrett, Penelope L. Hartmann, Jessica Taranto, Suzie Jackson-Fleurus, Phil G. Dinning, John M. Hutson, Warwick J. Teague, Sebastian K. King
Summary: This study evaluated the findings and completeness of screening after the implementation of standardized protocols. The results showed that complete screening can accurately diagnose associated anomalies in patients with anorectal malformation. Compared with previous data, the proportion of complete screening significantly increased after the implementation of standardized protocols.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Proceedings Paper
Gastroenterology & Hepatology
Simon Brookes, Nan Chen, Adam Humenick, Marcello Costa, Phil Dinning, Paul Heitmann, Dominic Parker, David Smolilo, Nick J. Spencer, David Wattchow
Summary: Distinguishing and characterizing different classes of neurons in the enteric nervous system is a long-term goal for neuroscientists. While studies on enteric neurons in laboratory animals have been extensive, research on the human enteric nervous system is less advanced. Recent studies using single cell sequencing have made progress in classifying enteric neurons in mice and humans, but a comprehensive classification is yet to be achieved. This study presents preliminary data on a method to distinguish classes of myenteric neurons in the human colon using immunohistochemical, morphological, projection, and size data on single cells.
ENTERIC NERVOUS SYSTEM II
(2022)
Proceedings Paper
Gastroenterology & Hepatology
Marcello Costa, Luke Wiklendt, Tim Hibberd, Phil Dinning, Nick J. Spencer, Simon Brookes
Summary: Over 150 years ago, methods for quantitative analysis of gastrointestinal motor patterns first appeared. Recently, the development of spatiotemporal mapping techniques has allowed for more detailed understanding of gut wall status and the role of enteric circuits and pacemaker cells in complex motor patterns.
ENTERIC NERVOUS SYSTEM II
(2022)